{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T12:21:44Z","timestamp":1791721304631,"version":"4.3.4"},"reference-count":90,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2017,7,22]],"date-time":"2017-07-22T00:00:00Z","timestamp":1500681600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nanomaterials"],"abstract":"<jats:p>Even though cancer treatment has improved over the recent decades, still more specific and effective treatment concepts are mandatory. Surgical removal is not always possible, metastases are challenging and chemo- and radiotherapy can not only have severe side-effects but also resistances may occur. To cope with these challenges more efficient therapies with fewer side-effects are required. One promising approach is the use of drug delivery vehicles. Here, mesoporous silica nanoparticles (MSN) are discussed as biodegradable drug carrier to improve efficacy and reduce side-effects. MSN excellently fulfill the criteria for nanoparticulate carriers: their distinct structure allows high loading capacity and a plethora of surface modifications. MSN synthesis permits fine-tuning of particle and pore sizes. Moreover, drug release can be tailored through various gatekeeper systems which are for example pH-sensitive or redox-sensitive. Furthermore, MSN can either enter tumors passively by the enhanced permeability and retention effect or can be actively targeted by various ligands. PEGylation prolongs circulation time and availability. A huge advantage of MSN is their explicitly low toxic profile in vivo. Yet, clinical translation remains challenging. Overall, mesoporous silica nanoparticles are a promising tool for innovative, more efficient and safer cancer therapies.<\/jats:p>","DOI":"10.3390\/nano7070189","type":"journal-article","created":{"date-parts":[[2017,7,24]],"date-time":"2017-07-24T10:04:13Z","timestamp":1500890653000},"page":"189","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":385,"title":["Mesoporous Silica Nanoparticles as Drug Delivery Vehicles in Cancer"],"prefix":"10.3390","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4600-9065","authenticated-orcid":false,"given":"Anna","family":"Watermann","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Mainz, Langenbeckstra\u00dfe 1, 55131 Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juergen","family":"Brieger","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Mainz, Langenbeckstra\u00dfe 1, 55131 Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2017,7,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21387","article-title":"Cancer statistics, 2017. CA","volume":"67","author":"Siegel","year":"2017","journal-title":"Cancer J. Clin."},{"key":"ref_2","first-page":"6387","article-title":"A New Concept for Macromolecular Therapeutics in Cancer Chemotherapy: Mechanism of Tumoritropic Accumulation of Proteins and the Antitumor Agent Smancs","volume":"46","author":"Matsumura","year":"1986","journal-title":"Cancer Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.1007\/s11095-016-1958-5","article-title":"Nanoparticle-Based Medicines: A Review of FDA-Approved Materials and Clinical Trials to Date","volume":"33","author":"Bobo","year":"2016","journal-title":"Pharm. Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1053\/j.seminoncol.2004.08.001","article-title":"Advantages of liposomal delivery systems for anthracyclines","volume":"31","author":"Allen","year":"2004","journal-title":"Semin. Oncol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1039\/C4TB02017K","article-title":"Silica-coated Au@ZnO Janus particles and their stability in epithelial cells","volume":"3","author":"Susewind","year":"2015","journal-title":"J. Mater. Chem. B"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1007\/s003300100908","article-title":"Superparamagnetic iron oxide contrast agents: Physicochemical characteristics and applications in MR imaging","volume":"11","author":"Wang","year":"2001","journal-title":"Eur. Radiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.cbpa.2005.10.005","article-title":"Applications of carbon nanotubes in drug delivery","volume":"9","author":"Bianco","year":"2005","journal-title":"Curr. Opin. Chem. Biol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1126\/science.281.5385.2013","article-title":"Semiconductor Nanocrystals as Fluorescent Biological Labels","volume":"281","author":"Bruchez","year":"1998","journal-title":"Science"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1002\/smll.200700005","article-title":"Mesoporous Silica Nanoparticles as a Delivery System for Hydrophobic Anticancer Drugs","volume":"3","author":"Lu","year":"2007","journal-title":"Small"},{"key":"ref_10","unstructured":"(2017, April 06). Targeted Silica Nanoparticles for Image-Guided Intraoperative Sentinel Lymph Node Mapping in Head and Neck Melanoma, Breast and Gynecologic Malignancies, Available online: https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02106598?term=silica+nanoparticle&rank=1."},{"key":"ref_11","unstructured":"(2017, April 07). US Food and Drug Administration GRAS Substances (SCOGS) Database\u2014Select Committee on GRAS Substances (SCOGS) Opinion: Silicates, Available online: https:\/\/www.fda.gov\/food\/ingredientspackaginglabeling\/gras\/scogs\/ucm260849.htm."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.surfrep.2014.07.001","article-title":"Synthesis and surface functionalization of silica nanoparticles for nanomedicine","volume":"69","author":"Liberman","year":"2014","journal-title":"Surf. Sci. Rep."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1038\/359710a0","article-title":"Ordered mesoporous molecular sieves synthesized by a liquid-crystal template mechanism","volume":"359","author":"Kresge","year":"1992","journal-title":"Nature"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1002\/adma.201104763","article-title":"Mesoporous silica nanoparticles: Synthesis, biocompatibility and drug delivery","volume":"24","author":"Tang","year":"2012","journal-title":"Adv. Mater."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1126\/science.279.5350.548","article-title":"Triblock copolymer syntheses of mesoporous silica with periodic 50 to 300 angstrom pores","volume":"279","author":"Zhao","year":"1998","journal-title":"Science"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1002\/smll.201200028","article-title":"Efficient functional delivery of siRNA using mesoporous silica nanoparticles with ultralarge pores","volume":"8","author":"Na","year":"2012","journal-title":"Small"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1002\/adma.201505524","article-title":"Large Pore-Sized Hollow Mesoporous Organosilica for Redox-Responsive Gene Delivery and Synergistic Cancer Chemotherapy","volume":"28","author":"Wu","year":"2016","journal-title":"Adv. Mater."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Roberts, C.M., Shahin, S.A., Wen, W., Finlay, J.B., Dong, J., Wang, R., Dellinger, T.H., Zink, J.I., Tamanoi, F., and Glackin, C.A. (2016). Nanoparticle delivery of siRNA against TWIST to reduce drug resistance and tumor growth in ovarian cancer models. Nanomed. Nanotechnol. Biol. Med.","DOI":"10.1016\/j.nano.2016.11.010"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"4830","DOI":"10.1039\/C4NJ00579A","article-title":"A dual responsive targeted drug delivery system based on smart polymer coated mesoporous silica for laryngeal carcinoma treatment","volume":"38","author":"Liu","year":"2014","journal-title":"New J. Chem."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2647","DOI":"10.1021\/acs.molpharmaceut.6b00190","article-title":"Functionalized Mesoporous Silica Nanoparticle with Antioxidants as a New Carrier That Generates Lower Oxidative Stress Impact on Cells","volume":"13","author":"Rahmani","year":"2016","journal-title":"Mol. Pharm."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev-bioeng-071811-150124","article-title":"The Effect of Nanoparticle Size, Shape, and Surface Chemistry on Biological Systems","volume":"14","author":"Albanese","year":"2012","journal-title":"Annu. Rev. Biomed. Eng."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"4355","DOI":"10.1039\/C4DT03758H","article-title":"Enzyme and voltage stimuli-responsive controlled release system based on \u03b2-cyclodextrin-capped mesoporous silica nanoparticles","volume":"44","author":"Xiao","year":"2015","journal-title":"Dalton Trans."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"4291","DOI":"10.1039\/c3nr00294b","article-title":"Intracellular cleavable poly(2-dimethylaminoethyl methacrylate) functionalized mesoporous silica nanoparticles for efficient siRNA delivery in vitro and in vivo","volume":"5","author":"Lin","year":"2013","journal-title":"Nanoscale"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"4007","DOI":"10.1039\/C5NR06246B","article-title":"Highly efficient siRNA delivery from core-shell mesoporous silica nanoparticles with multifunctional polymer caps","volume":"8","author":"Engelke","year":"2016","journal-title":"Nanoscale"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/nmat2992","article-title":"The targeted delivery of multicomponent cargos to cancer cells by nanoporous particle-supported lipid bilayers","volume":"10","author":"Ashley","year":"2011","journal-title":"Nat. Mater."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1007\/s11051-007-9317-4","article-title":"Measuring sub nanometre sizes using dynamic light scattering","volume":"10","author":"Kaszuba","year":"2008","journal-title":"J. Nanopart. Res."},{"key":"ref_27","first-page":"5577","article-title":"The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles","volume":"7","year":"2012","journal-title":"Int. J. Nanomed."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"14792","DOI":"10.1021\/ja0645943","article-title":"Effect of surface functionalization of MCM-41-type mesoporous silica nanoparticles on the endocytosis by human cancer cells","volume":"128","author":"Slowing","year":"2006","journal-title":"J. Am. Chem. Soc."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/nmat2442","article-title":"Understanding biophysicochemical interactions at the nano-bio interface","volume":"8","author":"Nel","year":"2009","journal-title":"Nat. Mater."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"11613","DOI":"10.1073\/pnas.0801763105","article-title":"The effect of particle design on cellular internalization pathways","volume":"105","author":"Gratton","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1002\/smll.200900005","article-title":"Size effect on cell uptake in well-suspended, uniform mesoporous silica nanoparticles","volume":"5","author":"Lu","year":"2009","journal-title":"Small"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/nrm883","article-title":"Signal transduction and endocytosis: Close encounters of many kinds","volume":"3","author":"Sorkin","year":"2002","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/j.biomaterials.2009.10.046","article-title":"The effect of PEGylation of mesoporous silica nanoparticles on nonspecific binding of serum proteins and cellular responses","volume":"31","author":"He","year":"2010","journal-title":"Biomaterials"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.nano.2015.10.018","article-title":"Advances in silica based nanoparticles for targeted cancer therapy","volume":"12","author":"Yang","year":"2016","journal-title":"Nanomed. Nanotechnol. Biol. Med."},{"key":"ref_35","first-page":"339","article-title":"Switch to the angiogenic phenotype during tumorigenesis","volume":"22","author":"Folkman","year":"1991","journal-title":"Princess Takamatsu Symp."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/natrevmats.2016.14","article-title":"Analysis of nanoparticle delivery to tumours","volume":"1","author":"Wilhelm","year":"2016","journal-title":"Nat. Rev. Mater."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.addr.2010.04.009","article-title":"The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect","volume":"63","author":"Fang","year":"2011","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_38","first-page":"845","article-title":"The mononuclear phagocyte system: A new classification of macrophages, monocytes, and their precursor cells","volume":"46","author":"Cohn","year":"1972","journal-title":"Bull. World Health Organ."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"5390","DOI":"10.1021\/nn200365a","article-title":"The shape effect of mesoporous silica nanoparticles on biodistribution, clearance, and biocompatibility in vivo","volume":"5","author":"Huang","year":"2011","journal-title":"ACS Nano"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1002\/smll.201000538","article-title":"Biocompatibility, biodistribution, and drug-delivery efficiency of mesoporous silica nanoparticles for cancer therapy in animals","volume":"6","author":"Lu","year":"2010","journal-title":"Small"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1002\/jat.1486","article-title":"Cellular uptake and toxicity of gold nanoparticles in prostate cancer cells: A comparative study of rods and spheres","volume":"30","author":"Malugin","year":"2010","journal-title":"J. Appl. Toxicol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1078\/0171-9335-00363","article-title":"PEGylation significantly affects cellular uptake and intracellular trafficking of non-viral gene delivery particles","volume":"83","author":"Mishra","year":"2004","journal-title":"Eur. J. Cell Biol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.micromeso.2010.11.013","article-title":"PEGylated hollow mesoporous silica nanoparticles as potential drug delivery vehicles","volume":"141","author":"Zhu","year":"2011","journal-title":"Microporous Mesoporous Mater."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1038\/nrc1456","article-title":"High interstitial fluid pressure\u2014An obstacle in cancer therapy","volume":"4","author":"Heldin","year":"2004","journal-title":"Nat. Rev. Cancer"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.ab.2004.12.026","article-title":"Folate receptor expression in carcinomas and normal tissues determined by a quantitative radioligand binding assay","volume":"338","author":"Parker","year":"2005","journal-title":"Anal. Biochem."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1007\/s13277-015-4007-9","article-title":"Targeting CD133+ laryngeal carcinoma cells with chemotherapeutic drugs and siRNA against ABCG2 mediated by thermo\/pH-sensitive mesoporous silica nanoparticles","volume":"37","author":"Qi","year":"2016","journal-title":"Tumor Biol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.tranon.2016.12.011","article-title":"Dual Functional Mesoporous Silicon Nanoparticles Enhance the Radiosensitivity of VPA in Glioblastoma","volume":"10","author":"Zhang","year":"2017","journal-title":"Transl. Oncol."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Cheng, W., Nie, J., Xu, L., Liang, C., Peng, Y., Liu, G., Wang, T., Mei, L., Huang, L., and Zeng, X. (2017). A pH-sensitive delivery vehicle based on folic acid-conjugated polydopamine-modified mesoporous silica nanoparticles for targeted cancer therapy. ACS Appl. Mater. Interfaces.","DOI":"10.1021\/acsami.7b02457"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.colsurfb.2017.01.010","article-title":"Transferrin gated mesoporous silica nanoparticles for redox-responsive and targeted drug delivery","volume":"152","author":"Chen","year":"2017","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1016\/j.nano.2017.03.014","article-title":"Lectin-functionalized mesoporous silica nanoparticles for endoscopic detection of premalignant colonic lesions","volume":"13","author":"Chen","year":"2017","journal-title":"Nanomed. Nanotechnol. Biol. Med."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1166\/jbn.2017.2339","article-title":"Peptide-Mediated Targeting Mesoporous Silica Nanoparticles: A Novel Tool for Fighting Bladder Cancer","volume":"13","author":"Sweeney","year":"2017","journal-title":"J. Biomed. Nanotechnol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1002\/jbm.820251209","article-title":"Synthesis and cell attachment activity of bioactive oligopeptides: RGD, RGDS, RGDV, and RGDT","volume":"25","author":"Hirano","year":"1991","journal-title":"J. Biomed. Mater. Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"13447","DOI":"10.3390\/ijms140713447","article-title":"The functions and applications of RGD in tumor therapy and tissue engineering","volume":"14","author":"Wang","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"6742","DOI":"10.1002\/adma.201402752","article-title":"MSN-mediated sequential vascular-to-cell nuclear-targeted drug delivery for efficient tumor regression","volume":"26","author":"Pan","year":"2014","journal-title":"Adv. Mater."},{"key":"ref_55","first-page":"668","article-title":"Tumor targeting by an aptamer","volume":"47","author":"Hicke","year":"2006","journal-title":"J. Nucl. Med."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Babaei, M., Abnous, K., Taghdisi, S.M., Amel Farzad, S., Peivandi, M.T., Ramezani, M., and Alibolandi, M. (2017). Synthesis of theranostic epithelial cell adhesion molecule targeted mesoporous silica nanoparticle with gold gatekeeper for hepatocellular carcinoma. Nanomedicine.","DOI":"10.2217\/nnm-2017-0028"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"6304","DOI":"10.1039\/C4NR07493A","article-title":"An aptamer-targeting photoresponsive drug delivery system using \u201coff\u2013on\u201d graphene oxide wrapped mesoporous silica nanoparticles","volume":"7","author":"Tang","year":"2015","journal-title":"Nanoscale"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"8325","DOI":"10.1021\/acsnano.6b02819","article-title":"Mesoporous Silica Nanoparticle-Supported Lipid Bilayers (Protocells) for Active Targeting and Delivery to Individual Leukemia Cells","volume":"10","author":"Durfee","year":"2016","journal-title":"ACS Nano"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s13046-017-0492-6","article-title":"Intracellular pH-responsive and rituximab-conjugated mesoporous silica nanoparticles for targeted drug delivery to lymphoma B cells","volume":"36","author":"Zhou","year":"2017","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.1182\/blood.V90.6.2188","article-title":"IDEC-C2B8 (Rituximab) Anti-CD20 Monoclonal Antibody Therapy in Patients With Relapsed Low-Grade Non-Hodgkin\u2019s Lymphoma","volume":"9","author":"Maloney","year":"1997","journal-title":"Blood"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"5080","DOI":"10.1038\/srep05080","article-title":"Engineering of Hollow Mesoporous Silica Nanoparticles for Remarkably Enhanced Tumor Active Targeting Efficacy","volume":"4","author":"Chen","year":"2014","journal-title":"Sci. Rep."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"4007","DOI":"10.1021\/mp500306k","article-title":"In vivo tumor vasculature targeted PET\/NIRF Imaging with TRC105(Fab)-conjugated, dual-labeled mesoporous silica nanoparticles","volume":"11","author":"Chen","year":"2014","journal-title":"Mol. Pharm."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.addr.2015.09.009","article-title":"Development of mesoporous silica-based nanoparticles with controlled release capability for cancer therapy","volume":"95","author":"Mekaru","year":"2015","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1038\/nrc1478","article-title":"Why do cancers have high aerobic glycolysis?","volume":"4","author":"Gatenby","year":"2004","journal-title":"Nat. Rev. Cancer"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"12690","DOI":"10.1021\/ja104501a","article-title":"Autonomous in vitro anticancer drug release from mesoporous silica nanoparticles by pH-sensitive nanovalves","volume":"132","author":"Meng","year":"2010","journal-title":"J. Am. Chem. Soc."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"4735","DOI":"10.1002\/smll.201600531","article-title":"Magnetic Core-Shell Silica Nanoparticles with Large Radial Mesopores for siRNA Delivery","volume":"12","author":"Xiong","year":"2016","journal-title":"Small"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"11173","DOI":"10.1039\/c2jm30501a","article-title":"A pH-responsive drug delivery system based on chitosan coated mesoporous silica nanoparticles","volume":"22","author":"Popat","year":"2012","journal-title":"J. Mater. Chem."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.biomaterials.2016.01.008","article-title":"Hollow mesoporous silica nanoparticles facilitated drug delivery via cascade pH stimuli in tumor microenvironment for tumor therapy","volume":"83","author":"Liu","year":"2016","journal-title":"Biomaterials"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1080\/10408360500523878","article-title":"Glutathione in Cancer Biology and Therapy","volume":"43","author":"Estrela","year":"2006","journal-title":"Crit. Rev. Clin. Lab. Sci."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"4280","DOI":"10.1002\/adma.201001417","article-title":"Glutathione-induced intracellular release of guests from mesoporous silica nanocontainers with cyclodextrin gatekeepers","volume":"22","author":"Kim","year":"2010","journal-title":"Adv. Mater."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"14418","DOI":"10.1021\/ja8060886","article-title":"Tunable Redox-Responsive Hybrid Nanogated Ensembles","volume":"130","author":"Liu","year":"2008","journal-title":"J. Am. Chem. Soc."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.ijpharm.2016.07.029","article-title":"Ammonium salt modified mesoporous silica nanoparticles for dual intracellular-responsive gene delivery","volume":"511","author":"Li","year":"2016","journal-title":"Int. J. Pharm."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"5271","DOI":"10.1002\/chem.201400148","article-title":"Enzyme-responsive intracellular-controlled release using silica mesoporous nanoparticles capped with \u03b5-poly-L-lysine","volume":"20","author":"Mas","year":"2014","journal-title":"Chemistry"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"6353","DOI":"10.1021\/nn101499d","article-title":"Enzyme-responsive intracellular controlled release using nanometric silica mesoporous supports capped with \u201csaccharides\u201d","volume":"4","author":"Bernardos","year":"2010","journal-title":"ACS Nano"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"14000","DOI":"10.1021\/ja407331n","article-title":"Activation of snap-top capped mesoporous silica nanocontainers using two near-infrared photons","volume":"135","author":"Russell","year":"2013","journal-title":"J. Am. Chem. Soc."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"13813","DOI":"10.1002\/anie.201308647","article-title":"Two-photon-triggered drug delivery in cancer cells using nanoimpellers","volume":"52","author":"Croissant","year":"2013","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"2535","DOI":"10.1039\/c0jm02590a","article-title":"Multifunctional magnetically removable nanogated lids of Fe3O4\u2013capped mesoporous silica nanoparticles for intracellular controlled release and MR imaging","volume":"21","author":"Chen","year":"2011","journal-title":"J. Mater. Chem."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"10623","DOI":"10.1021\/ja1022267","article-title":"Noninvasive remote-controlled release of drug molecules in vitro using magnetic actuation of mechanized nanoparticles","volume":"132","author":"Thomas","year":"2010","journal-title":"J. Am. Chem. Soc."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1080\/09205063.2012.690282","article-title":"Modeling the proton sponge hypothesis: examining proton sponge effectiveness for enhancing intracellular gene delivery through multiscale modeling","volume":"24","author":"Freeman","year":"2013","journal-title":"J. Biomater. Sci. Polym. Ed."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1016\/j.nano.2015.05.011","article-title":"Mesoporous silica nanoparticle delivery of chemically modified siRNA against TWIST1 leads to reduced tumor burden","volume":"11","author":"Finlay","year":"2015","journal-title":"Nanomedicine"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"6415","DOI":"10.1039\/c4nr00018h","article-title":"Enhancing endosomal escape for nanoparticle mediated siRNA delivery","volume":"6","author":"Ma","year":"2014","journal-title":"Nanoscale"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"6097","DOI":"10.1021\/bi00267a011","article-title":"Transbilayer redistribution of phosphatidylethanolamine during fusion of phospholipid vesicles. Dependence on fusion rate, lipid phase separation, and formation of nonbilayer structures","volume":"21","author":"Hoekstra","year":"1982","journal-title":"Biochemistry"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"3650","DOI":"10.1016\/j.biomaterials.2014.01.013","article-title":"Biofunctionalized polymer-lipid supported mesoporous silica nanoparticles for release of chemotherapeutics in multidrug resistant cancer cells","volume":"35","author":"Zhang","year":"2014","journal-title":"Biomaterials"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1016\/j.biomaterials.2012.10.072","article-title":"A mesoporous silica nanoparticle\u2014PEI\u2014Fusogenic peptide system for siRNA delivery in cancer therapy","volume":"34","author":"Li","year":"2013","journal-title":"Biomaterials"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/nmat2398","article-title":"Biodegradable luminescent porous silicon nanoparticles for in vivo applications","volume":"8","author":"Park","year":"2009","journal-title":"Nat. Mater."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/adma.201404256","article-title":"Large-pore ultrasmall mesoporous organosilica nanoparticles: Micelle\/precursor co-templating assembly and nuclear-targeted gene delivery","volume":"27","author":"Wu","year":"2015","journal-title":"Adv. Mater."},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Duan, J., Yu, Y., Li, Y., Yu, Y., Li, Y., Zhou, X., Huang, P., and Sun, Z. (2013). Toxic effect of silica nanoparticles on endothelial cells through DNA damage response via Chk1-dependent G2\/M checkpoint. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0062087"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.ejpb.2009.12.006","article-title":"Cytotoxicity study of ordered mesoporous silica MCM-41 and SBA-15 microparticles on Caco-2 cells","volume":"74","author":"Santos","year":"2010","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1021\/ar3000986","article-title":"Mesoporous silica nanoparticle nanocarriers: Biofunctionality and biocompatibility","volume":"46","author":"Tarn","year":"2013","journal-title":"Acc. Chem. Res."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1002\/smll.201001459","article-title":"In vivo biodistribution and urinary excretion of mesoporous silica nanoparticles: Effects of particle size and PEGylation","volume":"7","author":"He","year":"2011","journal-title":"Small"}],"container-title":["Nanomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-4991\/7\/7\/189\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T18:43:39Z","timestamp":1760208219000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-4991\/7\/7\/189"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,22]]},"references-count":90,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2017,7]]}},"alternative-id":["nano7070189"],"URL":"https:\/\/doi.org\/10.3390\/nano7070189","relation":{},"ISSN":["2079-4991"],"issn-type":[{"value":"2079-4991","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,22]]}}}