{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T15:36:43Z","timestamp":1792683403111,"version":"4.5.0"},"reference-count":159,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,1,28]],"date-time":"2023-01-28T00:00:00Z","timestamp":1674864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurology International"],"abstract":"<jats:p>Alzheimer\u2019s disease (AD) is a neurodegenerative disorder that slowly disintegrates memory and thinking skills. Age is known to be the major risk factor in AD, but there are several nonmodifiable and modifiable causes. The nonmodifiable risk factors such as family history, high cholesterol, head injuries, gender, pollution, and genetic aberrations are reported to expediate disease progression. The modifiable risk factors of AD that may help prevent or delay the onset of AD in liable people, which this review focuses on, includes lifestyle, diet, substance use, lack of physical and mental activity, social life, sleep, among other causes. We also discuss how mitigating underlying conditions such as hearing loss and cardiovascular complications could be beneficial in preventing cognitive decline. As the current medications can only treat the manifestations of AD and not the underlying process, healthy lifestyle choices associated with modifiable factors is the best alternative strategy to combat the disease.<\/jats:p>","DOI":"10.3390\/neurolint15010013","type":"journal-article","created":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T11:25:47Z","timestamp":1675077947000},"page":"162-187","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Thwarting Alzheimer\u2019s Disease through Healthy Lifestyle Habits: Hope for the Future"],"prefix":"10.3390","volume":"15","author":[{"given":"Vijaya Laxmi","family":"Govindugari","sequence":"first","affiliation":[{"name":"Department of Biotechnology, Chaitanya Bharathi Institute of Technology, Hyderabad 500075, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sowmya","family":"Golla","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Chaitanya Bharathi Institute of Technology, Hyderabad 500075, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Deepak Mohan","family":"Reddy","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Chaitanya Bharathi Institute of Technology, Hyderabad 500075, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8851-6631","authenticated-orcid":false,"given":"Alisha","family":"Chunduri","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Chaitanya Bharathi Institute of Technology, Hyderabad 500075, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lakshmayya S. V.","family":"Nunna","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Chaitanya Bharathi Institute of Technology, Hyderabad 500075, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jahanavi","family":"Madasu","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Chaitanya Bharathi Institute of Technology, Hyderabad 500075, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishwanutha","family":"Shamshabad","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Chaitanya Bharathi Institute of Technology, Hyderabad 500075, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mounica","family":"Bandela","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, University of Illinois, Chicago, IL 60612, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4081-2989","authenticated-orcid":false,"given":"Vidyani","family":"Suryadevara","sequence":"additional","affiliation":[{"name":"Department of Radiology, Stanford University, Stanford, CA 94305, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1212\/WNL.0000000000000240","article-title":"Contribution of Alzheimer disease to mortality in the United States","volume":"82","author":"James","year":"2014","journal-title":"Neurology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.jalz.2018.02.018","article-title":"NIA-AA Research Framework: Toward a biological definition of Alzheimer\u2019s disease","volume":"14","author":"Jack","year":"2018","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/s41573-022-00391-w","article-title":"The amyloid hypothesis in Alzheimer disease: New insights from new therapeutics","volume":"21","author":"Karran","year":"2022","journal-title":"Nat. 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