{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T10:14:58Z","timestamp":1775211298768,"version":"3.50.1"},"reference-count":45,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T00:00:00Z","timestamp":1730764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000057","name":"NIH","doi-asserted-by":"publisher","award":["T32GM152342"],"award-info":[{"award-number":["T32GM152342"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"NIH","doi-asserted-by":"publisher","award":["F30MH136802"],"award-info":[{"award-number":["F30MH136802"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NeuroSci"],"abstract":"<jats:p>Essential tremor (ET) is a prevalent movement disorder characterized by action tremors, predominantly affecting the upper limbs. While various pharmacological and non-pharmacological interventions have shown efficacy in managing ET, the therapeutic role of repetitive transcranial magnetic stimulation (rTMS) remains uncertain. This systematic review synthesizes evidence from clinical trials investigating rTMS as a treatment for ET. Despite some open-label trials reporting reductions in tremor severity, double-blinded studies revealed no significant difference between active and sham rTMS, suggesting a strong placebo effect. The findings indicate that while rTMS can reduce tremor scores, its therapeutic efficacy in ET remains unproven. Future research should focus on improving sham designs and conducting larger, rigorously controlled trials to clarify rTMS\u2019s role in ET management. Current evidence supports considering alternative treatments, such as deep brain stimulation, over rTMS for ET.<\/jats:p>","DOI":"10.3390\/neurosci5040038","type":"journal-article","created":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T11:36:39Z","timestamp":1730806599000},"page":"523-533","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Limited Potential of Repetitive Transcranial Magnetic Stimulation for Treatment of Essential Tremor: A Systematic Review"],"prefix":"10.3390","volume":"5","author":[{"given":"Andrew A. E. D.","family":"Bishay","sequence":"first","affiliation":[{"name":"Physiological Sciences Interdepartmental Program, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA"},{"name":"Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1218-2912","authenticated-orcid":false,"given":"Anton","family":"Guo","sequence":"additional","affiliation":[{"name":"Physiological Sciences Interdepartmental Program, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rhea","family":"Desai","sequence":"additional","affiliation":[{"name":"Physiological Sciences Interdepartmental Program, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel","family":"Mushinski","sequence":"additional","affiliation":[{"name":"Physiological Sciences Interdepartmental Program, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3247-0453","authenticated-orcid":false,"given":"Andy","family":"Au","sequence":"additional","affiliation":[{"name":"Neuroscience Undergraduate Interdepartmental Program, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew J.","family":"Swenson","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA"},{"name":"Weill Cornell Medical College, Cornell University, New York, NY 10065, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0035-5413","authenticated-orcid":false,"given":"Marco","family":"Iacoboni","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Bystritsky","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2386-2987","authenticated-orcid":false,"given":"Norman M.","family":"Spivak","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA"},{"name":"Department of Neurosurgery, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA"},{"name":"UCLA-Caltech Medical Scientist Training Program, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,5]]},"reference":[{"key":"ref_1","unstructured":"Cleveland Clinic (2024, April 12). 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