{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:41:57Z","timestamp":1760168517861,"version":"build-2065373602"},"reference-count":14,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T00:00:00Z","timestamp":1631059200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurology International"],"abstract":"<jats:p>Liver and renal involvement is a rare event in Sj\u00f6gren\u2019s syndrome. Sj\u00f6gren\u2019s syndrome is characterized by the progressive immune-mediated destruction of epithelial tissues of the salivary and lacrimal glands. Sensory ganglionitis, accompanied by T-cell invasion, occurs in patients with Sj\u00f6gren\u2019s syndrome, resulting in sensory neuropathy of the face or limbs. Patients are assessed by quantitative sensory testing. A 76-year-old woman presented with numbness of her left face and was subsequently diagnosed with Sj\u00f6gren\u2019s syndrome and primary biliary cirrhosis, and was found to have renal failure. Detection of her serum anti-Ro\/SSA antibody was strongly positive. Shirmer\u2019s test or a salivary volume in the gum test also showed positive results. Her somatosensory disturbance severity was higher in the trigeminal area than in the forearm, suggesting that the trigeminal nerve is more susceptible than other parts of the nervous system in patients with Sj\u00f6gren\u2019s syndrome and primary biliary cirrhosis. A simple sensory test could be performed during regular check-ups, as sensory deficits might develop after patients are diagnosed with Sj\u00f6gren\u2019s syndrome and primary biliary cirrhosis.<\/jats:p>","DOI":"10.3390\/neurolint13030045","type":"journal-article","created":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T21:28:45Z","timestamp":1631136525000},"page":"464-468","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Unilateral Trigeminal Sensory Neuropathy with Sj\u00f6gren\u2019s Syndrome with Liver and Renal Impairment"],"prefix":"10.3390","volume":"13","author":[{"given":"Kana","family":"Ozasa","sequence":"first","affiliation":[{"name":"Department of Oral Diagnostic Sciences, Nihon University School of Dentistry, Tokyo 101-8310, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noboru","family":"Noma","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnostic Sciences, Nihon University School of Dentistry, Tokyo 101-8310, Japan"},{"name":"Clinical Research Division, Dental Research Institute, Nihon University, Tokyo 101-8310, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jumi","family":"Nakata","sequence":"additional","affiliation":[{"name":"Division of International Medicine, Towa Hospital, Tokyo 120-0003, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiki","family":"Imamura","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnostic Sciences, Nihon University School of Dentistry, Tokyo 101-8310, Japan"},{"name":"Clinical Research Division, Dental Research Institute, Nihon University, Tokyo 101-8310, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1002\/ana.410280609","article-title":"Normal proprioceptive trigeminal afferents in patients with Sj\u00f6gren\u2019s syndrome and sensory neuronopathy","volume":"28","author":"Graus","year":"1990","journal-title":"Ann. Neurol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1097\/00005792-198207000-00004","article-title":"Neurologic complications of primary Sjogren\u2019s syndrome","volume":"61","author":"Alexander","year":"1982","journal-title":"Medicine"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1002\/ana.410200416","article-title":"Subacute sensory neuronopathy secondary to dorsal root ganglionitis in primary Sj\u00f6gren\u2019s syndrome","volume":"20","author":"Malinow","year":"1986","journal-title":"Ann. Neurol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1097\/WCO.0b013e32833de6ab","article-title":"Neurological manifestations of primary Sjogren\u2019s syndrome","volume":"23","author":"Chai","year":"2010","journal-title":"Curr. Opin. Neurol."},{"key":"ref_5","first-page":"481","article-title":"Trois cas de neuropathies p\u00e9riph\u00e9riques rares associ\u00e9es au syndrome de Gougerot\u2013Sj\u00f6gren primitif","volume":"149","year":"1993","journal-title":"Rev. Neurol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1007\/s004150050495","article-title":"Isolated trochlear nerve palsy and repetitive Raynaud\u2019s phenomenon of the tongue in primary Sj\u00f6gren\u2019s syndrome","volume":"246","author":"Kuhl","year":"1999","journal-title":"J. Neurol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1212\/WNL.38.10.1637","article-title":"Sensory neuronopathy and Sj\u00f6gren\u2019s syndrome: Clinical and immunological study of two patients","volume":"38","author":"Graus","year":"1988","journal-title":"Neurology"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1093\/rheumatology\/34.5.484-a","article-title":"Abducent and trochlear palsies in a patient with Sj\u00f6gren\u2019s syndrome","volume":"34","author":"Matsukawa","year":"1995","journal-title":"Br. J. Rheumatol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0022-510X(01)00501-9","article-title":"Sensory neuropathy of the trigeminal, glossopharyngeal, and vagal nerves in Sjogren\u2019s syndrome","volume":"186","author":"Urban","year":"2001","journal-title":"J. Neurol. Sci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.pain.2006.01.041","article-title":"Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): Standardized protocol and reference values","volume":"123","author":"Rolke","year":"2006","journal-title":"Pain"},{"key":"ref_11","unstructured":"ICOP (2020). International Classification of Orofacial Pain (ICOP), Cephalalgia. [1st ed.]."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.jneuroim.2018.08.005","article-title":"Case report of primary Sj\u00f6gren Syndrome with simple trigeminal lesion as initial symptom","volume":"324","author":"Yuan","year":"2018","journal-title":"J. Neuroimmunol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.1093\/brain\/awh605","article-title":"The wide spectrum of clinical manifestations in Sjogren\u2019s syndrome-associated neuropathy","volume":"128","author":"Mori","year":"2005","journal-title":"Brain"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1097\/MD.0b013e318181e6af","article-title":"Primary Sj\u00f6gren syndrome in Spain: Clinical and immunologic expression in 1010 patients","volume":"87","author":"Solans","year":"2008","journal-title":"Medicine"}],"container-title":["Neurology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2035-8377\/13\/3\/45\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:58:36Z","timestamp":1760165916000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2035-8377\/13\/3\/45"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,8]]},"references-count":14,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2021,9]]}},"alternative-id":["neurolint13030045"],"URL":"https:\/\/doi.org\/10.3390\/neurolint13030045","relation":{},"ISSN":["2035-8377"],"issn-type":[{"type":"electronic","value":"2035-8377"}],"subject":[],"published":{"date-parts":[[2021,9,8]]}}}