{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:40:20Z","timestamp":1760060420400,"version":"build-2065373602"},"reference-count":38,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T00:00:00Z","timestamp":1755734400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Italian Ministry of Education, University and Research (MIUR)","award":["PONa3_00011","GR-2016-02364526","PNC-E3-2022-23683266"],"award-info":[{"award-number":["PONa3_00011","GR-2016-02364526","PNC-E3-2022-23683266"]}]},{"name":"Italian Ministry of Health","award":["PONa3_00011","GR-2016-02364526","PNC-E3-2022-23683266"],"award-info":[{"award-number":["PONa3_00011","GR-2016-02364526","PNC-E3-2022-23683266"]}]},{"name":"project \u201cINNOVA\u201d (Italian Network of Excellence for Advanced Diagnosis)\u2014Hub Life Science\u2014Advanced Diagnostics (HLS-DA)","award":["PONa3_00011","GR-2016-02364526","PNC-E3-2022-23683266"],"award-info":[{"award-number":["PONa3_00011","GR-2016-02364526","PNC-E3-2022-23683266"]}]},{"name":"Italian Ministry of Health within the National Plan for Complementary Investments (PNC) to the National Recovery and Resilience Plan (PNRR)","award":["PONa3_00011","GR-2016-02364526","PNC-E3-2022-23683266"],"award-info":[{"award-number":["PONa3_00011","GR-2016-02364526","PNC-E3-2022-23683266"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurology International"],"abstract":"<jats:p>Background\/Objectives: Essential tremor (ET) is the most common movement disorder worldwide. It negatively affects patients\u2019 activities of daily living (ADL) and quality of life. Unilateral transcranial magnetic resonance-guided focused ultrasound (tcMRgFUS) thalamotomy has been proven as a highly effective and safe treatment option for patients with refractory ET. The aims of this study are to explore the effectiveness and safety of tcMRgFUS thalamotomy in patients with ET in a real-world setting. Methods: Patients who underwent tcMRgFUS thalamotomy at the University Hospital of Palermo were prospectively enrolled. Scores obtained by Quality of Life in Essential Tremor Questionnaire (QUEST) and The Essential Tremor Rating Assessment Scale (TETRAS) were compared before and after tcMRgFUS thalamotomy. Predictors of tcMRgFUS thalamotomy effectiveness were explored by multivariable Cox regression analyses. All the adverse events (AEs) during and after the procedure were collected. Results: Fifty patients were included (80% male; median age at tcMRgFUS 67.4 years). After procedure, the QUEST score decreased by 46.2%, while TETRAS-ADL and TETRAS Performance (TETRAS-PE) decreased by 52.2% and 51.8%, respectively. Temperature peak and longitudinal lesion diameter positively correlated with the magnitude of QUEST and TETRAS-PE reduction. A higher baseline TETRAS-PE score predicted a good prognosis (HR = HR 6.6 [95% CI: 2.1\u201321.3]; p = 0.001). AEs were mild to moderate and transient, while permanent AE was observed only in one case. Conclusions: This real-world study confirms the higher effectiveness and the favorable safety profile of tcMRgFUS thalamotomy in patients with ET by reducing the tremor-related interference in quality of life, disability in ADL, and tremor severity.<\/jats:p>","DOI":"10.3390\/neurolint17080131","type":"journal-article","created":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T14:46:04Z","timestamp":1755787564000},"page":"131","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Safety and Effectiveness of Unilateral Transcranial Magnetic Resonance-Guided Focused Ultrasound in Essential Tremor: One-Year Single-Center Real-World Results"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0035-5859","authenticated-orcid":false,"given":"Salvatore","family":"Iacono","sequence":"first","affiliation":[{"name":"Department of Biomedicine, Neurosciences and Advanced Diagnostics (BIND), University of Palermo, 90127 Palermo, Italy"},{"name":"Neurology Unit, Fondazione Istituto G. Giglio, Cefal\u00f9, 90015 Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4088-2020","authenticated-orcid":false,"given":"Cesare","family":"Gagliardo","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Neurosciences and Advanced Diagnostics (BIND), University of Palermo, 90127 Palermo, Italy"},{"name":"Neuroradiology Unit, University-Hospital Paolo Giaccone, 90127 Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domenico Gerardo","family":"Iacopino","sequence":"additional","affiliation":[{"name":"Neurosurgical Clinic, AOUP \u201cPaolo Giaccone\u201d, Post Graduate Residency Program in Neurologic Surgery, Department of Biomedicine Neurosciences and Advanced Diagnostics, School of Medicine, University of Palermo, 90127 Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Schir\u00f2","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Neurosciences and Advanced Diagnostics (BIND), University of Palermo, 90127 Palermo, Italy"},{"name":"Neurology Unit, Fondazione Istituto G. Giglio, Cefal\u00f9, 90015 Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosario","family":"Maugeri","sequence":"additional","affiliation":[{"name":"Neurosurgical Clinic, AOUP \u201cPaolo Giaccone\u201d, Post Graduate Residency Program in Neurologic Surgery, Department of Biomedicine Neurosciences and Advanced Diagnostics, School of Medicine, University of Palermo, 90127 Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Mastrilli","sequence":"additional","affiliation":[{"name":"Neurology Unit, Ospedale Buccheri La Ferla, 90123 Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Picciolo","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Neurosciences and Advanced Diagnostics (BIND), University of Palermo, 90127 Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleonora","family":"Bruno","sequence":"additional","affiliation":[{"name":"Neuroradiology Unit, University-Hospital Paolo Giaccone, 90127 Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0091-3243","authenticated-orcid":false,"given":"Maurizio","family":"Marrale","sequence":"additional","affiliation":[{"name":"Department of Physics and Chemistry \u201cEmilio Segr\u00e8\u201d, University of Palermo, 90133 Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Midiri","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Neurosciences and Advanced Diagnostics (BIND), University of Palermo, 90127 Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"D\u2019Amelio","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Neurosciences and Advanced Diagnostics (BIND), University of Palermo, 90127 Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"106086","DOI":"10.1016\/j.parkreldis.2024.106086","article-title":"Updates in essential tremor","volume":"122","author":"Okelberry","year":"2024","journal-title":"Park. 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