{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T11:10:31Z","timestamp":1767006631357,"version":"build-2065373602"},"reference-count":54,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2021,11,19]],"date-time":"2021-11-19T00:00:00Z","timestamp":1637280000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurology International"],"abstract":"<jats:p>Background and Purpose: The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first detected in Wuhan, China in December 2019. Symptoms range from mild flu-like symptoms to more severe presentations, including pneumonia, acute respiratory distress syndrome (ARDS), and even death. In response to the COVID-19 pandemic, the Emergency Use Authorization (EUA) approved the use of several vaccines. Because vaccines have been fast-tracked for emergency use, the short and long-term safety profile has been an area of concern. The aim of this paper is to extensively review published literature regarding post-COVID-19 vaccination neurological complications and characterize neuroimaging findings from three case presentations for early diagnosis and treatment. Methods: The analysis includes data from PubMed and Google Scholar. Articles included were retrieved from database inception beginning December 2020 with no language restrictions. Terms used include \u201cSARS-CoV-2\u201d, \u201cpost Covid vaccination\u201d, \u201cneurological complications\u201d, \u201cGuillain-barre Syndrome\u201d, \u201cTransverse-myelitis\u201d, \u201cCerebral Venous Sinus thrombosis\u201d, and \u201cCerebral hemorrhage\u201d. Results: The literature review yielded several neurological complications post vaccination, including cerebral sinus venous thrombosis, transverse myelitis, Guillain-Barr\u00e9 Syndrome and optic neuritis, to name a few. Patient case presentation findings were consistent with documented results in published literature. Conclusions: We present a case series with a thorough literature review documenting adverse neurological affects following COVID-19 vaccination. Our case presentations and literature review highlight the importance of neuroimaging when diagnosing post-COVID-19 vaccination adverse effects. MRI imaging study is an important tool to be considered in patients presenting with post-COVID-19 vaccination-related unexplained neurological symptoms for accurate diagnosis.<\/jats:p>","DOI":"10.3390\/neurolint13040061","type":"journal-article","created":{"date-parts":[[2021,11,21]],"date-time":"2021-11-21T21:02:06Z","timestamp":1637528526000},"page":"622-639","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Spectrum of Neuroimaging Findings in Post-COVID-19 Vaccination: A Case Series and Review of Literature"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6844-3287","authenticated-orcid":false,"given":"Shitiz","family":"Sriwastava","sequence":"first","affiliation":[{"name":"Department of Neurology, Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV 26506, USA"},{"name":"School of Medicine, West Virginia University, Morgantown, WV 26506, USA"},{"name":"West Virginia Clinical and Translational Science Institute, Morgantown, WV 26506, USA"},{"name":"Department of Neurology, Wayne State University, Detroit, MI 48201, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4614-7783","authenticated-orcid":false,"given":"Ashish K.","family":"Shrestha","sequence":"additional","affiliation":[{"name":"Katmandu Medical College, School of Medicine, Kathmandu 44600, Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syed Hassan","family":"Khalid","sequence":"additional","affiliation":[{"name":"Department of Neurology, Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV 26506, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark A.","family":"Colantonio","sequence":"additional","affiliation":[{"name":"School of Medicine, West Virginia University, Morgantown, WV 26506, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7347-9524","authenticated-orcid":false,"given":"Divine","family":"Nwafor","sequence":"additional","affiliation":[{"name":"School of Medicine, West Virginia University, Morgantown, WV 26506, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samiksha","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Department of Neurology, Wayne State University, Detroit, MI 48201, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1001\/jama.2021.3199","article-title":"SARS-CoV-2 vaccines","volume":"325","author":"Creech","year":"2021","journal-title":"JAMA"},{"key":"ref_2","unstructured":"(2021, September 25). 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