{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:52:38Z","timestamp":1791262358237,"version":"4.1.0"},"reference-count":134,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:00:00Z","timestamp":1791072000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"King Faisal University","award":["KFU265408"],"award-info":[{"award-number":["KFU265408"]}],"id":[{"id":"https:\/\/ror.org\/00dn43547","id-type":"ROR","asserted-by":"crossref"}]},{"award":["KFU265408"],"award-info":[{"award-number":["KFU265408"]}],"id":[{"id":"https:\/\/ror.org\/00dn43547","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nanomaterials"],"abstract":"<jats:p>Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies worldwide due to late-stage diagnosis, aggressive progression, and limited therapeutic responsiveness. Although herbal-derived bioactive compounds have demonstrated promising anticancer potential, their clinical application is often restricted by poor aqueous solubility, low bioavailability, rapid metabolic degradation, and insufficient tumor targeting. Nanomedicine has emerged as a promising platform to overcome these limitations through enhanced drug delivery, improved pharmacokinetics, and controlled release capabilities. In recent years, the integration of green nanotechnology with herbal therapeutics has gained increasing attention as a sustainable and biocompatible strategy for PDAC management. Green synthesis approaches utilizing plant extracts, microbial systems, and biopolymers provide environmentally friendly alternatives to conventional physicochemical nanoparticle (NP) fabrication methods while simultaneously enhancing biological functionality. This review aims to explore green nanotechnology-based strategies for improving the therapeutic potential of herbal-derived bioactive compounds in PDAC, with particular emphasis on nanoformulation approaches that enhance solubility, bioavailability, tumor targeting, and anticancer efficacy. In addition, the review discusses the advantages of green synthesis approaches, NP characterization strategies, translational barriers, biosafety considerations, and current clinical challenges. Overall, this review highlights the growing potential of green nanomedicine to improve herbal-based therapeutic strategies against PDAC while emphasizing the key obstacles that must be addressed to facilitate successful clinical translation.<\/jats:p>","DOI":"10.3390\/nano16191256","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:00:22Z","timestamp":1791187222000},"page":"1256","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["From Nature to Medicine: Overcoming the Limitations of Herbal Therapeutics for Pancreatic Cancer Treatment Based on Nanotechnology"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3328-3559","authenticated-orcid":false,"given":"Ghazala","family":"Muteeb","sequence":"first","affiliation":[{"name":"Department of Nursing, College of Applied Medical Sciences, King Faisal University, Al-Ahsa 31982, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3529-4706","authenticated-orcid":false,"given":"Youssef","family":"Basem","sequence":"additional","affiliation":[{"name":"Medical and Pharmaceutical Industrial Biotechnology Department, College of Biotechnology, Misr University for Science and Technology (MUST), 6th of October City 12566, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amira A.","family":"Kotb","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, Faculty of Science, Cairo University, Giza 12613, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naiera T.","family":"Magdy","sequence":"additional","affiliation":[{"name":"Faculty of Biotechnology, German International University (GIU), New Administration Capital 11835, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghannimah Yousef","family":"Alghuwainem","sequence":"additional","affiliation":[{"name":"Department of Nursing, College of Applied Medical Sciences, King Faisal University, Al-Ahsa 31982, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1748-2160","authenticated-orcid":false,"given":"Mohammad","family":"Aatif","sequence":"additional","affiliation":[{"name":"Department of Public Health, College of Applied Medical Sciences, King Faisal University, Al-Ahsa 31982, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1519-9644","authenticated-orcid":false,"given":"Mohd","family":"Farhan","sequence":"additional","affiliation":[{"name":"Department of Chemistry, College of Science, King Faisal University, Al-Ahsa 31982, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0576-0100","authenticated-orcid":false,"given":"Doaa S. 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