{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T04:57:28Z","timestamp":1778907448563,"version":"3.51.4"},"reference-count":45,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2020,11,24]],"date-time":"2020-11-24T00:00:00Z","timestamp":1606176000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurology International"],"abstract":"<jats:p>Objective: to find the most up-to-date evidence of the effectiveness and safety of supervised physical therapy in polymyositis\/dermatomyositis patients. Methods: a systematic review of the literature in the main scientific databases was carried out. We searched for randomized controlled trials concerning supervised physical therapy and polymyositis\/dermatomyositis. The PICOS method was used for the formulation of the clinical query. Methodological quality and the level of evidence of the included studies were assessed using the modified Jadad scale and the Oxford Centre for Evidence-Based Medicine Levels of Evidence guide, respectively. Results: a total of 2591 articles were found. By applying the inclusion\/exclusion criteria, six randomized controlled clinical trials were admitted to the final phase of the review. The compared approaches concerned supervised exercise programs based on strategies of muscle strengthening or aerobic work. Following these exercises, an increase in the maximum rate of oxygen consumption, a decrease in creatine phosphokinase levels, an enhancement in the patient\u2019s aerobic performance and an improvement in the quality of life indexes were registered. The methodological quality of the included studies ranged from 3 to 4.5. All the studies were classified as presenting an evidence level of 2b. Conclusions: supervised physical therapy in polymyositis\/dermatomyositis is an effective, safe and free-of-contraindications tool to be used both in the acute and in the established phases of the pathology. However, further and higher-quality studies are necessary to confirm those findings, to clarify the timing of exercise delivery and to guide the choice towards different types of muscle contraction exercises.<\/jats:p>","DOI":"10.3390\/neurolint12030015","type":"journal-article","created":{"date-parts":[[2020,11,24]],"date-time":"2020-11-24T02:34:42Z","timestamp":1606185282000},"page":"77-88","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Supervised Physical Therapy and Polymyositis\/Dermatomyositis\u2014A Systematic Review of the Literature"],"prefix":"10.3390","volume":"12","author":[{"given":"Bruno","family":"Corrado","sequence":"first","affiliation":[{"name":"Department of Public Health, Federico II University of Naples, Via S. Pansini 5, 80131 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6062-2288","authenticated-orcid":false,"given":"Gianluca","family":"Ciardi","sequence":"additional","affiliation":[{"name":"Department of Public Health, Federico II University of Naples, Via S. Pansini 5, 80131 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Lucignano","sequence":"additional","affiliation":[{"name":"Department of Public Health, Federico II University of Naples, Via S. Pansini 5, 80131 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,11,24]]},"reference":[{"key":"ref_1","unstructured":"Cheeti, A., and Panginikkod, S. (2019, September 16). Dermatomyositis and polymyositis, StatPearls, Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK532860\/."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/S0140-6736(03)14368-1","article-title":"Polymyositis and dermatomyositis","volume":"362","author":"Dalakas","year":"2003","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Mandel, D.E., Malemud, C.J., and Askari, A.D. (2017). Idiopathic Inflammatory Myopathies: A Review of the Classification and Impact of Pathogenesis. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18051084"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1007\/s10067-019-04512-6","article-title":"Comparison of the 2017 EULAR\/ACR criteria with Bohan and Peter criteria for the classification of idiopathic inflammatory myopathies","volume":"38","author":"Pinto","year":"2019","journal-title":"Clin. Rheumatol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12948-018-0084-9","article-title":"Bench to bedside review of myositis autoantibodies","volume":"16","author":"Palterer","year":"2018","journal-title":"Clin. Mol. Allergy"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.clindermatol.2018.04.003","article-title":"Dermatomyositis: Current concepts","volume":"36","author":"Bogdanov","year":"2018","journal-title":"Clin. Dermatol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1002\/mus.24566","article-title":"An overview of polymyositis and dermatomyositis","volume":"51","author":"Findlay","year":"2015","journal-title":"Muscle Nerve"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"125","DOI":"10.4081\/reumatismo.2014.785","article-title":"Osteoporosis and rheumatic diseases","volume":"66","author":"Maruotti","year":"2014","journal-title":"Reumatismo"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Mugii, n., Hasegawa, M., Matsushita, T., Hamaguchi, Y., Oohata, S., Okita, H., Yahata, T., Someya, F., Inoue, K., and Murono, S. (2016). Oropharyngeal Dysphagia in Dermatomyositis: Associations with Clinical and Laboratory Features Including Autoantibodies. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0154746"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Zhang, L., Wu, G., Gao, D., Liu, G., Pan, L., Ni, L., Li, Z., and Wang, Q. (2016). Factors Associated with Interstitial Lung Disease in Patients with Polymyositis and Dermatomyositis: A Systematic Review and Meta-Analysis. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0155381"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1097\/CRD.0000000000000241","article-title":"Cardiac Manifestations in Idiopathic Inflammatory Myopathies","volume":"27","author":"Jayakumar","year":"2019","journal-title":"Cardiol. Rev."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/S0889-857X(02)00021-2","article-title":"Idiopathic inflammatory myopathies: Epidemiology, classification, and diagnostic criteria","volume":"28","author":"Mastaglia","year":"2002","journal-title":"Rheum. Dis. Clin. N. Am."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1056\/NEJM197502202920807","article-title":"Polymyositis and Dermatomyositis","volume":"292","author":"Bohan","year":"1975","journal-title":"N. Engl. J. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s13317-014-0060-4","article-title":"Myositis autoantibodies and clinical phenotypes","volume":"5","author":"Ghirardello","year":"2014","journal-title":"Autoimmun. Highlights"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"75","DOI":"10.4081\/reumatismo.2017.923","article-title":"First report of anti-TIF1\u03b3 dermatomyositis in a patient with myelodysplastic syndrome","volume":"69","author":"Palterer","year":"2017","journal-title":"Reumatismo"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1056\/NEJM199111213252107","article-title":"Polymyositis, Dermatomyositis, and Inclusion-Body Myositis","volume":"325","author":"Dalakas","year":"1991","journal-title":"N. Engl. J. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1002\/art.1780260804","article-title":"Esophageal abnormalities and dysphagia in polymyositis and dermatomyositis","volume":"26","author":"Verity","year":"1983","journal-title":"Arthritis Rheum."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s11940-010-0111-8","article-title":"Inflammatory Myopathies","volume":"13","author":"Distad","year":"2011","journal-title":"Curr. Treat. Options Neurol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/nrrheum.2010.2","article-title":"Immunotherapy of myositis: Issues, concerns and future prospects","volume":"6","author":"Dalakas","year":"2010","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s11940-011-0119-8","article-title":"Immunotherapy of Inflammatory Myopathies: Practical Approach and Future Prospects","volume":"13","author":"Dalakas","year":"2011","journal-title":"Curr. Treat. Options Neurol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1007\/s10067-011-1713-6","article-title":"Combination with corticosteroids and cyclosporin-A improves pulmonary function test results and chest HRCT findings in dermatomyositis patients with acute\/subacute interstitial pneumonia","volume":"30","author":"Kotani","year":"2011","journal-title":"Clin. Rheumatol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"78","DOI":"10.4081\/reumatismo.2018.1011","article-title":"The use of rituximab in idiopathic inflammatory myopathies: Description of a monocentric cohort and review of the literature","volume":"70","author":"Barsotti","year":"2018","journal-title":"Reumatismo"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1002\/acr.20212","article-title":"Mycophenolate mofetil for interstitial lung disease in dermatomyositis","volume":"62","author":"Morganroth","year":"2010","journal-title":"Arthritis Care Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1007\/s00296-009-0859-x","article-title":"Rituximab in life threatening antisynthetase syndrome","volume":"29","author":"Vandenbroucke","year":"2009","journal-title":"Rheumatol. Int."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"841","DOI":"10.3899\/jrheum.170541","article-title":"Rituximab in the Treatment of Interstitial Lung Disease Associated with Antisynthetase Syndrome: A Multicenter Retrospective Case Review","volume":"45","author":"Doyle","year":"2018","journal-title":"J. Rheumatol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1002\/acr.20219","article-title":"Rituximab therapy for myopathy associated with anti-signal recognition particle antibodies: A case series","volume":"62","author":"Valiyil","year":"2010","journal-title":"Arthritis Care Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1136\/annrheumdis-2012-202794","article-title":"A phase 1b clinical trial evaluating sifalimumab, an anti-IFN-\u03b1 monoclonal antibody, shows target neutralisation of a type I IFN signature in blood of dermatomyositis and polymyositis patients","volume":"73","author":"Higgs","year":"2013","journal-title":"Ann. Rheum. Dis."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2381","DOI":"10.1589\/jpts.27.2381","article-title":"Facioscapulohumeral distrophy and physiotherapy: A literary review","volume":"27","author":"Corrado","year":"2015","journal-title":"J. Phys. Ther. Sci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e3278","DOI":"10.1097\/MD.0000000000003278","article-title":"Rehabilitation Management of the Charcot\u2013Marie\u2013Tooth Syndrome","volume":"95","author":"Corrado","year":"2016","journal-title":"Medicine"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"7983","DOI":"10.4081\/ni.2019.7983","article-title":"Rehabilitation management of Pompe disease, from childhood trough adulthood: A systematic review of the literature","volume":"11","author":"Corrado","year":"2019","journal-title":"Neurol. Int."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Fonzo, M., Sirico, F., and Corrado, B. (2020). Evidence-based physical therapy for individuals with Rett syndrome: A systematic review. Brain Sci., 10.","DOI":"10.3390\/brainsci10070410"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Voet, N.B., Van Der Kooi, E.L., IRiphagen, I., Lindeman, E., Van Engelen, B.G.M., and Geurts, A.C.H. (2013). Strength training and aerobic exercise training for muscle disease. Cochrane Database Syst. Rev., CD003907.","DOI":"10.1002\/14651858.CD003907.pub4"},{"key":"ref_33","first-page":"CD005263","article-title":"Supervised exercise therapy versus non-supervised exercise therapy for intermittent claudication","volume":"8","author":"Bendermacher","year":"2013","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/2046-4053-4-1","article-title":"Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement","volume":"4","author":"Moher","year":"2015","journal-title":"Syst. Rev."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"R83","DOI":"10.1186\/ar4263","article-title":"Improved exercise performance and increased aerobic capacity after endurance training of patients with stable polymyositis and dermatomyositis","volume":"15","author":"Munters","year":"2013","journal-title":"Arthritis Res. Ther."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1002\/acr.22068","article-title":"Improvement in Health and Possible Reduction in Disease Activity Using Endurance Exercise in Patients With Established Polymyositis and Dermatomyositis: A Multicenter Randomized Controlled Trial With a 1-Year Open Extension Followup","volume":"65","author":"Munters","year":"2013","journal-title":"Arthritis Care Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.3899\/jrheum.131145","article-title":"Resistive Home Exercise in Patients with Recent-onset Polymyositis and Dermatomyositis\u2014A Randomized Controlled Single-blinded Study with a 2-year Followup","volume":"41","author":"Alexanderson","year":"2014","journal-title":"J. Rheumatol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.apmr.2016.09.125","article-title":"Postrehabilitation Functional Improvements in Patients With Inflammatory Myopathies: The Results of a Randomized Controlled Trial","volume":"98","author":"Tiffreau","year":"2017","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1093\/rheumatology\/37.2.196","article-title":"Improvement of physical fitness and muscle strength in polymyositis\/dermatomyositis patients by a training programme","volume":"37","author":"Wiesinger","year":"1998","journal-title":"Br. J. Rheumatol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1093\/rheumatology\/37.12.1338","article-title":"Benefit of 6 months long-term physical training in polymyositis\/dermatomyositis patients","volume":"37","author":"Wiesinger","year":"1998","journal-title":"Br. J. Rheumatol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0197-2456(95)00134-4","article-title":"Assessing the quality of reports of randomized clinical trials: Is blinding necessary?","volume":"17","author":"Jadad","year":"1996","journal-title":"Control. Clin. Trials"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Atkins, D.C., Eccles, M.P., Flottorp, S., Guyatt, G.H., Henry, D., Hill, S., Liberati, A., O\u2019Connell, D., Oxman, A.D., and Phillips, B. (2004). Systems for grading the quality of evidence and the strength of recommendations I: Critical appraisal of existing approaches The GRADE Working Group. BMC Health Serv. Res., 4.","DOI":"10.1186\/1472-6963-4-38"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1080\/030097400447679","article-title":"The safety of a resistive home exercise program in patients with recent onset active polymyositis or dermatomyositis","volume":"29","author":"Alexanderson","year":"2000","journal-title":"Scand. J. Rheumatol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1186\/s13075-014-0473-5","article-title":"Safety and possible effects of low-intensity resistance training associated with partial blood flow restriction in polymyositis and dermatomyositis","volume":"16","author":"Mattar","year":"2014","journal-title":"Arthritis Res. Ther."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1191\/0269215503cr572oa","article-title":"The effect of physical exercise following acute disease exacerbation in patients with dermato\/polymyositis","volume":"17","author":"Kutas","year":"2003","journal-title":"Clin. Rehabil."}],"container-title":["Neurology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2035-8377\/12\/3\/15\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:36:26Z","timestamp":1760178986000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2035-8377\/12\/3\/15"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,24]]},"references-count":45,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2020,12]]}},"alternative-id":["neurolint12030015"],"URL":"https:\/\/doi.org\/10.3390\/neurolint12030015","relation":{},"ISSN":["2035-8377"],"issn-type":[{"value":"2035-8377","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,24]]}}}