{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T09:09:49Z","timestamp":1789981789053,"version":"4.0.1"},"reference-count":57,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2019,5,20]],"date-time":"2019-05-20T00:00:00Z","timestamp":1558310400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nanomaterials"],"abstract":"<jats:p>Gold nanoparticles (AuNPs), which are strongly hydrophilic and dimensionally suitable for drug delivery, were used in loading and release studies of two different copper(I)-based antitumor complexes, namely [Cu(PTA)4]+ [BF4]\u2212 (A; PTA = 1, 3, 5-triaza-7-phosphadamantane) and [HB(pz)3Cu(PCN)] (B; HB(pz)3 = tris(pyrazolyl)borate, PCN = tris(cyanoethyl)phosphane). In the homoleptic, water-soluble compound A, the metal is tetrahedrally arranged in a cationic moiety. Compound B is instead a mixed-ligand (scorpionate\/phosphane), neutral complex insoluble in water. In this work, the loading procedures and the loading efficiency of A and B complexes on the AuNPs were investigated, with the aim to improve their bioavailability and to obtain a controlled release. The non-covalent interactions of A and B with the AuNPs surface were studied by means of dynamic light scattering (DLS), UV\u2013Vis, FT-IR and high-resolution x-ray photoelectron spectroscopy (HR-XPS) measurements. As a result, the AuNPs-A system proved to be more stable and efficient than the AuNPs-B system. In fact, for AuNPs-A the drug loading reached 90%, whereas for AuNPs-B it reached 65%. For AuNPs-A conjugated systems, a release study in water solution was performed over 4 days, showing a slow release up to 10%.<\/jats:p>","DOI":"10.3390\/nano9050772","type":"journal-article","created":{"date-parts":[[2019,5,20]],"date-time":"2019-05-20T11:05:07Z","timestamp":1558350307000},"page":"772","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Highly Hydrophilic Gold Nanoparticles as Carrier for Anticancer Copper(I) Complexes: Loading and Release Studies for Biomedical Applications"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5172-0636","authenticated-orcid":false,"given":"Ilaria","family":"Fratoddi","sequence":"first","affiliation":[{"name":"Chemistry Department Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9306-573X","authenticated-orcid":false,"given":"Iole","family":"Venditti","sequence":"additional","affiliation":[{"name":"Sciences Department  Roma Tre University of Rome, via della Vasca navale 79, 00146 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4590-0865","authenticated-orcid":false,"given":"Chiara","family":"Battocchio","sequence":"additional","affiliation":[{"name":"Sciences Department  Roma Tre University of Rome, via della Vasca navale 79, 00146 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Carlini","sequence":"additional","affiliation":[{"name":"Sciences Department  Roma Tre University of Rome, via della Vasca navale 79, 00146 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Amatori","sequence":"additional","affiliation":[{"name":"Chemistry Department Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0435-6576","authenticated-orcid":false,"given":"Marina","family":"Porchia","sequence":"additional","affiliation":[{"name":"ICMATE, National Research Council (CNR), Corso Stati Uniti, 4-35127 Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Tisato","sequence":"additional","affiliation":[{"name":"ICMATE, National Research Council (CNR), Corso Stati Uniti, 4-35127 Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Bondino","sequence":"additional","affiliation":[{"name":"IOM-CNR Laboratorio TASC, SS 14, km 163,5 Basovizza, I-34149 Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6465-807X","authenticated-orcid":false,"given":"Elena","family":"Magnano","sequence":"additional","affiliation":[{"name":"IOM-CNR Laboratorio TASC, SS 14, km 163,5 Basovizza, I-34149 Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5020-1730","authenticated-orcid":false,"given":"Maura","family":"Pellei","sequence":"additional","affiliation":[{"name":"School of Science and Technology, University of Camerino, 62032 Camerino (MC) Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3942-1713","authenticated-orcid":false,"given":"Carlo","family":"Santini","sequence":"additional","affiliation":[{"name":"School of Science and Technology, University of Camerino, 62032 Camerino (MC) Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,5,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"19442","DOI":"10.1038\/srep19442","article-title":"Imaging and radiation effects of gold nanoparticles in tumour cells","volume":"6","author":"McQuaid","year":"2016","journal-title":"Sci. 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