{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T09:28:12Z","timestamp":1785403692968,"version":"3.56.0"},"reference-count":26,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T00:00:00Z","timestamp":1775174400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["EXC 2145 SyNergy\u2014ID 390857198"],"award-info":[{"award-number":["EXC 2145 SyNergy\u2014ID 390857198"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["DFG SPP2177"],"award-info":[{"award-number":["DFG SPP2177"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"award":["EXC 2145 SyNergy\u2014ID 390857198"],"award-info":[{"award-number":["EXC 2145 SyNergy\u2014ID 390857198"]}],"id":[{"id":"https:\/\/ror.org\/018mejw64","id-type":"ROR","asserted-by":"publisher"}]},{"award":["DFG SPP2177"],"award-info":[{"award-number":["DFG SPP2177"]}],"id":[{"id":"https:\/\/ror.org\/018mejw64","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004563","name":"Bavarian State Ministry for Science and Art","doi-asserted-by":"publisher","award":["F.4-V0134.K5.1\/86\/34"],"award-info":[{"award-number":["F.4-V0134.K5.1\/86\/34"]}],"id":[{"id":"10.13039\/501100004563","id-type":"DOI","asserted-by":"publisher"}]},{"award":["F.4-V0134.K5.1\/86\/34"],"award-info":[{"award-number":["F.4-V0134.K5.1\/86\/34"]}],"id":[{"id":"https:\/\/ror.org\/01a44gd51","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurology International"],"abstract":"<jats:p>Background: Fever occurs frequently in patients with intracerebral hemorrhage (ICH) and is associated with worse functional outcomes. Rapid identification of the fever\u2019s cause is crucial for guiding diagnostics and treatment. Data on the distribution of different fever causes in ICH are limited, and the diagnostic value of the day of fever onset remains uncertain. This study aimed to assess the distribution of fever causes in a large cohort of ICH patients and to evaluate whether temporal patterns of fever onset are associated with its underlying cause in a clinically meaningful manner. Methods: This retrospective single-center study included 547 patients with spontaneous ICH. Fever was defined as a body temperature exceeding 38.3 \u00b0C for at least two consecutive days. Fever causes were evaluated by two blinded investigators and categorized as infectious, central, or other causes. Infectious fever causes were further specified. Results: Fever occurred in 213 patients (39%) and was associated with longer hospital and ICU stays (both p &lt; 0.01) and poor functional outcome (odds ratio 2.0, 95% CI 1.1\u20133.6). The three most frequent fever etiologies (&gt;90% of cases) were pneumonia, central fever, and catheter-associated infections (i.e., urethral tract infections, ventriculitis, and central line-associated bloodstream infections). Median onset day differed across etiologies (overall p &lt; 0.001): central fever developed earliest (2 [IQR 1\u20133] days), followed by pneumonia (5 [IQR 4\u20137] days) and catheter-associated infections (8 [IQR 5\u201312] days). Conclusions: In ICH, the day of fever onset may provide a useful clue to its etiology and could support clinical decision-making, but prospective validation is needed.<\/jats:p>","DOI":"10.3390\/neurolint18040068","type":"journal-article","created":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T04:10:27Z","timestamp":1775448627000},"page":"68","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Temporal Patterns of Fever Onset as an Indicator of Etiology in Intracerebral Hemorrhage"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-1052-1088","authenticated-orcid":false,"given":"Felix","family":"Hess","sequence":"first","affiliation":[{"name":"Department of Neurology, School of Medicine and Health, Technical University of Munich, 81675 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4766-2781","authenticated-orcid":false,"given":"Enayatullah","family":"Baki","sequence":"additional","affiliation":[{"name":"Department of Neurology, School of Medicine and Health, Technical University of Munich, 81675 Munich, Germany"},{"name":"Department of Anesthesiology and Intensive Care Medicine, School of Medicine and Health, Technical University of Munich, 80333 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2224-7600","authenticated-orcid":false,"given":"Julian","family":"McGinnis","sequence":"additional","affiliation":[{"name":"Department of Neurology, School of Medicine and Health, Technical University of Munich, 81675 Munich, Germany"},{"name":"Department of Computer Science, School of Computation, Information and Technology, Technical University of Munich, 80333 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tun","family":"Wiltgen","sequence":"additional","affiliation":[{"name":"Department of Neurology, School of Medicine and Health, Technical University of Munich, 81675 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Scholz","sequence":"additional","affiliation":[{"name":"Department of Neurology, School of Medicine and Health, Technical University of Munich, 81675 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9295-2580","authenticated-orcid":false,"given":"Kathleen","family":"Bernkopf","sequence":"additional","affiliation":[{"name":"Department of Neurology, School of Medicine and Health, Technical University of Munich, 81675 Munich, Germany"},{"name":"Department of Anesthesiology and Intensive Care Medicine, School of Medicine and Health, Technical University of Munich, 80333 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Schneider","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Medicine, School of Medicine and Health, Technical University of Munich, 80333 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7557-0003","authenticated-orcid":false,"given":"Jan","family":"Kirschke","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Neuroradiology, School of Medicine and Health, Technical University of Munich, 80333 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik","family":"Sepp","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Neuroradiology, School of Medicine and Health, Technical University of Munich, 80333 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Hemmer","sequence":"additional","affiliation":[{"name":"Department of Neurology, School of Medicine and Health, Technical University of Munich, 81675 Munich, Germany"},{"name":"Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silke","family":"Wunderlich","sequence":"additional","affiliation":[{"name":"Department of Neurology, School of Medicine and Health, Technical University of Munich, 81675 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9545-2709","authenticated-orcid":false,"given":"Mark","family":"M\u00fchlau","sequence":"additional","affiliation":[{"name":"Department of Neurology, School of Medicine and Health, Technical University of Munich, 81675 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1212\/WNL.54.2.354","article-title":"Incidence and prognostic significance of fever following intracerebral hemorrhage","volume":"54","author":"Schwarz","year":"2000","journal-title":"Neurology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"3535","DOI":"10.1161\/STROKEAHA.114.006435","article-title":"Infection after intracerebral hemorrhage: Risk factors and association with outcomes in the ethnic\/racial variations of intracerebral hemorrhage study","volume":"45","author":"Lord","year":"2014","journal-title":"Stroke"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"3029","DOI":"10.1161\/STROKEAHA.108.521583","article-title":"Impact of fever on outcome in patients with stroke and neurologic injury: A comprehensive meta-analysis","volume":"39","author":"Greer","year":"2008","journal-title":"Stroke"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/S0140-6736(96)90008-2","article-title":"Body temperature in acute stroke: Relation to stroke severity, infarct size, mortality, and outcome","volume":"347","author":"Reith","year":"1996","journal-title":"Lancet"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1001\/jama.2024.14745","article-title":"Fever Prevention in Patients With Acute Vascular Brain Injury: The INTREPID Randomized Clinical Trial","volume":"332","author":"Greer","year":"2024","journal-title":"JAMA"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1161\/01.STR.29.2.529","article-title":"Combating Hyperthermia in Acute Stroke","volume":"29","author":"Ginsberg","year":"1998","journal-title":"Stroke"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"106165","DOI":"10.1016\/j.clineuro.2020.106165","article-title":"Temperature management in acute brain injury: A systematic review of clinical evidence","volume":"197","author":"Pegoli","year":"2020","journal-title":"Clin. Neurol. Neurosurg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/j.jstrokecerebrovasdis.2017.01.007","article-title":"Factors Associated with Fever in Intracerebral Hemorrhage","volume":"26","author":"Gillow","year":"2017","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Honig, A., Michael, S., Eliahou, R., and Leker, R.R. (2015). Central fever in patients with spontaneous intracerebral hemorrhage: Predicting factors and impact on outcome. BMC Neurol., 15.","DOI":"10.1186\/s12883-015-0258-8"},{"key":"ref_10","first-page":"1499","article-title":"Indicators of central fever in the neurologic intensive care unit","volume":"70","author":"Hocker","year":"2013","journal-title":"JAMA Neurol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1159\/000222778","article-title":"Central hyperthermia in acute stroke","volume":"62","author":"Sung","year":"2009","journal-title":"Eur. Neurol."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Hess, F., Baki, E., McGinnis, J., Wiltgen, T., Scholz, H., Bernkopf, K., Schneider, G., Kirschke, J.S., Sepp, D., and Hemmer, B. (2025). Differentiating central fever from infectious fever in intracerebral haemorrhage. Stroke Vasc. Neurol.","DOI":"10.1136\/svn-2025-004441"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"W\u00e4stfelt, M., Cao, Y., and Str\u00f6m, J.O. (2018). Predictors of post-stroke fever and infections: A systematic review and meta-analysis. BMC Neurol., 18.","DOI":"10.1186\/s12883-018-1046-z"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1136\/jnnp.2006.112730","article-title":"Non-infectious fever in the neurological intensive care unit: Incidence, causes and predictors","volume":"78","author":"Rabinstein","year":"2007","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.ajic.2008.03.002","article-title":"CDC\/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting","volume":"36","author":"Horan","year":"2008","journal-title":"Am. J. Infect. Control"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/s41592-020-01008-z","article-title":"nnU-Net: A self-configuring method for deep learning-based biomedical image segmentation","volume":"18","author":"Isensee","year":"2021","journal-title":"Nat. Methods"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e220096","DOI":"10.1148\/ryai.220096","article-title":"Semantic Segmentation of Spontaneous Intracerebral Hemorrhage, Intraventricular Hemorrhage, and Associated Edema on CT Images Using Deep Learning","volume":"4","author":"Kok","year":"2022","journal-title":"Radiol. Artif. Intell."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s00062-025-01498-4","article-title":"Predictors and Implications of Myocardial Injury in Intracerebral Hemorrhage","volume":"35","author":"Hess","year":"2025","journal-title":"Clin. Neuroradiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1161\/01.STR.32.4.891","article-title":"The ICH score: A simple, reliable grading scale for intracerebral hemorrhage","volume":"32","author":"Hemphill","year":"2001","journal-title":"Stroke"},{"key":"ref_20","first-page":"422","article-title":"Predictors of mortality and poor functional outcome in severe spontaneous intracerebral hemorrhage: A prospective observational study","volume":"39","author":"Godoy","year":"2015","journal-title":"Med. Intensiva"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0891-5520(05)70288-9","article-title":"Fever in the elderly","volume":"10","author":"Norman","year":"1996","journal-title":"Infect. Dis. Clin. N. Am."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Ding, Y., Yan, Y., Niu, J., Zhang, Y., Gu, Z., Tang, P., and Liu, Y. (2019). Braden scale for assessing pneumonia after acute ischaemic stroke. BMC Geriatr., 19.","DOI":"10.1186\/s12877-019-1269-x"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Lindner, A., Kofler, M., Rass, V., Ianosi, B., Gaasch, M., Schiefecker, A.J., Beer, R., Loveys, S., Rhomberg, P., and Pfausler, B. (2019). Early Predictors for Infectious Complications in Patients With Spontaneous Intracerebral Hemorrhage and Their Impact on Outcome. Front. Neurol., 10.","DOI":"10.3389\/fneur.2019.00817"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/S0003-9993(98)90200-3","article-title":"Aspiration in patients with acute stroke","volume":"79","author":"Daniels","year":"1998","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Warusevitane, A., Karunatilake, D., Sim, J., Smith, C., and Roffe, C. (2016). Early Diagnosis of Pneumonia in Severe Stroke: Clinical Features and the Diagnostic Role of C-Reactive Protein. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0150269"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2921","DOI":"10.1161\/STROKEAHA.120.032615","article-title":"Association of Lesion Pattern and Dysphagia in Acute Intracerebral Hemorrhage","volume":"52","author":"Hess","year":"2021","journal-title":"Stroke"}],"container-title":["Neurology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2035-8377\/18\/4\/68\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T04:10:41Z","timestamp":1775535041000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2035-8377\/18\/4\/68"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,3]]},"references-count":26,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,4]]}},"alternative-id":["neurolint18040068"],"URL":"https:\/\/doi.org\/10.3390\/neurolint18040068","relation":{},"ISSN":["2035-8377"],"issn-type":[{"value":"2035-8377","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,3]]}}}