{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T14:06:19Z","timestamp":1779890779667,"version":"3.53.1"},"reference-count":30,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:00:00Z","timestamp":1779840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Sichuan Science and Technology Program","award":["2024YFTX0075"],"award-info":[{"award-number":["2024YFTX0075"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nanomaterials"],"abstract":"<jats:p>Current antibacterial sprays face major limitations, including rapid evaporation, short-lived efficacy, skin irritation, and poor adhesion to surfaces, highlighting an urgent need for a durable and biocompatible alternative. To address these challenges, we developed a ZIF-8-based spray (ZNS-WO20) composed of ZIF-8 nanoparticles dispersed in 50% ethanol and 20% OTES. OTES acts as a dispersant and binder, enabling wash-resistant coatings on gauze and glass. ZIF-8 exhibits pH-responsive Zn2+ release, achieving nearly 100% killing of S. aureus, E. coli, and methicillin-resistant S. aureus (MRSA) at 160 \u03bcg\/mL through intracellular reactive oxygen species (ROS) generation. The spray maintains &gt;95% antibacterial efficacy against S. aureus after five washing cycles and seven days of outdoor exposure, and causes no dermal irritation in rats. This work fills the gap for a long-lasting, skin-friendly antibacterial spray, showing promise for healthcare disinfection and surface protection.<\/jats:p>","DOI":"10.3390\/nano16110672","type":"journal-article","created":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T12:31:56Z","timestamp":1779885116000},"page":"672","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Biocompatible ZIF-8 Spray and Its Long-Lasting Antibiosis"],"prefix":"10.3390","volume":"16","author":[{"given":"Jiaxi","family":"Xia","sequence":"first","affiliation":[{"name":"School of Apparel and Art Design, Xi\u2019an Polytechnic University, Xi\u2019an 710048, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojing","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Mechanical Behavior of Materials, Xi\u2019an Jiaotong University, Xi\u2019an 710049, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dayan","family":"Ma","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Mechanical Behavior of Materials, Xi\u2019an Jiaotong University, Xi\u2019an 710049, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5443-9105","authenticated-orcid":false,"given":"Chunmei","family":"Tang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Clean and Efficient Turbomachinery Power Equipment, Deyang 618000, China"},{"name":"Dongfang Electric Corporation Dongfang Turbine Co., Ltd., Deyang 618000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Lou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Clean and Efficient Turbomachinery Power Equipment, Deyang 618000, China"},{"name":"Dongfang Electric Corporation Dongfang Turbine Co., Ltd., Deyang 618000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Clean and Efficient Turbomachinery Power Equipment, Deyang 618000, China"},{"name":"Dongfang Electric Corporation Dongfang Turbine Co., Ltd., Deyang 618000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2162-3333","authenticated-orcid":false,"given":"Lan","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Mechanical Behavior of Materials, Xi\u2019an Jiaotong University, Xi\u2019an 710049, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"126766","DOI":"10.1016\/j.ijpharm.2026.126766","article-title":"Therapeutic potential of spray-based delivery system for the treatment of dermatological disorders: Clinical insights and formulation advances","volume":"695","author":"Kumar","year":"2026","journal-title":"Int. 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