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Int.","Neurology International"],"abstract":"<jats:p>Background: The ingestion of polyunsaturated fatty acids is vital for brain health, supporting cognitive development and helping to prevent chronic diseases, including neurodegenerative processes. Objective: This study aimed to investigate the effects of corn oil on the biochemical and neurochemical parameters of Drosophila melanogaster expressing human amyloid precursor protein \u03b242 (APP-\u03b242). Methods: The flies were fed a diet supplemented with 37.8 mg\/mL of corn oil from the larval stage until adulthood. Results: A diet supplemented with corn oil induced significant changes in biochemical markers, such as a decrease in head cholesterol levels (p &lt; 0.001); decreased catalase activity and hydrogen peroxide levels in the heads (p &lt; 0.0001) and thoracic muscles (p &lt; 0.0001); reduced glutathione levels in the heads (p &lt; 0.0001) and muscles (p &lt; 0.01); and reduced formazan production (p &lt; 0.01) and citrate synthase (CS) activity (p &lt; 0.0001) in the head. However, in thoracic muscle, ingestion of corn oil led to an increase in formazan production (p &lt; 0.01) and no significant change in CS activity. Lactate levels decreased in the heads (p &lt; 0.0001) and thoraces (p &lt; 0.001) after flies were fed corn oil. Finally, ingestion of corn oil resulted in a significant rise in acetylcholinesterase activity in the heads (p &lt; 0.001) and thoracic muscles (p &lt; 0.01). Conclusions: These results suggest that consuming corn oil reduces the oxidative stress typical of an Alzheimer\u2019s disease model by enhancing antioxidant defenses.<\/jats:p>","DOI":"10.3390\/neurolint18090176","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T10:25:43Z","timestamp":1789986343000},"page":"176","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Corn Oil on Biochemical and Neurochemical Markers in an Animal Model of Alzheimer\u2019s Disease"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4564-4614","authenticated-orcid":false,"given":"Jadyellen Rondon","family":"Silva","sequence":"first","affiliation":[{"name":"Mitochondrial Metabolism and Neurotoxicology Laboratory, Department of Chemistry, Institute of Chemistry, Federal University of Mato Grosso, Cuiab\u00e1 79070-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"software","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"}]},{"given":"Maria Elisa Fonseca","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Mitochondrial Metabolism and Neurotoxicology Laboratory, Department of Chemistry, Institute of Chemistry, Federal University of Mato Grosso, Cuiab\u00e1 79070-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"software","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"}]},{"given":"Lira Kamila Palacios","family":"Campos","sequence":"additional","affiliation":[{"name":"Mitochondrial Metabolism and Neurotoxicology Laboratory, Department of Chemistry, Institute of Chemistry, Federal University of Mato Grosso, Cuiab\u00e1 79070-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos Jose","family":"Jacinto","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Institute of Chemistry, Federal University of Mato Grosso, Cuiab\u00e1 79070-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3067-380X","authenticated-orcid":false,"given":"Anderson Oliveira","family":"Souza","sequence":"additional","affiliation":[{"name":"Mitochondrial Metabolism and Neurotoxicology Laboratory, Department of Chemistry, Institute of Chemistry, Federal University of Mato Grosso, Cuiab\u00e1 79070-900, Brazil"},{"name":"Department of Chemistry, Institute of Chemistry, Federal University of Mato Grosso, Cuiab\u00e1 79070-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"},{"role":"conceptualization","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0140-6736(20)30367-6","article-title":"Dementia prevention, intervention, and care: 2020 report of the Lancet Commission","volume":"396","author":"Livingston","year":"2020","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"5481","DOI":"10.1038\/s41380-021-01249-0","article-title":"The Amyloid-\u03b2 Pathway in Alzheimer\u2019s Disease","volume":"26","author":"Hampel","year":"2021","journal-title":"Mol. 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