{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T13:37:58Z","timestamp":1781530678112,"version":"3.54.1"},"reference-count":23,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T00:00:00Z","timestamp":1757462400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurology International"],"abstract":"<jats:p>Background\/Objectives: Dizziness is a frequent medical complaint with neurological, otolaryngological, and psychological origins. Imaging studies such as CT (Computer Tomography), cervical X-rays, and ultrasound aid diagnosis, while MRI (Magnetic Resonance Imaging) is crucial for detecting brain abnormalities. Our purpose is to identify structural brain changes associated with vertigo, assess pre-MRI diagnostic approaches, and evaluate treatment strategies. Methods: A case-control study of 232 vertigo patients and 232 controls analyzed MRI findings, pre-MRI examinations, symptoms, and treatments. Statistical comparisons were performed using chi-square and t-tests (p &lt; 0.05). Results: White matter lesions, lacunar infarcts, Circle of Willis variations, and sinusitis were significantly more frequent in vertigo patients (p &lt; 0.05). Pre-MRI diagnostics frequently identified atherosclerosis (ultrasound) and spondylosis (X-ray). Common symptoms included headache, imbalance, and visual disturbances. The most frequent post-MRI diagnosis was Benign Paroxysmal Positional Vertigo (BPPV). Treatments included lifestyle modifications, physical therapy (e.g., Epley maneuver), and pharmacological therapies such as betahistine. Conclusions: MRI revealed structural brain changes linked to vertigo. Pre-MRI assessments are essential for ruling out vascular and musculoskeletal causes. A multidisciplinary treatment approach is recommended. Trial Registration: This study was registered in ClinicalTrials.gov with the trial registration number NCT06848712 on 22 February 2025.<\/jats:p>","DOI":"10.3390\/neurolint17090146","type":"journal-article","created":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T12:04:55Z","timestamp":1757505895000},"page":"146","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Structural Brain Abnormalities, Diagnostic Approaches, and Treatment Strategies in Vertigo: A Case-Control Study"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7463-7608","authenticated-orcid":false,"given":"Klaudia","family":"Sz\u00e9phelyi","sequence":"first","affiliation":[{"name":"Doctoral School of Health Sciences, Faculty of Health Sciences, University of P\u00e9cs, 7622 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1787-3711","authenticated-orcid":false,"given":"Szilvia","family":"K\u00f3ra","sequence":"additional","affiliation":[{"name":"Doctoral School of Health Sciences, Faculty of Health Sciences, University of P\u00e9cs, 7622 P\u00e9cs, Hungary"},{"name":"Faculty of Health Sciences and Social Studies, Department of Theoretical Health Sciences and Health Management, University of Szeged, 6726 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9388-2967","authenticated-orcid":false,"given":"Gergely","family":"Orsi","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical School, University of P\u00e9cs, 7622 P\u00e9cs, Hungary"},{"name":"HUN-REN-PTE Clinical Neuroscience MR Research Group, Hungarian Research Network, 7622 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7607-6739","authenticated-orcid":false,"given":"J\u00f3zsef","family":"Toll\u00e1r","sequence":"additional","affiliation":[{"name":"Doctoral School of Health Sciences, Faculty of Health Sciences, University of P\u00e9cs, 7622 P\u00e9cs, Hungary"},{"name":"Somogy County M\u00f3ricz Kaposi Teaching Hospital, 7400 Kaposv\u00e1r, Hungary"},{"name":"Digital Development Center, Sz\u00e9chenyi Istv\u00e1n University, 9026 Gy\u0151r, Hungary"},{"name":"Department of Otorhinolaryngology-Head and Neck Surgery, University of P\u00e9cs Medical School, 7622 P\u00e9cs, Hungary"},{"name":"J\u00e1nos Bolyai Research Scholarship of the Hungarian Academy of Science, 1051 Budapest, Hungary"},{"name":"Faculty of Health Sciences, University of P\u00e9cs, 7622 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/B978-0-444-63437-5.00005-4","article-title":"The epidemiology of dizziness and vertigo","volume":"137","author":"Neuhauser","year":"2016","journal-title":"Handb. 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