{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:34:02Z","timestamp":1791293642065,"version":"4.1.0"},"reference-count":85,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2019,10,2]],"date-time":"2019-10-02T00:00:00Z","timestamp":1569974400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nanomaterials"],"abstract":"<jats:p>Biomedical investigations using layered double hydroxide (LDH) nanoparticles have attracted tremendous attentions due to their advantages such as biocompatibility, variable-chemical compositions, anion-exchange capacity, host\u2013guest interactions, and crystallization-dissolution characters. Bio-imaging becomes more and more important since it allows theranostics to combine therapy and diagnosis, which is a concept of next-generation medicine. Based on the unique features mentioned above, LDHs create novel opportunities for bio-imaging and simultaneous therapy with LDHs-based nanohybrids. This review aims to explore the recent advances in multifunctional LDH nanohybrids ranging from synthesis to practical applications for various bio-imaging with therapeutic functions. Furthermore, their potential both as diagnostic agents and drug delivery carriers will be discussed with the improvement in noninvasive bio-imaging techniques.<\/jats:p>","DOI":"10.3390\/nano9101404","type":"journal-article","created":{"date-parts":[[2019,10,2]],"date-time":"2019-10-02T08:17:54Z","timestamp":1570004274000},"page":"1404","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Functional Layered Double Hydroxide Nanohybrids for Biomedical Imaging"],"prefix":"10.3390","volume":"9","author":[{"given":"Wenji","family":"Jin","sequence":"first","affiliation":[{"name":"Department of Nano Materials Science and Engineering, Kyungnam University, Changwon, Gyeongsangnamdo 51767, Korea"},{"name":"College of Chemistry and Environmental Engineering, Jiujiang University, Jiujiang 332005, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dae-Hwan","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Nano Materials Science and Engineering, Kyungnam University, Changwon, Gyeongsangnamdo 51767, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,10,2]]},"reference":[{"key":"ref_1","first-page":"1","article-title":"Structural Aspects of Layered Double Hydroxides","volume":"Volume 119","author":"Evans","year":"2006","journal-title":"Layered Double Hydroxides"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1016\/j.progpolymsci.2013.05.007","article-title":"Polymer\u2013inorganic supramolecular nanohybrids for red, white, green, and blue applications","volume":"38","author":"Park","year":"2013","journal-title":"Prog. 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