{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T08:40:35Z","timestamp":1785400835660,"version":"3.56.0"},"reference-count":14,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","award":["304623\/2025-3"],"award-info":[{"award-number":["304623\/2025-3"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","award":["406484\/2022-8"],"award-info":[{"award-number":["406484\/2022-8"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"award":["304623\/2025-3"],"award-info":[{"award-number":["304623\/2025-3"]}],"id":[{"id":"https:\/\/ror.org\/03swz6y49","id-type":"ROR","asserted-by":"publisher"}]},{"award":["406484\/2022-8"],"award-info":[{"award-number":["406484\/2022-8"]}],"id":[{"id":"https:\/\/ror.org\/03swz6y49","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Children\u2019s Cancer Institute"},{"name":"Center for Anatomo-Pathological Diagnosis"},{"DOI":"10.13039\/501100003593","name":"CNPq\/SETEC\/MCTI","doi-asserted-by":"publisher","award":["441938\/2024-8"],"award-info":[{"award-number":["441938\/2024-8"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["307616\/2023-1"],"award-info":[{"award-number":["307616\/2023-1"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurology International"],"abstract":"<jats:p>Introduction: A subependymal giant cell astrocytoma (SEGA) is a benign tumor typically associated with tuberous sclerosis complex (TSC), an autosomal dominant syndrome. Case report: The patient, a 15-year-old male, presented with headaches, nausea, and visual obscurations, consistent with increased intracranial pressure. Neuroimaging identified a mass in the anterior left lateral ventricle causing unilateral obstruction at the foramen of Monro. During microsurgery, smears showed a low-grade glial tumor with a biphasic mix of elongated astrocytes and large epithelioid-to-gemistocyte-like cells. Gross total resection was achieved. On permanent sections, a tumor with large polygonal, ganglioid, and gemistocytic-like cells was seen. Nuclear pleomorphism, a feature of SEGA, was present. On immunohistochemistry, the tumor was positive for glial fibrillary acidic protein (GFAP), S100, and CD34, and the cells also displayed nuclear staining for TTF-1. A diagnosis of SEGA in the absence of clinical features of TSC was established; however, definitive classification as sporadic remains limited by the lack of molecular data. Conclusions: This case highlights the importance of evaluating intraventricular masses through the integration of lineage-specific immunohistochemical panels to prevent misclassification of pleomorphic giant cells as high-grade gliomas.<\/jats:p>","DOI":"10.3390\/neurolint18070135","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T05:32:01Z","timestamp":1784007121000},"page":"135","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Subependymal Giant Cell Astrocytoma Without Clinical Evidence of Tuberous Sclerosis Complex: Diagnostic and Molecular Insights\u2014Case Report"],"prefix":"10.3390","volume":"18","author":[{"given":"Jos\u00e9 Guilherme Jasper","family":"Pickler","sequence":"first","affiliation":[{"name":"Department of Scientific Development and Innovation (DECIPE), Center for Anatomo-Pathological Diagnosis (CEDAP), Joinville 89201-330, Brazil"},{"name":"Graduate Program in Health and Environment, University of the Joinville Region (UNIVILLE), Joinville 89219-710, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herc\u00edlio","family":"Fronza Junior","sequence":"additional","affiliation":[{"name":"Department of Scientific Development and Innovation (DECIPE), Center for Anatomo-Pathological Diagnosis (CEDAP), Joinville 89201-330, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis Rossetti","family":"Pedack","sequence":"additional","affiliation":[{"name":"Department of Scientific Development and Innovation (DECIPE), Center for Anatomo-Pathological Diagnosis (CEDAP), Joinville 89201-330, Brazil"},{"name":"Graduate Program in Health and Environment, University of the Joinville Region (UNIVILLE), Joinville 89219-710, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa Andrade","family":"Gabardo","sequence":"additional","affiliation":[{"name":"Department of Scientific Development and Innovation (DECIPE), Center for Anatomo-Pathological Diagnosis (CEDAP), Joinville 89201-330, Brazil"},{"name":"Department of Teaching and Research, Hospital Municipal S\u00e3o Jos\u00e9, Joinville 89202-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel Coelho","family":"Barros","sequence":"additional","affiliation":[{"name":"Department of Scientific Development and Innovation (DECIPE), Center for Anatomo-Pathological Diagnosis (CEDAP), Joinville 89201-330, Brazil"},{"name":"Department of Teaching and Research, Hospital Municipal S\u00e3o Jos\u00e9, Joinville 89202-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzana Bastos","family":"Batista","sequence":"additional","affiliation":[{"name":"Department of Scientific Development and Innovation (DECIPE), Center for Anatomo-Pathological Diagnosis (CEDAP), Joinville 89201-330, Brazil"},{"name":"Department of Teaching and Research, Hospital Municipal S\u00e3o Jos\u00e9, Joinville 89202-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruna Louise","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Scientific Development and Innovation (DECIPE), Center for Anatomo-Pathological Diagnosis (CEDAP), Joinville 89201-330, Brazil"},{"name":"Department of Mechanical Engineering, Center for Technological Sciences, Graduate Program in Materials Science and Engineering, Universidade do Estado de Santa Caratina (UDESC), Joinville 89219-710, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1750-9132","authenticated-orcid":false,"given":"Paulo Henrique Condeixa","family":"de Fran\u00e7a","sequence":"additional","affiliation":[{"name":"Graduate Program in Health and Environment, University of the Joinville Region (UNIVILLE), Joinville 89219-710, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6016-2261","authenticated-orcid":false,"given":"Rafael","family":"Roesler","sequence":"additional","affiliation":[{"name":"National Science and Technology Institute for Children\u2019s Cancer Biology and Pediatric Oncology\u2014INCT BioOncoPed, Porto Alegre 90035-003, Brazil"},{"name":"Department of Pharmacology, Institute for Basic Health Sciences, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre 90035-003, Brazil"},{"name":"Cancer and Neurobiology Laboratory, Experimental Research Center, Clinical Hospital (CPE-HCPA), Federal University of Rio Grande do Sul, Porto Alegre 90035-903, Brazil"},{"name":"Center for Biotechnology, Federal University of Rio Grande do Sul, Porto Alegre 91501-970, Brazil"},{"name":"Graduate Program in Medical Sciences, Faculty of Medicine, Federal University of Rio Grande do Sul, Porto Alegre 90035-003, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina Munhoz de Paula Alves","family":"Coelho","sequence":"additional","affiliation":[{"name":"Department of Scientific Development and Innovation (DECIPE), Center for Anatomo-Pathological Diagnosis (CEDAP), Joinville 89201-330, Brazil"},{"name":"Graduate Program in Health and Environment, University of the Joinville Region (UNIVILLE), Joinville 89219-710, Brazil"},{"name":"National Science and Technology Institute for Children\u2019s Cancer Biology and Pediatric Oncology\u2014INCT BioOncoPed, Porto Alegre 90035-003, Brazil"},{"name":"Graduate Program in Medical Sciences, Faculty of Medicine, Federal University of Rio Grande do Sul, Porto Alegre 90035-003, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,14]]},"reference":[{"key":"ref_1","unstructured":"WHO Classification of Tumours Editorial Board (2021). 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