{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T15:52:42Z","timestamp":1783785162690,"version":"3.55.0"},"reference-count":76,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ncRNA"],"abstract":"<jats:p>The neurological damage of Alzheimer\u2019s disease (AD) is thought to be irreversible upon onset of dementia-like symptoms, as it takes years to decades for occult pathologic changes to become symptomatic. It is thus necessary to identify individuals at risk for the development of the disease before symptoms manifest in order to provide early intervention. Surrogate markers are critical for early disease detection, stratification of patients in clinical trials, prediction of disease progression, evaluation of response to treatment, and also insight into pathomechanisms. Here, we review the evidence for a number of microRNAs that may serve as biomarkers with possible mechanistic insights into the AD pathophysiologic processes, years before the clinical manifestation of the disease.<\/jats:p>","DOI":"10.3390\/ncrna7010008","type":"journal-article","created":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T11:40:48Z","timestamp":1612179648000},"page":"8","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["MicroRNAs as Candidate Biomarkers for Alzheimer\u2019s Disease"],"prefix":"10.3390","volume":"7","author":[{"given":"Colin","family":"Kanach","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Rhode Island Hospital, Lifespan Academic Medical Center, The Warren Alpert Medical School of Brown University, Providence, RI 02903, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan K.","family":"Blusztajn","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Boston University School of Medicine, 670 Albany Street, Boston, MA 02118, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre","family":"Fischer","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases, Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, 37075 G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana","family":"Delalle","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Rhode Island Hospital, Lifespan Academic Medical Center, The Warren Alpert Medical School of Brown University, Providence, RI 02903, USA"},{"name":"Department of Pathology and Laboratory Medicine, Boston University School of Medicine, 670 Albany Street, Boston, MA 02118, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,2,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/S1474-4422(10)70119-8","article-title":"Alzheimer\u2019s disease: Clinical trials and drug development","volume":"9","author":"Mangialasche","year":"2010","journal-title":"Lancet Neurol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1056\/NEJMoa1202753","article-title":"Clinical and biomarker changes in dominantly inherited Alzheimer\u2019s disease","volume":"367","author":"Bateman","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/nrn2967","article-title":"Amyloid-beta and tau--a toxic pas de deux in Alzheimer\u2019s disease","volume":"12","author":"Ittner","year":"2011","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1097\/NEN.0b013e31825018f7","article-title":"Correlation of Alzheimer disease neuropathologic changes with cognitive status: A review of the literature","volume":"71","author":"Nelson","year":"2012","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"17138","DOI":"10.1074\/jbc.RA120.014420","article-title":"Microtubule Affinity Regulating Kinase 4 with an Alzheimer\u2019s disease-related mutation promotes tau accumulation and exacerbates neurodegeneration","volume":"295","author":"Oba","year":"2020","journal-title":"J. Biol. Chem."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jalz.2011.03.005","article-title":"The diagnosis of dementia due to Alzheimer\u2019s disease: Recommendations from the National Institute on Aging-Alzheimer\u2019s Association workgroups on diagnostic guidelines for Alzheimer\u2019s disease","volume":"7","author":"McKhann","year":"2011","journal-title":"Alzheimers Dement."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/S1474-4422(14)70090-0","article-title":"Advancing research diagnostic criteria for Alzheimer\u2019s disease: The IWG-2 criteria","volume":"13","author":"Dubois","year":"2014","journal-title":"Lancet Neurol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-019-0299-y","article-title":"Diagnosis of Alzheimer\u2019s disease utilizing amyloid and tau as fluid biomarkers","volume":"51","author":"Lee","year":"2019","journal-title":"Exp. Mol. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.jalz.2018.02.018","article-title":"NIA-AA Research Framework: Toward a biological definition of Alzheimer\u2019s disease","volume":"14","author":"Jack","year":"2018","journal-title":"Alzheimers Dement."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1001\/jama.2020.12134","article-title":"Discriminative Accuracy of Plasma Phospho-tau217 for Alzheimer Disease vs Other Neurodegenerative Disorders","volume":"324","author":"Palmqvist","year":"2020","journal-title":"JAMA"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1002\/ana.25334","article-title":"Plasma Amyloid as Prescreener for the Earliest Alzheimer Pathological Changes","volume":"84","author":"Verberk","year":"2018","journal-title":"Ann. Neurol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/joim.12191","article-title":"Clinical trials and late-stage drug development for Alzheimer\u2019s disease: An appraisal from 1984 to 2014","volume":"275","author":"Schneider","year":"2014","journal-title":"J. Intern. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S0896-6273(00)81109-5","article-title":"Neuroplasticity failure in Alzheimer\u2019s disease: Bridging the gap between plaques and tangles","volume":"24","author":"Mesulam","year":"1999","journal-title":"Neuron"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nrm2101","article-title":"Soluble protein oligomers in neurodegeneration: Lessons from the Alzheimer\u2019s amyloid beta-peptide","volume":"8","author":"Haass","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1038\/nature02661","article-title":"Gene regulation and DNA damage in the ageing human brain","volume":"429","author":"Lu","year":"2004","journal-title":"Nature"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"15605","DOI":"10.1073\/pnas.0806883105","article-title":"Gene expression changes in the course of normal brain aging are sexually dimorphic","volume":"105","author":"Berchtold","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.neurobiolaging.2007.08.006","article-title":"Gene expression profile of the PDAPP mouse model for Alzheimer\u2019s disease with and without Apolipoprotein E","volume":"30","author":"Selwood","year":"2009","journal-title":"Neurobiol. Aging"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Cao, K., Chen-Plotkin, A.S., Plotkin, J.B., and Wang, L.S. (2010). Age-correlated gene expression in normal and neurodegenerative human brain tissues. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0013098"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1126\/science.1186088","article-title":"Altered histone acetylation is associated with age-dependent memory impairment in mice","volume":"328","author":"Peleg","year":"2010","journal-title":"Science"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Ray, M., and Zhang, W. (2010). Analysis of Alzheimer\u2019s disease severity across brain regions by topological analysis of gene co-expression networks. BMC Syst. Biol., 4.","DOI":"10.1186\/1752-0509-4-136"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1007\/s00401-018-1932-x","article-title":"Current state of Alzheimer\u2019s fluid biomarkers","volume":"136","author":"Molinuevo","year":"2018","journal-title":"Acta Neuropathol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1186\/1479-5876-11-304","article-title":"Analysis of organ-enriched microRNAs in plasma as an approach to development of Universal Screening Test: Feasibility study","volume":"11","author":"Sheinerman","year":"2013","journal-title":"J. Transl. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3389\/fnmol.2013.00039","article-title":"MicroRNAs as biomarkers for CNS disease","volume":"6","author":"Rao","year":"2013","journal-title":"Front. Mol. Neurosci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.neuroscience.2015.07.045","article-title":"MicroRNAs as biomarkers of resilience or vulnerability to stress","volume":"305","author":"Chen","year":"2015","journal-title":"Neuroscience"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/bs.pmbts.2016.12.013","article-title":"MicroRNAs as Peripheral Biomarkers in Aging and Age-Related Diseases","volume":"146","author":"Kumar","year":"2017","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"R78","DOI":"10.1186\/gb-2013-14-7-r78","article-title":"A blood based 12-miRNA signature of Alzheimer disease patients","volume":"14","author":"Leidinger","year":"2013","journal-title":"Genome Biol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.3233\/JAD-140756","article-title":"Circulating miRNAs as potential biomarkers in Alzheimer\u2019s disease","volume":"42","author":"Galimberti","year":"2014","journal-title":"J. Alzheimers Dis."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1038\/mp.2014.127","article-title":"Prognostic serum miRNA biomarkers associated with Alzheimer\u2019s disease shows concordance with neuropsychological and neuroimaging assessment","volume":"20","author":"Cheng","year":"2015","journal-title":"Mol. Psychiatry"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"3169","DOI":"10.1007\/s00018-016-2154-9","article-title":"Deep characterization of blood cell miRNomes by NGS","volume":"73","author":"Schwarz","year":"2016","journal-title":"Cell Mol. Life Sci."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s40478-017-0414-z","article-title":"Serum microRNA miR-501-3p as a potential biomarker related to the progression of Alzheimer\u2019s disease","volume":"5","author":"Hara","year":"2017","journal-title":"Acta Neuropathol. Commun."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"16122","DOI":"10.18632\/oncotarget.15109","article-title":"Profile of 6 microRNA in blood plasma distinguish early stage Alzheimer\u2019s disease patients from non-demented subjects","volume":"8","author":"Nagaraj","year":"2017","journal-title":"Oncotarget"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1515\/bmc-2016-0014","article-title":"Alzheimer\u2019s disease: Presence and role of microRNAs","volume":"7","author":"Basavaraju","year":"2016","journal-title":"Biomol. Concepts"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"4299","DOI":"10.1038\/emboj.2011.327","article-title":"microRNA-34c is a novel target to treat dementias","volume":"30","author":"Zovoilis","year":"2011","journal-title":"EMBO J."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.15252\/embj.201387576","article-title":"MicroRNA-125b induces tau hyperphosphorylation and cognitive deficits in Alzheimer\u2019s disease","volume":"33","author":"Benito","year":"2014","journal-title":"EMBO J."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/nrn.2017.90","article-title":"Noncoding RNAs in neurodegeneration","volume":"18","author":"Salta","year":"2017","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"478","DOI":"10.3389\/fgene.2019.00478","article-title":"The Potential for microRNA Therapeutics and Clinical Research","volume":"10","author":"Hanna","year":"2019","journal-title":"Front. Genet."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs: Genomics, biogenesis, mechanism, and function","volume":"116","author":"Bartel","year":"2004","journal-title":"Cell"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1016\/j.bbadis.2016.06.001","article-title":"Are circulating microRNAs peripheral biomarkers for Alzheimer\u2019s disease?","volume":"1862","author":"Kumar","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"522","DOI":"10.2174\/1389202919666171229145156","article-title":"Early Life Stress and Epigenetics in Late-onset Alzheimer\u2019s Dementia: A Systematic Review","volume":"19","author":"Lemche","year":"2018","journal-title":"Curr. Genom."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/s41593-018-0101-9","article-title":"Dysregulation of the epigenetic landscape of normal aging in Alzheimer\u2019s disease","volume":"21","author":"Nativio","year":"2018","journal-title":"Nat. Neurosci."},{"key":"ref_41","first-page":"M117-25","article-title":"Heritability for Alzheimer\u2019s Disease- The Study of Dementia in Swedish Twins","volume":"52","author":"Gatz","year":"1997","journal-title":"J. Gerontol."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Roman, G.C., Mancera-Paez, O., and Bernal, C. (2019). Epigenetic Factors in Late-Onset Alzheimer\u2019s Disease: MTHFR and CTH Gene Polymorphisms, Metabolic Transsulfuration and Methylation Pathways, and B Vitamins. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20020319"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1007\/s10571-019-00684-6","article-title":"The Missing Link: How Exosomes and miRNAs can Help in Bridging Psychiatry and Molecular Biology in the Context of Depression, Bipolar Disorder and Schizophrenia","volume":"39","author":"Gruzdev","year":"2019","journal-title":"Cell Mol. Neurobiol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2800","DOI":"10.1002\/dvdy.22109","article-title":"Different timings of Dicer deletion affect neurogenesis and gliogenesis in the developing mouse central nervous system","volume":"238","author":"Otaegi","year":"2009","journal-title":"Dev. Dyn."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"R13","DOI":"10.1186\/gb-2004-5-3-r13","article-title":"Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation","volume":"5","author":"Sempere","year":"2004","journal-title":"Genome Biol."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Presutti, C., Rosati, J., Vincenti, S., and Nasi, S. (2006). Non coding RNA and brain. BMC Neurosci., 7.","DOI":"10.1186\/1471-2202-7-S1-S5"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.bbagrm.2007.12.006","article-title":"MicroRNA function in neuronal development, plasticity and disease","volume":"1779","author":"Fiore","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"3987","DOI":"10.1007\/s00018-014-1671-7","article-title":"MicroRNA-132, -134, and -138: A microRNA troika rules in neuronal dendrites","volume":"71","author":"Bicker","year":"2014","journal-title":"Cell Mol. Life Sci."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1038\/nn.2891","article-title":"The brain-specific microRNA miR-128b regulates the formation of fear-extinction memory","volume":"14","author":"Lin","year":"2011","journal-title":"Nat. Neurosci."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1038\/nature09271","article-title":"A novel pathway regulates memory and plasticity via SIRT1 and miR-134","volume":"466","author":"Gao","year":"2010","journal-title":"Nature"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"6415","DOI":"10.1073\/pnas.0710263105","article-title":"Loss of microRNA cluster miR-29a\/b-1 in sporadic Alzheimer\u2019s disease correlates with increased BACE1\/beta-secretase expression","volume":"105","author":"Hebert","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"20130515","DOI":"10.1098\/rstb.2013.0515","article-title":"MicroRNAs and synaptic plasticity--a mutual relationship","volume":"369","author":"Zampa","year":"2014","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"11650","DOI":"10.1073\/pnas.1017576108","article-title":"MicroRNA regulation of homeostatic synaptic plasticity","volume":"108","author":"Cohen","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1038\/s41398-019-0579-2","article-title":"A combined miRNA-piRNA signature to detect Alzheimer\u2019s disease","volume":"9","author":"Jain","year":"2019","journal-title":"Transl. Psychiatry"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Kenny, A., McArdle, H., Calero, M., Rabano, A., Madden, S.F., Adamson, K., Forster, R., Spain, E., Prehn, J.H.M., and Henshall, D.C. (2019). Elevated Plasma microRNA-206 Levels Predict Cognitive Decline and Progression to Dementia from Mild Cognitive Impairment. Biomolecules, 9.","DOI":"10.2139\/ssrn.3429882"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1002\/ana.23588","article-title":"miR-206 regulates brain-derived neurotrophic factor in Alzheimer disease model","volume":"72","author":"Lee","year":"2012","journal-title":"Ann. Neurol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/j.neuropharm.2013.06.024","article-title":"BDNF mechanisms in late LTP formation: A synthesis and breakdown","volume":"76 Pt C","author":"Panja","year":"2014","journal-title":"Neuropharmacology"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.neuropharm.2013.05.043","article-title":"Pre- and postsynaptic twists in BDNF secretion and action in synaptic plasticity","volume":"76 Pt C","author":"Edelmann","year":"2014","journal-title":"Neuropharmacology"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S0169-328X(00)00023-1","article-title":"Quantitation of BDNF mRNA in human parietal cortex by competitive reverse transcription-polymerase chain reaction: Decreased levels in Alzheimer\u2019s disease","volume":"76","author":"Holsinger","year":"2000","journal-title":"Brain Res. Mol. Brain. Res."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1111\/j.1471-4159.2005.03135.x","article-title":"Precursor form of brain-derived neurotrophic factor and mature brain-derived neurotrophic factor are decreased in the pre-clinical stages of Alzheimer\u2019s disease","volume":"93","author":"Peng","year":"2005","journal-title":"J. Neurochem."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"245","DOI":"10.3233\/JAD-200396","article-title":"Performance of Validated MicroRNA Biomarkers for Alzheimer\u2019s Disease in Mild Cognitive Impairment","volume":"78","author":"Sandau","year":"2020","journal-title":"J. Alzheimers Dis."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"14191","DOI":"10.1523\/JNEUROSCI.1673-11.2011","article-title":"MicroRNA as repressors of stress-induced anxiety: The case of amygdalar miR-34","volume":"31","author":"Haramati","year":"2011","journal-title":"J. Neurosci."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"2894","DOI":"10.1007\/s12035-015-9156-8","article-title":"MicroRNA-29a Is a Candidate Biomarker for Alzheimer\u2019s Disease in Cell-Free Cerebrospinal Fluid","volume":"53","author":"Muller","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"19946","DOI":"10.1038\/srep19946","article-title":"Recombinant pre-miR-29b for Alzheimer s disease therapeutics","volume":"6","author":"Pereira","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1177\/1535370217720884","article-title":"miR-34a and miR-9 are overexpressed and SIRT genes are downregulated in peripheral blood mononuclear cells of aging humans","volume":"242","author":"Owczarz","year":"2017","journal-title":"Exp. Biol. Med."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.brainres.2016.05.026","article-title":"Expression of microRNA-34a in Alzheimer\u2019s disease brain targets genes linked to synaptic plasticity, energy metabolism, and resting state network activity","volume":"1646","author":"Sarkar","year":"2016","journal-title":"Brain Res."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.neurobiolaging.2013.07.005","article-title":"MicroRNAs in Alzheimer\u2019s disease: Differential expression in hippocampus and cell-free cerebrospinal fluid","volume":"35","author":"Muller","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"2815","DOI":"10.15252\/embj.201796821","article-title":"Formin 2 links neuropsychiatric phenotypes at young age to an increased risk for dementia","volume":"36","author":"Pinheiro","year":"2017","journal-title":"EMBO J."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nature10810","article-title":"The microRNA miR-34 modulates ageing and neurodegeneration in Drosophila","volume":"482","author":"Liu","year":"2012","journal-title":"Nature"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s11357-011-9324-3","article-title":"MiR-34 modulates Caenorhabditis elegans lifespan via repressing the autophagy gene atg9","volume":"35","author":"Yang","year":"2013","journal-title":"Age"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s13024-018-0285-1","article-title":"Deregulation of neuronal miRNAs induced by amyloid-beta or TAU pathology","volume":"13","author":"Sierksma","year":"2018","journal-title":"Mol. Neurodegener."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3389\/fneur.2018.00145","article-title":"Microbiome-Mediated Upregulation of MicroRNA-146a in Sporadic Alzheimer\u2019s Disease","volume":"9","author":"Zhao","year":"2018","journal-title":"Front. Neurol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1002\/emmm.201201974","article-title":"Alteration of the microRNA network during the progression of Alzheimer\u2019s disease","volume":"5","author":"Lau","year":"2013","journal-title":"EMBO Mol. Med."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"75","DOI":"10.3233\/JAD-2010-091603","article-title":"MiR-107 is reduced in Alzheimer\u2019s disease brain neocortex: Validation study","volume":"21","author":"Nelson","year":"2010","journal-title":"J. Alzheimers Dis."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.3389\/fnins.2019.01208","article-title":"miR-212 and miR-132 Are Downregulated in Neurally Derived Plasma Exosomes of Alzheimer\u2019s Patients","volume":"13","author":"Cha","year":"2019","journal-title":"Front. Neurosci."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"366","DOI":"10.3389\/fnagi.2019.00366","article-title":"miR-146a Plasma Levels Are Not Altered in Alzheimer\u2019s Disease but Correlate With Age and Illness Severity","volume":"11","author":"Maffioletti","year":"2019","journal-title":"Front. Aging Neurosci."}],"container-title":["Non-Coding RNA"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2311-553X\/7\/1\/8\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:18:16Z","timestamp":1760159896000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2311-553X\/7\/1\/8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,1]]},"references-count":76,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,3]]}},"alternative-id":["ncrna7010008"],"URL":"https:\/\/doi.org\/10.3390\/ncrna7010008","relation":{},"ISSN":["2311-553X"],"issn-type":[{"value":"2311-553X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,1]]}}}