{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T01:07:50Z","timestamp":1792112870642,"version":"4.4.0"},"reference-count":267,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T00:00:00Z","timestamp":1705536000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Swiss National Science Foundation (SNSF)","award":["IZSTZ0_198887"],"award-info":[{"award-number":["IZSTZ0_198887"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ncRNA"],"abstract":"<jats:p>Recently, myriad studies have defined the versatile abilities of gasotransmitters and their synthesizing enzymes to play a \u201cMaestro\u201d role in orchestrating several oncological and non-oncological circuits and, thus, nominated them as possible therapeutic targets. Although a significant amount of work has been conducted on the role of nitric oxide (NO) and carbon monoxide (CO) and their inter-relationship in the field of oncology, research about hydrogen sulfide (H2S) remains in its infancy. Recently, non-coding RNAs (ncRNAs) have been reported to play a dominating role in the regulation of the endogenous machinery system of H2S in several pathological contexts. A growing list of microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are leading the way as upstream regulators for H2S biosynthesis in different mammalian cells during the development and progression of human diseases; therefore, their targeting can be of great therapeutic benefit. In the current review, the authors shed the light onto the biosynthetic pathways of H2S and their regulation by miRNAs and lncRNAs in various oncological and non-oncological disorders.<\/jats:p>","DOI":"10.3390\/ncrna10010007","type":"journal-article","created":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T06:41:22Z","timestamp":1705560082000},"page":"7","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Role of Hydrogen Sulfide in Oncological and Non-Oncological Disorders and Its Regulation by Non-Coding RNAs: A Comprehensive Review"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6268-7942","authenticated-orcid":false,"given":"Rana A.","family":"Youness","sequence":"first","affiliation":[{"name":"Biochemistry Department, Faculty of Pharmacy and Biotechnology, German University in Cairo (GUC), Cairo 11835, Egypt"},{"name":"Biology and Biochemistry Department, Faculty of Biotechnology, German International University (GIU), New Administrative Capital, Cairo 11835, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3890-6820","authenticated-orcid":false,"given":"Danira Ashraf","family":"Habashy","sequence":"additional","affiliation":[{"name":"Pharmacology and Toxicology Department, Faculty of Pharmacy and Biotechnology, German University in Cairo (GUC), Cairo 11835, Egypt"},{"name":"Clinical Pharmacy Department, Faculty of Pharmacy and Biotechnology, German University in Cairo (GUC), Cairo 11835, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nour","family":"Khater","sequence":"additional","affiliation":[{"name":"Biochemistry Department, Faculty of Pharmacy and Biotechnology, German University in Cairo (GUC), Cairo 11835, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1546-7459","authenticated-orcid":false,"given":"Kareem","family":"Elsayed","sequence":"additional","affiliation":[{"name":"Biochemistry Department, Faculty of Pharmacy and Biotechnology, German University in Cairo (GUC), Cairo 11835, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyaa","family":"Dawoud","sequence":"additional","affiliation":[{"name":"Biochemistry Department, Faculty of Pharmacy and Biotechnology, German University in Cairo (GUC), Cairo 11835, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sousanna","family":"Hakim","sequence":"additional","affiliation":[{"name":"Pharmacology and Toxicology Department, Faculty of Pharmacy and Biotechnology, German University in Cairo (GUC), Cairo 11835, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heba","family":"Nafea","sequence":"additional","affiliation":[{"name":"Biochemistry Department, Faculty of Pharmacy and Biotechnology, German University in Cairo (GUC), Cairo 11835, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3862-4583","authenticated-orcid":false,"given":"Carole","family":"Bourquin","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Institute of Pharmaceutical Sciences of Western Switzerland, Department of Anaesthesiology, Pharmacology, Intensive Care and Emergency Medicine, University of Geneva, 1211 Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3584-0045","authenticated-orcid":false,"given":"Reham M.","family":"Abdel-Kader","sequence":"additional","affiliation":[{"name":"Pharmacology and Toxicology Department, Faculty of Pharmacy and Biotechnology, German University in Cairo (GUC), Cairo 11835, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1173-8628","authenticated-orcid":false,"given":"Mohamed Z.","family":"Gad","sequence":"additional","affiliation":[{"name":"Biochemistry Department, Faculty of Pharmacy and Biotechnology, German University in Cairo (GUC), Cairo 11835, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.bcp.2017.11.014","article-title":"A review of hydrogen sulfide (H2S) donors: Chemistry and potential therapeutic applications","volume":"149","author":"Powell","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1523\/JNEUROSCI.16-03-01066.1996","article-title":"The possible role of hydrogen sulfide as an endogenous neuromodulator","volume":"16","author":"Abe","year":"1996","journal-title":"J. Neurosci."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1096\/fj.02-0211hyp","article-title":"Two\u2019s company, three\u2019s a crowd: Can H2S be the third endogenous gaseous transmitter?","volume":"16","author":"Wang","year":"2002","journal-title":"FASEB J."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1089\/ars.2009.2938","article-title":"Hydrogen sulfide: The third gasotransmitter in biology and medicine","volume":"12","author":"Wang","year":"2010","journal-title":"Antioxid. Redox Signal."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1253\/circj.CJ-14-0728","article-title":"Discoveries of hydrogen sulfide as a novel cardiovascular therapeutic","volume":"78","author":"Barr","year":"2014","journal-title":"Circ. J."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1089\/ars.2014.5933","article-title":"The therapeutic potential of cystathionine \u03b2-synthetase\/hydrogen sulfide inhibition in cancer","volume":"22","author":"Hellmich","year":"2015","journal-title":"Antioxid. Redox Signal."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1089\/152308603768295249","article-title":"The gasotransmitter role of hydrogen sulfide","volume":"5","author":"Wang","year":"2003","journal-title":"Antioxid. Redox Signal."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.niox.2013.07.002","article-title":"Hydrogen sulfide chemical biology: Pathophysiological roles and detection","volume":"35","author":"Kolluru","year":"2013","journal-title":"Nitric Oxide"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"R1930","DOI":"10.1152\/ajpregu.00025.2008","article-title":"Reappraisal of H2S\/sulfide concentration in vertebrate blood and its potential significance in ischemic preconditioning and vascular signaling","volume":"294","author":"Whitfield","year":"2008","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1096\/fj.04-1815fje","article-title":"Hydrogen sulfide protects neurons from oxidative stress","volume":"18","author":"Kimura","year":"2004","journal-title":"FASEB J."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1097\/00004872-200310000-00015","article-title":"The role of hydrogen sulfide generation in the pathogenesis of hypertension in rats induced by inhibition of nitric oxide synthase","volume":"21","author":"Zhong","year":"2003","journal-title":"J. Hypertens."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1097\/SHK.0000000000001562","article-title":"Serum Hydrogen Sulfide and Outcome Association in Pneumonia by the SARS-CoV-2 Coronavirus","volume":"54","author":"Renieris","year":"2020","journal-title":"Shock"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Escaffre, O., Szaniszlo, P., T\u00f6r\u0151, G., Vilas, C.L., Servantes, B.J., Lopez, E., Juelich, T.L., Levine, C.B., McLellan, S.L.F., and Cardenas, J.C. (2023). Hydrogen Sulfide Ameliorates SARS-CoV-2-Associated Lung Endothelial Barrier Disruption. Biomedicines, 11.","DOI":"10.20944\/preprints202305.1639.v1"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.ncrna.2019.01.003","article-title":"Long non-coding RNAs: Functional regulatory players in breast cancer","volume":"4","author":"Youness","year":"2019","journal-title":"Noncoding RNA Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.ncrna.2020.01.001","article-title":"MicroRNA-486-5p and microRNA-486-3p: Multifaceted pleiotropic mediators in oncological and non-oncological conditions","volume":"5","author":"ElKhouly","year":"2020","journal-title":"Noncoding RNA Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.ncrna.2022.09.011","article-title":"Circular RNAs: New layer of complexity evading breast cancer heterogeneity","volume":"8","author":"Dawoud","year":"2023","journal-title":"Noncoding RNA Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1002\/jcp.31076","article-title":"Decoding hepatocarcinogenesis from a noncoding RNAs perspective","volume":"238","author":"Dawoud","year":"2023","journal-title":"J. Cell. Physiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"586","DOI":"10.2174\/1871520621666210419093652","article-title":"Hindering the Synchronization Between miR-486-5p and H19 lncRNA by Hesperetin Halts Breast Cancer Aggressiveness Through Tuning ICAM-1","volume":"22","author":"Abdallah","year":"2022","journal-title":"Anticancer Agents Med. Chem."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"101653","DOI":"10.1016\/j.tranon.2023.101653","article-title":"MALAT-1: Immunomodulatory lncRNA hampering the innate and the adaptive immune arms in triple negative breast cancer","volume":"31","author":"Mekky","year":"2023","journal-title":"Transl. Oncol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1080\/08977194.2016.1200571","article-title":"Contradicting interplay between insulin-like growth factor-1 and miR-486-5p in primary NK cells and hepatoma cell lines with a contemporary inhibitory impact on HCC tumor progression","volume":"34","author":"Youness","year":"2016","journal-title":"Growth Factors"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.3892\/ol.2016.4914","article-title":"MicroRNA-486-5p enhances hepatocellular carcinoma tumor suppression through repression of IGF-1R and its downstream mTOR, STAT3 and c-Myc","volume":"12","author":"Youness","year":"2016","journal-title":"Oncol. Lett."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1080\/14786419.2017.1366478","article-title":"Destabilizing the interplay between miR-1275 and IGF2BPs by Tamarix articulata and quercetin in hepatocellular carcinoma","volume":"32","author":"Shaalan","year":"2018","journal-title":"Nat. Prod. Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.ncrna.2021.11.001","article-title":"What is beyond LncRNAs in breast cancer: A special focus on colon cancer-associated Transcript-1 (CCAT-1)","volume":"6","author":"Selem","year":"2021","journal-title":"Noncoding RNA Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"103792","DOI":"10.1016\/j.pdpdt.2023.103792","article-title":"Phytochemical-derived tumor-associated macrophage remodeling strategy using Phoenix dactylifera L. boosted photodynamic therapy in melanoma via H19\/iNOS\/PD-L1 axis","volume":"44","author":"Soliman","year":"2023","journal-title":"Photodiagnosis Photodyn. Ther."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1007\/s11010-022-04378-4","article-title":"MALAT-1\/p53\/miR-155\/miR-146a ceRNA circuit tuned by methoxylated quercitin glycoside alters immunogenic and oncogenic profiles of breast cancer","volume":"477","author":"Riad","year":"2022","journal-title":"Mol. Cell. Biochem."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"161","DOI":"10.3233\/BD-200454","article-title":"miR-744\/eNOS\/NO axis: A novel target to halt triple negative breast cancer progression","volume":"40","author":"Youness","year":"2021","journal-title":"Breast Dis."},{"key":"ref_27","first-page":"346","article-title":"miRNA-506-3p Directly Regulates rs10754339 (A\/G) in the Immune Checkpoint Protein B7-H4 in Breast Cancer","volume":"9","author":"Youness","year":"2020","journal-title":"Microrna"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"769","DOI":"10.32604\/biocell.2022.016636","article-title":"Uncoupling tumor necrosis factor-\u03b1 and interleukin-10 at tumor immune microenvironment of breast cancer through miR-17-5p\/MALAT-1\/H19 circuit","volume":"46","author":"Soliman","year":"2022","journal-title":"Biocell"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s10911-022-09511-z","article-title":"Decoding Insulin-Like Growth Factor Signaling Pathway From a Non-coding RNAs Perspective: A Step Towards Precision Oncology in Breast Cancer","volume":"27","author":"ZeinElAbdeen","year":"2022","journal-title":"J. Mammary Gland. Biol. Neoplasia"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"El-Daly, S.M., Talaat, R.M., Braoudaki, M., Youness, R.A., and Cho, W.C. (2023). Editorial: Recent breakthroughs in the decoding of circulating nucleic acids and their applications to human diseases. Front. Mol. Biosci., 10.","DOI":"10.3389\/fmolb.2023.1203495"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.jare.2020.07.006","article-title":"Targeting hydrogen sulphide signaling in breast cancer","volume":"27","author":"Youness","year":"2021","journal-title":"J. Adv. Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1007\/s11357-020-00299-6","article-title":"Exogenous hydrogen sulfide and miR-21 antagonism attenuates macrophage-mediated inflammation in ischemia reperfusion injury of the aged kidney","volume":"43","author":"Pushpakumar","year":"2021","journal-title":"Geroscience"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.bbrc.2022.09.111","article-title":"The hepato-protective effect of H2S-modified and non-modified mesenchymal stem cell exosomes on liver ischemia-reperfusion injury in mice: The role of MALAT1","volume":"635","author":"Sameri","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s11011-022-01130-1","article-title":"H2S-mediated inhibition of RhoA\/ROCK pathway and noncoding RNAs in ischemic stroke","volume":"38","author":"Lu","year":"2023","journal-title":"Metab. Brain Dis."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/j.biopha.2017.06.007","article-title":"Cross-talk of MicroRNA and hydrogen sulfide: A novel therapeutic approach for bone diseases","volume":"92","author":"Zhai","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"R900","DOI":"10.1152\/ajpregu.00199.2022","article-title":"Hydrogen sulfide and miR21 are suitable biomarkers of hypoxic exposure","volume":"323","author":"Garcia","year":"2022","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Fahmy, S.A., Dawoud, A., Zeinelabdeen, Y.A., Kiriacos, C.J., Daniel, K.A., Eltahtawy, O., Abdelhalim, M.M., Braoudaki, M., and Youness, R.A. (2022). Molecular Engines, Therapeutic Targets, and Challenges in Pediatric Brain Tumors: A Special Emphasis on Hydrogen Sulfide and RNA-Based Nano-Delivery. Cancers, 14.","DOI":"10.3390\/cancers14215244"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"e21063","DOI":"10.1016\/j.heliyon.2023.e21063","article-title":"Dual targeting of H2S synthesizing enzymes; cystathionine \u03b2-synthase and cystathionine \u03b3-lyase by miR-939-5p effectively curbs triple negative breast cancer","volume":"9","author":"Nafea","year":"2023","journal-title":"Heliyon"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-3-319-42059-2_1","article-title":"Non-coding RNAs: Classification, Biology and Functioning","volume":"937","author":"Hombach","year":"2016","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1093\/nar\/15.5.2089","article-title":"The isolation and characterization of RNA coded by the micF gene in Escherichia coli","volume":"15","author":"Andersen","year":"1987","journal-title":"Nucleic Acids Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"17961","DOI":"10.1016\/S0021-9258(19)84666-5","article-title":"The function of micF RNA. micF RNA is a major factor in the thermal regulation of OmpF protein in Escherichia coli","volume":"264","author":"Andersen","year":"1989","journal-title":"J. Biol. Chem."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/0092-8674(93)90529-Y","article-title":"The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14","volume":"75","author":"Lee","year":"1993","journal-title":"Cell"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1038\/35888","article-title":"Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans","volume":"391","author":"Fire","year":"1998","journal-title":"Nature"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/S0092-8674(00)80531-0","article-title":"Wnt signaling and an APC-related gene specify endoderm in early C. elegans embryos","volume":"90","author":"Rocheleau","year":"1997","journal-title":"Cell"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Abaza, T., El-Aziz, M.K.A., Daniel, K.A., Karousi, P., Papatsirou, M., Fahmy, S.A., Hamdy, N.M., Kontos, C.K., and Youness, R.A. (2023). Emerging Role of Circular RNAs in Hepatocellular Carcinoma Immunotherapy. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms242216484"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cell.2009.01.002","article-title":"MicroRNAs: Target recognition and regulatory functions","volume":"136","author":"Bartel","year":"2009","journal-title":"Cell"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.cell.2009.01.035","article-title":"Origins and Mechanisms of miRNAs and siRNAs","volume":"136","author":"Carthew","year":"2009","journal-title":"Cell"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1515\/hsz-2014-0116","article-title":"Assembly and function of small RNA\u2014Argonaute protein complexes","volume":"395","author":"Dueck","year":"2014","journal-title":"Biol. Chem."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1242\/dev.005629","article-title":"The growing catalog of small RNAs and their association with distinct Argonaute\/Piwi family members","volume":"135","author":"Farazi","year":"2008","journal-title":"Development"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/nature02873","article-title":"Mechanisms of gene silencing by double-stranded RNA","volume":"431","author":"Meister","year":"2004","journal-title":"Nature"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1016\/j.cell.2012.02.005","article-title":"MicroRNAs in stress signaling and human disease","volume":"148","author":"Mendell","year":"2012","journal-title":"Cell"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/nature07754","article-title":"On the road to reading the RNA-interference code","volume":"457","author":"Siomi","year":"2009","journal-title":"Nature"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/nrm3089","article-title":"PIWI-interacting small RNAs: The vanguard of genome defence","volume":"12","author":"Siomi","year":"2011","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.3390\/life5041638","article-title":"tRNA-Derived Fragments (tRFs): Emerging New Roles for an Ancient RNA in the Regulation of Gene Expression","volume":"5","author":"Keam","year":"2015","journal-title":"Life"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3390\/ncrna9060069","article-title":"The Typical tRNA Co-Expresses Multiple 5&prime; tRNA Halves Whose Sequences and Abundances Depend on Isodecoder and Isoacceptor and Change with Tissue Type, Cell Type, and Disease","volume":"9","author":"Akins","year":"2023","journal-title":"Non-Coding RNA"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nature11233","article-title":"Landscape of transcription in human cells","volume":"489","author":"Djebali","year":"2012","journal-title":"Nature"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"International Human Genome Sequencing (2004). Finishing the euchromatic sequence of the human genome. Nature, 431, 931\u2013945.","DOI":"10.1038\/nature03001"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1093\/embo-reports\/kve230","article-title":"Non-coding RNAs: The architects of eukaryotic complexity","volume":"2","author":"Mattick","year":"2001","journal-title":"EMBO Rep."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/0092-8674(93)90530-4","article-title":"Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans","volume":"75","author":"Wightman","year":"1993","journal-title":"Cell"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/978-94-017-7417-8_2","article-title":"Non-coding RNAs: An Introduction","volume":"886","author":"Yang","year":"2016","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1038\/35002607","article-title":"The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans","volume":"403","author":"Reinhart","year":"2000","journal-title":"Nature"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1126\/science.1066315","article-title":"Molecular biology. Glimpses of a tiny RNA world","volume":"294","author":"Ruvkun","year":"2001","journal-title":"Science"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"3126","DOI":"10.1080\/14786419.2019.1686372","article-title":"An acetylated derivative of vitexin halts MDA-MB-231 cellular progression and improves its immunogenic profile through tuning miR-20a-MICA\/B axis","volume":"35","author":"Awad","year":"2021","journal-title":"Nat. Prod. Res."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1152\/physrev.00006.2010","article-title":"MicroRNAs in development and disease","volume":"91","author":"Sayed","year":"2011","journal-title":"Physiol. Rev."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"483","DOI":"10.2217\/pme-2022-0005","article-title":"miR-516a-3P, a potential circulating biomarker in hepatocellular carcinoma, correlated with rs738409 polymorphism in PNPLA3","volume":"19","author":"Youssef","year":"2022","journal-title":"Pers. Med."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1101\/gr.082701.108","article-title":"Most mammalian mRNAs are conserved targets of microRNAs","volume":"19","author":"Friedman","year":"2009","journal-title":"Genome Res."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1038\/nrg3074","article-title":"Non-coding RNAs in human disease","volume":"12","author":"Esteller","year":"2011","journal-title":"Nat. Rev. Genet."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/nrc3932","article-title":"MicroRNA biogenesis pathways in cancer","volume":"15","author":"Lin","year":"2015","journal-title":"Nat. Rev. Cancer"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1080\/08977194.2017.1354859","article-title":"MiR-615-5p depresses natural killer cells cytotoxicity through repressing IGF-1R in hepatocellular carcinoma patients","volume":"35","author":"Rahmoon","year":"2017","journal-title":"Growth Factors"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Ramzy, A., ElSafy, S., A Elshoky, H., Soliman, A., Youness, R., Mansour, S., and Sebak, A. (2022). Drugless nanoparticles tune-up an array of intertwined pathways contributing to immune checkpoint signaling and metabolic reprogramming in triple-negative breast cancer. Biomed. Mater., 18.","DOI":"10.1088\/1748-605X\/aca85d"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.devcel.2010.03.010","article-title":"MicroRNA regulatory networks in cardiovascular development","volume":"18","author":"Liu","year":"2010","journal-title":"Dev. Cell"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Solly, E.L., Dimasi, C.G., Bursill, C.A., Psaltis, P.J., and Tan, J.T.M. (2019). MicroRNAs as Therapeutic Targets and Clinical Biomarkers in Atherosclerosis. J. Clin. Med., 8.","DOI":"10.3390\/jcm8122199"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/nrn3879","article-title":"Determining the role of microRNAs in psychiatric disorders","volume":"16","author":"Issler","year":"2015","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Huang, S., Yoshitake, K., and Asakawa, S. (2021). A Review of Discovery Profiling of PIWI-Interacting RNAs and Their Diverse Functions in Metazoans. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222011166"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3892\/or.2016.5236","article-title":"Non-coding RNAs as regulators in epigenetics (Review)","volume":"37","author":"Wei","year":"2017","journal-title":"Oncol. Rep."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/978-94-017-7417-8_4","article-title":"The piRNA Pathway Guards the Germline Genome against Transposable Elements","volume":"886","author":"Toth","year":"2016","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/nrg3495","article-title":"PIWI-interacting RNAs: From generation to transgenerational epigenetics","volume":"14","author":"Luteijn","year":"2013","journal-title":"Nat. Rev. Genet."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1101\/sqb.2009.74.052","article-title":"Molecular evolution of piRNA and transposon control pathways in Drosophila","volume":"74","author":"Malone","year":"2009","journal-title":"Cold Spring Harb. Symp. Quant. Biol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1038\/nrg2072","article-title":"Transposable elements and the epigenetic regulation of the genome","volume":"8","author":"Slotkin","year":"2007","journal-title":"Nat. Rev. Genet."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1146\/annurev.neuro.29.051605.112839","article-title":"Noncoding RNAs in the mammalian central nervous system","volume":"29","author":"Cao","year":"2006","journal-title":"Annu Rev. Neurosci."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/nrg2521","article-title":"Long non-coding RNAs: Insights into functions","volume":"10","author":"Mercer","year":"2009","journal-title":"Nat. Rev. Genet."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"5362","DOI":"10.1002\/jcp.30234","article-title":"LncRNA HEIH\/miR-939-5p interplay modulates triple-negative breast cancer progression through NOS2-induced nitric oxide production","volume":"236","author":"Nafea","year":"2021","journal-title":"J. Cell. Physiol."},{"key":"ref_83","first-page":"154579","article-title":"Let-7a\/cMyc\/CCAT1\/miR-17-5p Circuit Re-sensitizes Atezolizumab Resistance in Triple Negative Breast Cancer through Modulating PD-L1. Pathol","volume":"248","author":"Selem","year":"2023","journal-title":"Res. Pract."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.cell.2009.02.006","article-title":"Evolution and functions of long noncoding RNAs","volume":"136","author":"Ponting","year":"2009","journal-title":"Cell"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1080\/15476286.2015.1020271","article-title":"Regulation of circRNA biogenesis","volume":"12","author":"Chen","year":"2015","journal-title":"RNA Biol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"3852","DOI":"10.1073\/pnas.73.11.3852","article-title":"Viroids are single-stranded covalently closed circular RNA molecules existing as highly base-paired rod-like structures","volume":"73","author":"Sanger","year":"1976","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/0092-8674(93)90279-Y","article-title":"Circular transcripts of the testis-determining gene Sry in adult mouse testis","volume":"73","author":"Capel","year":"1993","journal-title":"Cell"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1002\/j.1460-2075.1992.tb05148.x","article-title":"Splicing with inverted order of exons occurs proximal to large introns","volume":"11","author":"Cocquerelle","year":"1992","journal-title":"EMBO J."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/0092-8674(76)90223-3","article-title":"Isolation and characterization of Sendai virus DI-RNAs","volume":"8","author":"Kolakofsky","year":"1976","journal-title":"Cell"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"7628","DOI":"10.1073\/pnas.87.19.7628","article-title":"Circular single-stranded RNA replicon in Saccharomyces cerevisiae","volume":"87","author":"Matsumoto","year":"1990","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"2985","DOI":"10.1128\/MCB.17.6.2985","article-title":"Exon skipping and circular RNA formation in transcripts of the human cytochrome P-450 2C18 gene in epidermis and of the rat androgen binding protein gene in testis","volume":"17","author":"Zaphiropoulos","year":"1997","journal-title":"Mol. Cell. Biol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"6536","DOI":"10.1073\/pnas.93.13.6536","article-title":"Circular RNAs from transcripts of the rat cytochrome P450 2C24 gene: Correlation with exon skipping","volume":"93","author":"Zaphiropoulos","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/0092-8674(91)90244-S","article-title":"Scrambled exons","volume":"64","author":"Nigro","year":"1991","journal-title":"Cell"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.pharmthera.2018.01.010","article-title":"Circular RNA and its mechanisms in disease: From the bench to the clinic","volume":"187","author":"Han","year":"2018","journal-title":"Pharmacol. Ther."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1261\/rna.035667.112","article-title":"Circular RNAs are abundant, conserved, and associated with ALU repeats","volume":"19","author":"Jeck","year":"2013","journal-title":"RNA"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/j.molcel.2015.03.027","article-title":"Circular RNAs in the Mammalian Brain Are Highly Abundant, Conserved, and Dynamically Expressed","volume":"58","author":"Stottmeister","year":"2015","journal-title":"Mol. Cell"},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Salzman, J., Chen, R.E., Olsen, M.N., Wang, P.L., and Brown, P.O. (2013). Cell-type specific features of circular RNA expression. PLoS Genet., 9.","DOI":"10.1371\/annotation\/f782282b-eefa-4c8d-985c-b1484e845855"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/nature11993","article-title":"Natural RNA circles function as efficient microRNA sponges","volume":"495","author":"Hansen","year":"2013","journal-title":"Nature"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"2602","DOI":"10.1093\/eurheartj\/ehv713","article-title":"A circular RNA protects the heart from pathological hypertrophy and heart failure by targeting miR-223","volume":"37","author":"Wang","year":"2016","journal-title":"Eur. Heart J."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.molcel.2014.08.019","article-title":"circRNA biogenesis competes with pre-mRNA splicing","volume":"56","author":"Meyer","year":"2014","journal-title":"Mol. Cell"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1038\/nsmb.2959","article-title":"Exon-intron circular RNAs regulate transcription in the nucleus","volume":"22","author":"Li","year":"2015","journal-title":"Nat. Struct. Mol. Biol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"2846","DOI":"10.1093\/nar\/gkw027","article-title":"Foxo3 circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2","volume":"44","author":"Du","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/nrd.2015.1","article-title":"Gasotransmitters in cancer: From pathophysiology to experimental therapy","volume":"15","author":"Szabo","year":"2016","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1089\/ars.2009.2882","article-title":"Novel insights into hydrogen sulfide\u2014Mediated cytoprotection","volume":"12","author":"Calvert","year":"2010","journal-title":"Antioxid. Redox Signal."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1146\/annurev-pharmtox-010510-100505","article-title":"Hydrogen sulfide and cell signaling","volume":"51","author":"Li","year":"2011","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/j.1471-4159.2010.06580.x","article-title":"Hydrogen sulfide as a gasotransmitter","volume":"113","author":"Gadalla","year":"2010","journal-title":"J. Neurochem."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"29871","DOI":"10.1074\/jbc.R400005200","article-title":"Cystathionine beta-synthase: Structure, function, regulation, and location of homocystinuria-causing mutations","volume":"279","author":"Miles","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1089\/ars.2011.4349","article-title":"Role of cystathionine gamma-lyase\/hydrogen sulfide pathway in cardiovascular disease: A novel therapeutic strategy?","volume":"17","author":"Pan","year":"2012","journal-title":"Antioxid. Redox Signal."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1089\/ars.2008.2253","article-title":"3-Mercaptopyruvate sulfurtransferase produces hydrogen sulfide and bound sulfane sulfur in the brain","volume":"11","author":"Shibuya","year":"2009","journal-title":"Antioxid. Redox Signal."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1007\/s00018-016-2406-8","article-title":"H2S biosynthesis and catabolism: New insights from molecular studies","volume":"74","author":"Rose","year":"2017","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1002\/(SICI)1097-010X(19981015)282:3<310::AID-JEZ4>3.0.CO;2-P","article-title":"Sulfur reduction by human erythrocytes","volume":"282","author":"Searcy","year":"1998","journal-title":"J. Exp. Zool."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0378-4347(01)00046-9","article-title":"Determination of hydrogen sulfide and acid-labile sulfur in animal tissues by gas chromatography and ion chromatography","volume":"757","author":"Ubuka","year":"2001","journal-title":"J. Chromatogr. B Biomed. Sci. Appl."},{"key":"ref_113","first-page":"E3790","article-title":"Structural basis of regulation and oligomerization of human cystathionine beta-synthase, the central enzyme of transsulfuration","volume":"110","author":"Majtan","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_114","first-page":"E3845","article-title":"Structural insight into the molecular mechanism of allosteric activation of human cystathionine beta-synthase by S-adenosylmethionine","volume":"111","author":"Majtan","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Zuhra, K., Augsburger, F., Majtan, T., and Szabo, C. (2020). Cystathionine-\u03b2-Synthase: Molecular Regulation and Pharmacological Inhibition. Biomolecules, 10.","DOI":"10.3390\/biom10050697"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1006\/bbrc.1995.1886","article-title":"Genomic organization of the human cystathionine beta-synthase gene: Evidence for various cDNAs","volume":"211","author":"Chasse","year":"1995","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"12679","DOI":"10.1073\/pnas.1308487110","article-title":"Oxygen-sensitive mitochondrial accumulation of cystathionine beta-synthase mediated by Lon protease","volume":"110","author":"Teng","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"50333","DOI":"10.18632\/oncotarget.10385","article-title":"5-FU targets rpL3 to induce mitochondrial apoptosis via cystathionine-beta-synthase in colon cancer cells lacking p53","volume":"7","author":"Pagliara","year":"2016","journal-title":"Oncotarget"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.niox.2018.07.004","article-title":"A novel role of sONE\/NOS3\/NO signaling cascade in mediating hydrogen sulphide bilateral effects on triple negative breast cancer progression","volume":"80","author":"Youness","year":"2018","journal-title":"Nitric Oxide"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/0006-291X(92)92265-Y","article-title":"Cloning and nucleotide sequence of human liver cDNA encoding for cystathionine gamma-lyase","volume":"189","author":"Lu","year":"1992","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1042\/bj3470291","article-title":"Human cystathionine gamma-lyase: Developmental and in vitro expression of two isoforms","volume":"347","author":"Levonen","year":"2000","journal-title":"Biochem. J."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/nrd2425","article-title":"Hydrogen sulphide and its therapeutic potential","volume":"6","year":"2007","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1126\/science.1162667","article-title":"H2S as a physiologic vasorelaxant: Hypertension in mice with deletion of cystathionine gamma-lyase","volume":"322","author":"Yang","year":"2008","journal-title":"Science"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"2801","DOI":"10.1016\/j.cellsig.2014.08.023","article-title":"Wnt\/beta-catenin signaling induces the transcription of cystathionine-gamma-lyase, a stimulator of tumor in colon cancer","volume":"26","author":"Fan","year":"2014","journal-title":"Cell. Signal."},{"key":"ref_125","doi-asserted-by":"crossref","unstructured":"Rao, S.P., Dobariya, P., Bellamkonda, H., and More, S.S. (2023). Role of 3-Mercaptopyruvate Sulfurtransferase (3-MST) in Physiology and Disease. Antioxidants, 12.","DOI":"10.3390\/antiox12030603"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0076-6879(81)77040-X","article-title":"3-Mercaptopyruvate sulfurtransferase","volume":"77","author":"Jarabak","year":"1981","journal-title":"Methods Enzym."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1515\/hsz-2020-0249","article-title":"3-Mercaptopyruvate sulfurtransferase: An enzyme at the crossroads of sulfane sulfur trafficking","volume":"402","author":"Pedre","year":"2021","journal-title":"Biol. Chem."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1111\/bph.14574","article-title":"3-Mercaptopyruvate sulfurtransferase supports endothelial cell angiogenesis and bioenergetics","volume":"177","author":"Govar","year":"2020","journal-title":"Br. J. Pharmacol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"104083","DOI":"10.1016\/j.phrs.2018.11.034","article-title":"Potential role of the 3-mercaptopyruvate sulfurtransferase (3-MST)-hydrogen sulfide (H2S) pathway in cancer cells","volume":"154","author":"Augsburger","year":"2020","journal-title":"Pharmacol. Res."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/978-3-319-18144-8_12","article-title":"Hydrogen Sulfide and Cancer","volume":"230","author":"Hellmich","year":"2015","journal-title":"Handb. Exp. Pharmacol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.bcp.2017.10.011","article-title":"Role of endogenous and exogenous nitric oxide, carbon monoxide and hydrogen sulfide in HCT116 colon cancer cell proliferation","volume":"149","author":"Hellmich","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"100992","DOI":"10.1016\/j.esmoop.2023.100992","article-title":"26P 3MST: A potential workhorse in H2S signaling trimmed by microRNA-548 in breast cancer","volume":"8","author":"Dawoud","year":"2023","journal-title":"ESMO Open"},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Bhattacharyya, S., Saha, S., Giri, K., Lanza, I.R., Nair, K.S., Jennings, N.B., Rodriguez-Aguayo, C., Lopez-Berestein, G., Basal, E., and Weaver, A.L. (2013). Cystathionine beta-synthase (CBS) contributes to advanced ovarian cancer progression and drug resistance. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0079167"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/pcmr.12312","article-title":"Role of the cystathionine gamma lyase\/hydrogen sulfide pathway in human melanoma progression","volume":"28","author":"Panza","year":"2015","journal-title":"Pigment. Cell Melanoma Res."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1111\/liv.15228","article-title":"3-Mercaptopyruvate sulfurtransferase represses tumour progression and predicts prognosis in hepatocellular carcinoma","volume":"42","author":"Li","year":"2022","journal-title":"Liver Int."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"110628","DOI":"10.1016\/j.cellsig.2023.110628","article-title":"Hydrogen sulfide and its donors: Novel antitumor and antimetastatic agents for liver cancer","volume":"106","author":"Zhang","year":"2023","journal-title":"Cell. Signal."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"3001","DOI":"10.3892\/or.2017.5513","article-title":"Role of the cystathionine beta-synthase\/H2S system in liver cancer cells and the inhibitory effect of quinolone-indolone conjugate QIC2 on the system","volume":"37","author":"Jia","year":"2017","journal-title":"Oncol. Rep."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"36125","DOI":"10.1038\/srep36125","article-title":"Inhibition of hydrogen sulfide biosynthesis sensitizes lung adenocarcinoma to chemotherapeutic drugs by inhibiting mitochondrial DNA repair and suppressing cellular bioenergetics","volume":"6","author":"Szczesny","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"166.e15","DOI":"10.1016\/j.urolonc.2015.06.020","article-title":"Expression profile of hydrogen sulfide and its synthases correlates with tumor stage and grade in urothelial cell carcinoma of bladder","volume":"34","author":"Gai","year":"2016","journal-title":"Urol. Oncol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.bbrc.2004.11.110","article-title":"Hydrogen sulphide: A novel inhibitor of hypochlorous acid-mediated oxidative damage in the brain?","volume":"326","author":"Whiteman","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1615\/JEnvironPatholToxicolOncol.2020034851","article-title":"Cystathionine beta Synthase\/Hydrogen Sulfide Signaling in Multiple Myeloma Regulates Cell Proliferation and Apoptosis","volume":"39","author":"Zhang","year":"2020","journal-title":"J. Environ. Pathol. Toxicol. Oncol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"8108549","DOI":"10.1155\/2016\/8108549","article-title":"Hydrogen Sulfide Signaling Axis as a Target for Prostate Cancer Therapeutics","volume":"2016","author":"Liu","year":"2016","journal-title":"Prostate Cancer"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1038\/aja.2013.32","article-title":"Further evidence of endogenous hydrogen sulphide as a mediator of relaxation in human and rat bladder","volume":"15","author":"Gai","year":"2013","journal-title":"Asian J. Androl."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"2360945","DOI":"10.1155\/2019\/2360945","article-title":"Hydrogen Sulfide: Emerging Role in Bladder, Kidney, and Prostate Malignancies","volume":"2019","author":"Akbari","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"636410","DOI":"10.1155\/2015\/636410","article-title":"An Anticancer Role of Hydrogen Sulfide in Human Gastric Cancer Cells","volume":"2015","author":"Zhang","year":"2015","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1248\/bpb.b15-01015","article-title":"Endogenous Hydrogen Sulfide Enhances Cell Proliferation of Human Gastric Cancer AGS Cells","volume":"39","author":"Sekiguchi","year":"2016","journal-title":"Biol. Pharm. Bull."},{"key":"ref_147","first-page":"3423","article-title":"Increased Nicotinamide Phosphoribosyltransferase and Cystathionine-\u03b2-Synthase in Renal Oncocytomas, Renal Urothelial Carcinoma, and Renal Clear Cell Carcinoma","volume":"37","author":"Shackelford","year":"2017","journal-title":"Anticancer Res."},{"key":"ref_148","doi-asserted-by":"crossref","unstructured":"Breza, J., Soltysova, A., Hudecova, S., Penesova, A., Szadvari, I., Babula, P., Chovancova, B., Lencesova, L., Pos, O., and Ondrias, K. (2018). Endogenous H2S producing enzymes are involved in apoptosis induction in clear cell renal cell carcinoma. BMC Cancer, 18.","DOI":"10.1186\/s12885-018-4508-1"},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"Peleli, M., Antoniadou, I., Rodrigues-Junior, D.M., Savvoulidou, O., Caja, L., Katsouda, A., Ketelhuth, D.F., Stubbe, J., Madsen, K., and Moustakas, A. (2023). Cystathionine gamma-lyase (CTH) inhibition attenuates glioblastoma formation. Redox Biol., 64.","DOI":"10.1016\/j.redox.2023.102773"},{"key":"ref_150","first-page":"171","article-title":"Hydrogen sulfide generation from l-cysteine in the human glioblastoma-astrocytoma U-87 MG and neuroblastoma SHSY5Y cell lines","volume":"64","author":"Bentke","year":"2017","journal-title":"Acta Biochim. Pol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"6085","DOI":"10.21873\/anticanres.12958","article-title":"Cystathione \u03b2-Synthase Is Increased in Thyroid Malignancies","volume":"38","author":"Kilpatrick","year":"2018","journal-title":"Anticancer Res."},{"key":"ref_152","first-page":"1818","article-title":"Expression of hydrogen sulfide synthases and Hh signaling pathway components correlate with the clinicopathological characteristics of papillary thyroid cancer patients","volume":"11","author":"Xu","year":"2018","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_153","doi-asserted-by":"crossref","unstructured":"Panza, E., Bello, I., Smimmo, M., Brancaleone, V., Mitidieri, E., Bucci, M., Cirino, G., Sorrentino, R., and Bianca, R.D.d.V. (2022). Endogenous and exogenous hydrogen sulfide modulates urothelial bladder carcinoma development in human cell lines. Biomed. Pharmacother., 151.","DOI":"10.1016\/j.biopha.2022.113137"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.3724\/abbs.2022173","article-title":"KRAS G12D mutation eliminates reactive oxygen species through the Nrf2\/CSE\/H2S axis and contributes to pancreatic cancer growth","volume":"54","author":"Fan","year":"2022","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s10571-014-0121-2","article-title":"Hydrogen sulfide-induced processing of the amyloid precursor protein in SH-SY5Y human neuroblastoma cells involves the PI3-K\/Akt signaling pathway","volume":"35","author":"Zhang","year":"2015","journal-title":"Cell. Mol. Neurobiol."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"3548","DOI":"10.1016\/j.febslet.2013.09.013","article-title":"Polysulfide exerts a protective effect against cytotoxicity caused by t-buthylhydroperoxide through Nrf2 signaling in neuroblastoma cells","volume":"587","author":"Koike","year":"2013","journal-title":"FEBS Lett."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"3843","DOI":"10.21873\/anticanres.12668","article-title":"Hydrogen Sulfide Is Increased in Oral Squamous Cell Carcinoma Compared to Adjacent Benign Oral Mucosae","volume":"38","author":"Meram","year":"2018","journal-title":"Anticancer Res."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.niox.2015.08.004","article-title":"Hydrogen sulfide in cancer: Friend or foe?","volume":"50","author":"Wu","year":"2015","journal-title":"Nitric Oxide"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"9408","DOI":"10.1200\/JCO.2005.01.5594","article-title":"Targeting the cell cycle: A new approach to cancer therapy","volume":"23","author":"Schwartz","year":"2005","journal-title":"J. Clin. Oncol."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/35106065","article-title":"To cycle or not to cycle: A critical decision in cancer","volume":"1","author":"Malumbres","year":"2001","journal-title":"Nat. Rev. Cancer"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/j.cellsig.2012.02.003","article-title":"Sp1 is involved in regulation of cystathionine gamma-lyase gene expression and biological function by PI3K\/Akt pathway in human hepatocellular carcinoma cell lines","volume":"24","author":"Yin","year":"2012","journal-title":"Cell. Signal"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"6665","DOI":"10.1038\/s41598-017-06879-5","article-title":"Hydrogen sulphide donors selectively potentiate a green tea polyphenol EGCG-induced apoptosis of multiple myeloma cells","volume":"7","author":"Bae","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1111\/odi.12223","article-title":"Hydrogen sulfide accelerates cell cycle progression in oral squamous cell carcinoma cell lines","volume":"21","author":"Ma","year":"2015","journal-title":"Oral Dis."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1042\/CBI20090368","article-title":"Hydrogen sulfide induces human colon cancer cell proliferation: Role of Akt, ERK and p21","volume":"34","author":"Cai","year":"2010","journal-title":"Cell Biol. Int."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1038\/nrc2254","article-title":"Role of autophagy in cancer","volume":"7","author":"Mathew","year":"2007","journal-title":"Nat. Rev. Cancer"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.mrfmmm.2014.03.002","article-title":"Hydrogen sulfide (H2S)\/cystathionine gamma-lyase (CSE) pathway contributes to the proliferation of hepatoma cells","volume":"763\u2013764","author":"Pan","year":"2014","journal-title":"Mutat. Res."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"2194","DOI":"10.3892\/ijo.2015.2914","article-title":"Exogenous hydrogen sulfide exerts proliferation\/anti-apoptosis\/angiogenesis\/migration effects via amplifying the activation of NF-kappaB pathway in PLC\/PRF\/5 hepatoma cells","volume":"46","author":"Zhen","year":"2015","journal-title":"Int. J. Oncol."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1111\/j.1476-5381.2010.00887.x","article-title":"Protective effect of hydrogen sulphide against 6-OHDA-induced cell injury in SH-SY5Y cells involves PKC\/PI3K\/Akt pathway","volume":"161","author":"Tiong","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/nature10144","article-title":"Molecular mechanisms and clinical applications of angiogenesis","volume":"473","author":"Carmeliet","year":"2011","journal-title":"Nature"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1002\/ijc.24362","article-title":"Vaccination with xenogeneic tumor endothelial proteins isolated in situ inhibits tumor angiogenesis and spontaneous metastasis","volume":"125","author":"Zhang","year":"2009","journal-title":"Int. J. Cancer"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"21972","DOI":"10.1073\/pnas.0908047106","article-title":"Hydrogen sulfide is an endogenous stimulator of angiogenesis","volume":"106","author":"Papapetropoulos","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1681\/ASN.2013030291","article-title":"Hydrogen sulfide attenuates sFlt1-induced hypertension and renal damage by upregulating vascular endothelial growth factor","volume":"25","author":"Holwerda","year":"2014","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1089\/ars.2009.2945","article-title":"The hydrogen sulfide donor NaHS promotes angiogenesis in a rat model of hind limb ischemia","volume":"12","author":"Wang","year":"2010","journal-title":"Antioxid. Redox Signal."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"12474","DOI":"10.1073\/pnas.1306241110","article-title":"Tumor-derived hydrogen sulfide, produced by cystathionine-beta-synthase, stimulates bioenergetics, cell proliferation, and angiogenesis in colon cancer","volume":"110","author":"Szabo","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.niox.2014.03.001","article-title":"Effect of S-adenosyl-L-methionine (SAM), an allosteric activator of cystathionine-beta-synthase (CBS) on colorectal cancer cell proliferation and bioenergetics in vitro","volume":"41","author":"Coletta","year":"2014","journal-title":"Nitric Oxide"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"2915","DOI":"10.4161\/cc.26064","article-title":"Endogenously produced hydrogen sulfide supports tumor cell growth and proliferation","volume":"12","author":"Szabo","year":"2013","journal-title":"Cell Cycle"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.7150\/jca.35375","article-title":"Aminooxyacetic acid (AOAA) sensitizes colon cancer cells to oxaliplatin via exaggerating apoptosis induced by ROS","volume":"11","author":"Yue","year":"2020","journal-title":"J. Cancer"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1038\/s41416-021-01681-7","article-title":"The CBS-H2S axis promotes liver metastasis of colon cancer by upregulating VEGF through AP-1 activation","volume":"126","author":"Guo","year":"2022","journal-title":"Br. J. Cancer"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.canlet.2019.09.006","article-title":"Inhibition of hydrogen sulfide synthesis reverses acquired resistance to 5-FU through miR-215-5p-EREG\/TYMS axis in colon cancer cells","volume":"466","author":"Chen","year":"2019","journal-title":"Cancer Lett."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.freeradbiomed.2015.05.024","article-title":"Role of cystathionine beta-synthase in human breast Cancer","volume":"86","author":"Sen","year":"2015","journal-title":"Free. Radic. Biol. Med."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"S1235","DOI":"10.1016\/j.annonc.2020.08.2219","article-title":"60P Curbing the interplay between miR-939-5p and HEIH lncRNA by EGCG represses hydrogen sulphide machinery and hinders breast cancer progression","volume":"31","author":"Nafea","year":"2020","journal-title":"Ann. Oncol."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"S70","DOI":"10.1016\/S0959-8049(20)30714-0","article-title":"Interplay between the Pan-Tumor Suppressor miR-939-5p and the oncogenic lncRNA-HEIH dually curbs Hydrogen Sulphide and Nitric Oxide production in breast cancer cells","volume":"138","author":"Nafea","year":"2020","journal-title":"Eur. J. Cancer"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"S1169","DOI":"10.1016\/j.annonc.2023.09.1308","article-title":"2280P MiR-193a-3p: A pan-repressor of H2S synthesizing enzymes regulates tumorigenesis and immunosurveillance in breast cancer","volume":"34","author":"Dawoud","year":"2023","journal-title":"Ann. Oncol."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1016\/j.annonc.2021.01.027","article-title":"14P MALAT-1: A novel LncRNA modulating STAT-3 regulated cystathionine-\u03b3-lyase (CSE) in breast cancer","volume":"32","author":"Khater","year":"2021","journal-title":"Ann. Oncol."},{"key":"ref_185","first-page":"8484","article-title":"Increased H(2)S and its synthases in urothelial cell carcinoma of the bladder, and enhanced cisplatin-induced apoptosis following H(2)S inhibition in EJ cells","volume":"15","author":"Wahafu","year":"2018","journal-title":"Oncol. Lett."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"829","DOI":"10.4103\/jcrt.JCRT_423_17","article-title":"Effects of exogenous hydrogen sulfide on the proliferation and invasion of human Bladder cancer cells","volume":"13","author":"Liu","year":"2017","journal-title":"J. Cancer Res. Ther."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1038\/s41418-019-0304-y","article-title":"Long noncoding RNA LINC00336 inhibits ferroptosis in lung cancer by functioning as a competing endogenous RNA","volume":"26","author":"Wang","year":"2019","journal-title":"Cell Death Differ."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1080\/00207454.2020.1782904","article-title":"LncRNA SNHG1 alleviated apoptosis and inflammation during ischemic stroke by targeting miR-376a and modulating CBS\/H2S pathway","volume":"131","author":"Lv","year":"2021","journal-title":"Int. J. Neurosci."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.niox.2018.05.004","article-title":"MiR-125b-5p is involved in oxygen and glucose deprivation injury in PC-12 cells via CBS\/H2S pathway","volume":"78","author":"Shen","year":"2018","journal-title":"Nitric Oxide"},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.niox.2021.10.007","article-title":"The regulatory role of MiR-203 in oxidative stress induced cell injury through the CBS\/H2S pathway","volume":"118","author":"Zhang","year":"2022","journal-title":"Nitric Oxide"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.jare.2021.10.001","article-title":"Hypoxia inducible lncRNA-CBSLR modulates ferroptosis through m6A-YTHDF2-dependent modulation of CBS in gastric cancer","volume":"37","author":"Yang","year":"2022","journal-title":"J. Adv. Res."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.bbrc.2016.01.003","article-title":"Cystathionine \u03b3-lyase(CSE)\/hydrogen sulfide system is regulated by miR-216a and influences cholesterol efflux in macrophages via the PI3K\/AKT\/ABCA1 pathway","volume":"470","author":"Gong","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.atherosclerosis.2016.04.030","article-title":"MicroRNA-186 promotes macrophage lipid accumulation and secretion of pro-inflammatory cytokines by targeting cystathionine \u03b3-lyase in THP-1 macrophages","volume":"250","author":"Yao","year":"2016","journal-title":"Atherosclerosis"},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1089\/ars.2014.5909","article-title":"miRNA-30 family inhibition protects against cardiac ischemic injury by regulating cystathionine-\u03b3-lyase expression","volume":"22","author":"Shen","year":"2015","journal-title":"Antioxid. Redox Signal."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"e1800735","DOI":"10.1002\/mnfr.201800735","article-title":"Dietary Methionine Restriction Upregulates Endogenous H2S via miR-328-3p: A Potential Mechanism to Improve Liver Protein Metabolism Efficiency in a Mouse Model of High-fat-diet-induced Obesity","volume":"63","author":"Wu","year":"2019","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"117699","DOI":"10.1016\/j.lfs.2020.117699","article-title":"LncRNA Oprm1 overexpression attenuates myocardial ischemia\/reperfusion injury by increasing endogenous hydrogen sulfide via Oprm1\/miR-30b-5p\/CSE axis","volume":"254","author":"Hu","year":"2020","journal-title":"Life Sci."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"2124","DOI":"10.1210\/en.2014-1362","article-title":"MiR-22\/Sp-1 Links Estrogens with the Up-Regulation of Cystathionine \u03b3-Lyase in Myocardium, which Contributes to Estrogenic Cardioprotection against Oxidative Stress","volume":"156","author":"Wang","year":"2015","journal-title":"Endocrinology"},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1124\/jpet.109.152801","article-title":"Hydrogen sulfide prevents ethanol-induced gastric damage in mice: Role of ATP-sensitive potassium channels and capsaicin-sensitive primary afferent neurons","volume":"330","author":"Medeiros","year":"2009","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.tox.2007.07.020","article-title":"A protective role of hydrogen sulfide against oxidative stress in rat gastric mucosal epithelium","volume":"241","author":"Yonezawa","year":"2007","journal-title":"Toxicology"},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.pharmthera.2010.12.006","article-title":"Regulatory mechanism of duodenal bicarbonate secretion: Roles of endogenous prostaglandins and nitric oxide","volume":"130","author":"Takeuchi","year":"2011","journal-title":"Pharmacol. Ther."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.freeradbiomed.2008.11.013","article-title":"Pharmacological profile of a novel H2S-releasing aspirin","volume":"46","author":"Sparatore","year":"2009","journal-title":"Free Radic. Biol. Med."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1089\/ars.2009.2900","article-title":"Physiological and pathophysiological roles of hydrogen sulfide in the gastrointestinal tract","volume":"12","author":"Wallace","year":"2010","journal-title":"Antioxid. Redox Signal."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"e14488","DOI":"10.1111\/nmo.14488","article-title":"Dysregulated cystathionine-beta-synthase\/hydrogen sulfide signaling promotes chronic stress-induced colonic hypermotility in rats","volume":"35","author":"Lin","year":"2023","journal-title":"Neurogastroenterol. Motil."},{"key":"ref_204","doi-asserted-by":"crossref","unstructured":"Zhang, J., Cen, L., Zhang, X., Tang, C., Chen, Y., Zhang, Y., Yu, M., Lu, C., Li, M., and Li, S. (2022). MPST deficiency promotes intestinal epithelial cell apoptosis and aggravates inflammatory bowel disease via AKT. Redox Biol., 56.","DOI":"10.1016\/j.redox.2022.102469"},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"H801","DOI":"10.1152\/ajpheart.00377.2008","article-title":"Hydrogen sulfide attenuates hepatic ischemia-reperfusion injury: Role of antioxidant and antiapoptotic signaling","volume":"295","author":"Jha","year":"2008","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1002\/mnfr.200800007","article-title":"Antiglycative and anti-VEGF effects of s-ethyl cysteine and s-propyl cysteine in kidney of diabetic mice","volume":"52","author":"Lin","year":"2008","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1002\/lt.21810","article-title":"Role of hydrogen sulfide in hepatic ischemia-reperfusion-induced injury in rats","volume":"15","author":"Kang","year":"2009","journal-title":"Liver Transpl."},{"key":"ref_208","doi-asserted-by":"crossref","unstructured":"Huang, X., Gao, Y., Qin, J., and Lu, S. (2014). The role of miR-34a in the hepatoprotective effect of hydrogen sulfide on ischemia\/reperfusion injury in young and old rats. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0113305"},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1124\/jpet.108.149963","article-title":"Production and actions of hydrogen sulfide, a novel gaseous bioactive substance, in the kidneys","volume":"329","author":"Xia","year":"2009","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"F410","DOI":"10.1152\/ajprenal.00145.2009","article-title":"Hydrogen sulfide ameliorates hyperhomocysteinemia-associated chronic renal failure","volume":"297","author":"Sen","year":"2009","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.tox.2008.07.062","article-title":"Diallyl trisulfide (DATS) effectively attenuated oxidative stress-mediated liver injury and hepatic mitochondrial dysfunction in acute ethanol-exposed mice","volume":"252","author":"Zeng","year":"2008","journal-title":"Toxicology"},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.lfs.2010.10.004","article-title":"Curative effects of hydrogen sulfide against acetaminophen-induced hepatotoxicity in mice","volume":"87","author":"Morsy","year":"2010","journal-title":"Life Sci."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1089\/ars.2016.6773","article-title":"Cystathionine gamma-Lyase Deficiency Exacerbates CCl4-Induced Acute Hepatitis and Fibrosis in the Mouse Liver","volume":"27","author":"Ci","year":"2017","journal-title":"Antioxid. Redox Signal."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1053\/j.gastro.2005.02.034","article-title":"Cystathionine beta synthase deficiency promotes oxidative stress, fibrosis, and steatosis in mice liver","volume":"128","author":"Robert","year":"2005","journal-title":"Gastroenterology"},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"e72","DOI":"10.4142\/jvs.22064","article-title":"Hydrogen sulfide protects from acute kidney injury via attenuating inflammation activated by necroptosis in dogs","volume":"23","author":"Wang","year":"2022","journal-title":"J. Vet. Sci."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.febslet.2008.12.026","article-title":"Glucose-induced production of hydrogen sulfide may protect the pancreatic beta-cells from apoptotic cell death by high glucose","volume":"583","author":"Kaneko","year":"2009","journal-title":"FEBS Lett."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1111\/j.1476-5381.2010.01119.x","article-title":"Hydrogen sulphide protects mouse pancreatic beta-cells from cell death induced by oxidative stress, but not by endoplasmic reticulum stress","volume":"162","author":"Taniguchi","year":"2011","journal-title":"Br. J. Pharmacol."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1254\/jphs.11R01CP","article-title":"Significance of hydrogen sulfide production in the pancreatic beta-cell","volume":"116","author":"Taniguchi","year":"2011","journal-title":"J. Pharmacol. Sci."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/bjp.2008.296","article-title":"Biosynthesis of H2S is impaired in non-obese diabetic (NOD) mice","volume":"155","author":"Brancaleone","year":"2008","journal-title":"Br. J. Pharmacol."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/s00210-011-0601-6","article-title":"The vasorelaxant effect of hydrogen sulfide is enhanced in streptozotocin-induced diabetic rats","volume":"383","author":"Denizalti","year":"2011","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/bjp.2008.359","article-title":"Potential importance of alterations in hydrogen sulphide (H2S) bioavailability in diabetes","volume":"155","author":"Lefer","year":"2008","journal-title":"Br. J. Pharmacol."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1007\/s00125-010-1761-5","article-title":"Adiposity is a major determinant of plasma levels of the novel vasodilator hydrogen sulphide","volume":"53","author":"Whiteman","year":"2010","journal-title":"Diabetologia"},{"key":"ref_223","doi-asserted-by":"crossref","unstructured":"Peng, S., Wang, M., Zhang, S., Liu, N., Li, Q., Kang, J., Chen, L., Li, M., Pang, K., and Huang, J. (2023). Hydrogen sulfide regulates SERCA2a SUMOylation by S-Sulfhydration of SENP1 to ameliorate cardiac systole-diastole function in diabetic cardiomyopathy. Biomed. Pharmacother., 160.","DOI":"10.1016\/j.biopha.2022.114200"},{"key":"ref_224","doi-asserted-by":"crossref","unstructured":"Xue, W., Zhang, Q., Chen, Y., and Zhu, Y. (2022). Hydrogen Sulfide Improves Angiogenesis by Regulating the Transcription of pri-miR-126 in Diabetic Endothelial Cells. Cells, 11.","DOI":"10.3390\/cells11172651"},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"C305","DOI":"10.1152\/ajpcell.00230.2015","article-title":"Hydrogen sulfide promotes angiogenesis by downregulating miR-640 via the VEGFR2\/mTOR pathway","volume":"310","author":"Zhou","year":"2016","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1161\/CIRCRESAHA.109.199919","article-title":"Hydrogen sulfide mediates cardioprotection through Nrf2 signaling","volume":"105","author":"Calvert","year":"2009","journal-title":"Circ. Res."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"15560","DOI":"10.1073\/pnas.0705891104","article-title":"Hydrogen sulfide attenuates myocardial ischemia-reperfusion injury by preservation of mitochondrial function","volume":"104","author":"Elrod","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1161\/CIRCULATIONAHA.109.920991","article-title":"Genetic and pharmacologic hydrogen sulfide therapy attenuates ischemia-induced heart failure in mice","volume":"122","author":"Calvert","year":"2010","journal-title":"Circulation"},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1586\/ecp.10.130","article-title":"Hydrogen sulfide in the pathogenesis of atherosclerosis and its therapeutic potential","volume":"4","author":"Lynn","year":"2011","journal-title":"Expert Rev. Clin. Pharmacol."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1161\/CIRCULATIONAHA.108.833491","article-title":"Hydrogen sulfide improves survival after cardiac arrest and cardiopulmonary resuscitation via a nitric oxide synthase 3-dependent mechanism in mice","volume":"120","author":"Minamishima","year":"2009","journal-title":"Circulation"},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1586\/ecp.10.56","article-title":"Hydrogen sulfide-mediated myocardial pre- and post-conditioning","volume":"4","author":"Predmore","year":"2011","journal-title":"Expert Rev. Clin. Pharmacol."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.bbrc.2011.08.101","article-title":"Hydrogen sulphide inhibits cardiomyocyte hypertrophy by up-regulating miR-133a","volume":"413","author":"Liu","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_233","first-page":"29","article-title":"Effects of hydrogen sulfide (H2S) on cardiac hypertrophy and miRNA-133a-mediated Ca2+\/calcineurin\/NFATc4 signal pathway in rats","volume":"34","author":"Wu","year":"2018","journal-title":"Zhongguo Ying Yong Sheng Li Xue Za Zhi"},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1161\/CIRCGENETICS.113.000381","article-title":"Induction of microRNA-21 with exogenous hydrogen sulfide attenuates myocardial ischemic and inflammatory injury in mice","volume":"7","author":"Toldo","year":"2014","journal-title":"Circ. Cardiovasc. Genet."},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1172\/JCI119212","article-title":"Peroxynitrite inhibits leukocyte-endothelial cell interactions and protects against ischemia-reperfusion injury in rats","volume":"99","author":"Lefer","year":"1997","journal-title":"J. Clin. Investig."},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"H868","DOI":"10.1152\/ajpheart.01111.2007","article-title":"Hydrogen sulfide triggers late-phase preconditioning in postischemic small intestine by an NO- and p38 MAPK-dependent mechanism","volume":"296","author":"Yusof","year":"2009","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"C849","DOI":"10.1152\/ajpcell.00283.2008","article-title":"Radical-free biology of oxidative stress","volume":"295","author":"Jones","year":"2008","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1096\/fj.06-6270fje","article-title":"Hydrogen sulfide is an endogenous modulator of leukocyte-mediated inflammation","volume":"20","author":"Zanardo","year":"2006","journal-title":"FASEB J."},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1007\/s00296-010-1682-0","article-title":"Inhibitors of p38 and ERK1\/2 MAPkinase and hydrogen sulphide block constitutive and IL-1beta-induced IL-6 and IL-8 expression in the human chondrocyte cell line C-28\/I2","volume":"32","author":"Kloesch","year":"2012","journal-title":"Rheumatol. Int."},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.freeradbiomed.2006.03.021","article-title":"Hydrogen sulfide inhibits nitric oxide production and nuclear factor-kappaB via heme oxygenase-1 expression in RAW264.7 macrophages stimulated with lipopolysaccharide","volume":"41","author":"Oh","year":"2006","journal-title":"Free Radic. Biol. Med."},{"key":"ref_241","doi-asserted-by":"crossref","unstructured":"Pan, L.L., Liu, X.H., Gong, Q.H., Wu, D., and Zhu, Y.Z. (2011). Hydrogen sulfide attenuated tumor necrosis factor-alpha-induced inflammatory signaling and dysfunction in vascular endothelial cells. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0019766"},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"H1330","DOI":"10.1152\/ajpheart.00244.2008","article-title":"Endogenous hydrogen sulphide mediates the cardioprotection induced by ischemic postconditioning","volume":"295","author":"Yong","year":"2008","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.freeradbiomed.2009.04.014","article-title":"GYY4137, a novel hydrogen sulfide-releasing molecule, protects against endotoxic shock in the rat","volume":"47","author":"Li","year":"2009","journal-title":"Free Radic. Biol. Med."},{"key":"ref_244","first-page":"794","article-title":"TNF-alpha-Mediated Endothelial Cell Apoptosis Is Rescued by Hydrogen Sulfide","volume":"12","author":"Sanchez","year":"2023","journal-title":"Antioxidants"},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1248\/bpb.b17-00769","article-title":"MicroRNA-21-Regulated Activation of the Akt Pathway Participates in the Protective Effects of H2S against Liver Ischemia-Reperfusion Injury","volume":"41","author":"Lu","year":"2018","journal-title":"Biol. Pharm. Bull."},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"H802","DOI":"10.1152\/ajpheart.00660.2015","article-title":"Emerging role of hydrogen sulfide-microRNA crosstalk in cardiovascular diseases","volume":"310","author":"Hackfort","year":"2016","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"C25","DOI":"10.1152\/ajpcell.00084.2014","article-title":"Type-2 pericytes participate in normal and tumoral angiogenesis","volume":"307","author":"Birbrair","year":"2014","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/nrm2183","article-title":"Molecular regulation of angiogenesis and lymphangiogenesis","volume":"8","author":"Adams","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"59","DOI":"10.7748\/ns.19.43.59.s55","article-title":"The physiological basics of wound healing","volume":"19","author":"Johnstone","year":"2005","journal-title":"Nurs. Stand."},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.cardiores.2007.05.026","article-title":"The novel proangiogenic effect of hydrogen sulfide is dependent on Akt phosphorylation","volume":"76","author":"Cai","year":"2007","journal-title":"Cardiovasc. Res."},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"14082","DOI":"10.1073\/pnas.0804597105","article-title":"Dicer-dependent endothelial microRNAs are necessary for postnatal angiogenesis","volume":"105","author":"Yu","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.neuint.2009.08.008","article-title":"Hydrogen sulfide: A novel signaling molecule in the central nervous system","volume":"56","author":"Tan","year":"2010","journal-title":"Neurochem. Int."},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"878052","DOI":"10.1155\/2012\/878052","article-title":"Hydrogen sulfide as an endogenous modulator in mitochondria and mitochondria dysfunction","volume":"2012","author":"Guo","year":"2012","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_254","doi-asserted-by":"crossref","unstructured":"Li, L., Jiang, H.K., Li, Y.P., and Guo, Y.P. (2015). Hydrogen sulfide protects spinal cord and induces autophagy via miR-30c in a rat model of spinal cord ischemia-reperfusion injury. J. Biomed. Sci., 22.","DOI":"10.1186\/s12929-015-0135-1"},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1016\/j.biopha.2017.12.079","article-title":"Hydrogen sulfide upregulated lncRNA CasC7 to reduce neuronal cell apoptosis in spinal cord ischemia-reperfusion injury rat","volume":"98","author":"Liu","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1002\/glia.20905","article-title":"Hydrogen sulfide-releasing NSAIDs attenuate neuroinflammation induced by microglial and astrocytic activation","volume":"58","author":"Lee","year":"2010","journal-title":"Glia"},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.neuint.2010.11.010","article-title":"Hydrogen sulfide reduces mRNA and protein levels of beta-site amyloid precursor protein cleaving enzyme 1 in PC12 cells","volume":"58","author":"Zhang","year":"2011","journal-title":"Neurochem. Int."},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1111\/j.1440-1681.2010.05462.x","article-title":"Heat shock protein 90 mediates cytoprotection by H2S against chemical hypoxia-induced injury in PC12 cells","volume":"38","author":"Meng","year":"2011","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.neuroscience.2010.02.006","article-title":"Hydrogen sulfide protects neurons against hypoxic injury via stimulation of ATP-sensitive potassium channel\/protein kinase C\/extracellular signal-regulated kinase\/heat shock protein 90 pathway","volume":"167","author":"Tay","year":"2010","journal-title":"Neuroscience"},{"key":"ref_260","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1167\/iovs.09-3999","article-title":"ACS67, a hydrogen sulfide-releasing derivative of latanoprost acid, attenuates retinal ischemia and oxidative stress to RGC-5 cells in culture","volume":"51","author":"Osborne","year":"2010","journal-title":"Investig. Opthalmol. Vis. Sci."},{"key":"ref_261","first-page":"1275","article-title":"Inhalative preconditioning with hydrogen sulfide attenuated apoptosis after retinal ischemia\/reperfusion injury","volume":"17","author":"Biermann","year":"2011","journal-title":"Mol. Vis."},{"key":"ref_262","doi-asserted-by":"crossref","first-page":"39379","DOI":"10.1074\/jbc.M111.298208","article-title":"Hydrogen sulfide protects the retina from light-induced degeneration by the modulation of Ca2+ influx","volume":"286","author":"Mikami","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref_263","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.neuint.2009.11.002","article-title":"Hydrogen sulfide mitigates matrix metalloproteinase-9 activity and neurovascular permeability in hyperhomocysteinemic mice","volume":"56","author":"Tyagi","year":"2010","journal-title":"Neurochem. Int."},{"key":"ref_264","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1016\/j.bbrc.2016.08.116","article-title":"Hydrogen sulfide protects against TNF-alpha induced neuronal cell apoptosis through miR-485-5p\/TRADD signaling","volume":"478","author":"Chen","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_265","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1159\/000452521","article-title":"Involvement of microRNA-135a-5p in the Protective Effects of Hydrogen Sulfide Against Parkinson\u2019s Disease","volume":"40","author":"Liu","year":"2016","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_266","doi-asserted-by":"crossref","unstructured":"Lugli, G., Cohen, A.M., Bennett, D.A., Shah, R.C., Fields, C.J., Hernandez, A.G., and Smalheiser, N.R. (2015). Plasma Exosomal miRNAs in Persons with and without Alzheimer Disease: Altered Expression and Prospects for Biomarkers. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0139233"},{"key":"ref_267","doi-asserted-by":"crossref","unstructured":"Hromadnikova, I., Kotlabova, K., Hympanova, L., and Krofta, L. (2015). Cardiovascular and Cerebrovascular Disease Associated microRNAs are Dysregulated in Placental Tissues Affected with Gestational Hypertension, Preeclampsia and Intrauterine Growth Restriction. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0138383"}],"container-title":["Non-Coding RNA"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2311-553X\/10\/1\/7\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T13:49:13Z","timestamp":1760104153000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2311-553X\/10\/1\/7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,18]]},"references-count":267,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,2]]}},"alternative-id":["ncrna10010007"],"URL":"https:\/\/doi.org\/10.3390\/ncrna10010007","relation":{},"ISSN":["2311-553X"],"issn-type":[{"value":"2311-553X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,18]]}}}