{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T15:41:14Z","timestamp":1779205274987,"version":"3.51.4"},"reference-count":22,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T00:00:00Z","timestamp":1634688000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurology International"],"abstract":"<jats:p>Central precocious puberty (CPP) is a condition that causes early gonadotropin-dependent sexual development; CPP is idiopathic in girls in most cases, whereas more than 50% of boys have an identifiable etiology. We conducted a qualitative systematic review following the ENTREQ (enhancing transparency in reporting the synthesis of qualitative research) framework. A search was made in MEDLINE\/Pubmed and MeSH Database using the terms \u201cprecocious puberty\u201d AND \u201cbrain tumor\u201d OR \u201cposterior fossa tumor\u201d OR \u201ccerebellar tumor\u201d OR \u201cinfratentorial tumor\u201d, identifying five cases of pediatric patients with infratentorial tumors and CPP and a case of cerebellar ganglioglioma without hypothalamic\u2212pituitary\u2212gonadal axis involvement and\/or intracranial hypertension. Our work highlights the importance of a multidisciplinary approach and extensive central nervous system imaging for patients presenting with CPP in order to detect possible tumor association. Moreover, we believe that this manuscript could contribute to stimulate other research because the exact mechanism of CPP in infratentorial brain lesions has not been understood yet.<\/jats:p>","DOI":"10.3390\/neurolint13040053","type":"journal-article","created":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T22:07:04Z","timestamp":1634767624000},"page":"535-540","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A Rare Case of Posterior Fossa Tumor and Central Precocious Puberty: Case Presentation and Review of the Literature"],"prefix":"10.3390","volume":"13","author":[{"given":"Roberta","family":"Rana","sequence":"first","affiliation":[{"name":"Department of Pediatric Oncology and Hematology, University \u201cAldo Moro\u201d of Bari, 70124 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Perillo","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology and Hematology, University \u201cAldo Moro\u201d of Bari, 70124 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Santoro","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology and Hematology, University \u201cAldo Moro\u201d of Bari, 70124 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Ortolani","sequence":"additional","affiliation":[{"name":"Department of Metabolic Diseases, Clinical Genetics and Diabetology, Giovanni XXIII Children\u2019s Hospital, 70124 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2819-3938","authenticated-orcid":false,"given":"Raffaella","family":"Messina","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Department of Basic Medical Sciences, Neurosciences and Sense Organs, University \u201cAldo Moro\u201d of Bari, 70124 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariachiara","family":"Resta","sequence":"additional","affiliation":[{"name":"Division of Neuroradiology, Department of Basic Medical Sciences, Neurosciences and Sense Organs, University \u201cAldo Moro\u201d of Bari, 70124 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilenia","family":"Perrucci","sequence":"additional","affiliation":[{"name":"Division of Neuroradiology, Department of Basic Medical Sciences, Neurosciences and Sense Organs, University \u201cAldo Moro\u201d of Bari, 70124 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4792-3545","authenticated-orcid":false,"given":"Giuseppe","family":"Ingravallo","sequence":"additional","affiliation":[{"name":"Department of Emergency and Organ Transplantation\u2014Section of Pathology, University \u201cAldo Moro\u201d of Bari, 70124 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0325-4316","authenticated-orcid":false,"given":"Gerardo","family":"Cazzato","sequence":"additional","affiliation":[{"name":"Department of Emergency and Organ Transplantation\u2014Section of Pathology, University \u201cAldo Moro\u201d of Bari, 70124 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Grassi","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology and Hematology, University \u201cAldo Moro\u201d of Bari, 70124 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabino","family":"Pesce","sequence":"additional","affiliation":[{"name":"Department of Metabolic Diseases, Clinical Genetics and Diabetology, Giovanni XXIII Children\u2019s Hospital, 70124 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5040-1916","authenticated-orcid":false,"given":"Francesco","family":"Signorelli","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Department of Basic Medical Sciences, Neurosciences and Sense Organs, University \u201cAldo Moro\u201d of Bari, 70124 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"164","DOI":"10.4274\/jcrpe.v1i4.3","article-title":"Precocious Puberty and Normal Variant Puberty: Definition, etiology, diagnosis and","volume":"1","author":"Berberoglu","year":"2009","journal-title":"J. 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