{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T14:05:54Z","timestamp":1791381954830,"version":"4.3.3"},"reference-count":51,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T00:00:00Z","timestamp":1673827200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Operational Program \u201cCompetitiveness, Entrepreneurship and Innovation\u201d","award":["NSRFm2014-2020"],"award-info":[{"award-number":["NSRFm2014-2020"]}]},{"name":"Greece","award":["NSRFm2014-2020"],"award-info":[{"award-number":["NSRFm2014-2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurology International"],"abstract":"<jats:p>Predicting functional outcome following stroke is considered to be of key importance in an attempt to optimize overall stroke care. Although clinical prognostic tools have been widely implemented, optimal blood biomarkers might be able to yield additional information regarding each stroke survivor\u2019s propensity for recovery. Copeptin seems to have interesting prognostic potential poststroke. The present review aims to explore the prognostic significance of copeptin in stroke patients. Literature research of two databases (MEDLINE and Scopus) was conducted to trace all relevant studies published between 16 February 2012 and 16 February 2022 that focused on the utility of copeptin as a prognostic marker in acute stroke setting. 25 studies have been identified and included in the present review. The predictive ability of copeptin regarding both functional outcome and mortality appears to be in the range of established clinical variables, thus highlighting the added value of copeptin evaluation in stroke management. Apart from acute ischemic stroke, the discriminatory accuracy of the biomarker was also demonstrated among patients with transient ischemic attack, intracerebral hemorrhage, and subarachnoid hemorrhage. Overall, copeptin represents a powerful prognostic tool, the clinical implementation of which is expected to significantly facilitate the individualized management of stroke patients.<\/jats:p>","DOI":"10.3390\/neurolint15010008","type":"journal-article","created":{"date-parts":[[2023,1,17]],"date-time":"2023-01-17T04:28:47Z","timestamp":1673929727000},"page":"83-99","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Copeptin Implementation on Stroke Prognosis"],"prefix":"10.3390","volume":"15","author":[{"given":"Stella","family":"Karatzetzou","sequence":"first","affiliation":[{"name":"Neurology Department, Democritus University of Thrace, 68100 Alexandroupolis, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1601-8788","authenticated-orcid":false,"given":"Dimitrios","family":"Tsiptsios","sequence":"additional","affiliation":[{"name":"Neurology Department, Democritus University of Thrace, 68100 Alexandroupolis, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2092-6313","authenticated-orcid":false,"given":"Anastasia","family":"Sousanidou","sequence":"additional","affiliation":[{"name":"Neurology Department, Democritus University of Thrace, 68100 Alexandroupolis, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9819-4824","authenticated-orcid":false,"given":"Styliani","family":"Fotiadou","sequence":"additional","affiliation":[{"name":"Neurology Department, Democritus University of Thrace, 68100 Alexandroupolis, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Foteini","family":"Christidi","sequence":"additional","affiliation":[{"name":"Neurology Department, Democritus University of Thrace, 68100 Alexandroupolis, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos","family":"Kokkotis","sequence":"additional","affiliation":[{"name":"Department of Physical Education and Sport Science, Democritus University of Thrace, 69100 Komotini, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0890-4069","authenticated-orcid":false,"given":"Aimilios","family":"Gkantzios","sequence":"additional","affiliation":[{"name":"Neurology Department, Democritus University of Thrace, 68100 Alexandroupolis, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleftherios","family":"Stefas","sequence":"additional","affiliation":[{"name":"Neurology Department, Democritus University of Thrace, 68100 Alexandroupolis, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8828-9093","authenticated-orcid":false,"given":"Pinelopi","family":"Vlotinou","sequence":"additional","affiliation":[{"name":"Neurology Department, Democritus University of Thrace, 68100 Alexandroupolis, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2610-4900","authenticated-orcid":false,"given":"Antonia","family":"Kaltsatou","sequence":"additional","affiliation":[{"name":"FAME Laboratory, Department of Physical Education and Sport Science, University of Thessaly, 42100 Trikala, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5108-7335","authenticated-orcid":false,"given":"Nikolaos","family":"Aggelousis","sequence":"additional","affiliation":[{"name":"Department of Physical Education and Sport Science, Democritus University of Thrace, 69100 Komotini, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0484-369X","authenticated-orcid":false,"given":"Konstantinos","family":"Vadikolias","sequence":"additional","affiliation":[{"name":"Neurology Department, Democritus University of Thrace, 68100 Alexandroupolis, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,16]]},"reference":[{"key":"ref_1","unstructured":"GBD 2019 Diseases and Injuries Collaborators (2020). 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