{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:42:08Z","timestamp":1785436928113,"version":"3.56.0"},"reference-count":67,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004881","name":"Instituto Mexicano del Seguro Social","doi-asserted-by":"crossref","award":["R-2020-785-130"],"award-info":[{"award-number":["R-2020-785-130"]}],"id":[{"id":"10.13039\/501100004881","id-type":"DOI","asserted-by":"crossref"}]},{"award":["R-2020-785-130"],"award-info":[{"award-number":["R-2020-785-130"]}],"id":[{"id":"https:\/\/ror.org\/03xddgg98","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ncRNA"],"abstract":"<jats:p>Recent evidence has highlighted the crucial role of non-coding genetic elements in regulating gene expression and has been linked to a broad range of biological functions. Notably, dysregulation of long non-coding RNAs has been strongly associated with tumorigenesis and cancer progression. Background\/Objectives: This study aimed to investigate the potential association between the H19 rs3741219 T&gt;C, MEG3 rs7158663 G&gt;A, POLR2E rs3787016 T&gt;C, and ANRIL rs10757274 A&gt;G variants and Breast Cancer (BC) susceptibility, as well as their relationship with clinicopathological characteristics in Mexican patients. Methods: DNA was obtained from peripheral blood samples of 505 women (254 patients and 251 control females). Genotyping was performed by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) methodology. Associations were calculated using odds ratios (ORs), with p-values adjusted by the Bonferroni test (p &lt; 0.012). In silico analyses were conducted to predict the functional impact of the variants associated. Results: Patients carrying the C\/C genotypes in H19 rs3741219 and POLR2E rs3787016 variants showed increased susceptibility to developing BC and with clinical and pathological characteristics (age at diagnosis, TNM stage, histologic type and molecular subtype) (p &lt; 0.001). Conclusions: The results suggest that H19 rs3741219 and POLR2E rs3787016 variants significantly influence BC risk.<\/jats:p>","DOI":"10.3390\/ncrna12030019","type":"journal-article","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T11:52:30Z","timestamp":1780573950000},"page":"19","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Investigation of Long Non-Coding RNAs H19 rs3741219, MEG3 rs7158663, POLR2E rs3787016, and ANRIL rs10757274 with Breast Cancer Susceptibility and Clinicopathological Characteristics in a Mexican Population"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0387-4996","authenticated-orcid":false,"given":"M\u00f3nica Alejandra","family":"Rosales-Reynoso","sequence":"first","affiliation":[{"name":"Divisi\u00f3n de Medicina Molecular, Centro de Investigaci\u00f3n Biom\u00e9dica de Occidente (CIBO), Centro M\u00e9dico Nacional de Occidente (CMNO), Instituto Mexicano del Seguro Social (IMSS), Guadalajara 44340, Jalisco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil\u00fa Margarita","family":"Saucedo-Sari\u00f1ana","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Molecular y Gen\u00f3mica, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara (UdeG), Guadalajara 44340, Jalisco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara Ibet","family":"Ju\u00e1rez-V\u00e1zquez","sequence":"additional","affiliation":[{"name":"Departamento de Estructura y Funci\u00f3n, Facultad de Medicina, Decanato de Medicina, Universidad Aut\u00f3noma de Guadalajara (UAG), Zapopan 45129, Jalisco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2866-6633","authenticated-orcid":false,"given":"C\u00e9sar de Jes\u00fas","family":"Tovar-J\u00e1come","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n de Medicina Molecular, Centro de Investigaci\u00f3n Biom\u00e9dica de Occidente (CIBO), Centro M\u00e9dico Nacional de Occidente (CMNO), Instituto Mexicano del Seguro Social (IMSS), Guadalajara 44340, Jalisco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rubria Alicia","family":"Gonz\u00e1lez-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n de Medicina Molecular, Centro de Investigaci\u00f3n Biom\u00e9dica de Occidente (CIBO), Centro M\u00e9dico Nacional de Occidente (CMNO), Instituto Mexicano del Seguro Social (IMSS), Guadalajara 44340, Jalisco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen Guadalupe","family":"Mestas-Villagran","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n de Medicina Molecular, Centro de Investigaci\u00f3n Biom\u00e9dica de Occidente (CIBO), Centro M\u00e9dico Nacional de Occidente (CMNO), Instituto Mexicano del Seguro Social (IMSS), Guadalajara 44340, Jalisco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo Andr\u00e9s","family":"Torres-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n de Medicina Molecular, Centro de Investigaci\u00f3n Biom\u00e9dica de Occidente (CIBO), Centro M\u00e9dico Nacional de Occidente (CMNO), Instituto Mexicano del Seguro Social (IMSS), Guadalajara 44340, Jalisco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 El\u00edas","family":"Garc\u00eda-Ort\u00edz","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n de Gen\u00e9tica, Centro de Investigaci\u00f3n Biom\u00e9dica de Occidente (CIBO), Centro M\u00e9dico Nacional de Occidente (CMNO), Instituto Mexicano del Seguro Social (IMSS), Guadalajara 44340, Jalisco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efra\u00edn","family":"Salas-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Servicio de Oncolog\u00eda M\u00e9dica, Unidad M\u00e9dica de Alta Especialidad, Hospital de Ginecolog\u00eda y Obstetricia, Centro M\u00e9dico Nacional de Occidente (CMNO), Instituto Mexicano del Seguro Social (IMSS), Guadalajara 44340, Jalisco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4539-1693","authenticated-orcid":false,"given":"Martha Patricia","family":"Gallegos-Arreola","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n de Gen\u00e9tica, Centro de Investigaci\u00f3n Biom\u00e9dica de Occidente (CIBO), Centro M\u00e9dico Nacional de Occidente (CMNO), Instituto Mexicano del Seguro Social (IMSS), Guadalajara 44340, Jalisco, 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Target. Ther."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2","DOI":"10.12968\/hmed.2021.0459","article-title":"Breast Cancer: Presentation, Investigation and Management","volume":"83","author":"Katsura","year":"2022","journal-title":"Br. J. Hosp. Med."},{"key":"ref_3","unstructured":"Ferlay, J., Ervik, M., Lam, F., Laversanne, M., Colombet, M., Mery, L., Pi\u00f1eros, M., Znaor, A., Soerjomataram, I., and Bray, F. (2024). Global Cancer Observatory: Cancer Today, International Agency for Research on Cancer. Available online: https:\/\/gco.iarc.who.int\/today."},{"key":"ref_4","first-page":"229","article-title":"Global Cancer Statistics 2022: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Jim\u00e9nez-L\u00f3pez, M.R., Tovar-J\u00e1come, C.d.J., Palacios-Ram\u00edrez, A., Gallegos-Arreola, M.P., Aguilar-Macedo, T.G.M., Gonz\u00e1lez-S\u00e1nchez, R.A., Salas-Gonz\u00e1lez, E., Garc\u00eda-Ortiz, J.E., Ju\u00e1rez-V\u00e1zquez, C.I., and Rosales-Reynoso, M.A. (2025). Genetic Variants in BIRC5 (Rs8073069, Rs17878467, and Rs9904341) Are Associated with Susceptibility in Mexican Patients with Breast Cancer: Clinical Associations and Their Analysis In Silico. Genes, 16.","DOI":"10.3390\/genes16070786"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1038\/s41417-022-00487-w","article-title":"LncRNAs in Breast Cancer: A Link to Future Approaches","volume":"29","author":"Sideris","year":"2022","journal-title":"Cancer Gene Ther."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Gurioli, G., Tedaldi, G., Farolfi, A., Petracci, E., Casanova, C., Comerci, G., Danesi, R., Arcangeli, V., Ravegnani, M., and Calistri, D. (2022). Clinical Impact of Next-Generation Sequencing Multi-Gene Panel Highlighting the Landscape of Germline Alterations in Ovarian Cancer Patients. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232415789"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"oyaf052","DOI":"10.1093\/oncolo\/oyaf052","article-title":"Exploring the Promoter Regions of Cancer Predisposition Genes in Patients with Triple-Negative Breast Cancer Reveals the Presence of Rare Germline Variants","volume":"30","author":"Palleschi","year":"2025","journal-title":"Oncologist"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/s41580-022-00566-8","article-title":"Long Non-Coding RNAs: Definitions, Functions, Challenges and Recommendations","volume":"24","author":"Mattick","year":"2023","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_10","first-page":"1354","article-title":"Emerging Roles of LncRNA in Cancer and Therapeutic Opportunities","volume":"9","author":"Jiang","year":"2019","journal-title":"Am. J. Cancer Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"9997212","DOI":"10.1155\/2022\/9997212","article-title":"Serum-Based LncRNA ANRIL, TUG1, UCA1, and HIT Expressions in Breast Cancer Patients","volume":"2022","author":"Alkhathami","year":"2022","journal-title":"Dis. Markers"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e1585","DOI":"10.1002\/mgg3.1585","article-title":"The Association of LncRNA SNPs and SNPs-Environment Interactions Based on GWAS with HBV-Related HCC Risk and Progression","volume":"9","author":"Liu","year":"2021","journal-title":"Mol. Genet. Genom. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e12342","DOI":"10.1016\/j.heliyon.2022.e12342","article-title":"A Novel Lnc-LAMC2-1:1 SNP Promotes Colon Adenocarcinoma Progression by Targeting MiR-216a-3p\/HMGB3","volume":"8","author":"Ji","year":"2022","journal-title":"Heliyon"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"101961","DOI":"10.1016\/j.mcp.2024.101961","article-title":"Role of LncRNA H19 in Tumor Progression and Treatment","volume":"75","author":"Li","year":"2024","journal-title":"Mol. Cell. Probes"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1080\/14737159.2021.1944808","article-title":"Dysregulation of LncRNA-H19 in Cardiometabolic Diseases and the Molecular Mechanism Involved: A Systematic Review","volume":"21","year":"2021","journal-title":"Expert Rev. Mol. Diagn."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Collette, J., Le Bourhis, X., and Adriaenssens, E. (2017). Regulation of Human Breast Cancer by the Long Non-Coding RNA H19. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18112319"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"109774","DOI":"10.1016\/j.biopha.2019.109774","article-title":"H19 LncRNA: Roles in Tumorigenesis","volume":"123","author":"Esmaeili","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"3188","DOI":"10.7150\/ijbs.62573","article-title":"LncRNA H19: A Novel Oncogene in Multiple Cancers","volume":"17","author":"Yang","year":"2021","journal-title":"Int. J. Biol. Sci."},{"key":"ref_19","first-page":"7","article-title":"The Role of Long Non-Coding RNA H19 in Breast Cancer","volume":"19","author":"Wang","year":"2019","journal-title":"Oncol. Lett."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"6191","DOI":"10.7150\/jca.36707","article-title":"The Clinicopathological Characteristic Associations of Long Non-Coding RNA Gene H19 Polymorphisms with Uterine Cervical Cancer","volume":"10","author":"Huang","year":"2019","journal-title":"J. Cancer"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.omtn.2020.02.003","article-title":"Associations of LncRNA H19 Polymorphisms at MicroRNA Binding Sites with Glioma Susceptibility and Prognosis","volume":"20","author":"Deng","year":"2020","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Yang, M., Zhang, M., Wang, Q., Guo, X., Geng, P., Gu, J., Ji, W., and Zhang, L. (2023). Six Polymorphisms in the LncRNA H19 Gene and the Risk of Cancer: A Systematic Review and Meta-Analysis. BMC Cancer, 23.","DOI":"10.1186\/s12885-023-11164-y"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"e3271","DOI":"10.1002\/jgm.3271","article-title":"Polymorphism of LncRNAs in Breast Cancer: Meta-Analysis Shows No Association with Susceptibility","volume":"22","author":"Mathias","year":"2020","journal-title":"J. Gene Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"e19322","DOI":"10.1097\/MD.0000000000019322","article-title":"Significant Association between Long Non-Coding RNA H19 Polymorphisms and Cancer Susceptibility","volume":"99","author":"Li","year":"2020","journal-title":"Medicine"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"15311","DOI":"10.18632\/oncotarget.3840","article-title":"Tag SNPs in Long Non-Coding RNA H19 Contribute to Susceptibility to Gastric Cancer in the Chinese Han Population","volume":"6","author":"Yang","year":"2015","journal-title":"Oncotarget"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Yin, Z., Cui, Z., Li, H., Li, J., and Zhou, B. (2018). Polymorphisms in the H19 Gene and the Risk of Lung Cancer among Female Never Smokers in Shenyang, China. BMC Cancer, 18.","DOI":"10.1186\/s12885-018-4795-6"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Kong, Y., Hsieh, C.-H., and Alonso, L.C. (2018). ANRIL: A LncRNA at the CDKN2A\/B Locus with Roles in Cancer and Metabolic Disease. Front. Endocrinol., 9.","DOI":"10.3389\/fendo.2018.00405"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.biopha.2017.09.107","article-title":"Long Non-Coding RNA ANRIL Promotes Carcinogenesis via Sponging MiR-199a in Triple-Negative Breast Cancer","volume":"96","author":"Xu","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"120810","DOI":"10.1016\/j.lfs.2022.120810","article-title":"Long Non-Coding RNA ANRIL Promotes Chemoresistance in Triple-Negative Breast Cancer via Enhancing Aerobic Glycolysis","volume":"306","author":"Ma","year":"2022","journal-title":"Life Sci."},{"key":"ref_30","first-page":"72","article-title":"ANRIL Genetic Variants in Iranian Breast Cancer Patients","volume":"19","author":"Khorshidi","year":"2017","journal-title":"Cell J."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"e18841","DOI":"10.1097\/MD.0000000000018841","article-title":"Rs10757274 Gene Polymorphisms in Coronary Artery Disease","volume":"99","author":"Xu","year":"2020","journal-title":"Medicine"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1007\/s11033-024-09420-w","article-title":"The Effects of ANRIL Polymorphisms on Colorectal Cancer, Tumor Stage, and Tumor Grade among Iranian Population","volume":"51","author":"Darashti","year":"2024","journal-title":"Mol. Biol. Rep."},{"key":"ref_33","unstructured":"NIH National Center for Biotechnology Information (2026, March 13). POLR2E RNA Polymerase II, I and III Subunit E [Homo sapiens], Available online: https:\/\/www.ncbi.nlm.nih.gov\/gene\/5434."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"BSR20180853","DOI":"10.1042\/BSR20180853","article-title":"The Association of POLR2E Rs3787016 Polymorphism and Cancer Risk: A Chinese Case-Control Study and Meta-Analysis","volume":"38","author":"Chen","year":"2018","journal-title":"Biosci. Rep."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Han, X., Anthon, C., Geissler, A.S., Sabarinathan, R., Seemann, S.E., Havgaard, J.H., and Gorodkin, J. (2025). Associating Cancer-Related RNA Structure Disrupting SNPs in LincRNAs to Function. BMC Genom., 26.","DOI":"10.1186\/s12864-025-12226-0"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/j.prp.2018.04.008","article-title":"Long Non-Coding RNA POLR2E Rs3787016 Is Associated with the Risk of Papillary Thyroid Carcinoma in Chinese Population","volume":"214","author":"Chen","year":"2018","journal-title":"Pathol. Res. Pract."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/15257770.2017.1391394","article-title":"Long Non-Coding RNA POLR2E Gene Polymorphisms Increased the Risk of Prostate Cancer in a Sample of the Iranian Population","volume":"38","author":"Sattarifard","year":"2019","journal-title":"Nucleosides Nucleotides Nucleic Acids"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.7150\/jca.18055","article-title":"Association between SNPs in Long Non-Coding RNAs and the Risk of Female Breast Cancer in a Chinese Population","volume":"8","author":"Xu","year":"2017","journal-title":"J. Cancer"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1007\/s12253-019-00614-3","article-title":"MEG3: An Oncogenic Long Non-Coding RNA in Different Cancers","volume":"25","author":"Alanazi","year":"2019","journal-title":"Pathol. Oncol. Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"R107","DOI":"10.1093\/hmg\/ddaa133","article-title":"Temple Syndrome and Kagami-Ogata Syndrome: Clinical Presentations, Genotypes, Models and Mechanisms","volume":"29","author":"Prasasya","year":"2020","journal-title":"Hum. Mol. Genet."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"154850","DOI":"10.1016\/j.prp.2023.154850","article-title":"The Complex Role of MEG3: An Emerging Long Non-Coding RNA in Breast Cancer","volume":"251","author":"Hussain","year":"2023","journal-title":"Pathol. Res. Pract."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"19054","DOI":"10.18632\/oncotarget.7764","article-title":"Associations between Polymorphisms of Long Non-Coding RNA MEG3 and Risk of Colorectal Cancer in Chinese","volume":"7","author":"Cao","year":"2016","journal-title":"Oncotarget"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Gao, X., Li, X., Zhang, S., and Wang, X. (2021). The Association of MEG3 Gene Rs7158663 Polymorphism with Cancer Susceptibility. Front. Oncol., 11.","DOI":"10.3389\/fonc.2021.796774"},{"key":"ref_44","unstructured":"Comit\u00e9 Consultivo Nacional de Normalizaci\u00f3n de Prevenci\u00f3n y Control de Enfermedades (2011). NORMA Oficial Mexicana NOM-041-SSA2-2011, Para La Prevenci\u00f3n, Diagn\u00f3stico, Tratamiento, Control y Vigilancia Epidemiol\u00f3gica Del C\u00e1ncer de Mama, Secretar\u00eda de Salud."},{"key":"ref_45","unstructured":"National Institute for Health and Care Excellence (2013). Familial Breast Cancer: Classification and Care of People at Risk of Familial Breast Cancer and Management of Breast Cancer and Related Risks in People with a Family History of Breast Cancer, NICE. NICE Clinical Guideline CG164."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/j.annonc.2022.07.007","article-title":"ESO-ESMO Fifth International Consensus Guidelines for Breast Cancer in Young Women (BCY5)","volume":"33","author":"Cardoso","year":"2022","journal-title":"Ann. Oncol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1186\/s13058-014-0427-5","article-title":"Biology of Breast Cancer in Young Women","volume":"16","author":"Azim","year":"2014","journal-title":"Breast Cancer Res."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"3308","DOI":"10.1200\/JCO.2015.65.8013","article-title":"Subtype-Dependent Relationship Between Young Age at Diagnosis and Breast Cancer Survival","volume":"34","author":"Partridge","year":"2016","journal-title":"J. Clin. Oncol."},{"key":"ref_49","unstructured":"Instituto Mexicano del Seguro Social (2023). Protocolo de Atenci\u00f3n Integral C\u00e1ncer de Mama, IMSS."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"JE20220206","DOI":"10.2188\/jea.JE20220206","article-title":"Dose-Response Relationships Between Cigarette Smoking and Breast Cancer Risk: A Systematic Review and Meta-Analysis","volume":"33","author":"Scala","year":"2023","journal-title":"J. Epidemiol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"e2771","DOI":"10.1097\/MD.0000000000002771","article-title":"Genetic Polymorphisms in Long Noncoding RNA H19 Are Associated with Susceptibility to Breast Cancer in Chinese Population","volume":"95","author":"Xia","year":"2016","journal-title":"Medicine"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"e22826","DOI":"10.1002\/jcla.22826","article-title":"Association of the Study between LncRNA-H19 Gene Polymorphisms with the Risk of Breast Cancer","volume":"33","author":"Abdollahzadeh","year":"2019","journal-title":"J. Clin. Lab. Anal."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1080\/03630242.2022.2096748","article-title":"Association between Long Non-Coding RNA H19 Polymorphisms and Breast Cancer Risk: A Meta-Analysis","volume":"62","author":"Li","year":"2022","journal-title":"Women Health"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Yuan, Y., Wang, Y., Niu, X., Han, Y., Li, W., Cheng, M., Li, Z., Tan, J., Zhao, Y., and Wang, W. (2022). Association of LncRNA H19 Polymorphisms with Cancer Susceptibility: An Updated Meta-Analysis Based on 53 Studies. Front. Genet., 13.","DOI":"10.3389\/fgene.2022.1051766"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1093\/jnci\/djz174","article-title":"A Polygenic Risk Score for Breast Cancer in U.S. Latinas and Latin American Women","volume":"112","author":"Shieh","year":"2020","journal-title":"JNCI J. Natl. Cancer Inst."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1158\/1055-9965.EPI-24-1247","article-title":"Evaluation of Multiple Breast Cancer Polygenic Risk Score Panels in Women of Latin American Heritage","volume":"34","author":"Huang","year":"2025","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_57","unstructured":"Pederson, H., Kucera, M., Hu, E., Hullinger, B., Simmons, T., and Hughes, E. (2024, January 10\u201313). Multi-Ancestry Breast Cancer Polygenic Risk Score Performance in Hispanic Women. Proceedings of the San Antonio Breast Cancer Symposium 2024, San Antonio, TX, USA."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1093\/nar\/16.3.1215","article-title":"A Simple Salting out Procedure for Extracting DNA from Human Nucleated Cells","volume":"16","author":"Miller","year":"1988","journal-title":"Nucleic Acids Res."},{"key":"ref_59","first-page":"377","article-title":"Association Between HOTAIR Rs920778 and H19 Rs3741219 Polymorphisms with Hashimoto\u2019s Thyroiditis (HT) and Graves\u2019 Disease (GD)","volume":"11","author":"Beiramzadeh","year":"2022","journal-title":"Rep. Biochem. Mol. Biol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1080\/09674845.2020.1829853","article-title":"Long Non-Coding RNA ANRIL Polymorphisms in Papillary Thyroid Cancer and Its Severity","volume":"78","author":"Heidari","year":"2021","journal-title":"Br. J. Biomed. Sci."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.gene.2018.07.002","article-title":"Genetic Variants in Long Noncoding RNA H19 and MEG3 Confer Risk of Type 2 Diabetes in an Iranian Population","volume":"675","author":"Ghaedi","year":"2018","journal-title":"Gene"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"D886","DOI":"10.1093\/nar\/gky1016","article-title":"CADD: Predicting the Deleteriousness of Variants throughout the Human Genome","volume":"47","author":"Rentzsch","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"D1143","DOI":"10.1093\/nar\/gkad989","article-title":"CADD v1.7: Using Protein Language Models, Regulatory CNNs and Other Nucleotide-Level Scores to Improve Genome-Wide Variant Predictions","volume":"52","author":"Schubach","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1101\/gr.137323.112","article-title":"Annotation of Functional Variation in Personal Genomes Using RegulomeDB","volume":"22","author":"Boyle","year":"2012","journal-title":"Genome Res."},{"key":"ref_65","unstructured":"(2026, March 16). The Human Protein Atlas. Available online: https:\/\/www.proteinatlas.org."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"D199","DOI":"10.1093\/nar\/gkac984","article-title":"LncTarD 2.0: An Updated Comprehensive Database for Experimentally-Supported Functional LncRNA-Target Regulations in Human Diseases","volume":"51","author":"Zhao","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"W556","DOI":"10.1093\/nar\/gkz430","article-title":"GEPIA2: An Enhanced Web Server for Large-Scale Expression Profiling and Interactive Analysis","volume":"47","author":"Tang","year":"2019","journal-title":"Nucleic Acids Res."}],"container-title":["Non-Coding RNA"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2311-553X\/12\/3\/19\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T04:53:37Z","timestamp":1780721617000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2311-553X\/12\/3\/19"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,4]]},"references-count":67,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["ncrna12030019"],"URL":"https:\/\/doi.org\/10.3390\/ncrna12030019","relation":{},"ISSN":["2311-553X"],"issn-type":[{"value":"2311-553X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,4]]}}}