{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T17:54:46Z","timestamp":1768586086053,"version":"3.49.0"},"reference-count":63,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000038","name":"National Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN-2023-04490"],"award-info":[{"award-number":["RGPIN-2023-04490"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018359","name":"Fondation de l\u2019H\u00f4pital Maisonneuve-Rosemont","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100018359","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Pierre Th\u00e9roux Family Foundation for Alzheimer\u2019s Disease Research"},{"name":"molecular biology department of Universit\u00e9 de Montr\u00e9al"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurology International"],"abstract":"<jats:p>Late-onset sporadic Alzheimer\u2019s disease (LOAD) is the most common form of dementia. The disease is characterized by progressive loss of memory and behavioral changes followed by neurodegeneration of all cortical areas. While the contribution of genetic and environmental factors is important, advanced aging remains the most important disease risk factor. Because LOAD does not naturally occur in most animal species, except humans, studies have traditionally relied on the use of transgenic mouse models recapitulating early-onset familial Alzheimer\u2019s disease (EOAD). Hence, the development of more representative LOAD models through reprograming of patient-derived cells into neuronal, glial, and immune cells became a necessity to better understand the disease\u2019s origin and pathophysiology. Herein, and focusing on neurons, we review current work in the field and compare results obtained with two different reprograming methods to generate LOAD patient\u2019s neuronal cells: the induced pluripotent stem cell and induced neuron technologies. We also evaluate if these models can faithfully mimic cellular and molecular pathologies observed in LOAD patients\u2019 brains.<\/jats:p>","DOI":"10.3390\/neurolint18010017","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T11:01:14Z","timestamp":1768388474000},"page":"17","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Modeling Late-Onset Sporadic Alzheimer\u2019s Disease Using Patient-Derived Cells: A Review"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-5305-3543","authenticated-orcid":false,"given":"Alisar","family":"Katbe","sequence":"first","affiliation":[{"name":"Stem Cell and Developmental Biology Laboratory, Maisonneuve-Rosemont Hospital, 5690 Boulevard Rosemont, Montreal, QC H1T 2H2, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isma\u00efla","family":"Diagne","sequence":"additional","affiliation":[{"name":"Stem Cell and Developmental Biology Laboratory, Maisonneuve-Rosemont Hospital, 5690 Boulevard Rosemont, Montreal, QC H1T 2H2, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9649-6538","authenticated-orcid":false,"given":"Gilbert","family":"Bernier","sequence":"additional","affiliation":[{"name":"Stem Cell and Developmental Biology Laboratory, Maisonneuve-Rosemont Hospital, 5690 Boulevard Rosemont, Montreal, QC H1T 2H2, Canada"},{"name":"Department of Neurosciences, University of Montreal, Montreal, QC H3T 1J4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e105","DOI":"10.1016\/S2468-2667(21)00249-8","article-title":"Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: An analysis for the Global Burden of Disease Study 2019","volume":"7","author":"Nichols","year":"2022","journal-title":"Lancet Public Health"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1111\/joim.12816","article-title":"Biomarkers for Alzheimer\u2019s disease: Current status and prospects for the future","volume":"284","author":"Blennow","year":"2018","journal-title":"J. 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