{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T10:22:36Z","timestamp":1787566956896,"version":"build-2736575974"},"reference-count":33,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurol. Int.","Neurology International"],"abstract":"<jats:p>Background: Progressive supranuclear palsy (PSP) is a primary 4-repeat tauopathy in which neurodegeneration may be accompanied by neuroinflammatory and peripheral immune alterations. Whether peripheral inflammatory activity reflects structural degeneration within vulnerable brain networks remains unclear. Methods: This retrospective case\u2013control study included 12 patients with PSP and 12 patients with Parkinson\u2019s disease (PD). Automated volumetric analysis of 3-Tesla MRI was performed using volBrain 2.0. Blood-derived inflammatory indices included neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), systemic inflammation response index (SIRI), and red blood cell distribution with coefficient of variation (RDW-CV). Results: Patients with PSP showed significantly lower normalized superior frontal gyrus and pallidal volumes than patients with PD. Within the PSP group, higher values of selected blood-derived inflammatory indices were associated with lower frontal network volumes. After adjustment for age, MLR was inversely associated with the composite Frontal Network Score (partial r = \u22120.7333, p = 0.0067, FDR q = 0.020). The strongest regional association was observed between SIRI and medial frontal cortex volume (rho = \u22120.748, p = 0.0051); however, regional associations did not remain significant after FDR correction. Conclusions: Peripheral inflammatory markers were associated with MRI-derived measures of frontal network degeneration in PSP. The association between MLR and the composite Frontal Network Score supports a link between systemic immune alterations and network-level neurodegeneration in PSP.<\/jats:p>","DOI":"10.3390\/neurolint18090161","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T08:03:41Z","timestamp":1787558621000},"page":"161","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Associations Between Nonspecific Blood-Derived Inflammatory Indices and MRI-Derived Frontal Network Degeneration in Progressive Supranuclear Palsy"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8308-8121","authenticated-orcid":false,"given":"Bartosz","family":"Migda","sequence":"first","affiliation":[{"name":"Diagnostic Ultrasound Lab, Department of Pediatric Radiology, Medical University of Warsaw, 02-091\u00a0Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2202-9237","authenticated-orcid":false,"given":"Micha\u0142","family":"Kuty\u0142owski","sequence":"additional","affiliation":[{"name":"Department of Radiology, Mazovian Brodno Hospital, 03-242\u00a0Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8685-475X","authenticated-orcid":false,"given":"Natalia","family":"Madetko-Alster","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical University of Warsaw, 02-091 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8422-1454","authenticated-orcid":false,"given":"Anna","family":"Migda","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Warsaw, 02-091 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8592-1711","authenticated-orcid":false,"given":"Karol","family":"Kuty\u0142owski","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical University of Warsaw, 02-091 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5371-6817","authenticated-orcid":false,"given":"Piotr","family":"Alster","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical University of Warsaw, 02-091 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"4451","DOI":"10.1007\/s00415-023-11791-2","article-title":"The prevalence and incidence of progressive supranuclear palsy and corticobasal syndrome: A systematic review and meta-analysis","volume":"270","author":"Lyons","year":"2023","journal-title":"J. Neurol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1002\/mds.26987","article-title":"Clinical diagnosis of progressive supranuclear palsy: The movement disorder society criteria","volume":"32","author":"Hoglinger","year":"2017","journal-title":"Mov. Disord."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"fcae055","DOI":"10.1093\/braincomms\/fcae055","article-title":"Staging of progressive supranuclear palsy-Richardson syndrome using MRI brain charts for the human lifespan","volume":"6","author":"Planche","year":"2024","journal-title":"Brain Commun."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Alster, P., Madetko, N., Koziorowski, D., and Friedman, A. (2020). Microglial Activation and Inflammation as a Factor in the Pathogenesis of Progressive Supranuclear Palsy (PSP). Front. Neurosci., 14.","DOI":"10.3389\/fnins.2020.00893"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.ibneur.2024.04.008","article-title":"Progressive Supranuclear Palsy Syndrome: An Overview","volume":"16","year":"2024","journal-title":"IBRO Neurosci. Rep."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1136\/jnnp-2020-325549","article-title":"Neuroinflammation predicts disease progression in progressive supranuclear palsy","volume":"92","author":"Malpetti","year":"2021","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1093\/brain\/awaf078","article-title":"Post-mortem validation of in vivo TSPO PET as a microglial biomarker","volume":"148","author":"Wijesinghe","year":"2025","journal-title":"Brain"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1002\/mds.29924","article-title":"Neuroinflammation Parallels 18F-PI-2620 Positron Emission Tomography Patterns in Primary 4-Repeat Tauopathies","volume":"39","author":"Malpetti","year":"2024","journal-title":"Mov. Disord."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2650","DOI":"10.1093\/brain\/awaf135","article-title":"Midbrain cytotoxic T cells as a distinct neuropathological feature of progressive supranuclear palsy","volume":"148","author":"Couto","year":"2025","journal-title":"Brain"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"97","DOI":"10.5603\/PJNNS.a2020.0097","article-title":"Neutrophil-to-lymphocyte ratio (NLR) at boundaries of Progressive Supranuclear Palsy Syndrome (PSPS) and Corticobasal Syndrome (CBS)","volume":"55","author":"Alster","year":"2021","journal-title":"Neurol. Neurochir. Pol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1007\/s10072-019-04208-4","article-title":"The neutrophil-to-lymphocyte ratio as a marker of peripheral inflammation in progressive supranuclear palsy: A retrospective study","volume":"41","author":"Inci","year":"2020","journal-title":"Neurol. Sci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e16451","DOI":"10.1111\/ene.16451","article-title":"Peripheral immune profile and neutrophil-to-lymphocyte ratio in progressive supranuclear palsy: Case-control study and meta-analysis","volume":"31","author":"Zamora","year":"2024","journal-title":"Eur. J. Neurol."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Alagoz, A.N., Dagdas, A., Bunul, S.D., and Erci, G.C. (2025). The Relationship Between Systemic Inflammatory Index and Other Inflammatory Markers with Clinical Severity of the Disease in Patients with Parkinson\u2019s Disease. Biomedicines, 13.","DOI":"10.3390\/biomedicines13082029"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"105480","DOI":"10.1016\/j.parkreldis.2023.105480","article-title":"Neutrophil-to-lymphocyte ratio and lymphocyte count reflect alterations in central neurodegeneration-associated proteins and clinical severity in Parkinson Disease patients","volume":"112","author":"Grillo","year":"2023","journal-title":"Park. Relat. Disord."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Li, F., Wang, Z., Deng, M., Peng, J., He, G., Tong, Y., Xu, W., Feng, T., and Song, K. (2026). Correlation of systemic immune inflammation index and systemic inflammatory response index with the severity of Parkinson\u2019s disease. Front. Neurol., 17.","DOI":"10.3389\/fneur.2026.1736318"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Li, Y.M., Xu, X.H., Ren, L.N., Xu, X.F., Dai, Y.L., Yang, R.R., and Jin, C.Q. (2024). The diagnostic value of neutrophil to lymphocyte ratio, albumin to fibrinogen ratio, and lymphocyte to monocyte ratio in Parkinson\u2019s disease: A retrospective study. Front. Neurol., 15.","DOI":"10.3389\/fneur.2024.1450221"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Zhou, W., Zeng, T., Liu, D., Pang, R., and Gong, L. (2025). Association between inflammatory markers (SII and SIRI) and anxiety levels in Parkinson\u2019s disease. Front. Psychiatry, 16.","DOI":"10.3389\/fpsyt.2025.1635817"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1136\/jnnp-2017-316201","article-title":"Peripheral inflammatory markers in Alzheimer\u2019s disease: A systematic review and meta-analysis of 175 studies","volume":"88","author":"Lai","year":"2017","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.1007\/s00415-019-09400-2","article-title":"In vivo direct relation of tau pathology with neuroinflammation in early Alzheimer\u2019s disease","volume":"266","author":"Terada","year":"2019","journal-title":"J. Neurol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s13024-023-00627-2","article-title":"The role of peripheral inflammatory insults in Alzheimer\u2019s disease: A review and research roadmap","volume":"18","author":"Walker","year":"2023","journal-title":"Mol. Neurodegener."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e214434","DOI":"10.1212\/WNL.0000000000214434","article-title":"Patterns of Longitudinal Regional Brain Atrophy in Patients With Different Progressive Supranuclear Palsy Clinical Variants","volume":"105","author":"Kumar","year":"2025","journal-title":"Neurology"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.pscychresns.2011.07.013","article-title":"Morphometric analysis of subcortical structures in progressive supranuclear palsy: In vivo evidence of neostriatal and mesencephalic atrophy","volume":"194","author":"Looi","year":"2011","journal-title":"Psychiatry Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"103727","DOI":"10.1016\/j.nicl.2024.103727","article-title":"Functional connectivity abnormalities in clinical variants of progressive supranuclear palsy","volume":"45","author":"Sintini","year":"2025","journal-title":"NeuroImage Clin."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1002\/mds.29887","article-title":"Stepwise Functional Brain Architecture Correlates with Atrophy in Progressive Supranuclear Palsy","volume":"39","author":"Spinelli","year":"2024","journal-title":"Mov. Disord."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/s41582-021-00541-5","article-title":"Evolving concepts in progressive supranuclear palsy and other 4-repeat tauopathies","volume":"17","author":"Stamelou","year":"2021","journal-title":"Nat. Rev. Neurol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1002\/mds.26424","article-title":"MDS clinical diagnostic criteria for Parkinson\u2019s disease","volume":"30","author":"Postuma","year":"2015","journal-title":"Mov. Disord."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Manjon, J.V., Romero, J.E., Vivo-Hernando, R., Rubio, G., Aparici, F., de la Iglesia-Vaya, M., and Coupe, P. (2022). vol2Brain: A New Online Pipeline for Whole Brain MRI Analysis. Front. Neuroinform., 16.","DOI":"10.3389\/fninf.2022.862805"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"100781","DOI":"10.1016\/j.bbih.2024.100781","article-title":"Mapping pathways to neuronal atrophy in healthy, mid-aged adults: From chronic stress to systemic inflammation to neurodegeneration?","volume":"38","author":"Schaefer","year":"2024","journal-title":"Brain Behav. Immun.-Health"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Yi, H., Liang, X., Xu, F., Li, T., Yang, X., Wei, M., Ou, Z., Wang, L., and Tong, Q. (2024). Association between neutrophil-to-lymphocyte ratio and motor subtypes in idiopathic Parkinson\u2019s disease: A prospective observational study. BMC Neurol., 24.","DOI":"10.1186\/s12883-024-03887-7"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/s41531-023-00626-6","article-title":"Immunological shifts during early-stage Parkinson\u2019s disease identified with DNA methylation data on longitudinally collected blood samples","volume":"10","author":"Pike","year":"2024","journal-title":"npj Park. Dis."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"148","DOI":"10.5603\/PJNNS.a2022.0014","article-title":"Platelet-to-lymphocyte ratio and neutrophil-tolymphocyte ratio may reflect differences in PD and MSA-P neuroinflammation patterns","volume":"56","author":"Madetko","year":"2022","journal-title":"Neurol. Neurochir. Pol."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Markiewicz, M., Madetko-Alster, N., Otto-Slusarczyk, D., Duszynska-Was, K., Migda, B., Chunowski, P., Struga, M., and Alster, P. (2025). Possible Significance of Neutrophil-Hemoglobin Ratio in Differentiating Progressive Supranuclear Palsy from Depression: A Pilot Study. Diseases, 13.","DOI":"10.3390\/diseases13040119"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Yildiz, H., Atalay, B., and Ozdilek, B. (2026). Basal Ganglia and Thalamic Volumes as MRI Markers of Motor and Cognitive Dysfunction in Parkinson\u2019s Disease. R\u00f6Fo-Fortschritte Auf Dem Geb. Der Rontgenstrahlen Und Der Bild. Verfahr.","DOI":"10.1055\/a-2871-1475"}],"container-title":["Neurology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2035-8377\/18\/9\/161\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T08:38:59Z","timestamp":1787560739000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2035-8377\/18\/9\/161"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,24]]},"references-count":33,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["neurolint18090161"],"URL":"https:\/\/doi.org\/10.3390\/neurolint18090161","relation":{},"ISSN":["2035-8377"],"issn-type":[{"value":"2035-8377","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,24]]}}}