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Among the available architectures, magnetite-core\/mesoporous-silica-shell (Fe3O4@mSiO2) nanoparticles functionalized with thermoresponsive polymer gatekeepers are particularly attractive. These systems integrate a magnetic heat source, a mesoporous drug reservoir, and temperature-dependent control of pore accessibility. This review examines the fundamental principles of magnetic hyperthermia, including heat-generation mechanisms, specific absorption rate (SAR), intrinsic loss power (ILP), AMF parameters and safety, and the interplay between N\u00e9el and Brownian relaxation. It also critically discusses core\u2013shell synthesis and architecture, drug-loading strategies, PNIPAM-, PNVCL-, and other LCST-type gatekeepers, and the physicochemical characterization required to validate the complete nanocarrier. Evidence for combined magnetic hyperthermia and chemotherapy is assessed together with hemocompatibility, immunogenicity, oxidative stress, biodistribution, degradation, long-term retention, and clearance. Although promising magnetothermal release and therapeutic effects have been reported, evidence remains dominated by in vitro studies, with limited in vivo validation. Current clinical experience concerns locally administered iron-oxide hyperthermia rather than complete thermoresponsive Fe3O4@mSiO2 drug-delivery systems. Translation will require standardized magnetothermal and release testing, reproducible scale-up, validated sterilization and endotoxin control, component-resolved pharmacokinetics, and integrated development of the nanocarrier and AMF applicator.<\/jats:p>","DOI":"10.3390\/nano16161018","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T08:08:41Z","timestamp":1787040521000},"page":"1018","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Magnetothermally Responsive Mesoporous Silica Nanocarriers: Materials Design, Thermoresponsive Gates and Controlled Drug Release"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-6484-4145","authenticated-orcid":false,"given":"Juliana","family":"Jesus","sequence":"first","affiliation":[{"name":"i3N and Department of Physics, University of Aveiro, Campus Universit\u00e1rio de Santiago, 3810-193 Aveiro, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6858-9507","authenticated-orcid":false,"given":"Manuel","family":"Gra\u00e7a","sequence":"additional","affiliation":[{"name":"i3N and Department of Physics, University of Aveiro, Campus Universit\u00e1rio de Santiago, 3810-193 Aveiro, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7994-4650","authenticated-orcid":false,"given":"Ana Salom\u00e9","family":"Pires","sequence":"additional","affiliation":[{"name":"Coimbra Institute for Clinical and Biomedical Research (iCBR) Area of Environment Genetics and Oncobiology (CIMAGO), Institute of Biophysics, Faculty of Medicine, University of Coimbra, Azinhaga de Santa Comba, P\u00f3lo III\u2014P\u00f3lo das Ci\u00eancias da Sa\u00fade, 3000-548 Coimbra, Portugal"},{"name":"Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, Rua Larga, 3004-504 Coimbra, Portugal"},{"name":"Clinical Academic Center of Coimbra (CACC), Praceta Professor Mota Pinto, 3004-561 Coimbra, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2217-4584","authenticated-orcid":false,"given":"Susana","family":"Devesa","sequence":"additional","affiliation":[{"name":"Centre for Mechanical Engineering, Materials and Processes (CEMMPRE), Advanced Production and Intelligent Systems Associated Laboratory (ARISE), Department of Mechanical Engineering, University of Coimbra, Rua Lu\u00eds Reis Santos, 3030-788 Coimbra, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4084-5764","authenticated-orcid":false,"given":"S\u00edlvia Soreto","family":"Teixeira","sequence":"additional","affiliation":[{"name":"i3N and Department of Physics, University of Aveiro, Campus Universit\u00e1rio de Santiago, 3810-193 Aveiro, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/s41573-020-0090-8","article-title":"Engineering Precision Nanoparticles for Drug Delivery","volume":"20","author":"Mitchell","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Almatroudi, A. (2025). Advances in Mesoporous Silica and Hybrid Nanoparticles for Drug Delivery: Synthesis, Functionalization, and Biomedical Applications. Pharmaceutics, 17.","DOI":"10.3390\/pharmaceutics17121602"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Benk\u0151, F., Krist\u00f3, K., and Sov\u00e1ny, T. (2025). Mesoporous Silica Nanoparticles as Drug Delivery Systems. Pharmaceuticals, 18.","DOI":"10.3390\/ph18091392"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"20220867","DOI":"10.1515\/biol-2022-0867","article-title":"Mesoporous Silica Nanoparticles as a Drug Delivery Mechanism","volume":"19","author":"Zhang","year":"2024","journal-title":"Open Life Sci."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Santhamoorthy, M., Asaithambi, P., Ramkumar, V., Elangovan, N., Perumal, I., and Kim, S.C. (2025). A Review on the Recent Advancements of Polymer-Modified Mesoporous Silica Nanoparticles for Drug Delivery Under Stimuli-Trigger. Polymers, 17.","DOI":"10.3390\/polym17121640"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"e643","DOI":"10.1002\/mco2.643","article-title":"Biomedical Applications of Stimuli-Responsive Nanomaterials","volume":"5","author":"Chen","year":"2024","journal-title":"MedComm"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Xiang, Z., Liu, M., and Song, J. (2021). Stimuli-Responsive Polymeric Nanosystems for Controlled Drug Delivery. Appl. Sci., 11.","DOI":"10.3390\/app11209541"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"6024","DOI":"10.1039\/C7CS00219J","article-title":"Diverse Gatekeepers for Mesoporous Silica Nanoparticle Based Drug Delivery Systems","volume":"46","author":"Wen","year":"2017","journal-title":"Chem. Soc. Rev."},{"key":"ref_9","first-page":"1292","article-title":"Spatial, Temporal, and Dose Control of Drug Delivery Using Noninvasive Magnetic Stimulation","volume":"13","author":"Chen","year":"2019","journal-title":"ACS Nano"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"3793","DOI":"10.7150\/thno.40805","article-title":"Comprehensive Understanding of Magnetic Hyperthermia for Improving Antitumor Therapeutic Efficacy","volume":"10","author":"Liu","year":"2020","journal-title":"Theranostics"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"10532","DOI":"10.1038\/s41598-025-95544-3","article-title":"Magnetic Hyperthermia Therapy Enhances the Chemoradiosensitivity of Glioblastoma","volume":"15","author":"Rivera","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Manescu, V., Paltanea, G., Antoniac, I., and Vasilescu, M. (2021). Magnetic Nanoparticles Used in Oncology. Materials, 14.","DOI":"10.3390\/ma14205948"},{"key":"ref_13","unstructured":"U.S. National Library of Medicine (2026, July 13). FERAHEME- Ferumoxytol Injection, Available online: https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=32b0e320-a739-11dc-a704-0002a5d5c51b."},{"key":"ref_14","unstructured":"U.S. National Library of Medicine (2026, July 13). FERABRIGHT- Ferumoxytol Injection, Available online: https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=ac666008-a14f-43b4-9d06-ec70f45a4234."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"8992","DOI":"10.1039\/D0TB01559H","article-title":"Core-Shell Nanostructures: Perspectives towards Drug Delivery Applications","volume":"8","author":"Kumar","year":"2020","journal-title":"J. Mater. Chem. B"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Thirupathi, K., Santhamoorthy, M., Radhakrishnan, S., Ulagesan, S., Nam, T.J., Phan, T.T.V., and Kim, S.C. (2023). Thermosensitive Polymer-Modified Mesoporous Silica for PH and Temperature-Responsive Drug Delivery. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15030795"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"5809","DOI":"10.1021\/acsabm.3c00924","article-title":"Chitosan-Grafted-Poly(N-Vinylcaprolactam)-Decorated Fe3O4@SiO2 Core-Shell Nanoformulation as an Efficient Drug Delivery System for Poorly Soluble Drugs","volume":"6","author":"Asgari","year":"2023","journal-title":"ACS Appl. Bio Mater."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"113508","DOI":"10.1016\/j.colsurfb.2023.113508","article-title":"Effective Intracellular Release of Ibuprofen Triggered by Thermosensitive Magnetic Nanocarriers","volume":"230","author":"Peralta","year":"2023","journal-title":"Colloids Surf. B"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"\u00c1lvarez, E., Est\u00e9vez, M., Gallo-Cordova, A., Gonz\u00e1lez, B., Castillo, R.R., Morales, M.D.P., Colilla, M., Izquierdo-Barba, I., and Vallet-Reg\u00ed, M. (2022). Superparamagnetic Iron Oxide Nanoparticles Decorated Mesoporous Silica Nanosystem for Combined Antibiofilm Therapy. Pharmaceutics, 14.","DOI":"10.3390\/pharmaceutics14010163"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1039\/D1BM01963E","article-title":"Superparamagnetic Iron Oxide Nanoparticles for Magnetic Hyperthermia: Recent Advancements, Molecular Effects, and Future Directions in the Omics Era","volume":"10","author":"Pucci","year":"2022","journal-title":"Biomater. Sci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.colsurfb.2018.10.051","article-title":"Recent Advances in Magnetic Fluid Hyperthermia for Cancer Therapy","volume":"174","author":"Das","year":"2019","journal-title":"Colloids Surf. B"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"374","DOI":"10.3390\/macromol2030024","article-title":"Magnetic Nanoparticles for Medical Applications: Updated Review","volume":"2","author":"Mendizabal","year":"2022","journal-title":"Macromol"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Vajtai, L., Nemes, N.M., del Puerto Morales, M., Moln\u00e1r, K., Pinke, B.G., and Simon, F. (2024). Incidence of the Brownian Relaxation Process on the Magnetic Properties of Ferrofluids. Nanomaterials, 14.","DOI":"10.3390\/nano14070634"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.jmmm.2018.09.111","article-title":"In-Gel Study of the Effect of Magnetic Nanoparticles Immobilization on Their Heating Efficiency for Application in Magnetic Fluid Hyperthermia","volume":"471","author":"Avolio","year":"2019","journal-title":"J. Magn. Magn. Mater."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"6400","DOI":"10.1016\/j.biomaterials.2014.04.036","article-title":"Magnetic Hyperthermia Efficiency in the Cellular Environment for Different Nanoparticle Designs","volume":"35","author":"Espinosa","year":"2014","journal-title":"Biomaterials"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.actbio.2025.08.031","article-title":"Impact of the Intracellular Mechanical Microenvironment of Breast Cancer and Normal Mammary Epithelial Cells on Magnetic Hyperthermia of Fe3O4 Nanoparticles","volume":"205","author":"Wang","year":"2025","journal-title":"Acta Biomater."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"4737","DOI":"10.1007\/s00289-022-04324-w","article-title":"A Review on an Effect of Dispersant Type and Medium Viscosity on Magnetic Hyperthermia of Nanoparticles","volume":"80","author":"Vijayakanth","year":"2022","journal-title":"Polym. Bull."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"495003","DOI":"10.1088\/0022-3727\/47\/49\/495003","article-title":"On the Reliable Measurement of Specific Absorption Rates and Intrinsic Loss Parameters in Magnetic Hyperthermia Materials","volume":"47","author":"Wildeboer","year":"2014","journal-title":"J. Phys. D Appl. Phys."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1109\/TBME.1984.325372","article-title":"Usable Frequencies in Hyperthermia with Thermal Seeds","volume":"31","author":"Atkinson","year":"1984","journal-title":"IEEE Trans. Biomed. Eng."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.jmmm.2006.10.1156","article-title":"Magnetic Particle Hyperthermia-Biophysical Limitations of a Visionary Tumour Therapy","volume":"311","author":"Hergt","year":"2007","journal-title":"J. Magn. Magn. Mater."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"035009","DOI":"10.1088\/1361-6560\/adaad0","article-title":"Revisiting the Safety Limit in Magnetic Nanoparticle Hyperthermia: Insights from Eddy Current Induced Heating","volume":"70","author":"Pilpilidis","year":"2025","journal-title":"Phys. Med. Biol."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Herrero de la Parte, B., Rodrigo, I., Guti\u00e9rrez-Basoa, J., Correcher, S.I., Medina, C.M., Echevarr\u00eda-Uraga, J.J., Garcia, J.A., Plazaola, F., and Garc\u00eda-Alonso, I. (2022). Proposal of New Safety Limits for In Vivo Experiments of Magnetic Hyperthermia Antitumor Therapy. Cancers, 14.","DOI":"10.3390\/cancers14133084"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"15585","DOI":"10.1039\/D4NR01388C","article-title":"Tailoring the Pore Structure of Iron Oxide Core@stellate Mesoporous Silica Shell Nanocomposites: Effects on MRI and Magnetic Hyperthermia Properties and Applicability to Anti-Cancer Therapies","volume":"16","author":"Bizeau","year":"2024","journal-title":"Nanoscale"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"3422","DOI":"10.1039\/D2TB02630A","article-title":"Ultrasmall Superparamagnetic Iron Oxide Nanoparticles for Enhanced Tumor Penetration","volume":"11","author":"Feng","year":"2023","journal-title":"J. Mater. Chem. B"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Wallyn, J., Anton, N., and Vandamme, T.F. (2019). Synthesis, Principles, and Properties of Magnetite Nanoparticles for In Vivo Imaging Applications\u2014A Review. Pharmaceutics, 11.","DOI":"10.3390\/pharmaceutics11110601"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Salehirozveh, M., Dehghani, P., and Mijakovic, I. (2024). Synthesis, Functionalization, and Biomedical Applications of Iron Oxide Nanoparticles (IONPs). J. Funct. Biomater., 15.","DOI":"10.3390\/jfb15110340"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1002\/nano.202000162","article-title":"Recent Progress of Magnetic Nanoparticles in Biomedical Applications: A Review","volume":"2","author":"Anik","year":"2021","journal-title":"Nano Sel."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"9180","DOI":"10.1002\/chem.202000679","article-title":"Liquid-Phase Synthesis of Iron Oxide Nanostructured Materials and Their Applications","volume":"26","author":"Li","year":"2020","journal-title":"Chem.-Eur. J."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Ajinkya, N., Yu, X., Kaithal, P., Luo, H., Somani, P., and Ramakrishna, S. (2020). Magnetic Iron Oxide Nanoparticle (IONP) Synthesis to Applications: Present and Future. Materials, 13.","DOI":"10.3390\/ma13204644"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"127419","DOI":"10.1016\/j.jcrysgro.2023.127419","article-title":"Unveiling the Formation Mechanism of Polydisperse Iron Oxide Nanoparticles in Coprecipitation Route","volume":"624","author":"Ravikumar","year":"2023","journal-title":"J. Cryst. Growth"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"3531","DOI":"10.1007\/s11837-022-05380-3","article-title":"Synthesis of Fe3O4 Nanoparticles with Different Shapes Through a Co-Precipitation Method and Their Application","volume":"74","author":"Benamour","year":"2022","journal-title":"JOM"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"21356","DOI":"10.1021\/acs.jpcc.2c05380","article-title":"Size Control of Iron Oxide Nanoparticles Synthesized by Thermal Decomposition Methods","volume":"126","author":"Fokina","year":"2022","journal-title":"J. Phys. Chem. C"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"8693","DOI":"10.1021\/acs.chemmater.1c02654","article-title":"A Milestone in the Chemical Synthesis of Fe3O4 Nanoparticles: Unreported Bulklike Properties Lead to a Remarkable Magnetic Hyperthermia","volume":"33","author":"Arriortua","year":"2021","journal-title":"Chem. Mater."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.jcis.2024.09.134","article-title":"Hydrophobic Iron Oxide Nanoparticles: Controlled Synthesis and Phase Transfer via Flash Nanoprecipitation","volume":"678","author":"Bandyopadhyay","year":"2025","journal-title":"J. Colloid Interface Sci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"504","DOI":"10.17776\/csj.1284327","article-title":"Effect of Synthesizing Process on the Formation of Fe3O4 Magnetic Nanoparticles","volume":"44","author":"Aka","year":"2023","journal-title":"Cumhur. Sci. J."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"140537","DOI":"10.1016\/j.matlet.2026.140537","article-title":"Pre-Reaction Mixing Temperature and Time Control Shape and Size Anisotropy in Solvothermal Fe3O4 Nanostructures","volume":"414","author":"Odion","year":"2026","journal-title":"Mater. Lett."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"8232","DOI":"10.1021\/acs.inorgchem.7b00956","article-title":"Tuning Sizes, Morphologies, and Magnetic Properties of Monocore Versus Multicore Iron Oxide Nanoparticles through the Controlled Addition of Water in the Polyol Synthesis","volume":"56","author":"Hemery","year":"2017","journal-title":"Inorg. Chem."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"45870","DOI":"10.1021\/acsami.1c12323","article-title":"Stable Iron Oxide Nanoflowers with Exceptional Magnetic Heating Efficiency: Simple and Fast Polyol Synthesis","volume":"13","author":"Storozhuk","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Salvador, M., Guti\u00e9rrez, G., Noriega, S., Moyano, A., Blanco-L\u00f3pez, M.C., and Matos, M. (2021). Microemulsion Synthesis of Superparamagnetic Nanoparticles for Bioapplications. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22010427"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"4563","DOI":"10.1039\/D5NA00244C","article-title":"Optimizing Superparamagnetic Ferrite Nanoparticles: Microwave-Assisted vs. Thermal Decomposition Synthesis Methods","volume":"7","author":"Moghaddari","year":"2025","journal-title":"Nanoscale Adv."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"20651","DOI":"10.1021\/acs.iecr.4c02583","article-title":"Toward More Sustainable Magnetic Nanoparticle Synthesis on Microwave-Assisted Continuous-Flow Processes","volume":"63","author":"Simeonidis","year":"2024","journal-title":"Ind. Eng. Chem. Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"108438","DOI":"10.1016\/j.cep.2021.108438","article-title":"High Performance Magnetically Recoverable Fe3O4 Nanocatalysts: Fast Microwave Synthesis and Photo-Fenton Catalysis under Visible-Light","volume":"166","author":"Zanchettin","year":"2021","journal-title":"Chem. Eng. Process."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"100742","DOI":"10.1016\/j.pmatsci.2020.100742","article-title":"Design and Engineering of Magneto-Responsive Devices for Cancer Theranostics: Nano to Macro Perspective","volume":"116","author":"Soares","year":"2021","journal-title":"Prog. Mater. Sci."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Nguyen, M.D., Tran, H.V., Xu, S., and Lee, T.R. (2021). Fe3O4 Nanoparticles: Structures, Synthesis, Magnetic Properties, Surface Functionalization, and Emerging Applications. Appl. Sci., 11.","DOI":"10.3390\/app112311301"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.pnsc.2016.09.004","article-title":"Structural Effects on the Magnetic Hyperthermia Properties of Iron Oxide Nanoparticles","volume":"26","author":"Abenojar","year":"2016","journal-title":"Prog. Nat. Sci. Mater. Int."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Mohapatra, J., Xing, M., and Liu, J.P. (2019). Inductive Thermal Effect of Ferrite Magnetic Nanoparticles. Nanomaterials, 12.","DOI":"10.3390\/ma12193208"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Ferrero, R., Barrera, G., Celegato, F., Vicentini, M., S\u00f6zeri, H., Y\u0131ld\u0131z, N., Atila Din\u00e7er, C., Co\u00efsson, M., Manzin, A., and Tiberto, P. (2021). Experimental and Modelling Analysis of the Hyperthermia Properties of Iron Oxide Nanocubes. Nanomaterials, 11.","DOI":"10.3390\/nano11092179"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1038\/srep01652","article-title":"Learning from Nature to Improve the Heat Generation of Iron-Oxide Nanoparticles for Magnetic Hyperthermia Applications","volume":"3","author":"Simeonidis","year":"2013","journal-title":"Sci. Rep."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"2996","DOI":"10.1002\/asia.201601042","article-title":"Anisotropic Magnetite Nanorods for Enhanced Magnetic Hyperthermia","volume":"11","author":"Geng","year":"2016","journal-title":"Chem. Asian J."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"8370","DOI":"10.1021\/acs.jpcc.6b01426","article-title":"Enhanced Magnetic Hyperthermia in Iron Oxide Nano-Octopods: Size and Anisotropy Effects","volume":"120","author":"Nemati","year":"2016","journal-title":"J. Phys. Chem. C"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"10801","DOI":"10.1021\/acs.chemmater.2c00708","article-title":"Correlating Magnetic Hyperthermia and Magnetic Resonance Imaging Contrast Performance of Cubic Iron Oxide Nanoparticles with Crystal Structural Integrity","volume":"34","author":"Shingte","year":"2022","journal-title":"Chem. Mater."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"e202400023","DOI":"10.1002\/cphc.202400023","article-title":"Structure-Function Relationship of Iron Oxide Nanoflowers: Optimal Sizes for Magnetic Hyperthermia Depending on Alternating Magnetic Field Conditions","volume":"25","author":"Bejko","year":"2024","journal-title":"ChemPhysChem"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1109\/TMAG.2025.3618008","article-title":"Comparative Characterization of Structural, Magnetic Properties, and Heating Efficiency of Single- and Multicore Iron Oxide Nanoparticles","volume":"61","author":"Khmara","year":"2025","journal-title":"IEEE Trans. Magn."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Zel\u011bn\u00e1kov\u00e1, A., Sz\u0171csov\u00e1, J., Nagy, \u013d., Girman, V., Zele\u0148\u00e1k, V., and Hunto\u0161ov\u00e1, V. (2021). Magnetic Characterization and Moderate Cytotoxicity of Magnetic Mesoporous Silica Nanocomposite for Drug Delivery of Naproxen. Nanomaterials, 11.","DOI":"10.3390\/nano11040901"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"6858","DOI":"10.1021\/acsami.8b22600","article-title":"Comparative Heating Efficiency of Cobalt-, Manganese-, and Nickel-Ferrite Nanoparticles for a Hyperthermia Agent in Biomedicines","volume":"11","author":"Manna","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"9017","DOI":"10.1021\/acsami.9b20496","article-title":"Cubic Anisotropic Co- and Zn-Substituted Ferrite Nanoparticles as Multimodal Magnetic Agents","volume":"12","author":"Pardo","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"15664","DOI":"10.1039\/D4RA01600A","article-title":"Preparation and Characterization of Various PVPylated Divalent Metal-Doped Ferrite Nanoparticles for Magnetic Hyperthermia","volume":"14","author":"Lemine","year":"2024","journal-title":"RSC Adv."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"4337","DOI":"10.1021\/acs.jproteome.6b00411","article-title":"Metabolic Effects of Cobalt Ferrite Nanoparticles on Cervical Carcinoma Cells and Nontumorigenic Keratinocytes","volume":"15","author":"Oliveira","year":"2016","journal-title":"J. Proteome Res."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"40075","DOI":"10.1038\/srep40075","article-title":"Physiological Remediation of Cobalt Ferrite Nanoparticles by Ferritin","volume":"7","author":"Volatron","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"111367","DOI":"10.1016\/j.molliq.2019.111367","article-title":"A Robust Method for Fabrication of Monodisperse Magnetic Mesoporous Silica Nanoparticles with Core-Shell Structure as Anticancer Drug Carriers","volume":"292","author":"Asgari","year":"2019","journal-title":"J. Mol. Liq."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1007\/s11051-009-9661-7","article-title":"High Quality and Tuneable Silica Shell\u2013Magnetic Core Nanoparticles","volume":"12","author":"Vogt","year":"2009","journal-title":"J. Nanopart. Res."},{"key":"ref_72","first-page":"1","article-title":"The Effect of Silica Shell Thickness on Magnetic and Proton Relaxometric Properties: Fe3O4@mSiO2 Nanoparticles","volume":"58","author":"Taib","year":"2022","journal-title":"IEEE Trans. Magn."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1186\/s11671-015-0920-5","article-title":"Fabrication of Fe3O4@mSiO2 Core-Shell Composite Nanoparticles for Drug Delivery Applications","volume":"10","author":"Pal","year":"2015","journal-title":"Nanoscale Res. Lett."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Niroumand, U., Firouzabadi, N., Goshtasbi, G., Hassani, B., Ghasemiyeh, P., and Mohammadi-Samani, S. (2023). The Effect of Size, Morphology and Surface Properties of Mesoporous Silica Nanoparticles on Pharmacokinetic Aspects and Potential Toxicity Concerns. Front. Mater., 10.","DOI":"10.3389\/fmats.2023.1189463"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"2967","DOI":"10.1007\/s00204-017-1993-y","article-title":"Toxicology of Silica Nanoparticles: An Update","volume":"91","author":"Murugadoss","year":"2017","journal-title":"Arch. Toxicol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1080\/17435390.2024.2401448","article-title":"Immunological Properties of Silica Nanoparticles: A Structure-Activity Relationship Study","volume":"18","author":"Grunberger","year":"2024","journal-title":"Nanotoxicology"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"102746","DOI":"10.1016\/j.cis.2022.102746","article-title":"Cetyltrimethylammonium Bromide in the Synthesis of Mesoporous Silica Nanoparticles: General Aspects and in Vitro Toxicity","volume":"307","author":"Carvalho","year":"2022","journal-title":"Adv. Colloid Interface Sci."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Rascol, E., Daurat, M., Da Silva, A., Maynadier, M., Dorandeu, C., Charnay, C., Garcia, M., Lai-Kee-Him, J., Bron, P., and Auffan, M. (2017). Biological Fate of Fe3O4 Core-Shell Mesoporous Silica Nanoparticles Depending on Particle Surface Chemistry. Nanomaterials, 7.","DOI":"10.3390\/nano7070162"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"5717","DOI":"10.1021\/nn2013904","article-title":"Impact of Silica Nanoparticle Design on Cellular Toxicity and Hemolytic Activity","volume":"5","author":"Yu","year":"2011","journal-title":"ACS Nano"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"4834","DOI":"10.1021\/ja910846q","article-title":"Impacts of Mesoporous Silica Nanoparticle Size, Pore Ordering, and Pore Integrity on Hemolytic Activity","volume":"132","author":"Lin","year":"2010","journal-title":"J. Am. Chem. Soc."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"133675","DOI":"10.1016\/j.colsurfa.2024.133675","article-title":"Functional Surface Modifications Impact on the in Vitro\/in Vivo Toxicity and Intracellular Internalization Behavior of Mesoporous Silica Nanoparticles","volume":"689","author":"Ji","year":"2024","journal-title":"Colloids Surf. A"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"3467","DOI":"10.1007\/s13346-024-01575-0","article-title":"Immunomodulatory Potential of Rapamycin-Loaded Mesoporous Silica Nanoparticles: Pore Size-Dependent Drug Loading, Release, and in Vitro Cellular Responses","volume":"14","author":"Aranda","year":"2024","journal-title":"Drug Deliv. Transl. Res."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.jiec.2021.01.020","article-title":"Reduced Cytotoxicity of CTAB-Templated Silica Layer on Gold Nanorod Using Fluorescence Dyes and Its Application in Cancer Theranostics","volume":"96","author":"Han","year":"2021","journal-title":"J. Ind. Eng. Chem."},{"key":"ref_84","first-page":"261","article-title":"Drug Loading Methods and Kinetic Release Models Using of Mesoporous Silica Nanoparticles as a Drug Delivery System: A Review","volume":"50","author":"Khalbas","year":"2024","journal-title":"S. Afr. J. Chem. Eng."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Ostrowska, S., Szukowska, M., Kim, S., Kim, Y., Wawrzyniak, D., and Mr\u00f3wczy\u0144ski, R. (2025). Doxorubicin and Sorafenib Release from Mesoporous Silica Nanoparticles Coated with Polydopamine\u2014Influence of Mechanical and Chemical Stimuli on the Process. Front. Coat. Dye. Interface Eng., 3.","DOI":"10.3389\/frcdi.2025.1531144"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"e2104449","DOI":"10.1002\/smll.202104449","article-title":"Advanced Nanoengineering Approach for Target-Specific, Spatiotemporal, and Ratiometric Delivery of Gemcitabine\u2013Cisplatin Combination for Improved Therapeutic Outcome in Pancreatic Cancer","volume":"18","author":"Tarannum","year":"2022","journal-title":"Small"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1021\/acsabm.9b01111","article-title":"Fabrication of a PH\/Redox-Triggered Mesoporous Silica-Based Nanoparticle with Microfluidics for Anticancer Drugs Doxorubicin and Paclitaxel Codelivery","volume":"3","author":"Yan","year":"2020","journal-title":"ACS Appl. Bio Mater."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"e202500255","DOI":"10.1002\/anbr.202500255","article-title":"Mesoporous Silica Nanoparticles With Customized Drug Ratio\/Loading for Effective Treatment of Gemcitabine-Resistant Pancreatic Tumors","volume":"6","author":"Huq","year":"2026","journal-title":"Adv. Nanobiomed. Res."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Adam, A., and Mertz, D. (2023). Iron Oxide@Mesoporous Silica Core-Shell Nanoparticles as Multimodal Platforms for Magnetic Resonance Imaging, Magnetic Hyperthermia, Near-Infrared Light Photothermia, and Drug Delivery. Nanomaterials, 13.","DOI":"10.3390\/nano13081342"},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Spoial\u0103, A., Ilie, C.I., Cr\u0103ciun, L.N., Ficai, D., Ficai, A., and Andronescu, E. (2021). Magnetite-Silica Core\/Shell Nanostructures: From Surface Functionalization towards Biomedical Applications\u2014A Review. Appl. Sci., 11.","DOI":"10.3390\/app112211075"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jcis.2011.05.038","article-title":"Synthesis and Characterization of Pore Size-Tunable Magnetic Mesoporous Silica Nanoparticles","volume":"361","author":"Zhang","year":"2011","journal-title":"J. Colloid Interface Sci."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1007\/s10971-016-4090-4","article-title":"Carboxylic Acid-Functionalized Porous Silica Particles by a Co-Condensation Approach","volume":"81","author":"Feinle","year":"2017","journal-title":"J. Sol.-Gel Sci. Technol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1002\/open.202100227","article-title":"Mesoporous Silica Nanoparticles Functionalized with Amino Groups for Biomedical Applications","volume":"10","author":"Miletto","year":"2021","journal-title":"ChemistryOpen"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"4101","DOI":"10.1002\/pat.5417","article-title":"Design of Thermosensitive Polymer-Coated Magnetic Mesoporous Silica Nanocomposites with a Core-Shell-Shell Structure as a Magnetic\/Temperature Dual-Responsive Drug Delivery Vehicle","volume":"32","author":"Asgari","year":"2021","journal-title":"Polym. Adv. Technol."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Gon\u00e7alves, J.L.M., Castanheira, E.J., Alves, S.P.C., Baleiz\u00e3o, C., and Farinha, J.P. (2020). Grafting with RAFT\u2014GRAFT Strategies to Prepare Hybrid Nanocarriers with Core-Shell Architecture. Polymers, 12.","DOI":"10.3390\/polym12102175"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"9239","DOI":"10.1039\/c1jm10631g","article-title":"Thermo and PH Dual Responsive, Polymer Shell Coated, Magnetic Mesoporous Silica Nanoparticles for Controlled Drug Release","volume":"21","author":"Chang","year":"2011","journal-title":"J. Mater. Chem."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Zhao, J., Zeng, M., Zheng, K., He, X., Xie, M., and Fu, X. (2017). Preparation and Characterization of Thermoresponsive Poly(N-Isopropylacrylamide-Co-Acrylic Acid)-Grafted Hollow Fe3O4\/SiO2 Microspheres with Surface Holes for BSA Release. Materials, 10.","DOI":"10.3390\/ma10040411"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.jcis.2019.02.086","article-title":"Synthesis and in Vitro Testing of Thermoresponsive Polymer-Grafted Core-Shell Magnetic Mesoporous Silica Nanoparticles for Efficient Controlled and Targeted Drug Delivery","volume":"544","author":"Peralta","year":"2019","journal-title":"J. Colloid Interface Sci."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.msec.2018.11.076","article-title":"Investigation of Magnetic Silica with Thermoresponsive Chitosan Coating for Drug Controlled Release and Magnetic Hyperthermia Application","volume":"97","author":"Tithito","year":"2019","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Marsili, L., Dal Bo, M., Eisele, G., Donati, I., Berti, F., and Toffoli, G. (2021). Characterization of Thermoresponsive Poly-n-Vinylcaprolactam Polymers for Biological Applications. Polymers, 13.","DOI":"10.3390\/polym13162639"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.addr.2018.10.005","article-title":"Thermoresponsive Polymer Nanocarriers for Biomedical Applications","volume":"138","author":"Bordat","year":"2019","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"18056","DOI":"10.1039\/C4DT02441A","article-title":"P(EO-Co-LLA) Functionalized Fe3O4@mSiO2 Nanocomposites for Thermo\/PH Responsive Drug Controlled Release and Hyperthermia","volume":"43","author":"Guo","year":"2014","journal-title":"Dalton Trans."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1039\/D3LP00114H","article-title":"Thermoresponsive Polymers with LCST Transition: Synthesis, Characterization, and Their Impact on Biomedical Frontiers","volume":"1","author":"Yuan","year":"2023","journal-title":"RSC Appl. Polym."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"22005","DOI":"10.1039\/c2jm34364a","article-title":"Dissolution from inside: A Unique Degradation Behaviour of Core\u2013Shell Magnetic Mesoporous Silica Nanoparticles and the Effect of Polyethyleneimine Coating","volume":"22","author":"Chen","year":"2012","journal-title":"J. Mater. Chem."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1080\/02656736.2021.1892837","article-title":"RADIOMAG Consortium. Challenges and Recommendations for Magnetic Hyperthermia Characterization Measurements","volume":"38","author":"Wells","year":"2021","journal-title":"Int. J. Hyperth."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"e10453","DOI":"10.1002\/smll.202510453","article-title":"Machine Learning on Systematically Curated Data Reveals Key Determinants of Magnetic Hyperthermia Performance","volume":"22","author":"Ansari","year":"2026","journal-title":"Small"},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Trzeciak, K., Chotera-ouda, A., Bak-sypien, I.I., and Potrzebowski, M.J. (2021). Mesoporous Silica Particles as Drug Delivery Systems\u2014The State of the Art in Loading Methods and the Recent Progress in Analytical Techniques for Monitoring These Processes. Pharmaceutics, 13.","DOI":"10.3390\/pharmaceutics13070950"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1002\/adhm.201300209","article-title":"Temperature-Sensitive Magnetic Drug Carriers for Concurrent Gemcitabine Chemohyperthermia","volume":"3","author":"Kim","year":"2014","journal-title":"Adv. Healthc. Mater."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"12518","DOI":"10.1021\/acsami.8b02398","article-title":"Beyond Traditional Hyperthermia: In Vivo Cancer Treatment with Magnetic-Responsive Mesoporous Silica Nanocarriers","volume":"10","author":"Guisasola","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1038\/s41565-024-01673-7","article-title":"A Large-Scale Machine Learning Analysis of Inorganic Nanoparticles in Preclinical Cancer Research","volume":"19","author":"Mendes","year":"2024","journal-title":"Nat. Nanotechnol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.jconrel.2016.06.017","article-title":"DLS and Zeta Potential\u2014What They Are and What They Are Not?","volume":"235","author":"Bhattacharjee","year":"2016","journal-title":"J. Control. Release"},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Alswieleh, A.M., Beagan, A.M., Alsheheri, B.M., Alotaibi, K.M., Alharthi, M.D., and Almeataq, M.S. (2020). Hybrid Mesoporous Silica Nanoparticles Grafted with 2-(Tert-Butylamino)Ethyl Methacrylate-b-Poly(Ethylene Glycol) Methyl Ether Methacrylate Diblock Brushes as Drug Nanocarrier. Molecules, 25.","DOI":"10.3390\/molecules25010195"},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Mittal, A., Roy, I., and Gandhi, S. (2022). Magnetic Nanoparticles: An Overview for Biomedical Applications. Magnetochemistry, 8.","DOI":"10.3390\/magnetochemistry8090107"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1039\/C6CE02421A","article-title":"Oxidation of Magnetite Nanoparticles: Impact on Surface and Crystal Properties","volume":"19","author":"Schwaminger","year":"2017","journal-title":"CrystEngComm"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"834","DOI":"10.7150\/thno.9199","article-title":"Magnetically Responsive Smart Nanoparticles for Cancer Treatment with a Combination of Magnetic Hyperthermia and Remote-Control Drug Release","volume":"4","author":"Hayashi","year":"2014","journal-title":"Theranostics"},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Dobrovolskaia, M.A. (2022). Lessons Learned from Immunological Characterization of Nanomaterials at the Nanotechnology Characterization Laboratory. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.984252"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1039\/C6BM00374E","article-title":"Fe3O4@SiO2 Core\u2013Shell Nanoparticles for Biomedical Purposes: Adverse Effects on Blood Cells","volume":"4","author":"Achilli","year":"2016","journal-title":"Biomater. Sci."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.actbio.2016.11.007","article-title":"The Shape Effect of Magnetic Mesoporous Silica Nanoparticles on Endocytosis, Biocompatibility and Biodistribution","volume":"49","author":"Shao","year":"2017","journal-title":"Acta Biomater."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1039\/C5NR06122A","article-title":"Immune Response to Functionalized Mesoporous Silica Nanoparticles for Targeted Drug Delivery","volume":"8","author":"Heidegger","year":"2015","journal-title":"Nanoscale"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1002\/adhm.201501013","article-title":"Comprehensive Mechanism Analysis of Mesoporous-Silica-Nanoparticle-Induced Cancer Immunotherapy","volume":"5","author":"Wang","year":"2016","journal-title":"Adv. Healthc. Mater."},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Malvindi, M.A., De Matteis, V., Galeone, A., Brunetti, V., Anyfantis, G.C., Athanassiou, A., Cingolani, R., and Pompa, P.P. (2014). Toxicity Assessment of Silica Coated Iron Oxide Nanoparticles and Biocompatibility Improvement by Surface Engineering. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0085835"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1186\/s12951-026-04471-6","article-title":"In Vivo Toxicity Assessment of Silica-Coated Iron Oxide Nanoparticles for Nanowarming in Organ Cryopreservation","volume":"24","author":"Oziri","year":"2026","journal-title":"J. Nanobiotechnol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.jconrel.2020.05.027","article-title":"One-Year Chronic Toxicity Evaluation of Single Dose Intravenously Administered Silica Nanoparticles in Mice and Their Ex Vivo Human Hemocompatibility","volume":"324","author":"Mohammadpour","year":"2020","journal-title":"J. Control. Release"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"2101519","DOI":"10.1002\/smll.202101519","article-title":"In Vivo Tracking of the Degradation of Mesoporous Silica through 89Zr Radio-Labeled Core\u2013Shell Nanoparticles","volume":"17","author":"Bindini","year":"2021","journal-title":"Small"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1186\/s12951-022-01742-w","article-title":"Influence of Magnetic Nanoparticle Biotransformation on Contrasting Efficiency and Iron Metabolism","volume":"20","author":"Yaremenko","year":"2022","journal-title":"J. Nanobiotechnol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.micromeso.2019.04.050","article-title":"Systematic Investigation of in Vitro and in Vivo Safety, Toxicity and Degradation of Mesoporous Silica Nanoparticles Synthesized Using Commercial Sodium Silicate","volume":"284","author":"Bhavsar","year":"2019","journal-title":"Microporous Mesoporous Mater."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"129359","DOI":"10.1016\/j.colsurfa.2022.129359","article-title":"Magnetic Mesoporous Silica Nanoparticles Mediated Redox and PH Dual-Responsive Target Drug Delivery for Combined Magnetothermal Therapy and Chemotherapy","volume":"648","author":"Zhao","year":"2022","journal-title":"Colloids Surf. A"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.micromeso.2017.07.053","article-title":"Magnetic Mesoporous Silica Nanoparticles Coated with Thermo-Responsive Copolymer for Potential Chemo- and Magnetic Hyperthermia Therapy","volume":"256","author":"Tian","year":"2018","journal-title":"Microporous Mesoporous Mater."},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Szwed, M., and Marczak, A. (2024). Application of Nanoparticles for Magnetic Hyperthermia for Cancer Treatment-The Current State of Knowledge. Cancers, 16.","DOI":"10.3390\/cancers16061156"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"15482","DOI":"10.1039\/C4DT01984A","article-title":"Magnetic Mesoporous Silica Nanoparticles for Potential Delivery of Chemotherapeutic Drugs and Hyperthermia","volume":"43","author":"Tao","year":"2014","journal-title":"Dalton Trans."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1080\/02656736.2020.1800831","article-title":"In Vivo Magnetic Nanoparticle Hyperthermia: A Review on Preclinical Studies, Low-Field Nano-Heaters, Noninvasive Thermometry and Computer Simulations for Treatment Planning","volume":"37","author":"Rodrigues","year":"2020","journal-title":"Int. J. Hyperth."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1118\/1.1748629","article-title":"Description and Characterization of the Novel Hyperthermia- and Thermoablation-system for Clinical Magnetic Fluid Hyperthermia","volume":"31","author":"Gneveckow","year":"2004","journal-title":"Med. Phys."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1080\/02656730500158360","article-title":"Clinical Hyperthermia of Prostate Cancer Using Magnetic Nanoparticles: Presentation of a New Interstitial Technique","volume":"21","author":"Johannsen","year":"2005","journal-title":"Int. J. Hyperth."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1016\/j.eururo.2006.11.023","article-title":"Thermotherapy of Prostate Cancer Using Magnetic Nanoparticles: Feasibility, Imaging, and Three-Dimensional Temperature Distribution","volume":"52","author":"Johannsen","year":"2007","journal-title":"Eur. Urol."},{"key":"ref_135","first-page":"53","article-title":"Intracranial Thermotherapy Using Magnetic Nanoparticles Combined with External Beam Radiotherapy: Results of a Feasibility Study on Patients with Glioblastoma Multiforme","volume":"81","author":"Rothe","year":"2006","journal-title":"J. Neuro-Oncol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s11060-010-0389-0","article-title":"Efficacy and Safety of Intratumoral Thermotherapy Using Magnetic Iron-Oxide Nanoparticles Combined with External Beam Radiotherapy on Patients with Recurrent Glioblastoma Multiforme","volume":"103","author":"Ulrich","year":"2011","journal-title":"J. Neuro-Oncol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1039\/C7RA11472A","article-title":"Examining the Effect of Ions and Proteins on the Heat Dissipation of Iron Oxide Nanocrystals","volume":"8","author":"Kalidasan","year":"2018","journal-title":"RSC Adv."},{"key":"ref_138","unstructured":"(2026, August 08). U.S. Food and Drug Administration Drug Products, Including Biological Products, That Contain Nanomaterials Guidance for Industry, Available online: https:\/\/www.fda.gov\/regulatory-information\/search-fda-guidance-documents\/drug-products-including-biological-products-contain-nanomaterials-guidance-industry."},{"key":"ref_139","unstructured":"European Medicines Agency, and Heads of Medicines Agencies (2025). Nanotechnology-Based Medicinal Products for Human Use, EU-IN Horizon Scanning Report."},{"key":"ref_140","doi-asserted-by":"crossref","unstructured":"Bernal-Ch\u00e1vez, S.A., Del Prado-Audelo, M.L., Caballero-Flor\u00e1n, I.H., Giraldo-Gomez, D.M., Figueroa-Gonzalez, G., Reyes-Hernandez, O.D., Gonz\u00e1lez-Del Carmen, M., Gonz\u00e1lez-Torres, M., Cort\u00e9s, H., and Leyva-G\u00f3mez, G. (2021). Insights into Terminal Sterilization Processes of Nanoparticles for Biomedical Applications. Molecules, 26.","DOI":"10.3390\/molecules26072068"},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"M\u00e9nard, M., Ali, L.M.A., Vardanyan, A., Charnay, C., Raehm, L., Cunin, F., Bessi\u00e8re, A., Oliviero, E., Theodossiou, T.A., and Seisenbaeva, G.A. (2023). Upscale Synthesis of Magnetic Mesoporous Silica Nanoparticles and Application to Metal Ion Separation: Nanosafety Evaluation. Nanomaterials, 13.","DOI":"10.20944\/preprints202310.1429.v1"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1039\/D3RE00707C","article-title":"Scaling-up Continuous Production of Mesoporous Silica Particles at Kg Scale: Design & Operational Strategies","volume":"9","author":"Jundale","year":"2024","journal-title":"React. Chem. Eng."},{"key":"ref_143","unstructured":"(2026, August 08). U.S. Food and Drug Administration Current Good Manufacturing Practice Requirements for Combination Products: Guidance for Industry and FDA Staff, Available online: https:\/\/www.fda.gov\/regulatory-information\/search-fda-guidance-documents\/current-good-manufacturing-practice-requirements-combination-products."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"2790","DOI":"10.1021\/acs.chemmater.3c02986","article-title":"Superparamagnetic Core\u2013Mesoporous Silica Shell with Tunable Extra- and Intracellular Dissolution Rates","volume":"36","author":"Fiedler","year":"2024","journal-title":"Chem. Mater."},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Chen, F., Zhang, F., Wang, Y., Peng, J., Cao, L., Mei, Q., Ge, M., Li, L., Chen, M., and Dong, W.F. (2022). Biomimetic Redox-Responsive Mesoporous Organosilica Nanoparticles Enhance Cisplatin-Based Chemotherapy. Front. Bioeng. Biotechnol., 10.","DOI":"10.3389\/fbioe.2022.860949"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"13381","DOI":"10.1021\/acsnano.5c01399","article-title":"Iron Homeostasis-Regulated Metabolism of PEGylated Ultrasmall Iron Oxide Nanoparticles","volume":"19","author":"Wang","year":"2025","journal-title":"ACS Nano"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"e2404391","DOI":"10.1002\/adhm.202404391","article-title":"Metabolically-Driven Active Targeting of Magnetic Nanoparticles Functionalized with Glucuronic Acid to Glioblastoma: Application to MRI-Tracked Magnetic Hyperthermia Therapy","volume":"14","author":"Caro","year":"2025","journal-title":"Adv. Healthc. Mater."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"3699","DOI":"10.1021\/acsnano.8b00893","article-title":"Magnetic Particle Imaging-Guided Heating in Vivo Using Gradient Fields for Arbitrary Localization of Magnetic Hyperthermia Therapy","volume":"12","author":"Tay","year":"2018","journal-title":"ACS Nano"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"324","DOI":"10.7150\/thno.86759","article-title":"In Situ Theranostic Platform Combining Highly Localized Magnetic Fluid Hyperthermia, Magnetic Particle Imaging, and Thermometry in 3D","volume":"14","author":"Buchholz","year":"2024","journal-title":"Theranostics"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"8328","DOI":"10.1021\/acsnano.4c18732","article-title":"Optomagnetic Heater-Thermometer for Tumor Therapy with Operando Temperature Feedback","volume":"19","author":"Li","year":"2025","journal-title":"ACS Nano"}],"container-title":["Nanomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-4991\/16\/16\/1018\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T08:33:56Z","timestamp":1787042036000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-4991\/16\/16\/1018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,18]]},"references-count":150,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["nano16161018"],"URL":"https:\/\/doi.org\/10.3390\/nano16161018","relation":{},"ISSN":["2079-4991"],"issn-type":[{"value":"2079-4991","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,18]]}}}