{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T22:43:19Z","timestamp":1793227399189,"version":"4.5.0"},"reference-count":173,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2025,5,24]],"date-time":"2025-05-24T00:00:00Z","timestamp":1748044800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurology International"],"abstract":"<jats:p>Periodontal health is connected to many systemic diseases, such as cardiovascular, diabetes mellitus, and neurodegenerative diseases. The oral\u2013brain axis has gained increasing interest in the pathogenesis of diseases. Emerging studies have highlighted the potential role of periodontal disease in the development and progression of Alzheimer\u2019s disease. However, Alzheimer\u2019s disease also affects periodontal disease and oral health. In this review, we address the correlation between the two diseases and the mechanisms by which one contributes to the other. Exploring the correlation between Alzheimer\u2019s disease and periodontal disease will assist in better understanding the pathophysiology of diseases and pave the way for the development of therapeutic and preventive strategies.<\/jats:p>","DOI":"10.3390\/neurolint17060081","type":"journal-article","created":{"date-parts":[[2025,5,25]],"date-time":"2025-05-25T20:39:36Z","timestamp":1748205576000},"page":"81","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Reciprocal Interactions Between Periodontal Disease and Alzheimer\u2019s Disease: Implications for Mutual Triggering, Exacerbation, and Treatment Interventions\u2014A Comprehensive Review of the Literature"],"prefix":"10.3390","volume":"17","author":[{"given":"Shatha","family":"Gharaibeh","sequence":"first","affiliation":[{"name":"Division of Periodontics, Ministry of Health, Amman 11118, Jordan"},{"name":"Insight Research Institute, Flint, MI 48507, USA"},{"name":"Center for Cognition and Neuroethics, University of Michigan-Flint, Flint, MI 48502, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alameen","family":"Alsabbah","sequence":"additional","affiliation":[{"name":"Insight Research Institute, Flint, MI 48507, USA"},{"name":"Center for Cognition and Neuroethics, University of Michigan-Flint, Flint, MI 48502, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9217-9166","authenticated-orcid":false,"given":"Ahmad","family":"Alloubani","sequence":"additional","affiliation":[{"name":"Insight Research Institute, Flint, MI 48507, USA"},{"name":"Center for Cognition and Neuroethics, University of Michigan-Flint, Flint, MI 48502, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3549-1826","authenticated-orcid":false,"given":"Abeer","family":"Gharaibeh","sequence":"additional","affiliation":[{"name":"Insight Research Institute, Flint, MI 48507, USA"},{"name":"Insight Institute of Neurosurgery & Neuroscience, Flint, MI 48507, USA"},{"name":"Insight Hospital and Medical Center, Chicago, IL 60616, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/s41392-024-01911-3","article-title":"Recent Advances in Alzheimer\u2019s Disease: Mechanisms, Clinical Trials and New Drug Development Strategies","volume":"9","author":"Zhang","year":"2024","journal-title":"Signal Transduct. 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