{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T01:44:13Z","timestamp":1789436653782,"version":"build-2803163510"},"reference-count":161,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2024,10,12]],"date-time":"2024-10-12T00:00:00Z","timestamp":1728691200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NeuroSci"],"abstract":"<jats:p>Brain radiation is a crucial tool in neuro-oncology for enhancing local tumor control, but it can lead to mild-to-profound and progressive impairments in cognitive function. Radiation-induced brain injury is a significant adverse effect of radiotherapy for cranioencephalic tumors, primarily caused by indirect cellular damage through the formation of free radicals. This results in late neurotoxicity manifesting as cognitive impairment due to free radical production. The aim of this review is to highlight the role of different substances, such as drugs used in the clinical setting and antioxidants such as ascorbate, in reducing the neurotoxicity associated with radiation-induced brain injury. Currently, there is mainly preclinical and clinical evidence supporting the benefit of these interventions, representing a cost-effective and straightforward neuroprotective strategy.<\/jats:p>","DOI":"10.3390\/neurosci5040034","type":"journal-article","created":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T09:14:03Z","timestamp":1729156443000},"page":"462-484","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Exploring Neuroprotection against Radiation-Induced Brain Injury: A Review of Key Compounds"],"prefix":"10.3390","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0983-236X","authenticated-orcid":false,"given":"Lucas","family":"Gonz\u00e1lez-Johnson","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Universidad de Chile, Santiago 8330111, Chile"},{"name":"University of Chile Clinical Hospital, Santiago 8380453, Chile"},{"name":"Biomedical Neuroscience Institute (BNI), Faculty of Medicine, Universidad de Chile, Santiago 8330111, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariel","family":"Fari\u00f1a","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Arturo L\u00f3pez P\u00e9rez, Santiago 7500921, Chile"},{"name":"Faculty of Medicine, Universidad de los Andes, Santiago 12455, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7979-8398","authenticated-orcid":false,"given":"Gonzalo","family":"Far\u00edas","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Universidad de Chile, Santiago 8330111, Chile"},{"name":"University of Chile Clinical Hospital, Santiago 8380453, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Zomosa","sequence":"additional","affiliation":[{"name":"University of Chile Clinical Hospital, Santiago 8380453, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8308-1624","authenticated-orcid":false,"given":"V\u00edctor","family":"Pinilla-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Universidad de Chile, Santiago 8330111, Chile"},{"name":"Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago 8330111, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6565-297X","authenticated-orcid":false,"given":"Catalina","family":"Rojas-Sol\u00e9","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Universidad de Chile, Santiago 8330111, Chile"},{"name":"Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago 8330111, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.hoc.2021.08.006","article-title":"Update on Radiation Therapy for Central Nervous System Tumors","volume":"36","author":"Rahman","year":"2022","journal-title":"Hematol. 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