{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T18:12:46Z","timestamp":1770747166749,"version":"3.49.0"},"reference-count":59,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T00:00:00Z","timestamp":1653955200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NeuroSci"],"abstract":"<jats:p>Aim: The present study investigated the differences between the Panic Disorder (PD) patients groups\u2019 and healthy controls for the EEG alpha dynamics under the frontal cortex and reaction time during the oddball task. Material and Methods: The reaction time during the oddball paradigm concomitant to EEG alpha power was tested in nine PD patients and ten healthy controls before and after a computer simulation presentation. Results: The findings revealed a decrease in EEG alpha power in PD patients concerning the control group (p \u2264 0.0125). However, both groups demonstrated an increased cortical oscillation after the computer simulation, except for the Fp1 electrode during M3 moment in the experimental group. The experimental group has a fast reaction time compared to healthy individuals during the oddball task (p = 0.002). Conclusions: We propose that the decrease in EEG alpha power in the PD patients may indicate an increase in processing related to an anxiogenic stimulus and interference of the anxiety state that compromises the inhibitory control. The reaction time task reveals cognitive symptoms in the experimental group, which may be related to the faster reactivity and high impulsivity to stimuli.<\/jats:p>","DOI":"10.3390\/neurosci3020024","type":"journal-article","created":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T05:25:42Z","timestamp":1653974742000},"page":"332-346","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Computer Simulation for Triggering Anxiety in Panic Disorder Patients Modulates the EEG Alpha Power during an Oddball Task"],"prefix":"10.3390","volume":"3","author":[{"given":"Luiza Di Giorgio","family":"Silva","sequence":"first","affiliation":[{"name":"Neurophysiology and Neuropsychology of Attention Laboratory, Institute of Psychiatry, Federal University of Rio de Janeiro, Rio de Janeiro 22290-140, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5970-3497","authenticated-orcid":false,"given":"Danielle","family":"Aprigio","sequence":"additional","affiliation":[{"name":"Neurophysiology and Neuropsychology of Attention Laboratory, Institute of Psychiatry, Federal University of Rio de Janeiro, Rio de Janeiro 22290-140, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4800-7298","authenticated-orcid":false,"given":"Victor","family":"Marinho","sequence":"additional","affiliation":[{"name":"Neuro-Innovation Technology & Brain Mapping Laboratory, Federal University of Delta do Parna\u00edba, Parna\u00edba 64202-020, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9240-1228","authenticated-orcid":false,"given":"Silmar","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Neuro-Innovation Technology & Brain Mapping Laboratory, Federal University of Delta do Parna\u00edba, Parna\u00edba 64202-020, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesse","family":"Di Giacomo","sequence":"additional","affiliation":[{"name":"Brain Mapping and Sensory Motor Integration Laboratory, Institute of Psychiatry, Federal University of Rio de Janeiro, Rio de Janeiro 22290-140, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana","family":"Gongora","sequence":"additional","affiliation":[{"name":"Neurophysiology and Neuropsychology of Attention Laboratory, Institute of Psychiatry, Federal University of Rio de Janeiro, Rio de Janeiro 22290-140, Brazil"},{"name":"Brain Mapping and Sensory Motor Integration Laboratory, Institute of Psychiatry, Federal University of Rio de Janeiro, Rio de Janeiro 22290-140, Brazil"},{"name":"Institute of Applied Neuroscience, Rio de Janeiro 22290-140, 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