{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T10:21:01Z","timestamp":1781518861741,"version":"3.54.1"},"reference-count":32,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T00:00:00Z","timestamp":1740355200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ghent University Hospital"},{"name":"Research Foundation Flanders (FWO)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurology International"],"abstract":"<jats:p>Background\/Objectives: By leveraging the capabilities of a smartphone-based headache diary, the objective of this study was to determine the amount of agreement between migraine-associated symptomatology during headache events and the symptoms documented during clinician-led intake interviews. Methods: This was a 90-day longitudinal, smartphone-based headache calendar study for participants diagnosed with migraine. Registered headache events were labeled as \u201cdefinite migraine\u201d, \u201cprobable migraine\u201d, and \u201cnot migraine\u201d in accordance with the International Classification of Headache Disorders, Third Edition (ICHD-3) criteria. Symptoms\u2019 agreement with clinician-led intake interviews (agreement percentages and kappa coefficients), symptoms\u2019 similarity between headache events within users (percentage), and amount of newly registered ICHD-3 symptoms per participant were calculated. Results: Twenty-seven participants provided 505 headache events eligible for analysis. The median agreement between recorded headache event symptomatology and clinician-led intake interview phenotyping ranged between 40% (for events fulfilling \u201cnot migraine\u201d criteria) and 55.5% (\u201cdefinite migraine\u201d) (p &lt; 0.001). Higher intraparticipant headache event pair similarity was observed for \u201cdefinite migraine\u201d pairs (p &lt; 0.01), along with a decreasing trend in similarity as the attack-pair headache distance increases. Over half of the participants registered at least one new ICHD-3 symptom during the study. Conclusions: Electronic diary registrations show substantial longitudinal variability in intrapersonal headache symptomatology, with the similarity of headache events declining over time. The registration of a new ICHD-3 symptom was the rule rather than the exception.<\/jats:p>","DOI":"10.3390\/neurolint17030033","type":"journal-article","created":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T07:46:57Z","timestamp":1740383217000},"page":"33","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Tracking Migraine Symptoms: A Longitudinal Comparison of Smartphone-Based Headache Diaries and Clinical Interviews"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8400-1163","authenticated-orcid":false,"given":"Nicolas","family":"Vandenbussche","sequence":"first","affiliation":[{"name":"Department of Neurology, Ghent University Hospital, Corneel Heymanslaan 10, B-9000 Ghent, Belgium"},{"name":"Department of Basic and Applied Medical Sciences, Faculty of Medicine and Health Sciences, Ghent University, Corneel Heymanslaan 10, B-9000 Ghent, Belgium"},{"name":"Department of Neurology, AZ Sint-Jan Brugge, Ruddershove 10, B-8000 Bruges, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1440-7410","authenticated-orcid":false,"given":"Jonas","family":"Van Der Donckt","sequence":"additional","affiliation":[{"name":"IDLab, Ghent University\u2014imec, Technologiepark-Zwijnaarde 126, B-9052 Ghent, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"De Brouwer","sequence":"additional","affiliation":[{"name":"IDLab, Ghent University\u2014imec, Technologiepark-Zwijnaarde 126, B-9052 Ghent, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bram","family":"Steenwinckel","sequence":"additional","affiliation":[{"name":"IDLab, Ghent University\u2014imec, Technologiepark-Zwijnaarde 126, B-9052 Ghent, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9692-9874","authenticated-orcid":false,"given":"Marija","family":"Stojchevska","sequence":"additional","affiliation":[{"name":"IDLab, Ghent University\u2014imec, Technologiepark-Zwijnaarde 126, B-9052 Ghent, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2529-5477","authenticated-orcid":false,"given":"Femke","family":"Ongenae","sequence":"additional","affiliation":[{"name":"IDLab, Ghent University\u2014imec, Technologiepark-Zwijnaarde 126, B-9052 Ghent, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7865-6793","authenticated-orcid":false,"given":"Sofie","family":"Van Hoecke","sequence":"additional","affiliation":[{"name":"IDLab, Ghent University\u2014imec, Technologiepark-Zwijnaarde 126, B-9052 Ghent, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8103-3899","authenticated-orcid":false,"given":"Koen","family":"Paemeleire","sequence":"additional","affiliation":[{"name":"Department of Neurology, Ghent University Hospital, Corneel Heymanslaan 10, B-9000 Ghent, Belgium"},{"name":"Department of Basic and Applied Medical Sciences, Faculty of Medicine and Health Sciences, Ghent University, Corneel Heymanslaan 10, B-9000 Ghent, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,24]]},"reference":[{"key":"ref_1","unstructured":"(2018). Headache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders, 3rd Edition. Cephalalgia, 38, 1\u2013211."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1152\/physrev.00034.2015","article-title":"Pathophysiology of Migraine: A Disorder of Sensory Processing","volume":"97","author":"Goadsby","year":"2017","journal-title":"Physiol. Rev."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1111\/head.14362","article-title":"Comparison and Predictors of Chronic Migraine vs. New Daily Persistent Headache Presenting with a Chronic Migraine Phenotype","volume":"62","author":"Nagaraj","year":"2022","journal-title":"Headache"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1016\/S1474-4422(18)30322-3","article-title":"Global, Regional, and National Burden of Migraine and Tension-Type Headache, 1990\u20132016: A Systematic Analysis for the Global Burden of Disease Study 2016","volume":"17","author":"Stovner","year":"2018","journal-title":"Lancet Neurol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1097\/WNP.0000000000001055","article-title":"Neurophysiological and Clinical Outcomes in Episodic Migraine Without Aura: A Cross-Sectional Study","volume":"41","author":"Deodato","year":"2024","journal-title":"J. Clin. Neurophysiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1177\/0333102415613612","article-title":"Variability of the Characteristics of a Migraine Attack within Patients","volume":"36","author":"Viana","year":"2016","journal-title":"Cephalalgia"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1111\/j.1468-2982.1992.00369.x","article-title":"Presentation of a New Instrument: The Diagnostic Headache Diary","volume":"12","author":"Russell","year":"1992","journal-title":"Cephalalgia"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0072-9752(10)97010-3","article-title":"Headache Diaries and Calendars","volume":"Volume 97","author":"Torelli","year":"2010","journal-title":"Handbook of Clinical Neurology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"3795","DOI":"10.1007\/s10072-022-05910-6","article-title":"Telemedicine Application to Headache: A Critical Review","volume":"43","author":"Spina","year":"2022","journal-title":"Neurol. Sci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev.clinpsy.3.022806.091415","article-title":"Ecological Momentary Assessment","volume":"4","author":"Shiffman","year":"2008","journal-title":"Annu. Rev. Clin. Psychol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1007\/s11916-018-0718-0","article-title":"Digital Technology and Mobile Health in Behavioral Migraine Therapy: A Narrative Review","volume":"22","author":"Stubberud","year":"2018","journal-title":"Curr. Pain Headache Rep."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"De Brouwer, M., Vandenbussche, N., Steenwinckel, B., Stojchevska, M., Van Der Donckt, J., Degraeve, V., Vaneessen, J., De Turck, F., Volckaert, B., and Boon, P. (2022). mBrain: Towards the Continuous Follow-up and Headache Classification of Primary Headache Disorder Patients. BMC Med. Inform. Decis. Mak., 22.","DOI":"10.1186\/s12911-022-01813-w"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1177\/03331024211010306","article-title":"E-Diary Use in Clinical Headache Practice: A Prospective Observational Study","volume":"41","author":"Verhagen","year":"2021","journal-title":"Cephalalgia"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1111\/head.13184","article-title":"Electronic-Diary for Recording Headaches, Triggers, and Medication Use: Development and Evaluation","volume":"57","author":"Martin","year":"2017","journal-title":"Headache"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1111\/head.13341","article-title":"Privacy Issues in Smartphone Applications: An Analysis of Headache\/Migraine Applications","volume":"58","author":"Minen","year":"2018","journal-title":"Headache"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e19536","DOI":"10.2196\/19536","article-title":"Factors That Influence the Use of Electronic Diaries in Health Care: Scoping Review","volume":"9","author":"Hochstenbach","year":"2021","journal-title":"JMIR mHealth uHealth"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e21563","DOI":"10.2196\/21563","article-title":"Effectiveness of Mobile Apps to Promote Health and Manage Disease: Systematic Review and Meta-Analysis of Randomized Controlled Trials","volume":"9","author":"Iribarren","year":"2021","journal-title":"JMIR mHealth uHealth"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1056\/NEJMra1806949","article-title":"Mobile Devices and Health","volume":"381","author":"Sim","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1212\/01.WNL.0000052998.58526.A9","article-title":"Premonitory Symptoms in Migraine: An Electronic Diary Study","volume":"60","author":"Giffin","year":"2003","journal-title":"Neurology"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/j.1468-2982.2004.00816.x","article-title":"Variability of Reported Headache Symptoms and Diagnosis of Migraine at 12 Months","volume":"25","author":"Chrysostome","year":"2005","journal-title":"Cephalalgia"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s40120-018-0113-0","article-title":"Burden of Migraine in Europe Using Self-Reported Digital Diary Data from the Migraine Buddy\u00a9 Application","volume":"7","author":"Vo","year":"2018","journal-title":"Neurol. Ther."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1111\/head.14488","article-title":"Sex Differences in Migraine Attack Characteristics: A Longitudinal E-diary Study","volume":"63","author":"Verhagen","year":"2023","journal-title":"Headache"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1212\/WNL.0000000000002789","article-title":"The Migraine Postdrome: An Electronic Diary Study","volume":"87","author":"Giffin","year":"2016","journal-title":"Neurology"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Villar-Martinez, M.D., and Goadsby, P.J. (2022). Pathophysiology and Therapy of Associated Features of Migraine. Cells, 11.","DOI":"10.3390\/cells11172767"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1136\/practneurol-2020-002844","article-title":"Migraine: Beyond Pain","volume":"21","author":"Karsan","year":"2021","journal-title":"Pract. Neurol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1007\/s11916-019-0824-7","article-title":"Cognition and Cognitive Impairment in Migraine","volume":"23","author":"Martins","year":"2019","journal-title":"Curr. Pain Headache Rep."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"276","DOI":"10.11613\/BM.2012.031","article-title":"Interrater Reliability: The Kappa Statistic","volume":"22","author":"McHugh","year":"2012","journal-title":"Biochem. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/s41592-019-0686-2","article-title":"SciPy 1.0: Fundamental Algorithms for Scientific Computing in Python","volume":"17","author":"Virtanen","year":"2020","journal-title":"Nat. Methods"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"3021","DOI":"10.21105\/joss.03021","article-title":"Seaborn: Statistical Data Visualization","volume":"6","author":"Waskom","year":"2021","journal-title":"J. Open Source Softw."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/j.1526-4610.1980.hed2001044.x","article-title":"Reliability and Concurrent Validity of Headache Questionnaire Data","volume":"20","author":"Andrasik","year":"1980","journal-title":"Headache"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1111\/j.1468-2982.2008.01838.x","article-title":"The Course of Migraine\u2014A Diary Study in Unselected Patients","volume":"29","author":"Bartl","year":"2009","journal-title":"Cephalalgia"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"3331024231223979","DOI":"10.1177\/03331024231223979","article-title":"Premonitory Symptoms in Migraine: A REFORM Study","volume":"44","author":"Thuraiaiyah","year":"2024","journal-title":"Cephalalgia"}],"container-title":["Neurology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2035-8377\/17\/3\/33\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:41:08Z","timestamp":1760028068000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2035-8377\/17\/3\/33"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,24]]},"references-count":32,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,3]]}},"alternative-id":["neurolint17030033"],"URL":"https:\/\/doi.org\/10.3390\/neurolint17030033","relation":{},"ISSN":["2035-8377"],"issn-type":[{"value":"2035-8377","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,24]]}}}