{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T16:11:32Z","timestamp":1793376692281,"version":"4.5.0"},"reference-count":99,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T00:00:00Z","timestamp":1747094400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurology International"],"abstract":"<jats:p>Tau protein plays a pivotal role in maintaining neuronal structure and function through its regulation of microtubule stability and neuronal polarity. Encoded by the MAPT gene, Tau exists in multiple isoforms due to alternative mRNA splicing, with differential expression in the central and peripheral nervous systems. In healthy neurons, tau mRNA is selectively localized and translated in axons, a process tightly regulated by untranslated regions (UTRs) and RNA-binding proteins such as HuD and FMRP. Pathologically, Tau undergoes hyperphosphorylation, misfolding, and aggregation, which contribute to neurodegeneration in a range of disorders collectively known as tauopathies. Alzheimer\u2019s disease (AD) is the most prevalent tauopathy, where abnormal Tau accumulation in the temporal and frontal lobes correlates with cognitive decline and behavioral symptoms. Other tauopathies, including Progressive Supranuclear Palsy (PSP), Corticobasal Degeneration (CBD), Frontotemporal Dementia with Parkinsonism (FTDP-17), and Pick\u2019s disease, are distinguished by the predominance of specific Tau isoforms (3R or 4R), cellular distribution, and affected brain regions. Notably, astroglial tauopathies highlight the pathological role of Tau accumulation in glial cells, expanding the understanding of neurodegeneration beyond neurons. Despite advances in imaging biomarkers (e.g., Tau-PET) and molecular diagnostics, effective disease-modifying therapies for tauopathies remain elusive. Ongoing research targets Tau through immunotherapies, splicing modulators, kinase inhibitors, and antisense oligonucleotides, aiming to mitigate Tau pathology and its deleterious effects. Understanding the multifaceted roles of Tau in neuronal and glial contexts is critical for developing future therapeutic strategies against tauopathies.<\/jats:p>","DOI":"10.3390\/neurolint17050075","type":"journal-article","created":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T03:59:26Z","timestamp":1747108766000},"page":"75","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["The Role of Tau in Neuronal Function and Neurodegeneration"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8519-5473","authenticated-orcid":false,"given":"Gonzalo Emiliano","family":"Aranda-Abreu","sequence":"first","affiliation":[{"name":"Instituto de Investigaciones Cerebrales, Universidad Veracruzana, Av. Luis Castelazo Ayala s\/n, Col. Industrial Animas, Xalapa 91190, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4497-0909","authenticated-orcid":false,"given":"Fausto","family":"Rojas-Dur\u00e1n","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Cerebrales, Universidad Veracruzana, Av. Luis Castelazo Ayala s\/n, Col. Industrial Animas, Xalapa 91190, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1617-5636","authenticated-orcid":false,"given":"Mar\u00eda Elena","family":"Hern\u00e1ndez-Aguilar","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Cerebrales, Universidad Veracruzana, Av. Luis Castelazo Ayala s\/n, Col. Industrial Animas, Xalapa 91190, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5752-4700","authenticated-orcid":false,"given":"Deissy","family":"Herrera-Covarrubias","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Cerebrales, Universidad Veracruzana, Av. Luis Castelazo Ayala s\/n, Col. Industrial Animas, Xalapa 91190, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6967-1919","authenticated-orcid":false,"given":"Luis Isauro","family":"Garc\u00eda-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Cerebrales, Universidad Veracruzana, Av. Luis Castelazo Ayala s\/n, Col. 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Cell Biol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"4122","DOI":"10.1091\/mbc.e07-10-1079","article-title":"Microtubules Have Opposite Orientation in Axons and Dendrites of Dro-sophila Neurons","volume":"19","author":"Stone","year":"2008","journal-title":"Mol. Biol. Cell"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/j.1749-6632.1986.tb38392.x","article-title":"Differential Localization of MAP-2 and Tau in Mammalian Neurons in Situ","volume":"466","author":"Binder","year":"1986","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Corsi, A., Bombieri, C., Valenti, M.T., and Romanelli, M.G. (2022). Tau Isoforms: Gaining Insight into MAPT Alternative Splicing. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232315383"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"3606","DOI":"10.1002\/alz.13784","article-title":"The Six Brain-Specific TAU Isoforms and Their Role in Alzheimer\u2019s Disease and Rela-ted Neurodegenerative Dementia Syndromes","volume":"20","author":"Buchholz","year":"2024","journal-title":"Alzheimer.s Dement."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"ENEURO.0052-23.2023","DOI":"10.1523\/ENEURO.0052-23.2023","article-title":"Big Tau: What We Know, and We Need to Know","volume":"10","author":"Fischer","year":"2023","journal-title":"eNeuro"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s13024-015-0025-8","article-title":"Regulation of Human MAPT Gene Expression","volume":"10","author":"Sergeant","year":"2015","journal-title":"Mol. Neurodegener."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1046\/j.1471-4159.2000.0751408.x","article-title":"Tau Promoter Confers Neuronal Specificity and Binds Sp1 and AP-2","volume":"75","author":"Ginzburg","year":"2000","journal-title":"J. Neurochem."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1006\/jmbi.1996.0126","article-title":"Identification of a Tau Promoter Region Me-diating Tissue-Specific-Regulated Expression in PC12 Cells","volume":"256","author":"Sadot","year":"1996","journal-title":"J. Mol. Biol."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Brackhan, M., Arribas-Blazquez, M., and Lastres-Becker, I. (2023). Aging, NRF2, and TAU: A Perfect Match for Neurode-generation?. Antioxidants, 12.","DOI":"10.3390\/antiox12081564"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1471-4159.2010.07080.x","article-title":"CREB: A Multifaceted Regulator of Neuronal Plasticity and Protection","volume":"116","author":"Sakamoto","year":"2011","journal-title":"J. Neurochem."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1016\/0896-6273(94)90432-4","article-title":"Microtubules Are Involved in the Localization of Tau MRNA in Primary Neu-ronal Cell Cultures","volume":"13","author":"Litman","year":"1994","journal-title":"Neuron"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/BF02736927","article-title":"Identification of 3\u2019UTR Region Implicated in Tau MRNA Stabilization in Neuronal Cells","volume":"12","author":"Aronov","year":"1999","journal-title":"J. Mol. Neurosci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1152\/physrev.00023.2007","article-title":"Intracellular Transport and Kinesin Superfamily Proteins, KIFs: Structure, Function, and Dynamics","volume":"88","author":"Hirokawa","year":"2008","journal-title":"Physiol. Rev."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Turner-Bridger, B., Caterino, C., and Cioni, J.-M. (2020). Molecular Mechanisms behind MRNA Localization in Axons. Open Biol., 10.","DOI":"10.1098\/rsob.200177"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/s13024-022-00572-6","article-title":"Tau Interactome and RNA Binding Proteins in Neurodegenerative Diseases","volume":"17","author":"Kavanagh","year":"2022","journal-title":"Mol. Neurodegener."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1111\/tra.12733","article-title":"Regulation of RNA Granules by FMRP and Implications for Neurolo-gical Diseases","volume":"21","author":"Lai","year":"2020","journal-title":"Traffic"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.1093\/nar\/gkh552","article-title":"The Composition of Staufen-Containing RNA Granules from Human Cells Indicates Their Role in the Regulated Transport and Translation of Messenger RNAs","volume":"32","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"7145","DOI":"10.1007\/s00018-021-03965-w","article-title":"The Multifunctional RNA-Binding Protein Staufen1: An Emerging Regulator of Oncoge-nesis through Its Various Roles in Key Cellular Events","volume":"78","author":"Almasi","year":"2021","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1126\/science.1152993","article-title":"Differential Regulation of Dynein and Kinesin Motor Pro-teins by Tau","volume":"319","author":"Dixit","year":"2008","journal-title":"Science"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Fukao, A., Tomohiro, T., and Fujiwara, T. (2021). Translation Initiation Regulated by RNA-Binding Protein in Mammals: The Modulation of Translation Initiation Complex by Trans-Acting Factors. Cells, 10.","DOI":"10.3390\/cells10071711"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Mignone, F., Gissi, C., Liuni, S., and Pesole, G. (2002). Untranslated Regions of MRNAs. Genome Biol., 3.","DOI":"10.1186\/gb-2002-3-3-reviews0004"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1074\/mcp.RA118.000603","article-title":"HnRNPs Interacting with MRNA Localization Motifs Define Axonal RNA Regulons","volume":"17","author":"Lee","year":"2018","journal-title":"Mol. Cell. Proteom."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/s00401-018-1880-5","article-title":"MicroRNA-132 Provides Neuroprotection for Tauopathies via Multiple Signaling Pathways","volume":"136","author":"Li","year":"2018","journal-title":"Acta Neuropathol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0736-5748(95)00001-W","article-title":"Cis-Acting Signals and Trans-Acting Proteins Are Involved in Tau MRNA Targeting into Neurites of Differentiating Neuronal Cells","volume":"13","author":"Behar","year":"1995","journal-title":"Int. J. Dev. Neurosci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/s41580-021-00417-y","article-title":"Roles of MRNA Poly(A) Tails in Regulation of Eukaryotic Gene Expression","volume":"23","author":"Passmore","year":"2022","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"6907","DOI":"10.1523\/JNEUROSCI.19-16-06907.1999","article-title":"Embryonic Lethal Abnormal Vision-like RNA-Binding Proteins Regulate Neurite Outgrowth and Tau Expression in PC12 Cells","volume":"19","author":"Behar","year":"1999","journal-title":"J. Neurosci."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Silvestri, B., Mochi, M., Garone, M.G., and Rosa, A. (2022). Emerging Roles for the RNA-Binding Protein HuD (ELAVL4) in Nervous System Diseases. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232314606"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/84131","article-title":"Structural Basis for Recognition of AU-Rich Element RNA by the HuD Protein","volume":"8","author":"Wang","year":"2001","journal-title":"Nat. Struct. Biol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.molcel.2020.09.007","article-title":"Overlapping Activities of ELAV\/Hu Family RNA Binding Proteins Specify the Extended Neuronal 3\u2019 UTR Landscape in Drosophila","volume":"80","author":"Wei","year":"2020","journal-title":"Mol. Cell"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"747","DOI":"10.3892\/ijmm.2014.1629","article-title":"Regulation of MRNA Transport, Localization and Translation in the Nervous System of Mammals (Review)","volume":"33","author":"Schiera","year":"2014","journal-title":"Int. J. Mol. Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"4765","DOI":"10.1128\/MCB.20.13.4765-4772.2000","article-title":"HuD RNA Recognition Motifs Play Distinct Ro-les in the Formation of a Stable Complex with AU-Rich RNA","volume":"20","author":"Park","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"3817","DOI":"10.1242\/jcs.00058","article-title":"Visualization of Translated Tau Protein in the Axons of Neuronal P19 Cells and Characterization of Tau RNP Granules","volume":"115","author":"Aronov","year":"2002","journal-title":"J. Cell Sci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"102481","DOI":"10.1016\/j.arr.2024.102481","article-title":"Pathogenesis, Diagnostics, and Therapeutics for Alzhei-mer\u2019s Disease: Breaking the Memory Barrier","volume":"101","author":"Kamatham","year":"2024","journal-title":"Ageing Res. Rev."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"e49132","DOI":"10.7554\/eLife.49132","article-title":"Cortical Tau Deposition Follows Patterns of Entorhinal Functional Connectivity in Aging","volume":"8","author":"Adams","year":"2019","journal-title":"eLife"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s00401-006-0127-z","article-title":"Staging of Alzheimer Disease-Associated Neurofibrillary Pathology Using Paraffin Sections and Immunocytochemistry","volume":"112","author":"Braak","year":"2006","journal-title":"Acta Neuropathol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s13195-019-0510-3","article-title":"Associations between Quantitative [18F]Flortaucipir Tau PET and Atro-phy across the Alzheimer\u2019s Disease Spectrum","volume":"11","author":"Timmers","year":"2019","journal-title":"Alzheimer\u2019s Res. Ther."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"3192","DOI":"10.1523\/JNEUROSCI.3769-16.2017","article-title":"Tau and \u03b2-Amyloid Are Associated with Medial Temporal Lobe Structure, Function, and Memory Encoding in Normal Aging","volume":"37","author":"Marks","year":"2017","journal-title":"J. Neurosci."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2612","DOI":"10.1038\/s41467-020-15701-2","article-title":"Swedish BioFinder Study Spread of Pathological Tau Proteins through Com-municating Neurons in Human Alzheimer\u2019s Disease","volume":"11","author":"Vogel","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.bbi.2024.05.002","article-title":"Temporal Tau Asymmetry Spectrum Influences Divergent Behavior and Language Pat-terns in Alzheimer\u2019s Disease","volume":"119","author":"Younes","year":"2024","journal-title":"Brain Behav. Immun."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1186\/s40478-021-01275-7","article-title":"Ex Vivo MRI Atlas of the Human Medial Temporal Lobe: Characterizing Neurodegene-ration Due to Tau Pathology","volume":"9","author":"Ravikumar","year":"2021","journal-title":"Acta Neuropathol. Commun."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s00401-024-02789-9","article-title":"Association of Quantitative Histopathology Measurements with Antemortem Medial Temporal Lobe Cortical Thickness in the Alzheimer\u2019s Disease Continuum","volume":"148","author":"Denning","year":"2024","journal-title":"Acta Neuropathol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"4803","DOI":"10.1038\/s41467-024-49205-0","article-title":"Postmortem Imaging Reveals Patterns of Medial Temporal Lobe Vulnerability to Tau Pathology in Alzheimer\u2019s Disease","volume":"15","author":"Ravikumar","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.jalz.2019.09.079","article-title":"Tau-Positron Emission Tomography Correlates with Neuropathology Findings","volume":"16","author":"Lowe","year":"2020","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1093\/cercor\/bhz240","article-title":"CSF STREM2 and Tau Work Together in Predicting Increased Temporal Lobe Atrophy in Older Adults","volume":"30","author":"Halaas","year":"2020","journal-title":"Cereb. Cortex"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Liu, H., Tan, A.Y.S., Mehrabi, N.F., Turner, C.P., Curtis, M.A., Faull, R.L.M., Dragunow, M., Singh-Bains, M.K., and Smith, A.M. (2025). Astrocytic Proteins Involved in Regulation of the Extracellular Environment Are Increased in the Alzheimer\u2019s Disease Middle Temporal Gyrus. Neurobiol. Dis., 204.","DOI":"10.1016\/j.nbd.2024.106749"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2798","DOI":"10.1016\/j.neurobiolaging.2012.01.015","article-title":"Tau Phosphorylation in Human Brain: Relationship to Behavioral Disturbance in Dementia","volume":"33","author":"Guadagna","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"137330","DOI":"10.1016\/j.neulet.2023.137330","article-title":"Biochemical Analyses of Tau and Other Neuronal Markers in the Submandibular Gland and Frontal Cortex across Stages of Alzheimer Disease","volume":"810","author":"Hamsafar","year":"2023","journal-title":"Neurosci. Lett."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"123327","DOI":"10.1016\/j.jns.2024.123327","article-title":"Frontal Neurodegeneration Associated with Frontal Assessment Battery in Early Alzheimer\u2019s Disease","volume":"467","author":"Terada","year":"2024","journal-title":"J. Neurol. Sci."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"e70160","DOI":"10.1096\/fj.202401704R","article-title":"High-Molecular-Weight Oligomer Tau (HMWoTau) Species Are Dramatically Increased in Braak-Stage Dependent Manner in the Frontal Lobe of Hu-man Brains, Demonstrated by a Novel Oligomer Tau ELISA with a Mouse Monoclonal Antibody (APNmAb005)","volume":"38","author":"Fukumoto","year":"2024","journal-title":"FASEB J."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.regg.2019.04.002","article-title":"Progressive Supranuclear Palsy as Differential Diagnosis of Parkinson\u2019s Disease in the El-derly","volume":"54","year":"2019","journal-title":"Rev. Esp. Geriatr. Gerontol."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Shoeibi, A., Olfati, N., and Litvan, I. (2019). Frontrunner in Translation: Progressive Supranuclear Palsy. Front. Neurol., 10.","DOI":"10.3389\/fneur.2019.01125"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1111\/ane.12067","article-title":"Differentiation of Progressive Supranuclear Palsy: Clinical, Imaging and Laboratory Tools","volume":"127","author":"Liscic","year":"2013","journal-title":"Acta Neurol. Scand."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.3233\/JAD-201139","article-title":"Mole-cular Processing of Tau Protein in Progressive Supranuclear Palsy: Neuronal and Glial Degeneration","volume":"79","author":"Harrington","year":"2021","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"e202400180","DOI":"10.1002\/cmdc.202400180","article-title":"Tau Protein and Tauopathies: Exploring Tau Protein-Protein and Microtubule Interactions, Cross-Interactions and Therapeutic Strategies","volume":"19","year":"2024","journal-title":"ChemMedChem"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1002\/mds.27778","article-title":"Sensitivity and Specificity of Diagnostic Criteria for Progressive Supranuclear Palsy","volume":"34","author":"Stamelou","year":"2019","journal-title":"Mov. Disord."},{"key":"ref_58","first-page":"726","article-title":"Cognitive Syndromes Associated With Movement Disorders","volume":"28","author":"Goldman","year":"2022","journal-title":"Continuum"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1136\/practneurol-2020-002794","article-title":"Progressive Supranuclear Palsy: Diagnosis and Management","volume":"21","author":"Rowe","year":"2021","journal-title":"Pract. Neurol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/S1474-4422(20)30489-0","article-title":"Safety and Efficacy of Tilavonemab in Progressive Supranuclear Palsy: A Phase 2, Randomised, Placebo-Controlled Trial","volume":"20","author":"Litvan","year":"2021","journal-title":"Lancet Neurol."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Yang, J., Zhi, W., and Wang, L. (2024). Role of Tau Protein in Neurodegenerative Diseases and Development of Its Targeted Drugs: A Literature Review. Molecules, 29.","DOI":"10.3390\/molecules29122812"},{"key":"ref_62","first-page":"66","article-title":"Corticobasal Degeneration and Corticobasal Syndrome: A Review","volume":"1","author":"Constantinides","year":"2019","journal-title":"Clin. Park. Relat. Disord."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1002\/mds.1038","article-title":"Dystonia in Corticobasal Degeneration","volume":"16","author":"Vanek","year":"2001","journal-title":"Mov. Disord."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/nrneurol.2011.43","article-title":"Corticobasal Degeneration: A Patholo-gically Distinct 4R Tauopathy","volume":"7","author":"Kouri","year":"2011","journal-title":"Nat. Rev. Neurol."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Zareba-Paslawska, J., Patra, K., Kluzer, L., Revesz, T., and Svenningsson, P. (2020). Tau Isoform-Driven CBD Pathology Transmission in Oligodendrocytes in Humanized Tau Mice. Front. Neurol., 11.","DOI":"10.3389\/fneur.2020.589471"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1212\/WNL.0b013e31827f0fd1","article-title":"Criteria for the Diagnosis of Corticobasal Degeneration","volume":"80","author":"Armstrong","year":"2013","journal-title":"Neurology"},{"key":"ref_67","first-page":"1117","article-title":"Diagnostic Approach to Atypical Parkinsonian Syndromes","volume":"22","author":"McFarland","year":"2016","journal-title":"Continuum"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s40478-019-0664-z","article-title":"A Walk through Tau Therapeutic Strategies","volume":"7","author":"Jadhav","year":"2019","journal-title":"Acta Neuropathol. Commun."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.parkreldis.2014.06.004","article-title":"Parkinsonian Syndrome in Familial Frontotemporal Dementia","volume":"20","author":"Siuda","year":"2014","journal-title":"Park. Relat. Disord."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/jnc.13622","article-title":"Genetics of FTLD: Overview and What Else We Can Expect from Genetic Studies","volume":"138","author":"Pottier","year":"2016","journal-title":"J. Neurochem."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/nan.12213","article-title":"Invited Review: Frontotemporal Dementia Caused by Microtubule-Associated Protein Tau Gene (MAPT) Mutations: A Chameleon for Neuro-pathology and Neuroimaging","volume":"41","author":"Ghetti","year":"2015","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"11856","DOI":"10.1074\/jbc.M509420200","article-title":"FTDP-17 Mutations Compromise the Ability of Tau to Regulate Microtubule Dynamics in Cells","volume":"281","author":"Bunker","year":"2006","journal-title":"J. Biol. Chem."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1007\/s00401-019-02035-7","article-title":"Cellular and Regional Vulnerability in Frontotemporal Tauopathies","volume":"138","author":"Forrest","year":"2019","journal-title":"Acta Neuropathol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s12031-011-9632-1","article-title":"Parkinsonism and Frontotemporal Dementia: The Clinical Overlap","volume":"45","author":"Espay","year":"2011","journal-title":"J. Mol. Neurosci."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Wang, R., Gao, H., Xie, H., Jia, Z., and Chen, Q. (2022). Molecular Imaging Biomarkers in Familial Frontotemporal Lobar Degeneration: Progress and Prospects. Front. Neurol., 13.","DOI":"10.3389\/fneur.2022.933217"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"803","DOI":"10.4103\/NRR.NRR-D-23-02057","article-title":"Antisense Oligonucleotides Provide Optimism to the Therapeutic Landscape for Tauopathies","volume":"20","author":"Harris","year":"2025","journal-title":"Neural Regen. Res."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Tamvaka, N., Manne, S., Kondru, N., and Ross, O.A. (2023). Pick\u2019s Disease, Seeding an Answer to the Clinical Diagnosis Conundrum. Biomedicines, 11.","DOI":"10.3390\/biomedicines11061646"},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Rawat, P., Sehar, U., Bisht, J., Selman, A., Culberson, J., and Reddy, P.H. (2022). Phosphorylated Tau in Alzheimer\u2019s Disease and Other Tauopathies. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232112841"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1002\/ana.24559","article-title":"Deep Clinical and Neuropathological Phenotyping of Pick Disease","volume":"79","author":"Irwin","year":"2016","journal-title":"Ann. Neurol."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Dos Santos Mendes, R., do Valle, D.A., Dos Santos Bara, T., Furlin, V., da Silva Zeny, M., Schmitz Ferreira Santos, M.L., and Cordeiro, M.L. (2025). Clinical, Genotypic, and Neuropsychological Profile in a Series of Patients with Nie-mann-Pick Type C Disease. Front. Neurol., 16.","DOI":"10.3389\/fneur.2025.1542310"},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Reid, M.J., Beltran-Lobo, P., Johnson, L., Perez-Nievas, B.G., and Noble, W. (2020). Astrocytes in Tauopathies. Front. Neurol., 11.","DOI":"10.3389\/fneur.2020.572850"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1093\/jnen\/nlx007","article-title":"Evaluating the Patterns of Aging-Related Tau Astrogliopathy Unravels Novel Insights Into Brain Aging and Neurodegenerative Diseases","volume":"76","author":"Kovacs","year":"2017","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1186\/s40478-020-00967-w","article-title":"Tau Ser208 Phosphorylation Promotes Aggregation and Reveals Neuropathologic Diver-sity in Alzheimer\u2019s Disease and Other Tauopathies","volume":"8","author":"Xia","year":"2020","journal-title":"Acta Neuropathol. Commun."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1186\/s40478-024-01844-6","article-title":"Astrocyte Tau Deposition in Progressive Supranuclear Palsy Is Associated with Dysregulation of MAPT Transcription","volume":"12","author":"Jackson","year":"2024","journal-title":"Acta Neuropathol. Commun."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s00401-015-1509-x","article-title":"Aging-Related Tau Astrogliopathy (ARTAG): Harmonized Evaluation Strategy","volume":"131","author":"Kovacs","year":"2016","journal-title":"Acta Neuropathol"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1111\/j.1750-3639.1999.tb00549.x","article-title":"Tau-Positive Glial Inclusions in Progressive Supranuclear Palsy, Corticobasal Degeneration and Pick\u2019s Disease","volume":"9","author":"Komori","year":"1999","journal-title":"Brain Pathol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1097\/NEN.0000000000000030","article-title":"Glial and Neuronal Tau Pathology in Tauopathies: Characterization of Disease-Specific Phenotypes and Tau Pathology Progression","volume":"73","author":"Ferrer","year":"2014","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Antonioni, A., Raho, E.M., Lopriore, P., Pace, A.P., Latino, R.R., Assogna, M., Mancuso, M., Gragnaniello, D., Granieri, E., and Pugliatti, M. (2023). Frontotemporal Dementia, Where Do We Stand? A Narrative Review. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241411732"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1176\/appi.focus.20160018","article-title":"A Clinical Guide to Frontotemporal Dementias","volume":"14","author":"Ljubenkov","year":"2016","journal-title":"Focus"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"2992","DOI":"10.1007\/s00415-024-12314-3","article-title":"Genetic Forms of Tauopathies: Inherited Causes and Implications of Alzheimer\u2019s Disease-like TAU Pathology in Primary and Se-condary Tauopathies","volume":"271","author":"Langerscheidt","year":"2024","journal-title":"J. Neurol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.cpet.2022.09.010","article-title":"Brain PET Imaging: Frontotemporal Dementia","volume":"18","author":"Ward","year":"2023","journal-title":"PET Clin."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s11940-014-0319-0","article-title":"Treatment of Frontotemporal Dementia","volume":"16","author":"Tsai","year":"2014","journal-title":"Curr. Treat. Options Neurol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.cell.2011.06.001","article-title":"Gaucher Disease Glucocerebrosidase and \u03b1-Synuclein Form a Bidirectional Pathogenic Loop in Synucleinopathies","volume":"146","author":"Mazzulli","year":"2011","journal-title":"Cell"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.nbd.2015.09.009","article-title":"Glucocerebrosidase Gene Therapy Prevents \u03b1-Synucleinopathy of Midbrain Dopamine Neurons","volume":"82","author":"Rocha","year":"2015","journal-title":"Neurobiol. Dis."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Scerra, G., De Pasquale, V., Scarcella, M., Caporaso, M.G., Pavone, L.M., and D\u2019Agostino, M. (2022). Lysosomal Positioning Diseases: Beyond Substrate Storage. Open Biol., 12.","DOI":"10.1098\/rsob.220155"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1038\/nrd.2017.155","article-title":"Tau-Based Therapies in Neurodegeneration: Opportunities and Challenges","volume":"16","author":"Li","year":"2017","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Mu\u00f1iz, J.A., Facal, C.L., Urrutia, L., Clerici-Delville, R., Damianich, A., Ferrario, J.E., Falasco, G., and Avale, M.E. (2022). SMaRT Modulation of Tau Isoforms Rescues Cognitive and Motor Impairments in a Preclinical Model of Tauopathy. Front. Bioeng. Biotechnol., 10.","DOI":"10.3389\/fbioe.2022.951384"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1186\/s12974-023-02853-3","article-title":"Tau and Neuroinflammation in Alzheimer\u2019s Disease: Interplay Mechanisms and Clinical Translation","volume":"20","author":"Chen","year":"2023","journal-title":"J. Neuroinflamm."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"451","DOI":"10.2174\/0113892037338028241230092414","article-title":"Chaperones as Potential Pharmacological Targets for Treating Protein Aggregation Illness","volume":"26","author":"Rani","year":"2025","journal-title":"Curr. Protein Pept. Sci."}],"container-title":["Neurology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2035-8377\/17\/5\/75\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:31:34Z","timestamp":1760031094000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2035-8377\/17\/5\/75"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,13]]},"references-count":99,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,5]]}},"alternative-id":["neurolint17050075"],"URL":"https:\/\/doi.org\/10.3390\/neurolint17050075","relation":{},"ISSN":["2035-8377"],"issn-type":[{"value":"2035-8377","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,13]]}}}