{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T09:26:45Z","timestamp":1787218005544,"version":"build-2736575974"},"reference-count":15,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurol. Int.","Neurology International"],"abstract":"<jats:p>Background\/Objectives: Brain-derived neurotrophic factor (BDNF) and antioxidant networks mediated by Selenoprotein P (SEPP1) are core drivers of structural neuroplasticity and blood\u2013brain barrier integrity, yet their co-regulatory behavior during subacute stroke neurorehabilitation remains poorly understood. This pilot study quantified concurrent changes in serum BDNF and SEPP1 during rehabilitation. Methods: Sixteen subacute post-stroke patients with mild stroke severity were assigned to an intensive multi-modal neurorehabilitation protocol incorporating high-intensity interval training (Treated, n = 7) or standard care (Control, n = 9); the biomarker sampling window averaged 73.4 days. Fasting venous blood was collected at baseline and post-intervention and analyzed by ELISA. Results: BDNF changes (\u0394BDNF) differed significantly between arms (U = 57.0, p = 0.0081): the Treated cohort showed a uniform decrease (mean \u0394: \u22120.240 \u00b1 0.103 ng\/mL), while Controls showed stabilization or a slight increase (mean \u0394: +0.118 \u00b1 0.339 ng\/mL). \u0394BDNF and \u0394SEPP1 were significantly, positively correlated across the cohort (\u03c1 = 0.596, p = 0.015). Conclusions: The BDNF decline in the Treated group is consistent with the \u201ccentral sink\u201d hypothesis, but may more plausibly reflect stress\/cortisol-mediated suppression induced by the high training intensity, contrasting with increases typically reported after moderate-intensity subacute-phase exercise. The collinear coupling with SEPP1 suggests a link between neurotrophic synthesis and antioxidant buffering during post-stroke tissue remodeling, though this correlational finding does not by itself establish a single, coordinated mechanism.<\/jats:p>","DOI":"10.3390\/neurolint18080154","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T08:10:20Z","timestamp":1787213420000},"page":"154","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dynamics of Circulating Brain-Derived Neurotrophic Factor and Selenoprotein P in Subacute Stroke Patients Undergoing High-Intensity Interval Training-Based Neurorehabilitation: A Pilot Observational Study"],"prefix":"10.3390","volume":"18","author":[{"given":"Hunor-P\u00e1l","family":"Fodor","sequence":"first","affiliation":[{"name":"Faculty of Natural Sciences, University of P\u00e9cs, Ifj\u00fas\u00e1g \u00fatja 6., 7624 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Be\u00e1ta","family":"Albert","sequence":"additional","affiliation":[{"name":"Faculty of Natural Sciences, University of P\u00e9cs, Ifj\u00fas\u00e1g \u00fatja 6., 7624 P\u00e9cs, Hungary"},{"name":"Faculty of Economics, Socio-Human Sciences and Engineering, Sapientia Hungarian University of Transylvania, 530104 Miercurea Ciuc, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6803-1212","authenticated-orcid":false,"given":"P\u00e1l","family":"Salamon","sequence":"additional","affiliation":[{"name":"Faculty of Natural Sciences, University of P\u00e9cs, Ifj\u00fas\u00e1g \u00fatja 6., 7624 P\u00e9cs, Hungary"},{"name":"Faculty of Economics, Socio-Human Sciences and Engineering, Sapientia Hungarian University of Transylvania, 530104 Miercurea Ciuc, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.apmr.2022.12.141","article-title":"Relationship of Changes in Circulating BDNF and Motor Impairment Following a Stroke Rehabilitation Intervention","volume":"104","author":"Williams","year":"2023","journal-title":"Arch. 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