{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:37:57Z","timestamp":1791999477247,"version":"4.4.0"},"reference-count":116,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,11,16]],"date-time":"2024-11-16T00:00:00Z","timestamp":1731715200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Postdoctoral Fellowship Program of the Direcci\u00f3n General de Asuntos del Personal Acad\u00e9mico (DGAPA), Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM)","award":["IN228223"],"award-info":[{"award-number":["IN228223"]}]},{"name":"PAPIIT","award":["IN228223"],"award-info":[{"award-number":["IN228223"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurology International"],"abstract":"<jats:p>Depression is a mental disorder that depicts a wide variety of symptoms, including mood and cognitive alterations, as well as recurrent thoughts of death or suicide. It could become the second leading cause of premature death or disability worldwide. Treatments with conventional antidepressants have several limitations in terms of effectiveness, side effects, and high costs. Therefore, medicinal plants such as Mucuna pruriens are potent candidates for treating depressive disorders. This review shows a compendium of evidence supporting the antidepressant effect of the Mucuna pruriens plant in diverse animal models. This includes the mechanisms of action underlying the antidepressant activity of the treatment concerning dopamine, serotonin, norepinephrine, reactive oxygen species, nitric oxide, cortisol, and inflammation. Clinical trials are needed to study the efficacy and safety of Mucuna pruriens for depression.<\/jats:p>","DOI":"10.3390\/neurolint16060112","type":"journal-article","created":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T10:37:35Z","timestamp":1732099055000},"page":"1509-1527","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Mucuna pruriens, a Possible Treatment for Depressive Disorders"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2234-7019","authenticated-orcid":false,"given":"Alfonso","family":"Mata-Bermudez","sequence":"first","affiliation":[{"name":"Departamento de Fisiolog\u00eda, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Ciudad de M\u00e9xico 04510, Mexico"},{"name":"Departamento de Atenci\u00f3n a la Salud, Universidad Aut\u00f3noma Metropolitana Unidad Xochimilco, Ciudad de M\u00e9xico 04960, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1481-0966","authenticated-orcid":false,"given":"Araceli","family":"Diaz-Ruiz","sequence":"additional","affiliation":[{"name":"Departamento de Neuroqu\u00edmica, Instituto Nacional de Neurolog\u00eda y Neurocirug\u00eda Manuel Velasco Suarez, Ciudad de M\u00e9xico 14269, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6735-9774","authenticated-orcid":false,"given":"Luis Ricardo","family":"Silva-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Departamento de Atenci\u00f3n a la Salud, Universidad Aut\u00f3noma Metropolitana Unidad Xochimilco, Ciudad de M\u00e9xico 04960, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo Manuel","family":"Gines-Francisco","sequence":"additional","affiliation":[{"name":"Departamento de Atenci\u00f3n a la Salud, Universidad Aut\u00f3noma Metropolitana Unidad Xochimilco, Ciudad de M\u00e9xico 04960, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4724-569X","authenticated-orcid":false,"given":"Roxana","family":"Noriega-Navarro","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Ciudad de M\u00e9xico 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilo","family":"Rios","sequence":"additional","affiliation":[{"name":"Laboratorio de Neurofarmacolog\u00eda Molecular, Departamento de Sistemas Biol\u00f3gicos, Universidad Aut\u00f3noma Metropolitana Unidad Xochimilco, Ciudad de M\u00e9xico 04960, Mexico"},{"name":"Direcci\u00f3n de Investigaci\u00f3n, Instituto Nacional de Rehabilitaci\u00f3n Luis Guillermo Ibarra, Calzada Mexico-Xochimilco 289, Arenal de Guadalupe, Ciudad de M\u00e9xico 14389, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9ctor Alonso","family":"Romero-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Departamento de Atenci\u00f3n a la Salud, Universidad Aut\u00f3noma Metropolitana Unidad Xochimilco, Ciudad de M\u00e9xico 04960, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5624-6171","authenticated-orcid":false,"given":"Diego","family":"Arroyo","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Ciudad de M\u00e9xico 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abraham","family":"Landa","sequence":"additional","affiliation":[{"name":"Departamento de Microbiolog\u00eda y Parasitolog\u00eda, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Ciudad de M\u00e9xico 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5519-0871","authenticated-orcid":false,"given":"Luz","family":"Navarro","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Ciudad de M\u00e9xico 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"ITC5-1","DOI":"10.7326\/0003-4819-152-9-201005040-01005","article-title":"Depression","volume":"152","author":"Fancher","year":"2010","journal-title":"Ann. 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