{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:02:23Z","timestamp":1790416943168,"version":"4.1.0"},"reference-count":30,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2017,3,28]],"date-time":"2017-03-28T00:00:00Z","timestamp":1490659200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nanomaterials"],"abstract":"<jats:p>Multiple formulations of iron oxide nanoparticles (IONPs) have been proposed for enhancing contrast in magnetic resonance imaging (MRI) and for increasing efficacy in thermal ablation therapies. However, insufficient accumulation at the disease site and low magnetic performance hamper the clinical application of IONPs. Here, 20 nm iron oxide nanocubes were assembled into larger nanoconstructs externally stabilized by a serum albumin coating. The resulting assemblies of nanocubes (ANCs) had an average diameter of 100 nm and exhibited transverse relaxivity (r2 = 678.9 \u00b1 29.0 mM\u20121\u00b7s\u20121 at 1.41 T) and heating efficiency (specific absorption rate of 109.8 \u00b1 12.8 W\u00b7g\u20121 at 512 kHz and 10 kA\u00b7m\u20121). In mice bearing glioblastoma multiforme tumors, Cy5.5-labeled ANCs allowed visualization of malignant masses via both near infrared fluorescent and magnetic resonance imaging. Also, upon systemic administration of ANCs (5 mgFe\u00b7kg\u20121), 30 min of daily exposure to alternating magnetic fields for three consecutive days was sufficient to halt tumor progression. This study demonstrates that intravascular administration of ANCs can effectively visualize and treat neoplastic masses.<\/jats:p>","DOI":"10.3390\/nano7040072","type":"journal-article","created":{"date-parts":[[2017,3,28]],"date-time":"2017-03-28T10:24:33Z","timestamp":1490696673000},"page":"72","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Assembly of Iron Oxide Nanocubes for Enhanced Cancer Hyperthermia and Magnetic Resonance Imaging"],"prefix":"10.3390","volume":"7","author":[{"given":"Minjung","family":"Cho","sequence":"first","affiliation":[{"name":"Department of Translational Imaging &amp; Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX 77030, USA"},{"name":"Department of Chemistry, Rice University, Houston, TX 77005, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Cervadoro","sequence":"additional","affiliation":[{"name":"Laboratory of Nanotechnology for Precision Medicine, Fondazione Istituto Italiano di Tecnologia, 16163 Genova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maricela","family":"Ramirez","sequence":"additional","affiliation":[{"name":"Department of Translational Imaging &amp; Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cinzia","family":"Stigliano","sequence":"additional","affiliation":[{"name":"Department of Translational Imaging &amp; Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9536-1586","authenticated-orcid":false,"given":"Audrius","family":"Brazdeikis","sequence":"additional","affiliation":[{"name":"Department of Physics and Texas Center for Superconductivity, University of Houston, Houston, TX 77004, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicki","family":"Colvin","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Rice University, Houston, TX 77005, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierluigi","family":"Civera","sequence":"additional","affiliation":[{"name":"Dipartimento di Elettronica e Telecomunicazioni, Politecnico di Torino, I-10129 Torino, Italy"},{"name":"Pierluigi Civera died on 28 October 2014."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaehong","family":"Key","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Yonsei University, 1 Yonseidae-gil, Wonju, Gangwon-do 220-710, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Decuzzi","sequence":"additional","affiliation":[{"name":"Laboratory of Nanotechnology for Precision Medicine, Fondazione Istituto Italiano di Tecnologia, 16163 Genova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2017,3,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2729","DOI":"10.1002\/adma.201000260","article-title":"Synthesis, functionalization, and biomedical applications of multifunctional magnetic nanoparticles","volume":"22","author":"Hao","year":"2010","journal-title":"Adv. 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