{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T17:13:06Z","timestamp":1793812386695,"version":"4.6.1"},"reference-count":72,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T00:00:00Z","timestamp":1730160000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurology International"],"abstract":"<jats:p>Background: Olive leaves are a significant source of biophenols, which have a beneficial impact on cognitive performance. Objective: To examine, for the first time, in humans the effect of the daily consumption of a beverage containing olive leaf extract (OLE) versus a Mediterranean diet (MeDi) on patients diagnosed with mild Alzheimer\u2019s Disease (AD), in addition to their regular treatment. Methods: A randomized clinical trial compared OLE\u2019s effects on cognitive and functional performance in 55 mild AD patients. Each participant was randomly assigned to two groups: (1) Group 1 was given olive leaves for making a daily beverage and MeDi instructions through monthly diet programs; (2) Group 2 received only the MeDi instructions. After six months, all participants underwent a second neuropsychological evaluation. Results: Group 1 participants had statistically significantly higher MMSE scores compared to Group 2 with a p-value of 0.0135. Specifically, the mean MMSE difference in patients receiving OLE was close to 0, indicating no memory deterioration, whereas in controls it was \u22124.1, indicative of cognitive decline. The remaining neuropsychological assessments (FRSSD, FUCAS, ADAS-Cog, CDR, GDS, and NPI) revealed better results in the OLE group, except for GDS, which showed no change, but without statistically significant differences between the two groups.<\/jats:p>","DOI":"10.3390\/neurolint16060095","type":"journal-article","created":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T08:42:09Z","timestamp":1730191329000},"page":"1247-1265","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The Role of Greek Olive Leaf Extract in Patients with Mild Alzheimer\u2019s Disease (the GOLDEN Study): A Randomized Controlled Clinical Trial"],"prefix":"10.3390","volume":"16","author":[{"given":"Sofia","family":"Loukou","sequence":"first","affiliation":[{"name":"1st Department of Neurology, Medical School, \u201cAHEPA\u201d General Hospital Medical School, Faculty of Health Sciences, Aristotle University of Thessaloniki, Makedonia, 54124 Thessaloniki, Greece"},{"name":"Greek Association of Alzheimer\u2019s Disease and Related Disorders\u2014GAADRD, 54124 Thessaloniki, Greece"},{"name":"Laboratory of Neurodegenerative Diseases, Center for Interdisciplinary Research and Innovation (CIRI-AUTH), Balkan Center, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgia","family":"Papantoniou","sequence":"additional","affiliation":[{"name":"Laboratory of Neurodegenerative Diseases, Center for Interdisciplinary Research and Innovation (CIRI-AUTH), Balkan Center, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"},{"name":"Laboratory of Psychology, Department of Early Childhood Education, School of Education, University of Ioannina, 45110 Ioannina, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3791-6955","authenticated-orcid":false,"given":"Anastasia","family":"Pantazaki","sequence":"additional","affiliation":[{"name":"Laboratory of Neurodegenerative Diseases, Center for Interdisciplinary Research and Innovation (CIRI-AUTH), Balkan Center, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"},{"name":"Laboratory of Biochemistry, Department of Chemistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2072-8010","authenticated-orcid":false,"given":"Magdalini","family":"Tsolaki","sequence":"additional","affiliation":[{"name":"1st Department of Neurology, Medical School, \u201cAHEPA\u201d General Hospital Medical School, Faculty of Health Sciences, Aristotle University of Thessaloniki, Makedonia, 54124 Thessaloniki, Greece"},{"name":"Greek Association of Alzheimer\u2019s Disease and Related Disorders\u2014GAADRD, 54124 Thessaloniki, Greece"},{"name":"Laboratory of Neurodegenerative Diseases, Center for Interdisciplinary Research and Innovation (CIRI-AUTH), Balkan Center, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.neurobiolaging.2018.11.015","article-title":"Trajectories of cognitive decline differ in hippocampal sclerosis and Alzheimer\u2019s disease","volume":"75","author":"Smirnov","year":"2019","journal-title":"Neurobiol. 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