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In the implementation part of the study, the COMSOL program\u2019s top-notch modeling of a detailed investigation of how a scaffold\u2019s in vivo diffusion affects injured neurons. Michaelis\u2013Menten kinetics is used to characterize the enzyme process of releasing the outer covering shell of the scaffold, PGA, from a biomaterial matrix to the nerve cell. Results suggested that the injectable hydrogel scaffold theoretically reduces extracellular glutamate concentrations, presenting a potential mechanism to mitigate localized excitotoxicity. Future in vivo experimental validation is required to determine if this reduction prevents neural cell death<\/jats:p>","DOI":"10.3390\/nano16100638","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T15:02:27Z","timestamp":1779375747000},"page":"638","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Modeling Release Scaffolds for Spinal Cord Tissue Regeneration After Injury Using COMSOL Simulation"],"prefix":"10.3390","volume":"16","author":[{"given":"Tasnim Hasan","family":"Al Dabbas","sequence":"first","affiliation":[{"name":"Institute of Nanotechnology, Jordan University of Science and Technology, Irbid 22110, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7279-3324","authenticated-orcid":false,"given":"Ayat","family":"Bozeya","sequence":"additional","affiliation":[{"name":"Institute of Nanotechnology, Jordan University of Science and Technology, Irbid 22110, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3142-6894","authenticated-orcid":false,"given":"Ali","family":"Al Dabbas","sequence":"additional","affiliation":[{"name":"Jordan Atomic Energy Commission, Shafa Badran, P.O. 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