{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T22:47:36Z","timestamp":1777762056336,"version":"3.51.4"},"reference-count":21,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurology International"],"abstract":"<jats:p>Background\/Objectives: The Individualized Neuromuscular Quality-of-Life Questionnaire (INQoL) is a widely used measure of quality of life in patients with various neuromuscular diseases. This study aimed to adapt and test the validity and reliability of this measure in Hungarian patients with neuromuscular disease. Methods: According to the widely accepted method of validation, we first translated the original INQoL version into Hungarian, and then a native English speaker translated it back into English to test its validity. Following a pretest procedure, the INQoL was administered to 80 patients with various muscular diseases and 30 age-matched controls. The internal consistency and test\u2013retest reliability were assessed. Concurrent validity was measured using the 36-item Short Form Survey (SF-36) questionnaire. Results: For all INQoL subscales, Cronbach\u2019s alpha was above 0.7, demonstrating the reliability of the subscales. The highest Cronbach alpha value was for the Weakness subscale (0.983) and the lowest for the Treatment subscale (0.794). The intraclass correlation coefficient test values ranged from 0.810 (Treatment) to 0.988 (Pain), indicating excellent test\u2013retest reliability. There was a strong correlation between the SF-36 Physical Function and multiple INQoL subscales, including Weakness (r = 0.754, p &lt; 0.001), Fatigue (r = 0.704, p &lt; 0.001), Activities (r = 0.744) p &lt; 0.001, Independence (r = 0.791 p &lt; 0.001), Body Image (r = 0.714 p &lt; 0.001), and overall Quality of Life (r = 0.742 p &lt; 0.001). Conclusions: Our findings indicate that the Hungarian-language adaptation of the questionnaire possesses adequate reliability and construct validity for assessing the quality of life in patients with muscular disorders.<\/jats:p>","DOI":"10.3390\/neurolint18050082","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T13:32:22Z","timestamp":1777469542000},"page":"82","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hungarian Validation of the Individualized Neuromuscular Quality-of-Life Questionnaire (INQoL) in Adult Patients with Muscular Diseases"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-3430-2725","authenticated-orcid":false,"given":"Brigitta","family":"Ruszin-Perecz","sequence":"first","affiliation":[{"name":"Department of Neurology, Medical School, University of P\u00e9cs, 7623 P\u00e9cs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R\u00e9ka","family":"H\u00e9jas","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical School, University of P\u00e9cs, 7623 P\u00e9cs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1907-120X","authenticated-orcid":false,"given":"Alexandra","family":"Makai","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, University of P\u00e9cs, 7621 P\u00e9cs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4012-4932","authenticated-orcid":false,"given":"N\u00e1ndor","family":"Hajdu","sequence":"additional","affiliation":[{"name":"Institute of Psychology, E\u00f6tv\u00f6s Lor\u00e1nd University, 1053 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dalma","family":"Jedlicska","sequence":"additional","affiliation":[{"name":"Department of Primary Health Care, University of P\u00e9cs, 7623 P\u00e9cs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bence","family":"Ruszin-Perecz","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical School, University of P\u00e9cs, 7623 P\u00e9cs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Sipos","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical School, University of P\u00e9cs, 7623 P\u00e9cs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6525-0754","authenticated-orcid":false,"given":"Endre","family":"P\u00e1l","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical School, University of P\u00e9cs, 7623 P\u00e9cs, Hungary"},{"name":"Neuropathology Unit, Department of Pathology, University of P\u00e9cs, 7624 P\u00e9cs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D\u00e1vid","family":"Varga","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical School, University of P\u00e9cs, 7623 P\u00e9cs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"695","DOI":"10.3390\/brainsci15070695","article-title":"Living with Duchenne Muscular Dystrophy Beyond the Physical Implications: Cognitive Features, Psychopathology Aspects, and Psychosocial Re-sources-A Narrative Review","volume":"15","author":"Tizzoni","year":"2025","journal-title":"Brain Sci."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/S1474-4422(12)70204-1","article-title":"The myotonic dystrophies: Molecular, clinical, and therapeutic challenges","volume":"11","author":"Udd","year":"2012","journal-title":"Lancet Neurol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1097\/WCO.0000000000000739","article-title":"Update in Duchenne and Becker muscular dystrophy","volume":"32","author":"Waldrop","year":"2019","journal-title":"Curr. Opin. Neurol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s13023-022-02241-9","article-title":"Healthcare resource utilization, total costs, and comorbidities among patients with myotonic dystrophy using U.S. insurance claims data from 2012 to 2019","volume":"17","author":"Howe","year":"2022","journal-title":"Orphanet J. Rare Dis."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/978-90-481-9485-8_15","article-title":"Quality of life and rare diseases","volume":"686","author":"Rajmil","year":"2010","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Bonfield, B., Veighey, K., Blakeman, T., Murphy, E., and Vassilev, I.I. (2025). The role of social networks in supporting self-management in CKD: A narrative synthesis. BMC Nephrol., 27.","DOI":"10.1186\/s12882-025-04658-3"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"337","DOI":"10.3109\/07853890109002087","article-title":"EQ-5D: A measure of health status from the EuroQol Group","volume":"33","author":"Rabin","year":"2001","journal-title":"Ann. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"336","DOI":"10.2165\/00019053-199610040-00004","article-title":"A review of the progress towards developing health-related quality-of-life instruments for international clinical studies and outcomes research","volume":"10","author":"Anderson","year":"1996","journal-title":"Pharmacoeconomics"},{"key":"ref_9","first-page":"4","article-title":"P\u00e1ciens megel\u00e9gedetts\u00e9gi vizsg\u00e1lat SF-36 k\u00e9rd\u0151\u00edvvel, a magyarorsz\u00e1gi norm\u00e1l\u00e9rt\u00e9kek meghat\u00e1roz\u00e1sa","volume":"80","author":"Czimbalmos","year":"1999","journal-title":"N\u00e9peg\u00e9szs\u00e9g\u00fcgy"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s12955-025-02343-5","article-title":"Development of updated population norms for the SF-36 for Hungary and com-parison with 1997\u20131998 norms","volume":"23","author":"Brodszky","year":"2025","journal-title":"Health Qual. Life Outcomes"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1212\/01.wnl.0000257819.47628.41","article-title":"Construction and validation of a quality of life ques-tionnaire for neuromuscular disease (INQoL)","volume":"68","author":"Vincent","year":"2007","journal-title":"Neurology"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1111\/j.1468-1331.2010.02992.x","article-title":"Italian validation of INQoL, a quality of life questionnaire for adults with muscle diseases","volume":"17","author":"Sansone","year":"2010","journal-title":"Eur. J. Neurol."},{"key":"ref_13","first-page":"153","article-title":"Serbian validation of the Individualized Neuromuscular Quality of Life Questionnaire (INQoL) in adults with myotonic dystrophy type 1","volume":"1","author":"Peric","year":"2011","journal-title":"J. Neurol. Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1002\/mus.26071","article-title":"Validation of The Individualized Neuromuscular Quality of Life in Japanese patients with myotonic dystrophy","volume":"58","author":"Fujino","year":"2018","journal-title":"Muscle Nerve"},{"key":"ref_15","first-page":"194","article-title":"Translation and validation of the Individualized Neuromuscular Quality of Life scale for the Spanish population: Quality of life assessment for persons with neuromuscular diseases","volume":"64","author":"Fagoaga","year":"2017","journal-title":"Rev. Neurol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"514","DOI":"10.3988\/jcn.2022.18.5.514","article-title":"Validation of the Individualized Neuromuscular Quality of Life Questionnaire in Korean Patients with Genetic Neuromuscular Diseases","volume":"18","author":"Han","year":"2022","journal-title":"J. Clin. Neurol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1002\/mus.24337","article-title":"The individualized neu-romuscular quality of life questionnaire: Cultural translation and psychometric validation for the Dutch population","volume":"51","author":"Seesing","year":"2015","journal-title":"Muscle Nerve"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/1477-7525-9-114","article-title":"Muscle Study Group. Validation of the individualized neuromuscular quality of life for the USA with comparison of the impact of muscle disease on those living in USA versus UK","volume":"9","author":"Sadjadi","year":"2011","journal-title":"Health Qual. Life Outcomes"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1016\/0895-4356(93)90142-N","article-title":"Cross-cultural adaptation of health-related quality of life measures: Literature review and proposed guidelines","volume":"46","author":"Guillemin","year":"1993","journal-title":"J. Clin. Epidemiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"53","DOI":"10.5116\/ijme.4dfb.8dfd","article-title":"Making sense of Cronbach\u2019s alpha","volume":"2","author":"Tavakol","year":"2011","journal-title":"Int. J. Med. Educ."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jcm.2016.02.012","article-title":"A guideline of selecting and reporting intraclass correlation coefficients for reliability research","volume":"15","author":"Koo","year":"2016","journal-title":"J. Chiropr. Med."}],"container-title":["Neurology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2035-8377\/18\/5\/82\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T14:25:09Z","timestamp":1777472709000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2035-8377\/18\/5\/82"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,28]]},"references-count":21,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,5]]}},"alternative-id":["neurolint18050082"],"URL":"https:\/\/doi.org\/10.3390\/neurolint18050082","relation":{},"ISSN":["2035-8377"],"issn-type":[{"value":"2035-8377","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,28]]}}}