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Herein, Mn-doped (Fe3O4) magnetite nanoparticles (MNPs) were engineered and incorporated into a Maisine CC-based oil-in-water microemulsion (ME) to obtain a multifunctional nanoplatform for magnetic resonance imaging (MRI), hyperthermia, and controlled drug release. A series of Mn-doped MNPs (1\u201310% Mn:Fe3O4) was synthesized by coprecipitation. X-ray diffraction confirmed the preservation of the cubic spinel upon Mn incorporation. The Mn incorporation resulted in MNPs made of crystallites (~9\u201312 nm) whose magnetic properties were improved. Also, 10% Mn led to a very good magnetic heating efficiency under alternating magnetic fields with a specific absorption rate of ~111 W\u00b7g\u22121. The obtained MNPs proved to be T2-weighted MRI contrast agents, with an increase in the r2 values up to ~844 mM\u22121\u00b7s\u22121 after incorporation into ME. The optimized composition of Mn10% was subsequently loaded with doxorubicin (DOX) and integrated into ME. Drug-release studies revealed a biphasic profile, characterized by an initial burst phase followed by sustained release up to 48 h. These findings demonstrate that dopant-engineered MNPs combined with a ME carrier can provide a versatile platform for integrating magnetic hyperthermia potential, T2-weighted MRI contrast enhancement, and controlled chemotherapeutic delivery within a single nanostructured system.<\/jats:p>","DOI":"10.3390\/nano16171065","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:04:32Z","timestamp":1787756672000},"page":"1065","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Design and Physicochemical Characterization of a Multifunctional Maisine-Based Microemulsion Incorporating Doxorubicin@Mn-Doped Magnetite Nanoparticles for MRI, Hyperthermia, and Drug Delivery"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9885-616X","authenticated-orcid":false,"given":"Mirela","family":"Nistor","sequence":"first","affiliation":[{"name":"Nanotechnology Laboratory, TRANSCEND Department, Regional Institute of Oncology, 2-4 General Henri Mathias Berthelot, 700483 Iasi, Romania"},{"name":"Faculty of Chemistry, \u201cAlexandru Ioan Cuza\u201d University of Iasi, 11 Carol I Blvd., 700506 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Gherca","sequence":"additional","affiliation":[{"name":"National Institute of Research and Development for Technical Physics, 700050 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7563-1267","authenticated-orcid":false,"given":"Cristina Mariana","family":"Uritu","sequence":"additional","affiliation":[{"name":"Advanced Centre for Research-Development in Experimental Medicine \u201cProf. Ostin C. Mungiu\u201d (CEMEX), Grigore T. Popa University of Medicine and Pharmacy, 9-13 Mihail Kogalniceanu, 700259 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5618-1192","authenticated-orcid":false,"given":"Marian","family":"Grigoras","sequence":"additional","affiliation":[{"name":"National Institute of Research and Development for Technical Physics, 700050 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5255-7586","authenticated-orcid":false,"given":"Vera","family":"Balan","sequence":"additional","affiliation":[{"name":"Nanotechnology Laboratory, TRANSCEND Department, Regional Institute of Oncology, 2-4 General Henri Mathias Berthelot, 700483 Iasi, Romania"},{"name":"Biomedical Sciences Department, Faculty of Medical Bioengineering, Grigore T. Popa University of Medicine and Pharmacy of Iasi, 9-13 Kogalniceanu Street, 700454 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5559-8757","authenticated-orcid":false,"given":"Raluca M.","family":"Fratila","sequence":"additional","affiliation":[{"name":"Instituto de Nanociencia y Materiales de Arag\u00f3n, INMA (CSIC-Universidad de Zaragoza), C\/Pedro Cerbuna 12, 50009 Zaragoza, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Bioingenier\u00eda, Biomateriales y Nanomedicina (CIBER-BBN), 50018 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6769-1545","authenticated-orcid":false,"given":"Rares-Ionut","family":"Stiufiuc","sequence":"additional","affiliation":[{"name":"Nanotechnology Laboratory, TRANSCEND Department, Regional Institute of Oncology, 2-4 General Henri Mathias Berthelot, 700483 Iasi, Romania"},{"name":"Department of NanoSciences, Institute of Biomedical Research\u2014MedFUTURE, \u201cIuliu Hatieganu\u201d University of Medicine and Pharmacy, Louis Pasteur 4-6, 400349 Cluj Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brindusa","family":"Dragoi","sequence":"additional","affiliation":[{"name":"Nanotechnology Laboratory, TRANSCEND Department, Regional Institute of Oncology, 2-4 General Henri Mathias Berthelot, 700483 Iasi, Romania"},{"name":"Faculty of Chemistry, \u201cAlexandru Ioan Cuza\u201d University of Iasi, 11 Carol I Blvd., 700506 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0343-5718","authenticated-orcid":false,"given":"Aurel","family":"Pui","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry, \u201cAlexandru Ioan Cuza\u201d University of Iasi, 11 Carol I Blvd., 700506 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.matpr.2023.01.149","article-title":"Microemulsion and its application: An inside story","volume":"83","author":"Mitra","year":"2023","journal-title":"Mater. 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