{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T11:13:46Z","timestamp":1780053226735,"version":"3.54.0"},"reference-count":21,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurology International"],"abstract":"<jats:p>Background\/Objectives: Attention-deficit\/hyperactivity disorder (ADHD) is increasingly recognized as a neurodevelopmental condition shaped by early-life biological and environmental factors. Emerging evidence highlights the role of nutrition in modulating key brain processes involved in ADHD, from gestational development through childhood. This review aims to examine how dietary interventions influence neuroimaging outcomes in individuals with ADHD, assessing whether nutritional approaches can modulate brain structure, function, or connectivity. Methods: A systematic search of PubMed, Scopus, and Web of Science was conducted to identify studies examining the effects of dietary interventions on neuroimaging outcomes in individuals with ADHD. Study quality was assessed using Cochrane RoB 2.0, ROBINS-I, the Newcastle\u2013Ottawa Scale, and the JBI Critical Appraisal Checklist, according to study design. Results: A total of 1059 records were identified, and 4 studies met the final inclusion criteria. The included studies suggest that prenatal vitamin D exposure, omega-3 fatty acids, and micronutrients such as zinc may be associated with structural, functional, and neurometabolic brain characteristics relevant to ADHD. Reported findings included associations with brain volume, glutamatergic regulation, white matter organization, resting-state network integrity, and inattentive symptom. Conclusions: Current evidence supports the hypothesis that nutrition may influence neurodevelopmental processes involved in ADHD, including brain maturation and neural network organization. Although findings remain heterogeneous and limited in number, nutrition appears to represent a biologically plausible and potentially modifiable factor within the developmental framework of ADHD. Further longitudinal and multimodal neuroimaging studies are needed to clarify the mechanisms linking nutrition, brain development, and ADHD.<\/jats:p>","DOI":"10.3390\/neurolint18060107","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T10:06:56Z","timestamp":1780049216000},"page":"107","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Nutritional Influences on the Brain in ADHD: Evidence from Neuroimaging Studies"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5078-6636","authenticated-orcid":false,"given":"Daniele","family":"Corbo","sequence":"first","affiliation":[{"name":"Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, 25123 Brescia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Gasparotti","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, 25123 Brescia, Italy"},{"name":"Neuroradiology Unit, ASST Spedali Civili of Brescia, 25123 Brescia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8464-5927","authenticated-orcid":false,"given":"Francesca","family":"Bozzetti","sequence":"additional","affiliation":[{"name":"Neuroradiology Unit, Diagnostic Department, University Hospital of Parma, 43121 Parma, Italy"},{"name":"Department of Medicine and Surgery, University of Parma, 43121 Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4467-765X","authenticated-orcid":false,"given":"Stefano","family":"Renzetti","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, University of Parma, 43121 Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8174-5394","authenticated-orcid":false,"given":"Laura Clara","family":"Grandi","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine, University of Florence, 50134 Florence, Italy"},{"name":"Department of Biotechnology and Biosciences and NeuroMI (Milan Center for Neuroscience), University of Milano-Bicocca, 20126 Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3621-6394","authenticated-orcid":false,"given":"Antonio","family":"Vita","sequence":"additional","affiliation":[{"name":"Department of Mental Health and Addiction Services, ASST Spedali Civili of Brescia, 25123 Brescia, Italy"},{"name":"Department of Clinical and Experimental Sciences, University of Brescia, 25123 Brescia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Deste","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Sciences, University of Brescia, 25123 Brescia, Italy"},{"name":"Department of Mental Health and Addiction Services, ASST Valcamonica, 25040 Esine, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"22205","DOI":"10.1038\/s41598-021-01684-7","article-title":"Correlation between brain function and ADHD symptom changes in children with ADHD following a few-foods diet: An open-label intervention trial","volume":"11","author":"Hontelez","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.cofs.2015.01.005","article-title":"Impact of diet on the human intestinal microbiota","volume":"2","author":"Tan","year":"2015","journal-title":"Curr. Opin. Food Sci."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Wall, R., Cryan, J.F., Ross, R.P., Fitzgerald, G.F., Dinan, T.G., and Stanton, C. (2014). Bacterial neuroactive compounds produced by psychobiotics. Microbial Endocrinology: The Microbiota-Gut-Brain Axis in Health and Disease, Springer.","DOI":"10.1007\/978-1-4939-0897-4_10"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Corbo, D., and Grandi, L.C. (2026). Neurobiological Convergence in SPDs and ADHD: Insights from a Narrative Review. Biology, 15.","DOI":"10.3390\/biology15020198"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1111\/cch.12139","article-title":"ADHD: An updated review of the essential facts","volume":"40","author":"Tarver","year":"2014","journal-title":"Child Care Health Dev."},{"key":"ref_6","first-page":"PCC.12f01472","article-title":"Using stimulants for attention-deficit\/hyperactivity disorder: Clinical approaches and challenges","volume":"15","author":"Stevens","year":"2013","journal-title":"Prim. Care Companion CNS Disord."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Nyaradi, A., Li, J., Hickling, S., Foster, J., and Oddy, W.H. (2013). The role of nutrition in children\u2019s neurocognitive development, from pregnancy through childhood. Front. Hum. Neurosci., 7.","DOI":"10.3389\/fnhum.2013.00097"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.3945\/ajcn.111.030791","article-title":"Maternal folate status in early pregnancy and child emotional and behavioral problems: The Generation R Study","volume":"95","author":"Roza","year":"2012","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"You, W., Li, Q., Chen, L., He, N., Li, Y., Long, F., Wang, Y., Chen, Y., McNamara, R.K., and Sweeney, J.A. (2024). Common and distinct cortical thickness alterations in youth with autism spectrum disorder and attention-deficit\/hyperactivity disorder. BMC Med., 22.","DOI":"10.1186\/s12916-024-03313-2"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"19649","DOI":"10.1073\/pnas.0707741104","article-title":"Attention-deficit\/hyperactivity disorder is characterized by a delay in cortical maturation","volume":"104","author":"Shaw","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_11","unstructured":"Excellence NIfHaC Clinical Guideline 72 (2008). Attention Deficit Hyperactivity Disorder: Diagnosis and Management of ADHD in Children, Young People and Adults, National Institute for Health and Clinical Excellence."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"van Rooij, D., Mou, Y., White, T., Voortman, T., Jansen, P.W., and Buitelaar, J.K. (2025). Prenatal Vitamin D, Multivitamin, and Folic Acid Supplementation and Brain Structure in Children with ADHD and ASD Traits: The Generation R Study. Nutrients, 17.","DOI":"10.3390\/nu17182979"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: An updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"d5928","DOI":"10.1136\/bmj.d5928","article-title":"The Cochrane Collaboration\u2019s tool for assessing risk of bias in randomised trials","volume":"343","author":"Higgins","year":"2011","journal-title":"BMJ"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1080\/1028415X.2019.1574329","article-title":"Resting-state networks and neurometabolites in children with ADHD after 10 weeks of treatment with micronutrients: Results of a randomised placebo-controlled trial","volume":"23","author":"Borlase","year":"2020","journal-title":"Nutr. Neurosci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2298","DOI":"10.1038\/npp.2015.73","article-title":"Reduced Symptoms of Inattention after Dietary Omega-3 Fatty Acid Supplementation in Boys with and without Attentin Deficit\/Hyperactivity Disorder","volume":"40","author":"Bos","year":"2015","journal-title":"Neuropsychopharmacology"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1177\/13623613251326702","article-title":"Effects of micronutrients on neurodevelopmental disorders through the mediation of brain structure and function: A two-step Mendelian randomization analysis","volume":"29","author":"Li","year":"2025","journal-title":"Autism"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"e71240","DOI":"10.1002\/hsr2.71240","article-title":"Neural Correlates of Eating Habits and Nutritional Behaviors in the General Population: A Systematic Review of Observational Studies","volume":"8","author":"Soleymani","year":"2025","journal-title":"Health Sci. Rep."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/s44220-024-00226-0","article-title":"Associations of dietary patterns with brain health from behavioral, neuroimaging, biochemical and genetic analyses","volume":"2","author":"Zhang","year":"2024","journal-title":"Nat. Ment. Health"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s13668-023-00487-8","article-title":"Nutrition in the Management of ADHD: A Review of Recent Research","volume":"12","author":"Lange","year":"2023","journal-title":"Curr. Nutr. Rep."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e029422","DOI":"10.1136\/bmjopen-2019-029422","article-title":"Biomarker Research in ADHD: The Impact of Nutrition (BRAIN)-study protocol of an open-label trial to investigate the mechanisms underlying the effects of a few-foods diet on ADHD symptoms in children","volume":"9","author":"Stobernack","year":"2019","journal-title":"BMJ Open"}],"container-title":["Neurology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2035-8377\/18\/6\/107\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T10:50:00Z","timestamp":1780051800000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2035-8377\/18\/6\/107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,29]]},"references-count":21,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["neurolint18060107"],"URL":"https:\/\/doi.org\/10.3390\/neurolint18060107","relation":{},"ISSN":["2035-8377"],"issn-type":[{"value":"2035-8377","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,29]]}}}