{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T03:07:59Z","timestamp":1788664079050,"version":"build-2803163510"},"reference-count":21,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T00:00:00Z","timestamp":1749427200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Italian Multiple Sclerosis Foundation","award":["2014\/R20"],"award-info":[{"award-number":["2014\/R20"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurology International"],"abstract":"<jats:p>Background and Objectives: This cross-sectional study investigates the association between fatigue and upper limb (UL) function in people with Multiple Sclerosis (PwMS). Methods: Adult PwMS were recruited from five Italian MS centers. Fatigue was evaluated using the Modified Fatigue Impact Scale (MFIS), while UL function was assessed through the Box and Block Test (BBT), Nine-Hole Peg Test (9HPT), and Hand-Grip Strength (HGS). Data analysis included Spearman rank correlations and Mann\u2013Whitney U tests. Results: A total of 261 participants were involved. Significant correlations were found between fatigue severity, UL function, and patient-reported manual ability. Physical and cognitive aspects of fatigue were independently related to functional impairments. Participants with clinically relevant fatigue demonstrated lower subjective UL function, poorer BBT and HGS performance, and greater HGS asymmetry. Discussion: The study underscores the complex relationship between fatigue and functional impairments in MS. The findings suggest both strength and dexterity contribute to the perception of clinically relevant fatigue in PwMS, highlighting the importance of incorporating both domains to complement neurological assessment. Conclusion: Fatigue in PwMS is linked to both subjective and objective measures of UL function. Assessing strength and dexterity alongside fatigue may enhance clinical understanding and inform targeted rehabilitation strategies.<\/jats:p>","DOI":"10.3390\/neurolint17060088","type":"journal-article","created":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T09:13:01Z","timestamp":1749460381000},"page":"88","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Fatigue and Its Association with Upper Limb Function in People with Multiple Sclerosis"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5114-9276","authenticated-orcid":false,"given":"Erica","family":"Grange","sequence":"first","affiliation":[{"name":"Scientific Research Area, Italian Multiple Sclerosis Foundation (FISM), 16126 Genova, Italy"},{"name":"CRRF \u201cMons. Luigi Novarese\u201d, 13040 Moncrivello, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7107-0810","authenticated-orcid":false,"given":"Davide","family":"Marengo","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Turin, 10124 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachele","family":"Di Giovanni","sequence":"additional","affiliation":[{"name":"CRRF \u201cMons. Luigi Novarese\u201d, 13040 Moncrivello, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2026-3572","authenticated-orcid":false,"given":"Giampaolo","family":"Brichetto","sequence":"additional","affiliation":[{"name":"Scientific Research Area, Italian Multiple Sclerosis Foundation (FISM), 16126 Genova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margit","family":"Mueller","sequence":"additional","affiliation":[{"name":"Scientific Research Area, Italian Multiple Sclerosis Foundation (FISM), 16126 Genova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2263-7315","authenticated-orcid":false,"given":"Andrea","family":"Tacchino","sequence":"additional","affiliation":[{"name":"Scientific Research Area, Italian Multiple Sclerosis Foundation (FISM), 16126 Genova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9533-5716","authenticated-orcid":false,"given":"Rita","family":"Bertoni","sequence":"additional","affiliation":[{"name":"IRCSS Fondazione Don Carlo Gnocchi, 20148 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Zagari","sequence":"additional","affiliation":[{"name":"MS Center Institute of Neurological Sciences, University of Catania, 95124 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Pappalardo","sequence":"additional","affiliation":[{"name":"MS Center Institute of Neurological Sciences, University of Catania, 95124 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3237-6267","authenticated-orcid":false,"given":"Luca","family":"Prosperini","sequence":"additional","affiliation":[{"name":"Department of Neurology and Psychiatry, Sapienza University, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4921-374X","authenticated-orcid":false,"given":"Rosalba","family":"Rosato","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Turin, 10124 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Cattaneo","sequence":"additional","affiliation":[{"name":"IRCSS Fondazione Don Carlo Gnocchi, 20148 Milan, Italy"},{"name":"Department of Physiopathology and Transplants, University of Milan, 20122 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Solaro","sequence":"additional","affiliation":[{"name":"CRRF \u201cMons. 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Sci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s11940-016-0411-8","article-title":"Fatigue management in multiple sclerosis","volume":"18","author":"Tur","year":"2016","journal-title":"Curr. Treat. Options Neurol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.jns.2006.02.018","article-title":"Motor assessment of upper extremity function and its relation with fatigue, cognitive function and quality of life in multiple sclerosis patients","volume":"246","author":"Yozbatiran","year":"2006","journal-title":"J. Neurol. Sci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.jns.2006.11.016","article-title":"Reply to \u201cMotor assessment of upper extremity function and its relation with fatigue, cognitive function and quality of life in multiple sclerosis patients\u201d","volume":"253","author":"Padua","year":"2007","journal-title":"J. Neurol. Sci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.msard.2017.11.016","article-title":"Motor fatigability in persons with multiple sclerosis: Relation between different upper limb muscles, and with fatigue and the perceived use of the arm in daily life","volume":"19","author":"Severijns","year":"2018","journal-title":"Mult. Scler. Relat. Disord."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"101008","DOI":"10.1016\/j.bjpt.2024.101008","article-title":"Is there an association between upper limb function, fatigue and quality of life in individuals with multiple sclerosis? Cross-sectional study","volume":"28","author":"Mariano","year":"2024","journal-title":"Braz. J. Phys. Ther."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S1474-4422(17)30470-2","article-title":"Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria","volume":"17","author":"Thompson","year":"2018","journal-title":"Lancet Neurol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1191\/1352458505ms1148oa","article-title":"Does the Modified Fatigue Impact Scale offer a more comprehensive assessment of fatigue in MS?","volume":"11","author":"Nos","year":"2005","journal-title":"Mult. Scler. J."},{"key":"ref_11","first-page":"77","article-title":"Hand strength and dexterity","volume":"25","author":"Kellor","year":"1971","journal-title":"Am. J. Occup. Ther."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"386","DOI":"10.5014\/ajot.39.6.386","article-title":"Adult norms for the Box and Block Test of manual dexterity","volume":"39","author":"Mathiowetz","year":"1985","journal-title":"Am. J. Occup. Ther."},{"key":"ref_13","first-page":"69","article-title":"Grip and pinch strength: Normative data for adults","volume":"66","author":"Mathiowetz","year":"1985","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1007\/s10072-020-04263-2","article-title":"Italian translation and psychometric validation of the Manual Ability Measure-36 (MAM-36) and its correlation with an objective measure of upper limb function in patients with multiple sclerosis","volume":"41","author":"Solaro","year":"2020","journal-title":"Neurol. Sci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1191\/1352458502ms839oa","article-title":"Fatigue in multiple sclerosis: A comparison of different rating scales and correlation to clinical parameters","volume":"8","author":"Flachenecker","year":"2002","journal-title":"Mult. Scler. J."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"423","DOI":"10.23736\/S1973-9087.20.06446-1","article-title":"MAM-36 and ABILHAND as outcome measures of multiple sclerosis hand disability: An observational study","volume":"57","author":"Prada","year":"2021","journal-title":"Eur. J. Phys. Rehabil. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"3273","DOI":"10.1007\/s10072-020-04363-z","article-title":"Italian validation of the Arm Function in Multiple Sclerosis Questionnaire (AMSQ)","volume":"41","author":"Tacchino","year":"2020","journal-title":"Neurol. Sci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"102422","DOI":"10.1016\/j.msard.2020.102422","article-title":"Nine Hole Peg Test asymmetry in refining upper limb assessment in multiple sclerosis","volume":"45","author":"Solaro","year":"2020","journal-title":"Mult. Scler. Relat. Disord."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.apmr.2016.08.465","article-title":"Predictive and reactive grip force responses to rapid load increases in people with multiple sclerosis","volume":"98","author":"Kern","year":"2017","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1097\/EDE.0b013e3181a819a1","article-title":"Overadjustment bias and unnecessary adjustment in epidemiologic studies","volume":"20","author":"Schisterman","year":"2009","journal-title":"Epidemiology"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.jns.2007.10.002","article-title":"Cognitive impairment in different MS subtypes and clinically isolated syndromes","volume":"267","author":"Potagas","year":"2008","journal-title":"J. Neurol. 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