{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T02:26:39Z","timestamp":1788402399818,"version":"build-2803163510"},"reference-count":68,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurology International"],"abstract":"<jats:p>Background\/Objectives: Relapsing-remitting multiple sclerosis (RRMS) is a chronic neurological disease that significantly impacts health-related quality of life (HRQoL). This study aimed to analyze the evolution of HRQoL in individuals with RRMS, identify associated factors, and determine predictive variables. Methods: A prospective observational study was conducted with 35 participants diagnosed with RRMS at the Lucus Augusti University Hospital between January 2023 and March 2025. HRQoL was assessed using the MSQOL-54 questionnaire at baseline, 3 months, and 6 months. Data were analyzed using non-parametric tests to account for the small sample size and non-normal distribution of the variables. Results: Results showed overall stability in HRQoL (mean score: 62.4 \u00b1 14.1 at baseline, 62.8 \u00b1 12.7 at 3 months, and 62.4 \u00b1 11.8 at 6 months), although significant declines were observed in emotional limitations (64.4 \u00b1 23.0 at baseline to 58.9 \u00b1 20.5 at 6 months) and social functioning (70.5 \u00b1 16.7 at baseline to 65.5 \u00b1 12.8 at 6 months). Improvements were noted in pain perception (78.9 \u00b1 23.6 at baseline to 81.8 \u00b1 20.5 at 6 months) and stress (44.3 \u00b1 22.5 at baseline to 48.9 \u00b1 17.8 at 6 months). Factors such as family history (associated with mental health at diagnosis, p = 0.028), autoimmune diseases (associated with physical function at diagnosis, p = 0.035), and lifestyle habits (e.g., tobacco use associated with physical limitations at 3 months, p = 0.045) were significantly associated with HRQoL. Baseline HRQoL emerged as a strong predictor of future scores (Spearman\u2019s correlations, p &lt; 0.01), indicating that early assessments may guide interventions. Conclusions: Although overall HRQoL remains stable in RRMS, specific domains such as emotional and social functioning exhibit progressive decline, highlighting the need for tailored interventions. The findings underscore the importance of integrating early psychosocial support and lifestyle interventions into routine care to mitigate vulnerabilities in emotional and social domains of HRQoL.<\/jats:p>","DOI":"10.3390\/neurolint17120195","type":"journal-article","created":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T12:39:43Z","timestamp":1764679183000},"page":"195","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Predicting Quality of Life in Relapsing\u2013Remitting Multiple Sclerosis: Clinical Burden Meets Emotional Balance in Early Disease"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5515-9172","authenticated-orcid":false,"given":"Emilio Rub\u00e9n","family":"Pego P\u00e9rez","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Radiology, Public Health, Nursing and Medicine, University of Santiago de Compostela, Avda. Xo\u00e1n XXIII s\/n, 15704 Santiago de Compostela, Spain"},{"name":"Faculty of Nursing, Avda. Xo\u00e1n XXIII s\/n, 15704 Santiago de Compostela, Spain"},{"name":"Research Group CroniEduTec (Chronicity, Educational Innovation and Applied Health Technologies), Faculty of Nursing, University of Santiago de Compostela, 15704 Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Lourdes","family":"Bermello L\u00f3pez","sequence":"additional","affiliation":[{"name":"Nurses of Neurology and Neurosurgery of Lucus Augusti Hospital, 27004 Lugo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"G\u00f3mez Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Nurses of Neurology and Neurosurgery of Lucus Augusti Hospital, 27004 Lugo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7418-0457","authenticated-orcid":false,"given":"Mar\u00eda del Rosario","family":"Mar\u00edn Arn\u00e9s","sequence":"additional","affiliation":[{"name":"Nurses of Neurology and Neurosurgery of Lucus Augusti Hospital, 27004 Lugo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes","family":"Fern\u00e1ndez V\u00e1zquez","sequence":"additional","affiliation":[{"name":"Nurses of Neurology and Neurosurgery of Lucus Augusti Hospital, 27004 Lugo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Irene","family":"N\u00fa\u00f1ez Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Nurses of Neurology and Neurosurgery of Lucus Augusti Hospital, 27004 Lugo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilio","family":"Guti\u00e9rrez Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Clinical Psychology and Psychobiology, Research Group: GIBIOMED Group of Biomedical Research, Faculty of Psychology, University of Santiago de Compostela, 15703 Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Margoni, M., Preziosa, P., Rocca, M.A., and Filippi, M. 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