{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T13:20:53Z","timestamp":1773840053507,"version":"3.50.1"},"reference-count":26,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:00:00Z","timestamp":1773792000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurology International"],"abstract":"<jats:p>Introduction: Ischemic stroke in young adults is uncommon and is frequently associated with rare etiologies, including autoimmune diseases and vasculitis. Takayasu arteritis (TA) is a chronic inflammatory large-vessel arteriopathy involving the aorta and its major branches and may result in cerebral ischemia due to arterial stenosis or thrombosis. Case Presentation: We report the case of a 26-year-old woman with a history of suspected rheumatoid arthritis and Lyme disease who presented with acute left-sided hemiparesis and dysarthria. At admission, large-vessel vasculitis had not yet been suspected, and the patient was treated according to standard acute stroke protocols. Computed tomography angiography (CTA) revealed occlusion of the right middle cerebral artery bifurcation and the right common carotid artery, with inflammatory changes involving the brachiocephalic trunk and subclavian arteries. Intravenous thrombolysis (iv rtPA) was followed by mechanical thrombectomy (MT), resulting in neurological improvement. Outcome: Further diagnostic work-up confirmed TA, and immunosuppressive therapy with cyclophosphamide and infliximab was initiated. Conclusion: This case underscores the importance of considering inflammatory large-vessel disease in young patients presenting with acute ischemic stroke and illustrates that endovascular reperfusion may be feasible in this clinical setting.<\/jats:p>","DOI":"10.3390\/neurolint18030057","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T09:10:04Z","timestamp":1773825004000},"page":"57","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ischemic Stroke as the First Manifestation of Takayasu Arteritis: A Case Report"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4114-1195","authenticated-orcid":false,"given":"Dominika","family":"Jakubowicz-Lachowska","sequence":"first","affiliation":[{"name":"Department of Neurology, Medical University of Bialystok, 15-276 Bialystok, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Sarnowska","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical University of Bialystok, 15-276 Bialystok, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Chor\u0105\u017cy","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical University of Bialystok, 15-276 Bialystok, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alina","family":"Ku\u0142akowska","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical University of Bialystok, 15-276 Bialystok, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1177\/17474930241308142","article-title":"World Stroke Organization: Global Stroke Fact Sheet 2025","volume":"20","author":"Feigin","year":"2025","journal-title":"Int. J. Stroke"},{"key":"ref_2","first-page":"157","article-title":"Strokes in young adults: Epidemiology and prevention","volume":"11","year":"2015","journal-title":"Vasc. Health Risk Manag."},{"key":"ref_3","first-page":"e30472","article-title":"A Case Report of Takayasu\u2019s Arteritis with Cerebral Infarction As Initial Presentation","volume":"14","author":"Memon","year":"2022","journal-title":"Cureus"},{"key":"ref_4","first-page":"8","article-title":"Rola zapalenia naczy\u0144 w etiologii udaru m\u00f3zgu","volume":"10","author":"Wiszniewska","year":"2008","journal-title":"Udar. M\u00f3zgu."},{"key":"ref_5","first-page":"97","article-title":"Zapalenia naczy\u0144 w etiopatogenezie udaru m\u00f3zgu","volume":"7","author":"Budrewicz","year":"2011","journal-title":"Pol. Prz. Neurol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"387","DOI":"10.5797\/jnet.cr.2020-0074","article-title":"A Case of Acute Ischemic Stroke Treated with Endovascular Treatment for Tandem Occlusion of the Common Carotid Artery and Internal Carotid Artery Terminal Portion Related to Takayasu Arteritis","volume":"15","author":"Tatsuno","year":"2021","journal-title":"J. Neuroendovasc. Ther."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1186\/s13256-024-04989-z","article-title":"Long-term successfully endovascular treatment of a complicated Takayasu\u2019s arteritis with thrombectomy and stenting: A case report","volume":"19","author":"Chirico","year":"2025","journal-title":"J. Med. Case Rep."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"62","DOI":"10.14712\/23362936.2024.6","article-title":"Recurrent Stroke as a Presenting Feature of Takayasu Arteritis in an Adolescent: A Case Report and Literature Review","volume":"125","author":"Sgouropoulou","year":"2024","journal-title":"Prague Med. Rep."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e197","DOI":"10.1016\/j.lpm.2017.05.034","article-title":"Epidemiology of Takayasu arteritis","volume":"46","author":"Onen","year":"2017","journal-title":"Presse Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e7412","DOI":"10.1002\/ccr3.7412","article-title":"Ischemic stroke at first presentation of Takayasu arteritis in a young African male from Kenya, East Africa: Case report and brief literature review","volume":"11","author":"Owino","year":"2023","journal-title":"Clin. Case Rep."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.autrev.2011.08.001","article-title":"Pathogenesis of Takayasu\u2019s arteritis: A 2011 update","volume":"11","author":"Arnaud","year":"2011","journal-title":"Autoimmun. Rev."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1097\/MS9.0000000000001582","article-title":"Takayasu arteritis presenting as a stroke in young: A case report","volume":"86","author":"Oli","year":"2024","journal-title":"Ann. Med. Surg."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.radcr.2019.12.019","article-title":"Stroke as the initial presentation of Takayasu\u2019s arteritis: A case report","volume":"15","author":"Davari","year":"2020","journal-title":"Radiol. Case Rep."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"919","DOI":"10.7326\/0003-4819-120-11-199406010-00004","article-title":"Takayasu arteritis","volume":"120","author":"Kerr","year":"1994","journal-title":"Ann. Intern. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"bcr2017220001","DOI":"10.1136\/bcr-2017-220001","article-title":"Takayasu arteritis presenting as embolic stroke","volume":"2017","author":"Field","year":"2017","journal-title":"BMJ Case Rep."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"287","DOI":"10.46497\/ArchRheumatol.2020.7402","article-title":"Takayasu Arteritis: A Case Presenting with Neurological Symptoms and Proteinuria","volume":"35","author":"Aydin","year":"2020","journal-title":"Arch. Rheumatol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1002\/art.1780330811","article-title":"The American College of Rheumatology 1990 criteria for the classification of Takayasu arteritis","volume":"33","author":"Arend","year":"1990","journal-title":"Arthritis Rheum."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1136\/ard-2022-223482","article-title":"DCVAS Study Group. 2022 American College of Rheumatology\/EULAR classification criteria for Takayasu arteritis","volume":"81","author":"Grayson","year":"2022","journal-title":"Ann. Rheum. Dis."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1136\/annrheumdis-2019-215672","article-title":"2018 Update of the EULAR recommendations for the management of large vessel vasculitis","volume":"79","author":"Hellmich","year":"2020","journal-title":"Ann. Rheum. Dis."},{"key":"ref_20","first-page":"263","article-title":"Takayasu\u2019s arteritis presenting as ischemic stroke\u2014Case report","volume":"52","author":"Khealani","year":"2002","journal-title":"J. Pak. Med. Assoc."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1038\/nrrheum.2010.82","article-title":"Takayasu arteritis\u2014Advances in diagnosis and management","volume":"6","author":"Mason","year":"2010","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Russo, R.A.G., and Katsicas, M.M. (2018). Takayasu Arteritis. Front. Pediatr., 6.","DOI":"10.3389\/fped.2018.00265"},{"key":"ref_23","first-page":"e11980","article-title":"Unsuccessful Endovascular Treatment in a Patient with Stroke Onset of Takayasu Arteritis and Positive Clinical Outcome","volume":"12","author":"Mangiardi","year":"2020","journal-title":"Cureus"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"132","DOI":"10.4103\/2152-7806.102947","article-title":"Takayasu\u2019s arteritis: Is it a reversible disease? Case Report and Literature Review","volume":"3","author":"Hedna","year":"2012","journal-title":"Surg. Neurol. Int."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"788","DOI":"10.2298\/VSP150717092K","article-title":"Relapse of Takayasu arteritis as a cause of suicidal poisoning and subsequent major ischemic stroke successfully treated with thrombolytic therapy","volume":"73","author":"Komatina","year":"2016","journal-title":"Vojnosanit. Pregl."},{"key":"ref_26","first-page":"665","article-title":"A Case of Takayasu Arteritis with Acute Bilateral Occlusion of the Internal Carotid Arteries","volume":"69","author":"Ebata","year":"2017","journal-title":"Brain Nerve"}],"container-title":["Neurology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2035-8377\/18\/3\/57\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T09:40:08Z","timestamp":1773826808000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2035-8377\/18\/3\/57"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,18]]},"references-count":26,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,3]]}},"alternative-id":["neurolint18030057"],"URL":"https:\/\/doi.org\/10.3390\/neurolint18030057","relation":{},"ISSN":["2035-8377"],"issn-type":[{"value":"2035-8377","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,18]]}}}