{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T18:54:18Z","timestamp":1789757658329,"version":"4.0.1"},"reference-count":107,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2024,3,17]],"date-time":"2024-03-17T00:00:00Z","timestamp":1710633600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of University and Research (MUR)","award":["PE0000006"],"award-info":[{"award-number":["PE0000006"]}]},{"name":"Ministry of University and Research (MUR)","award":["1553 11.10.2022"],"award-info":[{"award-number":["1553 11.10.2022"]}]},{"name":"National Recovery and Resilience Plan (NRRP)","award":["PE0000006"],"award-info":[{"award-number":["PE0000006"]}]},{"name":"National Recovery and Resilience Plan (NRRP)","award":["1553 11.10.2022"],"award-info":[{"award-number":["1553 11.10.2022"]}]},{"name":"project MNESYS","award":["PE0000006"],"award-info":[{"award-number":["PE0000006"]}]},{"name":"project MNESYS","award":["1553 11.10.2022"],"award-info":[{"award-number":["1553 11.10.2022"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ncRNA"],"abstract":"<jats:p>Temporal lobe epilepsy (TLE) represents the most common form of refractory focal epilepsy. The identification of innovative clinical biomarkers capable of categorizing patients with TLE, allowing for improved treatment and outcomes, still represents an unmet need. Circulating microRNAs (c-miRNAs) are short non-coding RNAs detectable in body fluids, which play crucial roles in the regulation of gene expression. Their characteristics, including extracellular stability, detectability through non-invasive methods, and responsiveness to pathological changes and\/or therapeutic interventions, make them promising candidate biomarkers in various disease settings. Recent research has investigated c-miRNAs in various bodily fluids, including serum, plasma, and cerebrospinal fluid, of TLE patients. Despite some discrepancies in methodologies, cohort composition, and normalization strategies, a common dysregulated signature of c-miRNAs has emerged across different studies, providing the basis for using c-miRNAs as novel biomarkers for TLE patient management.<\/jats:p>","DOI":"10.3390\/ncrna10020018","type":"journal-article","created":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T04:25:15Z","timestamp":1710735915000},"page":"18","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Circulating miRNAs as Novel Clinical Biomarkers in Temporal Lobe Epilepsy"],"prefix":"10.3390","volume":"10","author":[{"given":"Lorenza","family":"Guarnieri","sequence":"first","affiliation":[{"name":"Section of Pharmacology, Science of Health Department, School of Medicine, University \u201cMagna Graecia\u201d of Catanzaro, 88100 Catanzaro, 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