{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T15:54:21Z","timestamp":1787846061828,"version":"build-2784847793"},"reference-count":37,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T00:00:00Z","timestamp":1726704000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurology International"],"abstract":"<jats:p>Background\/Objectives: The accurate quantification of peripheral nerve axonal regeneration after injury is critically important. Current strategies are limited to detecting early reinnervation. DTI is an MRI modality permitting the assessment of fractional anisotropy, which increases with axonal regeneration. The aim of this pilot study is to evaluate DTI as a potential predictive factor of clinical outcome after median nerve section and microsurgical repair. Methods: We included 10 patients with a complete section of the median nerve, who underwent microsurgical repair up to 7 days after injury. The follow-up period was 1 year, including the current strategy with clinical visits, the Ros\u00e9n\u2013Lundborg score and electroneuromyography. Additionally, DTI MRI of the injured wrist was planned 1, 3 and 12 months post-operatively and once for the contralateral wrist. Results: The interobserver reliability of DTI measures was almost perfect (ICC 0.802). We report an early statistically significant increase in the fractional anisotropy value after median nerve repair, especially in the region located distal to the suture. Meanwhile, Ros\u00e9n\u2013Lundborg score gradually increased between the third and sixth month, and continued to increase between the sixth and twelfth month. Conclusions: DTI outcomes three months post-operation could offer greater predictability compared to current strategies. This would enable faster decision-making regarding the need for a potential re-operation in cases of inadequate early reinnervation.<\/jats:p>","DOI":"10.3390\/neurolint16050078","type":"journal-article","created":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T08:12:27Z","timestamp":1726733547000},"page":"1026-1038","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Outcome Prediction by Diffusion Tensor Imaging (DTI) in Patients with Traumatic Injuries of the Median Nerve"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8996-9365","authenticated-orcid":false,"given":"Th\u00e9a","family":"Voser","sequence":"first","affiliation":[{"name":"Department of Plastic and Hand Surgery, Lausanne University Hospital, 1005 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6672-1324","authenticated-orcid":false,"given":"Manuel","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, Lausanne University Hospital, 1005 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3201-3196","authenticated-orcid":false,"given":"Issiaka","family":"Muriset","sequence":"additional","affiliation":[{"name":"Department of Ergotherapy, Lausanne University Hospital, 1005 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela","family":"Winkler","sequence":"additional","affiliation":[{"name":"Department of Plastic and Hand Surgery, Lausanne University Hospital, 1005 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Baptiste","family":"Ledoux","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, Lausanne University Hospital, 1005 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6067-8639","authenticated-orcid":false,"given":"Yasser","family":"Alem\u00e1n-G\u00f3mez","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, Lausanne University Hospital, 1005 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3753-1222","authenticated-orcid":false,"given":"S\u00e9bastien","family":"Durand","sequence":"additional","affiliation":[{"name":"Department of Plastic and Hand Surgery, Lausanne University Hospital, 1005 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1055\/s-0034-1399676","article-title":"Shear Wave Elastography May Be Superior to Greyscale Median for the Identification of Carotid Plaque Vulnerability: A Comparison with Histology","volume":"36","author":"Garrard","year":"2015","journal-title":"Ultraschall. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.4103\/1673-5374.147941","article-title":"Diffusion weighted MRI and tractography for evaluating peripheral nerve degeneration and regeneration","volume":"9","author":"Simon","year":"2014","journal-title":"Neural Regen. Res."},{"key":"ref_3","first-page":"12","article-title":"Kugelberg Lecture. Principles and pitfalls of nerve conduction studies","volume":"50","author":"Kimura","year":"1999","journal-title":"Electroencephalogr. Clin. Neurophysiol. Suppl."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1002\/1522-2594(200103)45:3<415::AID-MRM1054>3.0.CO;2-M","article-title":"MR properties of rat sciatic nerve following trauma","volume":"45","author":"Stanisz","year":"2001","journal-title":"Magn. Reason. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1006\/nimg.2001.0861","article-title":"Diffusion tensor imaging and axonal tracking in the human brainstem","volume":"14","author":"Stieltjes","year":"2001","journal-title":"Neuroimage"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1006\/jmrb.1996.0086","article-title":"Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI","volume":"111","author":"Basser","year":"1996","journal-title":"J. Magn. Reason. B"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1002\/nbm.782","article-title":"The basis of anisotropic water diffusion in the nervous system\u2014A technical review","volume":"15","author":"Beaulieu","year":"2002","journal-title":"NMR Biomed."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.mri.2014.09.005","article-title":"In vivo evaluation of rabbit sciatic nerve regeneration with diffusion tensor imaging (DTI): Correlations with histology and behavior","volume":"33","author":"Yamasaki","year":"2015","journal-title":"Magn. Reason. Imaging"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1016\/j.neuroimage.2008.09.022","article-title":"Visualization of peripheral nerve degeneration and regeneration: Monitoring with diffusion tensor tractography","volume":"44","author":"Takagi","year":"2009","journal-title":"Neuroimage"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.expneurol.2009.10.012","article-title":"Diffusion tensor imaging to assess axonal regeneration in peripheral nerves","volume":"223","author":"Lehmann","year":"2010","journal-title":"Exp. Neurol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1002\/1531-8249(199902)45:2<265::AID-ANA21>3.0.CO;2-3","article-title":"Three-dimensional tracking of axonal projections in the brain by magnetic resonance imaging","volume":"45","author":"Mori","year":"1999","journal-title":"Ann. Neurol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.expneurol.2005.12.014","article-title":"In vivo three-dimensional reconstruction of human median nerves by diffusion tensor imaging","volume":"198","author":"Meek","year":"2006","journal-title":"Exp. Neurol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1002\/jmri.25056","article-title":"Peripheral nerve diffusion tensor imaging is reliable and reproducible","volume":"43","author":"Simon","year":"2016","journal-title":"J. Magn. Reason. Imaging"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"E10","DOI":"10.3171\/2015.6.FOCUS15211","article-title":"Diffusion tensor imaging to visualize axons in the setting of nerve injury and recovery","volume":"39","author":"Gallagher","year":"2015","journal-title":"Neurosurg. Focus"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S0749-0712(03)00003-9","article-title":"A new model instrument for outcome after nerve repair","volume":"19","author":"Rosen","year":"2003","journal-title":"Hand Clin."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0363-5023(87)80189-2","article-title":"The repeatability of testing with Semmes-Weinstein monofilaments","volume":"12","author":"Tomancik","year":"1987","journal-title":"J. Hand Surg. Am."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"127","DOI":"10.2340\/165019971990127134","article-title":"Two-point discrimination test. A valuable part of hand surgical rehabilitation, e.g. in tetraplegia","volume":"22","author":"Moberg","year":"1989","journal-title":"Scand. J. Rehabil. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0894-1130(98)80020-3","article-title":"A new tactile gnosis instrument in sensibility testing","volume":"11","author":"Rosen","year":"1998","journal-title":"J. Hand Ther."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"167","DOI":"10.3109\/02844319509034334","article-title":"Sollerman hand function test. A standardised method and its use in tetraplegic patients","volume":"29","author":"Sollerman","year":"1995","journal-title":"Scand. J. Plast. Reconstr. Surg. Hand Surg."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0894-1130(12)80014-7","article-title":"Manual muscle strength testing: Intraobserver and interobserver reliabilities for the intrinsic muscles of the hand","volume":"8","author":"Brandsma","year":"1995","journal-title":"J. Hand Ther."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/S0363-5023(84)80146-X","article-title":"Reliability and validity of grip and pinch strength evaluations","volume":"9","author":"Mathiowetz","year":"1984","journal-title":"J. Hand Surg. Am."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1053\/jhsu.2000.6458","article-title":"A model instrument for the documentation of outcome after nerve repair","volume":"25","author":"Lundborg","year":"2000","journal-title":"J. Hand Surg. Am."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Wade, R.G., Lu, F., Poruslrani, Y., Karia, C., Feltbower, R.G., Plein, S., Bourke, G., and The, I. (2023). Meta-analysis of the normal diffusion tensor imaging values of the peripheral nerves in the upper limb. Sci. Rep., 13.","DOI":"10.1038\/s41598-023-31307-2"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s40336-020-00393-x","article-title":"Diffusion tensor imaging of the roots of the brachial plexus: A systematic review and meta-analysis of normative values","volume":"8","author":"Wade","year":"2020","journal-title":"Clin. Transl. Imaging"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1007\/s00276-023-03255-z","article-title":"MRI of brachial plexus using diffusion tensor imaging: A pilot study for the use of resolve sequence surgical and radiologic anatomy","volume":"45","author":"Payen","year":"2023","journal-title":"Surg. Radiol. Anat."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1002\/acn3.51270","article-title":"Initial findings in traumatic peripheral nerve injury and repair with diffusion tensor imaging","volume":"8","author":"Pridmore","year":"2021","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"91S","DOI":"10.1177\/15589447221096706","article-title":"Can Diffusion Tensor Imaging Apparent Diffusion Coefficient Diagnose Carpal Tunnel Syndrome? A Systematic Review and Meta-Analysis","volume":"18","author":"Evans","year":"2023","journal-title":"Hand"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Rojoa, D., Raheman, F., Rassam, J., and Wade, R.G. (2021). Meta-analysis of the normal diffusion tensor imaging values of the median nerve and how they change in carpal tunnel syndrome. Sci. Rep., 11.","DOI":"10.1038\/s41598-021-00353-z"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e120623217889","DOI":"10.2174\/1573405620666230612122725","article-title":"Application of Magnetic Resonance Diffusion Tensor Imaging in Diagnosis of Lumbosacral Nerve Root Compression","volume":"20","author":"Cheng","year":"2024","journal-title":"Curr. Med. Imaging"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Su, X., Wang, Z., Wang, Z., Cheng, M., Du, C., and Tian, Y. (2024). A novel indicator to predict the outcome of percutaneous stereotactic radiofrequency rhizotomy for trigeminal neuralgia patients: Diffusivity metrics of MR-DTI. Sci. Rep., 14.","DOI":"10.1038\/s41598-024-59828-4"},{"key":"ref_31","first-page":"4678","article-title":"Application of magnetic resonance neuroimaging in determining the relationship between tumors and peripheral nerves","volume":"15","author":"Wang","year":"2023","journal-title":"Am. J. Transl. Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"E16","DOI":"10.3171\/2015.6.FOCUS15235","article-title":"Visualization of nerve fibers and their relationship to peripheral nerve tumors by diffusion tensor imaging","volume":"39","author":"Cage","year":"2015","journal-title":"Neurosurg. Focus"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1007\/s10143-023-02214-x","article-title":"Application of diffusion tensor imaging of the facial nerve in preoperative planning for large vestibular schwannoma: A systematic review","volume":"46","year":"2023","journal-title":"Neurosurg. Rev."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"4123","DOI":"10.1007\/s00330-018-5838-8","article-title":"Diffusion-weighted imaging and diffusion tensor imaging as adjuncts to conventional MRI for the diagnosis and management of peripheral nerve sheath tumors: Current perspectives and future directions","volume":"29","author":"Mazal","year":"2019","journal-title":"Eur. Radiol."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Qin, Y., Liu, J., Zhang, X., Fan, X., Li, G., Chang, Y., and Li, L. (2023). To explore the pathogenesis of Bell\u2019s palsy using diffusion tensor image. Sci. Rep., 13.","DOI":"10.1038\/s41598-023-42570-8"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1177\/02841851221082419","article-title":"Quantitative assessment of the intraorbital segment of the optic nerve in patients with thyroid orbitopathy using diffusion tensor imaging","volume":"64","author":"Li","year":"2023","journal-title":"Acta Radiol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s41747-024-00444-2","article-title":"Diffusion tensor imaging in anisotropic tissues: Application of reduced gradient vector schemes in peripheral nerves","volume":"8","author":"Foesleitner","year":"2024","journal-title":"Eur. Radiol. Exp."}],"container-title":["Neurology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2035-8377\/16\/5\/78\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:59:18Z","timestamp":1760111958000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2035-8377\/16\/5\/78"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,19]]},"references-count":37,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2024,10]]}},"alternative-id":["neurolint16050078"],"URL":"https:\/\/doi.org\/10.3390\/neurolint16050078","relation":{},"ISSN":["2035-8377"],"issn-type":[{"value":"2035-8377","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,19]]}}}