{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T14:15:33Z","timestamp":1782742533674,"version":"3.54.5"},"reference-count":176,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T00:00:00Z","timestamp":1713225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Financial support was received from UCB SA for medical writing support services.","award":["NA"],"award-info":[{"award-number":["NA"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurology International"],"abstract":"<jats:p>In addition to motor symptoms, neurocognitive impairment (NCI) affects patients with prodromal Parkinson\u2019s disease (PD). NCI in PD ranges from subjective cognitive complaints to dementia. The purpose of this review is to present the available evidence of NCI in PD and highlight the heterogeneity of NCI phenotypes as well as the range of factors that contribute to NCI onset and progression. A review of publications related to NCI in PD up to March 2023 was performed using PubMed\/Medline. There is an interconnection between the neurocognitive and motor symptoms of the disease, suggesting a common underlying pathophysiology as well as an interconnection between NCI and non-motor symptoms, such as mood disorders, which may contribute to confounding NCI. Motor and non-motor symptom evaluation could be used prognostically for NCI onset and progression in combination with imaging, laboratory, and genetic data. Additionally, the implications of NCI on the social cognition of afflicted patients warrant its prompt management. The etiology of NCI onset and its progression in PD is multifactorial and its effects are equally grave as the motor effects. This review highlights the importance of the prompt identification of subjective cognitive complaints in PD patients and NCI management.<\/jats:p>","DOI":"10.3390\/neurolint16020032","type":"journal-article","created":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T09:15:20Z","timestamp":1713345320000},"page":"432-449","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Neurocognitive Impairment and Social Cognition in Parkinson\u2019s Disease Patients"],"prefix":"10.3390","volume":"16","author":[{"given":"Triantafyllos","family":"Doskas","sequence":"first","affiliation":[{"name":"Department of Neurology, Athens Naval Hospital, 11521 Athens, Greece"},{"name":"Department of Neurology, General University Hospital of Alexandroupoli, 68100 Alexandroupoli, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0484-369X","authenticated-orcid":false,"given":"Konstantinos","family":"Vadikolias","sequence":"additional","affiliation":[{"name":"Department of Neurology, General University Hospital of Alexandroupoli, 68100 Alexandroupoli, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Ntoskas","sequence":"additional","affiliation":[{"name":"251 Airforce General Hospital, 11525 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0413-4028","authenticated-orcid":false,"given":"George D.","family":"Vavougios","sequence":"additional","affiliation":[{"name":"Department of Neurology, Athens Naval Hospital, 11521 Athens, Greece"},{"name":"Department of Neurology, Faculty of Medicine, University of Cyprus, 1678 Lefkosia, Cyprus"},{"name":"Department of Respiratory Medicine, Faculty of Medicine, School of Health Sciences, University of Thessaly, 41500 Larissa, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1601-8788","authenticated-orcid":false,"given":"Dimitrios","family":"Tsiptsios","sequence":"additional","affiliation":[{"name":"Department of Neurology, General University Hospital of Alexandroupoli, 68100 Alexandroupoli, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Polyxeni","family":"Stamati","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine, School of Health Sciences, University of Thessaly, 41110 Larissa, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2958-5220","authenticated-orcid":false,"given":"Ioannis","family":"Liampas","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine, School of Health Sciences, University of Thessaly, 41110 Larissa, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasileios","family":"Siokas","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine, School of Health Sciences, University of Thessaly, 41110 Larissa, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3216-9025","authenticated-orcid":false,"given":"Lambros","family":"Messinis","sequence":"additional","affiliation":[{"name":"School of Psychology, Laboratory of Neuropsychology and Behavioural Neuroscience, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7495-6863","authenticated-orcid":false,"given":"Grigorios","family":"Nasios","sequence":"additional","affiliation":[{"name":"Department of Speech and Language Therapy, School of Health Sciences, University of Ioannina, 45500 Ioannina, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efthimios","family":"Dardiotis","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine, School of Health Sciences, University of Thessaly, 41110 Larissa, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"425","DOI":"10.2217\/nmt.15.34","article-title":"Mild cognitive impairment: An update in Parkinson\u2019s disease and lessons learned from Alzheimer\u2019s disease","volume":"5","author":"Goldman","year":"2015","journal-title":"Neurodegener. 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