{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T20:05:01Z","timestamp":1794341101094,"version":"4.9.0"},"reference-count":75,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T00:00:00Z","timestamp":1636502400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurology International"],"abstract":"<jats:p>Benzodiazepines (BZDs) are among one of the most widely prescribed drug classes in the United States. BZDs are a class of psychoactive drugs known for their depressant effect on the central nervous system (CNS). They quickly diffuse through the blood\u2013brain barrier to affect the inhibitory neurotransmitter GABA and exert sedative effects. Related to their rapid onset and immediate symptom relief, BZDs are used for those struggling with sleep, anxiety, spasticity due to CNS pathology, muscle relaxation, and epilepsy. One of the debilitating side effects of BZDs is their addictive potential. The dependence on BZDs generally leads to withdrawal symptoms, requiring careful tapering of the medication when prescribed. Regular use of BZDs has been shown to cause severe, harmful psychological and physical dependence, leading to withdrawal symptoms similar to that of alcohol withdrawal. Some of these withdrawal symptoms can be life threatening. The current treatment for withdrawal is through tapering with clonazepam. Many drugs have been tested as a treatment for withdrawal, with few proving efficacious in randomized control trials. Future research is warranted for further exploration into alternative methods of treating BZD withdrawal. This call to action proves especially relevant, as those seeking treatment for BZD dependence and withdrawal are on the rise in the United States.<\/jats:p>","DOI":"10.3390\/neurolint13040059","type":"journal-article","created":{"date-parts":[[2021,11,11]],"date-time":"2021-11-11T23:07:21Z","timestamp":1636672041000},"page":"594-607","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":338,"title":["Benzodiazepines: Uses, Dangers, and Clinical Considerations"],"prefix":"10.3390","volume":"13","author":[{"given":"Amber N.","family":"Edinoff","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Behavioral Medicine, Louisiana State University Health Shreveport, Shreveport, LA 71103, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine A.","family":"Nix","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Medicine, Louisiana State University Health Shreveport, Shreveport, LA 71103, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janice","family":"Hollier","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Medicine, Louisiana State University Health Shreveport, Shreveport, LA 71103, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline E.","family":"Sagrera","sequence":"additional","affiliation":[{"name":"School of Medicine, Louisiana State University Health Shreveport, Shreveport, LA 71103, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blake M.","family":"Delacroix","sequence":"additional","affiliation":[{"name":"School of Medicine, Louisiana State University Health Shreveport, Shreveport, LA 71103, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tunde","family":"Abubakar","sequence":"additional","affiliation":[{"name":"School of Medicine, Louisiana State University Health Shreveport, Shreveport, LA 71103, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elyse M.","family":"Cornett","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Louisiana State University Health Shreveport, Shreveport, LA 71103, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7224-3322","authenticated-orcid":false,"given":"Adam M.","family":"Kaye","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, Thomas J. 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Pharmacol."},{"key":"ref_3","first-page":"19","article-title":"The current role of long-term benzodiazepines for the treatment of generalized anxiety","volume":"7","author":"Louvet","year":"2015","journal-title":"Osteopath. Fam. Physician"},{"key":"ref_4","first-page":"5","article-title":"The role of high-potency benzodiazepines in the treatment of panic disorder","volume":"7","author":"Susman","year":"2005","journal-title":"Prim. Care Companion J. Clin. Psychiatry"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1177\/2045125317753340","article-title":"Challenges of the pharmacological management of benzodiazepine withdrawal, dependence, and discontinuation","volume":"8","author":"Fluyau","year":"2018","journal-title":"Ther. Adv. Psychopharmacol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"538","DOI":"10.4140\/TCP.n.2013.538","article-title":"The history of benzodiazepines","volume":"28","author":"Wick","year":"2013","journal-title":"Consult. Pharm."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1590\/1516-4446-2019-0773","article-title":"The rise and fall and rise of benzodiazepines: A return of the stigmatized and repressed","volume":"42","author":"Balon","year":"2020","journal-title":"Braz. J. Psychiatry"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"152","DOI":"10.18773\/austprescr.2015.055","article-title":"Management of benzodiazepine misuse and dependence","volume":"38","author":"Brett","year":"2015","journal-title":"Aust. Prescr."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"25","DOI":"10.2165\/00003495-199448010-00004","article-title":"Guidelines for the Rational Use of Benzodiazepines: When and What to Use","volume":"48","author":"Ashton","year":"1994","journal-title":"Drugs"},{"key":"ref_10","first-page":"CD006570","article-title":"Benzodiazepines for catatonia in people with schizophrenia or other serious mental illnesses","volume":"8","author":"Zaman","year":"2019","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"101","DOI":"10.2165\/00002018-199921020-00004","article-title":"Drug-induced cognition disorders in the elderly. Incidence, prevention and management","volume":"21","author":"Gray","year":"1999","journal-title":"Drug Saf."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1080\/14740338.2018.1429403","article-title":"Risks and benefits of medications for panic disorder: A comparison of SSRIs and benzodiazepines","volume":"17","author":"Quagliato","year":"2018","journal-title":"Expert Opin. Drug Saf."},{"key":"ref_13","first-page":"357","article-title":"Catatonic syndrome in a general psychiatric inpatient population: Frequency, clinical presentation, and response to lorazepam","volume":"51","author":"Rosebush","year":"1990","journal-title":"J. Clin. Psychiatry"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/j.1528-1157.1999.tb02000.x","article-title":"It\u2019s time to revise the definition of status epilepticus","volume":"40","author":"Lowenstein","year":"1999","journal-title":"Epilepsia"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s00228-020-03007-7","article-title":"Benzodiazepine withdrawal in older people: What is the prevalence, what are the signs, and which patients?","volume":"77","author":"Jobert","year":"2021","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.4065\/71.11.1124","article-title":"Use of benzodiazepines in elderly patients","volume":"71","author":"Bogunovic","year":"1996","journal-title":"Mayo Clin. Proc."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2086","DOI":"10.1111\/j.1360-0443.2011.03563.x","article-title":"Benzodiazepines revisited-will we ever learn?","volume":"106","author":"Lader","year":"2011","journal-title":"Addiction"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Authier, N., Balayssac, D., Sautereau, M., Zangarelli, A., Courty, P., Somogyi, A.A., Vennat, B., Llorca, P.M., and Eschalier, A. (2009). Benzodiazepine dependence: Focus on withdrawal syndrome. Annales Pharmaceutiques Francaises, Elsevier Masson.","DOI":"10.1016\/j.pharma.2009.07.001"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1002\/gps.891","article-title":"Consumption of psychotropic medication in the elderly: A re-evaluation of its effect on cognitive performance","volume":"18","author":"Allard","year":"2003","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/hup.453","article-title":"Cognitive effects of long-term benzodiazepine use in older adults","volume":"18","author":"McAndrews","year":"2003","journal-title":"Hum. Psychopharmacol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1002\/gps.1811","article-title":"The effect of chronic benzodiazepine use on cognitive functioning in older persons: Good, bad or indifferent?","volume":"22","author":"Bierman","year":"2007","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"61","DOI":"10.2165\/00002512-200825010-00007","article-title":"Benzodiazepines and Injurious Falls in Community Dwelling Elders","volume":"25","author":"Pariente","year":"2012","journal-title":"Drugs Aging"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1016\/S0895-4356(00)00254-7","article-title":"Benzodiazepines with different half-life and falling in a hospitalized population: The GIFA study","volume":"53","author":"Passaro","year":"2000","journal-title":"J. Clin. Epidemiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1002\/pds.1457","article-title":"Use of benzodiazepines and benzodiazepine receptor agonists during pregnancy: Neonatal outcome and congenital malformations","volume":"16","author":"Wikner","year":"2007","journal-title":"Pharmacoepidemiol. Drug Saf."},{"key":"ref_25","first-page":"90","article-title":"Side effects of treatment with benzodiazepines","volume":"22","author":"Uzun","year":"2010","journal-title":"Psychiatr. Danub."},{"key":"ref_26","first-page":"28","article-title":"Benzodiazepine Use, Abuse, and Dependence","volume":"66","year":"2005","journal-title":"Prim. Care Companion CNS Disord."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e187399","DOI":"10.1001\/jamanetworkopen.2018.7399","article-title":"Patterns in Outpatient Benzodiazepine Prescribing in the United States","volume":"2","author":"Agarwal","year":"2019","journal-title":"JAMA Netw. Open"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.drugpo.2015.08.005","article-title":"Prescription monitoring programs and emergency department visits involving benzodiazepine misuse: Early evidence from 11 United States metropolitan areas","volume":"28","author":"Bachhuber","year":"2016","journal-title":"Int. J. Drug Policy"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1001\/jamapsychiatry.2014.1763","article-title":"Benzodiazepine Use in the United States","volume":"72","author":"Olfson","year":"2015","journal-title":"JAMA Psychiatry"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/j.jpsychires.2011.03.006","article-title":"Gender differences in anxiety disorders: Prevalence, course of illness, comorbidity and burden of illness","volume":"45","author":"McLean","year":"2011","journal-title":"J. Psychiatr. Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.drugalcdep.2019.02.033","article-title":"The epidemiology of benzodiazepine misuse: A systematic review","volume":"200","author":"Votaw","year":"2019","journal-title":"Drug Alcohol Depend."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"106608","DOI":"10.1016\/j.addbeh.2020.106608","article-title":"Sex differences in benzodiazepine misuse among adults with substance use disorders","volume":"112","author":"McHugh","year":"2021","journal-title":"Addict. Behav."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.drugalcdep.2018.02.011","article-title":"Examining racial\/ethnic differences in patterns of benzodiazepine prescription and misuse","volume":"187","author":"Cook","year":"2018","journal-title":"Drug Alcohol Depend."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.drugalcdep.2014.01.026","article-title":"The misuse of benzodiazepines among adolescents: Psychosocial risk factors in a national sample","volume":"137","author":"Rigg","year":"2014","journal-title":"Drug Alcohol Depend."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.clinph.2017.03.009","article-title":"Sleep architecture in insomniacs with severe benzodiazepine abuse","volume":"128","author":"Manconi","year":"2017","journal-title":"Clin. Neurophysiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1016\/j.arth.2020.12.004","article-title":"Are Patients Taking Benzodiazepines at Increased Risk for Complications Following Primary Total Knee Arthroplasty?","volume":"36","author":"Hernandez","year":"2021","journal-title":"J. Arthroplast."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"A603","DOI":"10.1016\/j.chest.2019.08.592","article-title":"Takotsubo cardiomyopathy secondary to benzodiazepine tapering: An underreported complication","volume":"156","author":"Hashm","year":"2019","journal-title":"Chest"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/1381612023396708","article-title":"Benzodiazepine side-effects: From the bench to the clinic","volume":"8","author":"Stewart","year":"2002","journal-title":"Curr. Pharm. Des."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/1179546817746643","article-title":"Takotsubo Cardiomyopathy Precipitated by Tapering of Anxiolytic Medication: A Case Report","volume":"11","author":"Lafferty","year":"2017","journal-title":"Clin. Med. Insights Cardiol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.2147\/NDT.S290104","article-title":"Benzodiazepine and Z-Drug Use in Switzerland: Prevalence, Prescription Patterns and Association with Adverse Healthcare Outcomes","volume":"17","author":"Landolt","year":"2021","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"e112","DOI":"10.3399\/bjgp14X677176","article-title":"GPs\u2019 management strategies for patients with insomnia: A survey and qualitative interview study","volume":"64","author":"Everitt","year":"2014","journal-title":"Br. J. Gen. Pract."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1046\/j.1471-4159.2003.02216.x","article-title":"Diazepam-induced adaptive plasticity revealed by \u03b11 GABAA receptor-specific expression profiling","volume":"88","author":"Huopaniemi","year":"2004","journal-title":"J. Neurochem."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1002\/pds.1694","article-title":"A systematic review of research examining benzodiazepine-related mortality","volume":"18","author":"Charlson","year":"2009","journal-title":"Pharmacoepidemiol. Drug Saf."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1093\/jat\/27.2.57","article-title":"Oxycodone Involvement in Drug Abuse Deaths: A DAWN-Based Classification Scheme Applied to an Oxycodone Postmortem Database Containing Over 1000 Cases*","volume":"27","author":"Cone","year":"2003","journal-title":"J. Analylical Toxicol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1007\/BF02939579","article-title":"Co-abuse of opiates and benzodiazepines","volume":"168","author":"Rooney","year":"1999","journal-title":"Ir. J. Med. Sci."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Weich, S., Pearce, H.L., Croft, P., Singh, S., Crome, I., Bashford, J., and Frisher, M. (2014). Effect of anxiolytic and hypnotic drug prescriptions on mortality hazards: Retrospective cohort study. BMJ, 348.","DOI":"10.1136\/bmj.g1996"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Kripke, D.F., Langer, R.D., and Kline, L.E. (2012). Hypnotics\u2019 association with mortality or cancer: A matched cohort study. BMJ Open, 2.","DOI":"10.1136\/bmjopen-2012-000850"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.drugalcdep.2017.01.013","article-title":"Benzodiazepine, z-drug and pregabalin prescriptions and mortality among patients in opioid maintenance treatment\u2014A nation-wide register-based open cohort study","volume":"174","author":"Abrahamsson","year":"2017","journal-title":"Drug Alcohol Depend."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"h2698","DOI":"10.1136\/bmj.h2698","article-title":"Benzodiazepine prescribing patterns and deaths from drug overdose among US veterans receiving opioid analgesics: Case-cohort study","volume":"350","author":"Park","year":"2015","journal-title":"BMJ"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Dodds, T.J. (2017). Prescribed Benzodiazepines and Suicide Risk: A Review of the Literature. Prim. Care Companion CNS Disord., 19.","DOI":"10.4088\/PCC.16r02037"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1097\/01.yco.0000165594.60434.84","article-title":"The diagnosis and management of benzodiazepine dependence","volume":"18","author":"Ashton","year":"2005","journal-title":"Curr. Opin. Psychiatry"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0163-7258(03)00029-9","article-title":"Neuroadaptive processes in GABAergic and glutamatergic systems in benzodiazepine dependence","volume":"98","author":"Allison","year":"2003","journal-title":"Pharmacol. Ther."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1097\/ADM.0000000000000350","article-title":"A Review of Alprazolam Use, Misuse, and Withdrawal","volume":"12","author":"Hamby","year":"2018","journal-title":"J. Addict. Med."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/0006-3223(93)90198-M","article-title":"Treatment with carbamazepine may enhance \u03b12-noradrenergic autoreceptor sensitivity","volume":"34","author":"Dilsaver","year":"1993","journal-title":"Biol. Psychiatry"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnhum.2015.00323","article-title":"Age-related changes in sleep spindles characteristics during daytime recovery following a 25-hour sleep deprivation","volume":"9","author":"Rosinvil","year":"2015","journal-title":"Front. Hum. Neurosci."},{"key":"ref_56","first-page":"9","article-title":"The effects of benzodiazepines on cognition","volume":"66","author":"Stewart","year":"2005","journal-title":"J. Clin. Psychiatry"},{"key":"ref_57","first-page":"1","article-title":"Benzodiazepine use and risk of Alzheimer\u2019s disease: Case-control study","volume":"349","author":"Moride","year":"2014","journal-title":"BMJ Online"},{"key":"ref_58","first-page":"327","article-title":"Complicated withdrawal phenomena during benzodiazepine cessation in older adults","volume":"119","author":"Reeves","year":"2019","journal-title":"J. Am. Osteopath. Assoc."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/j.1478-5153.2008.00311.x","article-title":"Opioid and benzodiazepine withdrawal syndromes in the paediatric intensive care unit: A review of recent literature","volume":"14","author":"Birchley","year":"2009","journal-title":"Nurs. Crit. Care"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/S0278-5846(82)80142-5","article-title":"Benzodiazepine withdrawal effects","volume":"6","author":"Pecknold","year":"1982","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1081\/JA-200052433","article-title":"Predictors of benzodiazepine discontinuation in subjects manifesting complicated dependence","volume":"40","author":"Vorma","year":"2005","journal-title":"Subst. Use Misuse"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1177\/0269881112446532","article-title":"Withdrawal and psychological sequelae, and patient satisfaction associated with subcutaneous flumazenil infusion for the management of benzodiazepine withdrawal: A case series","volume":"27","author":"Hulse","year":"2013","journal-title":"J. Psychopharmacol. Oxf. Engl."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1192\/bjp.156.3.406","article-title":"Chronic benzodiazepine dependence. A comparative study of abrupt withdrawal under propranolol cover versus gradual withdrawal","volume":"156","author":"Cantopher","year":"1990","journal-title":"Br. J. Psychiatry J. Ment. Sci."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.psychres.2012.02.008","article-title":"High dose benzodiazepine dependence: Description of 29 patients treated with flumazenil infusion and stabilised with clonazepam","volume":"198","author":"Quaglio","year":"2012","journal-title":"Psychiatry Res."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.pbb.2010.04.023","article-title":"Reduction of aggression during benzodiazepine withdrawal: Effects of flumazenil","volume":"96","author":"Saxon","year":"2010","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"333","DOI":"10.3109\/00952990.2015.1125493","article-title":"Pilot trial of gabapentin for the treatment of benzodiazepine abuse or dependence in methadone maintenance patients","volume":"42","author":"Mariani","year":"2016","journal-title":"Am. J. Drug Alcohol Abuse"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/S0140-6736(81)92861-0","article-title":"Benzodiazepine withdrawal symptoms and propranolol","volume":"1","author":"Tyrer","year":"1981","journal-title":"Lancet Lond. Engl."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1185\/030079904125004457","article-title":"The role of captodiamine in the withdrawal from long-term benzodiazepine treatment","volume":"20","author":"Chabannes","year":"2004","journal-title":"Curr. Med. Res. Opin."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1080\/00952990802149021","article-title":"Oxcarbazepine in rapid benzodiazepine detoxification","volume":"34","author":"Croissant","year":"2008","journal-title":"Am. J. Drug Alcohol Abuse"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1046\/j.1360-0443.2002.00129.x","article-title":"Treatment of out-patients with complicated benzodiazepine dependence: Comparison of two approaches","volume":"97","author":"Vorma","year":"2002","journal-title":"Addict. Abingdon Engl."},{"key":"ref_71","first-page":"958","article-title":"Withdrawal from long-term benzodiazepine use: Randomised trial in family practice","volume":"56","author":"Vicens","year":"2006","journal-title":"Br. J. Gen. Pract. J. R. Coll. Gen. Pract."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1177\/1060028019882037","article-title":"Is Benzodiazepine Use Associated with the Risk of Dementia and Cognitive Impairment-Not Dementia in Older Persons? The Canadian Study of Health and Aging","volume":"54","author":"Nafti","year":"2020","journal-title":"Ann. Pharmacother."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.jamda.2019.08.006","article-title":"NILVAD Study Group Cognitive Outcomes of Long-term Benzodiazepine and Related Drug (BDZR) Use in People Living with Mild to Moderate Alzheimer\u2019s Disease: Results From NILVAD","volume":"21","author":"Dyer","year":"2020","journal-title":"J. Am. Med. Dir. Assoc."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"623","DOI":"10.3233\/JAD-181102","article-title":"Effects of Psychotropic Medication on Cognition, Caregiver Burden, and Neuropsychiatric Symptoms in Alzheimer\u2019s Disease over 12 Months: Results from a Prospective Registry of Dementia in Austria (PRODEM)","volume":"71","author":"Schmidt","year":"2019","journal-title":"J. Alzheimers Dis. JAD"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.pnpbp.2005.08.015","article-title":"Double-blind, comparative study of cyamemazine vs. bromazepam in the benzodiazepine withdrawal syndrome","volume":"30","author":"Lemoine","year":"2006","journal-title":"Prog. Neuropsychopharmacol. Biol. 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