{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T09:04:02Z","timestamp":1765357442908,"version":"build-2065373602"},"reference-count":92,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"project \u201cStudy of the interrelationships between neuroimaging, neurophysiological and biomechanical biomarkers in stroke rehabilitation (NEURO-BIOMECH in stroke rehab)\u201d","award":["MIS 5047286","NSRFm2014-2020"],"award-info":[{"award-number":["MIS 5047286","NSRFm2014-2020"]}]},{"name":"operational program \u201cCompetitiveness, Entrepreneurship and Innovation\u201d","award":["MIS 5047286","NSRFm2014-2020"],"award-info":[{"award-number":["MIS 5047286","NSRFm2014-2020"]}]},{"name":"Greece and the European Union (the European Regional Development Fund)","award":["MIS 5047286","NSRFm2014-2020"],"award-info":[{"award-number":["MIS 5047286","NSRFm2014-2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurology International"],"abstract":"<jats:p>Multiple sclerosis (MS) is a chronic immune-mediated disease of the central nervous system (CNS), characterized by the diffuse grey and white matter damage. Cognitive impairment (CI) is a frequent clinical feature in patients with MS (PwMS) that can be prevalent even in early disease stages, affecting the physical activity and active social participation of PwMS. Limited information is available regarding the influence of MS in social cognition (SC), which may occur independently from the overall neurocognitive dysfunction. In addition, the available information regarding the factors that influence SC in PwMS is limited, e.g., factors such as a patient\u2019s physical disability, different cognitive phenotypes, mood status, fatigue. Considering that SC is an important domain of CI in MS and may contribute to subjects\u2019 social participation and quality of life, we herein conceptualize and present the methodological design of a cross-sectional study in 100 PwMS of different disease subtypes. The study aims (a) to characterize SC impairment in PwMS in the Greek population and (b) to unveil the relationship between clinical symptoms, phenotypes of CI, mood status and fatigue in PwMS and the potential underlying impairment on tasks of SC.<\/jats:p>","DOI":"10.3390\/neurolint15030068","type":"journal-article","created":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T09:24:53Z","timestamp":1693560293000},"page":"1106-1116","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Social Cognition Impairments in Association to Clinical, Cognitive, Mood, and Fatigue Features in Multiple Sclerosis: A Study Protocol"],"prefix":"10.3390","volume":"15","author":[{"given":"Triantafyllos K.","family":"Doskas","sequence":"first","affiliation":[{"name":"Neurology Department, Athens Naval Hospital, 11521 Athens, Greece"},{"name":"Neurology Department, Democritus University of Thrace, 68100 Alexandroupolis, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Foteini","family":"Christidi","sequence":"additional","affiliation":[{"name":"Neurology Department, Democritus University of Thrace, 68100 Alexandroupolis, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanellos C.","family":"Spiliopoulos","sequence":"additional","affiliation":[{"name":"Neurology Department, Athens Naval Hospital, 11521 Athens, Greece"},{"name":"Neurology Department, University of Patras, 26504 Patras, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1601-8788","authenticated-orcid":false,"given":"Dimitrios","family":"Tsiptsios","sequence":"additional","affiliation":[{"name":"Neurology Department, Democritus University of Thrace, 68100 Alexandroupolis, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0413-4028","authenticated-orcid":false,"given":"George D.","family":"Vavougios","sequence":"additional","affiliation":[{"name":"Neurology Department, University of Cyprus, 20537 Nicosia, Cyprus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3341-4093","authenticated-orcid":false,"given":"Anna","family":"Tsiakiri","sequence":"additional","affiliation":[{"name":"Neurology Department, Democritus University of Thrace, 68100 Alexandroupolis, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theofanis","family":"Vorvolakos","sequence":"additional","affiliation":[{"name":"Psychiatry Department, Democritus University of Thrace, 68100 Alexandroupolis, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christos","family":"Kokkotis","sequence":"additional","affiliation":[{"name":"Department of Physical Education and Sport Science, Democritus University of Thrace, 69100 Komotini, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioannis","family":"Iliopoulos","sequence":"additional","affiliation":[{"name":"Neurology Department, Democritus University of Thrace, 68100 Alexandroupolis, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5108-7335","authenticated-orcid":false,"given":"Nikolaos","family":"Aggelousis","sequence":"additional","affiliation":[{"name":"Department of Physical Education and Sport Science, Democritus University of Thrace, 69100 Komotini, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0484-369X","authenticated-orcid":false,"given":"Konstantinos","family":"Vadikolias","sequence":"additional","affiliation":[{"name":"Neurology Department, Democritus University of Thrace, 68100 Alexandroupolis, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1212\/WNL.0b013e31828cf82f","article-title":"Cognitive impairment differs between primary progressive and relapsing-remitting MS","volume":"80","author":"Ruet","year":"2013","journal-title":"Neurology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1097\/WCO.0b013e328346a43b","article-title":"Cognition in multiple sclerosis","volume":"24","author":"Langdon","year":"2011","journal-title":"Curr. 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