{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T19:23:35Z","timestamp":1792869815595,"version":"4.5.0"},"reference-count":51,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T00:00:00Z","timestamp":1722211200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institute on Aging of the National Institutes of Health","award":["1R03AG072110-01A1"],"award-info":[{"award-number":["1R03AG072110-01A1"]}]},{"name":"National Institute on Aging of the National Institutes of Health","award":["1R03AG070579-01"],"award-info":[{"award-number":["1R03AG070579-01"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurology International"],"abstract":"<jats:p>High blood pressure (BP) and cerebral amyloid angiopathy (CAA) are two common risk factors for intracranial hemorrhage, potentially leading to cognitive impairment. Less is known about the relationship between BP and CAA, the examination of which was the objective of this study. We analyzed data from 2510 participants in the National Alzheimer\u2019s Coordinating Center (NACC) who had information on longitudinal BP measurements before death and on CAA from autopsy. Using the average of four systolic BPs (SBPs) prior to death, SBP was categorized into three groups: &lt;120 mmHg (n = 435), 120\u2013139 mmHg (n = 1335), and \u2265140 mmHg (n = 740). CAA was diagnosed using immunohistochemistry in 1580 participants and categorized as mild (n = 759), moderate (n = 529), or severe (n = 292). When adjusted for age at death, sex, APOE genotype, Braak, CERAD, antihypertensive medication use, and microinfarcts, the odds ratios (95% CIs) for CAA associated with SBPs of 120\u2013139 and \u2265140 mmHg were 0.91 (0.74\u20131.12) and 1.00 (0.80\u20131.26), respectively. Findings from predictor effect plots show no variation in the probability of CAA between the three SBP categories. Microbleeds had no association with CAA, but among those with SBP \u2265 130 mmHg, the proportion of those with microbleeds was numerically greater in those with more severe CAA (p for trend, 0.084). In conclusion, we found no evidence of an association between SBP and CAA. Future studies need to develop non-invasive laboratory tests to diagnose CAA and prospectively examine this association and its implication on the pathophysiology and outcome of Alzheimer\u2019s disease.<\/jats:p>","DOI":"10.3390\/neurolint16040061","type":"journal-article","created":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T18:04:59Z","timestamp":1722535499000},"page":"821-832","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Late-Life Blood Pressure and Cerebral Amyloid Angiopathy: Findings from the U.S. National Alzheimer\u2019s Coordinating Center Uniform Dataset"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7482-1782","authenticated-orcid":false,"given":"Mo-Kyung","family":"Sin","sequence":"first","affiliation":[{"name":"College of Nursing, Seattle University, Seattle, WA 98122, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Dowling","sequence":"additional","affiliation":[{"name":"Department of Acute & Chronic Care, School of Nursing, George Washington University, Washington, DC 20147, USA"},{"name":"Department of Epidemiology & Biostatistics, Milken School of Public Health, George Washington University, Washington, DC 20147, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Roseman","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6832-6424","authenticated-orcid":false,"given":"Ali","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Center for Data Science and Outcomes Research, Veterans Affairs Medical Center, Washington, DC 20242, USA"},{"name":"Department of Medicine, School of Medicine & Health Sciences, George Washington University, Washington, DC 20052, USA"},{"name":"Department of Medicine, School of Medicine, Georgetown University, Washington, DC 20057, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3685-4580","authenticated-orcid":false,"given":"Edward","family":"Zamrini","sequence":"additional","affiliation":[{"name":"Center for Data Science and Outcomes Research, Veterans Affairs Medical Center, Washington, DC 20242, USA"},{"name":"Department of Medicine, School of Medicine & Health Sciences, George Washington University, Washington, DC 20052, USA"},{"name":"Biomedical Informatics Center, School of Medicine & Health Sciences, George Washington University, Washington, DC 20052, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1046\/j.1365-2990.2003.00457.x","article-title":"APOE epsilon 4 influences the pathological phenotype of alzheimer\u2019s disease by favouring cerebrovascular over parenchymal accumulation of A beta protein","volume":"29","author":"Chalmers","year":"2003","journal-title":"Neuropathol. 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