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Paclitaxel, Violacein and Tetrandrine showed a significant reduction in their partition coefficient values by coupling with the carbon-based quantum dots. Paclitaxel\u2019s partition coefficient value decreased from 3.96 to 0.2, Violacein\u2019s from 3.34 to 1.17, and Tetrandrine\u2019s from 2.5 to 1.57, thus demonstrating a significant reduction in their hydrophobicity without being encapsulated. The efficiency of each type of carbon-based quantum dot in lowering each drug\u2019s Log P varied and this behavior was correlated with the nature of the surface interaction between each drug and each of the carbon-based quantum dots.<\/jats:p>","DOI":"10.3390\/nano16181166","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T10:09:17Z","timestamp":1789553357000},"page":"1166","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Improving the Hydrophilicity of the Drugs Paclitaxel, Violacein, and Tetrandrine Using Carbon-Based Quantum Dots"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-1484-9148","authenticated-orcid":false,"given":"Christine","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Chemistry, Smith College, Northampton, MA 01063, 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