{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T17:06:30Z","timestamp":1793639190191,"version":"4.5.1"},"reference-count":109,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T00:00:00Z","timestamp":1753056000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurology International"],"abstract":"<jats:p>Background: The central variant of posterior reversible encephalopathy syndrome (cvPRES) is an atypical subtype of PRES. Although no unifying definitions exists, it is most often characterized by vasogenic edema involving \u201ccentral\u201d structures, such as the brainstem, subcortical nuclei, and spinal cord, with relative sparing of the parieto-occipital lobes. Methods: This systematic review and meta-analysis followed the PRISMA guidelines and was pre-registered on PROSPERO [CRD42023483806]. Both the Joanna Briggs Institute and New-Castle Ottawa scale were used for case reports and cohort studies, respectively. The meta-analysis was completed using R-Studio and its associated \u201cmetafor\u201d package. Results: A comprehensive search in four databases yielded 70 case reports\/series (n = 100) and 12 cohort studies. The meta-analysis revealed a pooled incidence rate of 13% (95% CI: 9\u201318%) for cvPRES amongst included cohort studies on PRES. Significant heterogeneity was observed (I2 = 71% and a \u03c42 = 0.2046). The average age of affected individuals was 40.9 years, with a slightly higher prevalence in males (54%). The most common etiological factor was hypertension (72%). Fifty percent had an SBP &gt;200 mmHg at presentation and a mean arterial pressure (MAP) of 217.6 \u00b1 40.82. Imaging revealed an increased T2 signal involving the brain stem (88%), most often in the pons (62\/88; 70.45%), and 18\/100 (18%) cases of PRES with spinal cord involvement (PRES-SCI). Management primarily involved blood pressure reduction, with adjunctive therapies for underlying causes such as anti-seizure medications or hemodialysis. The MAP between isolated PRES-SCI and cvPRES without spinal cord involvement did not show significant differences (p = 0.5205). Favorable outcomes were observed in most cases, with a mortality rate of only 2%. Conclusions: cvPRES is most often associated with higher blood pressure compared to prior studies with typical PRES. The pons is most often involved. Despite the severity of blood pressure and critical brain stem involvement, those with cvPRES have favorable functional outcomes and a lower mortality rate than typical PRES, likely attributable to reversible vasogenic edema without significant neuronal dysfunction.<\/jats:p>","DOI":"10.3390\/neurolint17070113","type":"journal-article","created":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T11:44:05Z","timestamp":1753098245000},"page":"113","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The Central Variant of Posterior Reversible Encephalopathy Syndrome: A Systematic Review and Meta-Analysis"],"prefix":"10.3390","volume":"17","author":[{"given":"Bahadar S.","family":"Srichawla","sequence":"first","affiliation":[{"name":"Department of Neurology, University of Massachusetts Chan Medical School, 55 Lake Ave N, Worcester, MA 01655, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria A.","family":"Garcia-Dominguez","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Massachusetts Chan Medical School, 55 Lake Ave N, Worcester, MA 01655, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Silver","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Massachusetts Chan Medical School, 55 Lake Ave N, Worcester, MA 01655, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1056\/NEJM199602223340803","article-title":"A reversible posterior leukoencephalopathy syndrome","volume":"334","author":"Hinchey","year":"1996","journal-title":"N. Engl. J. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"631","DOI":"10.2214\/AJR.12.9677","article-title":"Central-variant posterior reversible encephalopathy syndrome: Brainstem or basal ganglia involvement lacking cortical or subcortical cerebral edema","volume":"201","author":"McKinney","year":"2013","journal-title":"AJR Am. J. Roentgenol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: An updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"242","DOI":"10.4103\/0974-2700.136876","article-title":"Recurrent posterior reversible encephalopathy syndrome of the brainstem in a hypertensive patient with end-stage renal disease","volume":"7","author":"Abe","year":"2014","journal-title":"J. Emergencies Trauma Shock"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1148\/radiol.2020181547","article-title":"Case 279: Central-Variant Posterior Reversible Encephalopathy Syndrome","volume":"296","author":"Abraham","year":"2020","journal-title":"Radiology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1007\/s00701-017-3228-7","article-title":"Life-threatening posterior reversible encephalopathy syndrome in the cerebellum treated by posterior fossa decompression","volume":"159","author":"Abusabha","year":"2017","journal-title":"Acta Neurochir. (Wien.)"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1007\/s00234-004-1276-1","article-title":"Atypical manifestations of reversible posterior leukoencephalopathy syndrome: Findings on diffusion imaging and ADC mapping","volume":"46","author":"Ahn","year":"2004","journal-title":"Neuroradiology"},{"key":"ref_8","first-page":"149","article-title":"A case report of Posterior reversible encephalopathy syndrome with spinal cord involvement (PRES-SCI) as an atypical presentation of PRES in children","volume":"16","author":"Akhondian","year":"2022","journal-title":"Iran. J. Child Neurol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.radcr.2022.10.079","article-title":"Posterior reversible encephalopathy syndrome (PRES): Should more attention be paid to the atypical forms?","volume":"18","author":"Andour","year":"2023","journal-title":"Radiol. Case Rep."},{"key":"ref_10","first-page":"64","article-title":"A reversible posterior leukoencephalopathy syndrome in a patient with classical polyarteritis nodosa","volume":"37","author":"Arai","year":"1997","journal-title":"Clin. Neurol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s10072-010-0465-4","article-title":"Reversible posterior leukoencephalopathy syndrome in a patient with thrombotic thrombocytopenic purpura","volume":"32","author":"Aridon","year":"2011","journal-title":"Neurol. Sci."},{"key":"ref_12","first-page":"56","article-title":"Posterior Reversible Encephalopathy Syndrome Mimicking Brainstem Infarction: A Dilemma","volume":"25","author":"Ho","year":"2016","journal-title":"Acta Neurol. Taiwan."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.2169\/internalmedicine.3603-19","article-title":"Brainstem Cerebellum-type Posterior Reversible Encephalopathy Syndrome","volume":"59","author":"Honda","year":"2020","journal-title":"Intern. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1177\/0961203309345749","article-title":"Central variant of posterior reversible encephalopathy syndrome in systemic lupus erythematosus: New associations?","volume":"19","author":"Bag","year":"2010","journal-title":"Lupus"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/s13760-014-0370-3","article-title":"Cerebellar and brainstem variant of posterior reversible encephalopathy syndrome","volume":"115","author":"Maier","year":"2015","journal-title":"Acta Neurol. Belg."},{"key":"ref_16","first-page":"e41572","article-title":"A Rare Association of Hypomagnesemia and Posterior Reversible Encephalopathy Syndrome (PRES)","volume":"15","author":"Ball","year":"2023","journal-title":"Cureus"},{"key":"ref_17","first-page":"62","article-title":"Convexity Subarachnoid Hemorrhage Secondary to Adalidumab in a Patient with Ulcerative Colitis","volume":"10","author":"Bandeo","year":"2018","journal-title":"J. Vasc. Interv. Neurol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"182","DOI":"10.4103\/aian.AIAN_379_18","article-title":"Clinical, Etiological and Imaging Profile of Posterior Reversible Encephalopathy Syndrome: A Prospective and Follow-Up Study","volume":"23","author":"Bansal","year":"2020","journal-title":"Ann. Indian. Acad. Neurol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.neurad.2013.05.002","article-title":"Atypical brainstem presentation of posterior reversible encephalopathy syndrome (PRES)","volume":"41","author":"Barnaure","year":"2014","journal-title":"J. Neuroradiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/j.neurol.2020.01.354","article-title":"Brainstem Posterior Reversible Encephalopathy Syndrome With Spinal Cord Involvement (PRES-SCI)","volume":"176","author":"Bing","year":"2020","journal-title":"Rev. Neurol. (Paris)"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1590\/0004-282X20130206","article-title":"Brainstem reversible leukoencephalopathy syndrome","volume":"72","author":"Braatz","year":"2014","journal-title":"Arq. Neuropsiquiatr."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.joad.2016.08.026","article-title":"A rare case of acute posterior reversible encephalopathy syndrome involving brainstem in a child","volume":"5","author":"Bacha","year":"2016","journal-title":"J. Acute Dis."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"245636","DOI":"10.1136\/bcr-2021-245636","article-title":"Central variant reversible encephalopathy syndrome","volume":"15","author":"Chaudhari","year":"2022","journal-title":"BMJ Case Rep."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"e164","DOI":"10.1212\/WNL.0000000000000407","article-title":"Teaching neuroimages: Central variant of posterior reversible encephalopathy syndrome","volume":"82","author":"Chen","year":"2014","journal-title":"Neurology"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e100","DOI":"10.1111\/hdi.12735","article-title":"Atypical posterior reversible encephalopathy syndrome in a noncompliant hemodialysis patient: Case report and literature review","volume":"23","author":"Chiang","year":"2019","journal-title":"Hemodial. Int."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S1607-551X(09)70174-3","article-title":"Posterior Reversible Encephalopathy Syndrome: Magnetic Resonance Imaging and Diffusion-Weighted Imaging in 12 Cases","volume":"20","author":"Chou","year":"2004","journal-title":"Kaohsiung J. Med. Sci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1097\/NRL.0b013e3181951ac7","article-title":"Radiographic and pathologic findings in an atypical brainstem variant of reversible posterior leukoencephalopathy syndrome","volume":"15","author":"Decker","year":"2009","journal-title":"Neurologist"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"915.e7","DOI":"10.1016\/j.jstrokecerebrovasdis.2012.02.005","article-title":"Malignant Hypertension with Reversible Brainstem Hypertensive Encephalopathy and Thrombotic Microangiopathy","volume":"21","author":"Deguchi","year":"2012","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1055\/s-0038-1675237","article-title":"A Child with Central Variant Posterior Reversible Encephalopathy Syndrome","volume":"50","author":"Dhawan","year":"2019","journal-title":"Neuropediatrics"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"231687","DOI":"10.1136\/bcr-2019-231687","article-title":"Tumour-like presentation of atypical posterior reversible encephalopathy syndrome with prominent brainstem involvement","volume":"13","author":"Rispoli","year":"2020","journal-title":"BMJ Case Rep."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"75","DOI":"10.2176\/nmc.46.75","article-title":"Hypertensive brainstem encephalopathy without parieto-occipital lesion\u2014Two case reports","volume":"46","author":"Doi","year":"2006","journal-title":"Neurol. Med.-Chir."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"3769","DOI":"10.1016\/j.radcr.2023.08.003","article-title":"Optic pathway involvement in the posterior reversible encephalopathy syndrome: A case report and review of the literature","volume":"18","author":"Fujii","year":"2023","journal-title":"Radiol. Case Rep."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1002\/ccr3.1888","article-title":"Isolated pan-pontine posterior reversible encephalopathy syndrome in a patient with uncontrolled hypertension","volume":"7","author":"Gowan","year":"2019","journal-title":"Clin. Case Rep."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.jocn.2013.07.005","article-title":"Hypertensive posterior reversible encephalopathy syndrome causing posterior fossa edema and hydrocephalus","volume":"21","author":"Grossbach","year":"2014","journal-title":"J. Clin. Neurosci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2901","DOI":"10.2169\/internalmedicine.2784-19","article-title":"Brainstem Posterior Reversible Encephalopathy Syndrome","volume":"58","author":"Hama","year":"2019","journal-title":"Intern. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s13760-020-01394-3","article-title":"Central-variant posterior reversible encephalopathy syndrome with bilateral corticospinal tract involvement: A case report","volume":"121","author":"Han","year":"2021","journal-title":"Acta Neurol. Belg."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"e05712","DOI":"10.1002\/ccr3.5712","article-title":"Posterior reversible encephalopathy syndrome (PRES) of the isolated brainstem","volume":"10","author":"Hayashi","year":"2022","journal-title":"Clin. Case Rep."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s13760-018-1055-0","article-title":"Atypical MRI presentation of posterior reversible encephalopathy syndrome with predominant brainstem involvement","volume":"119","author":"Hebant","year":"2019","journal-title":"Acta Neurol. Belg."},{"key":"ref_39","first-page":"e13431","article-title":"Systemic Lupus Erythematosus Induced Central Variant of Posterior Reversible Encephalopathy Syndrome: A Rare Association","volume":"13","author":"Jesrani","year":"2021","journal-title":"Cureus"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Jia, L.J., Qu, Z.Z., Zhang, X.Q., Tian, Y.J., and Wang, Y. (2017). Uremic encephalopathy with isolated brainstem involvement revealed by magnetic resonance image: A case report. BMC Neurol., 17.","DOI":"10.1186\/s12883-017-0936-9"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"159","DOI":"10.5692\/clinicalneurol.cn-001809","article-title":"Atypical posterior reversible encephalopathy syndrome associated with Sj\u00f6gren's syndrome: A case report","volume":"63","author":"Kachi","year":"2023","journal-title":"Rinsho Shinkeigaku"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/s10157-010-0293-0","article-title":"Apparent diffusion coefficient map based on diffusion-weighted magnetic resonance imaging is useful in diagnosing the brainstem variant of reversible posterior leukoencephalopathy syndrome with uremia","volume":"14","author":"Katano","year":"2010","journal-title":"Clin. Exp. Nephrol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1007\/s00234-005-1399-z","article-title":"A brainstem variant of reversible posterior leukoencephalopathy syndrome","volume":"47","author":"Kitaguchi","year":"2005","journal-title":"Neuroradiology"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"536","DOI":"10.4103\/0028-3886.314564","article-title":"Brainstem Predominant Posterior Reversible Encephalopathy Syndrome","volume":"69","author":"Lamotte","year":"2021","journal-title":"Neurol. India"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1159\/000486444","article-title":"Central-Variant Posterior Reversible Encephalopathy Syndrome with Albuminocytologic Dissociation","volume":"10","author":"Lee","year":"2018","journal-title":"Case Rep. Neurol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1080\/00207454.2018.1561452","article-title":"Isolated brainstem involvement in posterior reversible encephalopathy syndrome: A case report and review of the literature","volume":"129","author":"Liu","year":"2019","journal-title":"Int. J. Neurosci."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1177\/1941874414557082","article-title":"The Resolution of Central Variant of Posterior Reversible Encephalopathy Syndrome","volume":"5","author":"Maciel","year":"2015","journal-title":"Neurohospitalist"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/s13760-016-0686-2","article-title":"Atypical case of central-variant posterior reversible encephalopathy syndrome","volume":"117","author":"Malhotra","year":"2017","journal-title":"Acta Neurol. Belg."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s13760-018-1046-1","article-title":"Central-variant posterior reversible encephalopathy syndrome in a young patient with systemic lupus erythematosus","volume":"119","author":"Maier","year":"2019","journal-title":"Acta Neurol. Belg."},{"key":"ref_50","first-page":"e34843","article-title":"Simultaneous Presentation of Brainstem and Cerebellar Posterior Reversible Encephalopathy Syndrome With Acute Cerebral Infarction","volume":"15","author":"Maruyama","year":"2023","journal-title":"Cureus"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"297","DOI":"10.33160\/yam.2023.05.006","article-title":"Dramatic Amelioration in Serial Magnetic Resonance Imaging in an \"Isolated Brainstem\" Reversible Encephalopathy Syndrome Case","volume":"66","author":"Matsumoto","year":"2023","journal-title":"Yonago Acta Med."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.jstrokecerebrovasdis.2007.12.006","article-title":"Vanishing brainstem edema","volume":"17","author":"McCarron","year":"2008","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1177\/0883073811399802","article-title":"Reversible brainstem edema due to hypertensive encephalopathy in an 8-year-old girl","volume":"26","author":"Moosa","year":"2011","journal-title":"J. Child. Neurol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.braindev.2009.07.002","article-title":"A case of hypertensive encephalopathy with extensive spinal lesions on MRI","volume":"32","author":"Nagato","year":"2010","journal-title":"Brain Dev."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"440","DOI":"10.4103\/0976-3147.182767","article-title":"Subarachnoid hemorrhage due to ruptured intracranial aneurysm following posterior reversible encephalopathy syndrome","volume":"7","author":"Nanba","year":"2016","journal-title":"J. Neurosci. Rural. Pract."},{"key":"ref_56","first-page":"e16295","article-title":"Unusual Presentation of a Posterior Reversible Encephalopathy Syndrome With Brainstem Involvement and Subarachnoid Haemorrhage","volume":"13","year":"2021","journal-title":"Cureus"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1159\/000437386","article-title":"Central-Variant Posterior Reversible Encephalopathy due to Sulfasalazine: A Case Report","volume":"24","author":"Ocek","year":"2015","journal-title":"Med. Princ. Pract."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"3475","DOI":"10.1016\/j.radcr.2022.07.024","article-title":"Central-variant posterior reversible encephalopathy syndrome in an infant with mid-aortic syndrome: A rare case of symmetric basal ganglia lesions","volume":"17","author":"Ohashi","year":"2022","journal-title":"Radiol. Case Rep."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"e000296","DOI":"10.1136\/bmjno-2022-000296","article-title":"Posterior reversible encephalopathy syndrome presenting with thrombotic microangiopathy triggered by malignant hypertension: A case report and literature review","volume":"4","author":"Onomura","year":"2022","journal-title":"BMJ Neurol. Open"},{"key":"ref_60","first-page":"540947","article-title":"Isolated Brainstem Involvement in a Patient with Hypertensive Encephalopathy","volume":"2013","author":"Osman","year":"2013","journal-title":"Case Rep. Neurol. Med."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Ou, S., Xia, L., Wang, L., Xia, L., Zhou, Q., and Pan, S. (2018). Posterior Reversible Encephalopathy Syndrome With Isolated Involving Infratentorial Structures. Front. Neurol., 9.","DOI":"10.3389\/fneur.2018.00843"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1002\/ccr3.2625","article-title":"Atypical presentation of cerebellar posterior reversible encephalopathy syndrome in a patient with HIV","volume":"8","author":"Raya","year":"2020","journal-title":"Clin. Case Rep."},{"key":"ref_63","first-page":"455","article-title":"Posterior reversible encephalopathy with brainstem involvement","volume":"13","author":"Resorlu","year":"2018","journal-title":"Intern. Emerg. Med."},{"key":"ref_64","first-page":"e14523","article-title":"Extensive Brainstem Posterior Reversible Encephalopathy Syndrome in a Hemodialysis Non-Adherent Patient","volume":"13","author":"Sallah","year":"2021","journal-title":"Cureus"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"201495","DOI":"10.1136\/bcr-2013-201495","article-title":"Rare posterior reversible encephalopathy syndrome in a patient with HIV","volume":"2013","author":"Ribeiro","year":"2013","journal-title":"BMJ Case Rep."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"625","DOI":"10.2176\/nmc.49.625","article-title":"Blurred Vision With Acute Hypertension Indicating Hypertensive Brainstem Encephalopathy: Case Report","volume":"49","author":"Ogaki","year":"2009","journal-title":"Neurol. Med. -Chir."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1093\/tropej\/fmu019","article-title":"Atypical presentation of posterior reversible encephalopathy: In a child with bilateral grade IV vesicoureteric reflux","volume":"60","author":"Sharma","year":"2014","journal-title":"J. Trop. Pediatr."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1177\/197140091302600504","article-title":"Isolated posterior fossa involvement in posterior reversible encephalopathy syndrome","volume":"26","author":"Shimizu","year":"2013","journal-title":"Neuroradiol. J."},{"key":"ref_69","first-page":"TD01","article-title":"Central variant of posterior reversible encephalopathy syndrome\u2014A rare case report","volume":"11","author":"Srinivasan","year":"2017","journal-title":"J. Clin. Diagn. Res."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"511","DOI":"10.7861\/clinmed.2019-0247","article-title":"Hypertensive brainstem encephalopathy: A diagnosis often overlooked","volume":"19","author":"Tan","year":"2019","journal-title":"Clin. Med. (Lond.)"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1007\/s10072-014-1999-7","article-title":"A new case of brainstem variant of posterior reversible encephalopathy syndrome: Clinical and radiological features","volume":"36","author":"Candela","year":"2015","journal-title":"Neurol. Sci."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0022-510X(02)00379-9","article-title":"Hypertensive brainstem encephalopathy: Clinical and radiographic features","volume":"208","author":"Thambisetty","year":"2003","journal-title":"J. Neurol. Sci."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1177\/1971400915609336","article-title":"Brainstem variant of posterior reversible encephalopathy syndrome: A case report","volume":"28","author":"Tortora","year":"2015","journal-title":"Neuroradiol. J."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1016\/j.clineuro.2012.02.027","article-title":"Two cases of posterior reversible encephalopathy syndrome resembling brainstem glioma","volume":"114","author":"Tsutsumi","year":"2012","journal-title":"Clin. Neurol. Neurosurg."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1002\/ccr3.2245","article-title":"\"Highlighting\" red nuclei by atypical posterior reversible encephalopathy syndrome in a patient with systemic lupus erythematosus","volume":"7","author":"Vaysman","year":"2019","journal-title":"Clin. Case Rep."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"E53","DOI":"10.1016\/j.cradex.2005.01.001","article-title":"Hypertensive encephalopathy: A rare case of isolated pons involvement","volume":"60","author":"Wakely","year":"2005","journal-title":"Clin. Radiol. Extra"},{"key":"ref_77","first-page":"e3573","article-title":"Atypical Variant of Posterior Reversible Encephalopathy Syndrome in the Setting of Renovascular Hypertension: Case Report and Review of Literature","volume":"10","author":"Wittgrove","year":"2018","journal-title":"Cureus"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.wneu.2019.10.196","article-title":"Variant Type of Posterior Reversible Encephalopathy Syndrome Associated with Deep Brain Hemorrhage: Case Report and Review of the Literature","volume":"134","author":"Yamagami","year":"2020","journal-title":"World Neurosurg."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/cen3.12530","article-title":"Brainstem posterior reversible encephalopathy syndrome in a case with Guillain\u2013Barr\u00e9 syndrome","volume":"10","author":"Yokoyama","year":"2019","journal-title":"Clin. Exp. Neuroimmunol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"e233","DOI":"10.1016\/j.jstrokecerebrovasdis.2016.09.033","article-title":"Variant Type of Posterior Reversible Encephalopathy Syndrome with Diffuse Cerebral White Matter and Brainstem Involvement Associated with Intracranial Hemorrhage","volume":"25","author":"Zhang","year":"2016","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1212\/WNL.0000000000001026","article-title":"Posterior reversible encephalopathy syndrome with spinal cord involvement","volume":"83","author":"Joos","year":"2014","journal-title":"Neurology"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1007\/s00415-008-0698-9","article-title":"Spinal cord involvement during hypertensive encephalopathy: Clinical and radiological findings","volume":"255","author":"Milia","year":"2008","journal-title":"J. Neurol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.radcr.2019.02.009","article-title":"Posterior reversible encephalopathy syndrome with isolated infratentorial involvement: A case report","volume":"14","author":"Samara","year":"2019","journal-title":"Radiol. Case Rep."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"e13649","DOI":"10.1097\/MD.0000000000013649","article-title":"Posterior reversible encephalopathy syndrome with spinal cord involvement but without hemisphere lesions: A case report","volume":"98","author":"Liu","year":"2019","journal-title":"Medicine"},{"key":"ref_85","first-page":"115","article-title":"Reversible Hypertensive Myelopathy-The Spinal Cord Variant of Posterior Reversible Encephalopathy Syndrome","volume":"48","author":"Gocmen","year":"2017","journal-title":"Neuropediatrics"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"15001","DOI":"10.1038\/scsandc.2015.1","article-title":"PRES with asymptomatic spinal cord involvement. Is this scenario more common than we know?","volume":"2","author":"Marrone","year":"2016","journal-title":"Spinal Cord. Ser. Cases"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"161","DOI":"10.4103\/ijri.IJRI_320_17","article-title":"First case of neurofibromatosis with posterior reversible encephalopathy syndrome showing spinal cord involvement","volume":"28","author":"Chan","year":"2018","journal-title":"Indian. J. Radiol. Imaging"},{"key":"ref_88","first-page":"20150326","article-title":"Spinal cord involvement and contrast enhancement in posterior reversible encephalopathy syndrome","volume":"2","author":"Agarwal","year":"2016","journal-title":"BJR Case Rep."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"90","DOI":"10.4103\/0256-4947.75790","article-title":"Involvement of the cervical cord and medulla in posterior reversible encephalopathy syndrome","volume":"31","author":"Choh","year":"2011","journal-title":"Ann. Saudi Med."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"134","DOI":"10.4103\/0972-2327.165456","article-title":"Posterior reversible encephalopathy syndrome with spinal cord involvement (PRES-SCI): A case report","volume":"19","author":"Khokhar","year":"2016","journal-title":"Ann. Indian. Acad. Neurol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1016\/j.jstrokecerebrovasdis.2017.02.033","article-title":"Quantitative Magnetic Resonance Diffusion-Weighted Imaging Evaluation of the Supratentorial Brain Regions in Patients Diagnosed with Brainstem Variant of Posterior Reversible Encephalopathy Syndrome: A Preliminary Study","volume":"26","author":"Chen","year":"2017","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1007\/s13760-015-0431-2","article-title":"Features of infratentorial-predominant posterior reversible encephalopathy syndrome","volume":"115","author":"Fitzgerald","year":"2015","journal-title":"Acta Neurol. Belg."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"904","DOI":"10.2214\/AJR.07.2024","article-title":"Posterior reversible encephalopathy syndrome: Incidence of atypical regions of involvement and imaging findings","volume":"189","author":"McKinney","year":"2007","journal-title":"AJR Am. J. Roentgenol."},{"key":"ref_94","first-page":"800","article-title":"Clinical and Radiological Characteristics of Classical and Variant Type of Posterior Reversible Encephalopathy Syndrome on Prognosis Following Hematopoietic Stem Cell Transplantation in Pediatric Patients: A Single-Center Experience","volume":"22","author":"Aygunes","year":"2024","journal-title":"Exp. Clin. Transplant."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"e41625","DOI":"10.1097\/MD.0000000000041625","article-title":"Central-variant posterior reversible encephalopathy syndrome in association with adrenal insufficiency: A case report","volume":"104","author":"Srichawla","year":"2025","journal-title":"Med. (Baltim.)"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.braindev.2015.07.001","article-title":"Posterior reversible leukoencephalopathy syndrome with spinal cord involvement in a 9-year-old girl","volume":"38","author":"Kurul","year":"2016","journal-title":"Brain Dev."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"468.e1","DOI":"10.1016\/j.ajog.2013.02.015","article-title":"Posterior reversible encephalopathy syndrome in 46 of 47 patients with eclampsia","volume":"208","author":"Brewer","year":"2013","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.jstrokecerebrovasdis.2011.05.010","article-title":"Spectrum and Potential Pathogenesis of Reversible Posterior Leukoencephalopathy Syndrome","volume":"21","author":"Li","year":"2012","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"64","DOI":"10.12659\/PJR.899960","article-title":"Various Imaging Manifestations of Posterior Reversible Encephalopathy Syndrome (PRES) on Magnetic Resonance Imaging (MRI)","volume":"82","author":"Raman","year":"2017","journal-title":"Pol. J. Radiol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"206","DOI":"10.7461\/jcen.2013.15.3.206","article-title":"Clinical and radiological spectrum of posterior reversible encephalopathy syndrome","volume":"15","author":"Yoon","year":"2013","journal-title":"J. Cerebrovasc. Endovasc. Neurosurg."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.2169\/internalmedicine.4919-20","article-title":"Bilateral Optic Nerve Edema in Central-variant Posterior Reversible Encephalopathy Syndrome","volume":"59","author":"Doi","year":"2020","journal-title":"Intern. Med."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"427","DOI":"10.4065\/mcp.2009.0590","article-title":"Posterior reversible encephalopathy syndrome: Associated clinical and radiologic findings","volume":"85","author":"Fugate","year":"2010","journal-title":"Mayo Clin. Proc."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.jstrokecerebrovasdis.2011.03.011","article-title":"Blood pressure fluctuations in posterior reversible encephalopathy syndrome","volume":"21","author":"Rabinstein","year":"2012","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"97149","DOI":"10.5492\/wjccm.v13.i4.97149","article-title":"Regional dynamic cerebral autoregulation across anterior and posterior circulatory territories: A detailed exploration and its clinical implications","volume":"13","author":"Srichawla","year":"2024","journal-title":"World J. Crit. Care Med."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"3481","DOI":"10.1007\/s10072-023-06818-5","article-title":"Clinical characteristics and risk factors for bilateral lateral geniculate body pathology: A systematic review of the literature","volume":"44","author":"Srichawla","year":"2023","journal-title":"Neurol. Sci."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1097\/00127893-200201000-00003","article-title":"Hyperperfusion encephalopathies: Hypertensive encephalopathy and related conditions","volume":"8","author":"Schwartz","year":"2002","journal-title":"Neurologist"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/j.1748-1716.1981.tb06724.x","article-title":"Cerebral circulation in acute arterial hypertension--protective effects of sympathetic nervous activity","volume":"111","author":"Bill","year":"1981","journal-title":"Acta Physiol. Scand."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1111\/ene.12571","article-title":"Central pontine and extrapontine myelinolysis: A systematic review","volume":"21","author":"Singh","year":"2014","journal-title":"Eur. J. Neurol."},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Chen, P.-R., and Chen, S.-P. (2016). Posterior reversible encephalopathy as the first manifestation of Bickerstaff's brainstem encephalitis. BMC Neurol., 16.","DOI":"10.1186\/s12883-016-0737-6"}],"container-title":["Neurology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2035-8377\/17\/7\/113\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:13:17Z","timestamp":1760033597000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2035-8377\/17\/7\/113"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,21]]},"references-count":109,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,7]]}},"alternative-id":["neurolint17070113"],"URL":"https:\/\/doi.org\/10.3390\/neurolint17070113","relation":{},"ISSN":["2035-8377"],"issn-type":[{"value":"2035-8377","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,21]]}}}