{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T10:01:37Z","timestamp":1787738497945,"version":"build-2784847793"},"reference-count":72,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T00:00:00Z","timestamp":1759017600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.mdpi.com"],"crossmark-restriction":true},"short-container-title":["NeuroSci"],"abstract":"<jats:p>Background: The consequences of median nerve compression at the carpal tunnel level require a precise diagnostic evaluation before a frequently applied surgical intervention. Positive Tinel or Phalen signs are not always related to abnormal results in electroneurographic examinations of sensory and motor nerve fibers, which are intended to confirm final diagnoses, thereby confusing both surgeons and neurophysiologists. In the face of contradictory data, this study aims to reinvestigate these correlations in a randomly chosen population of patients with a primary diagnosis of carpal tunnel syndrome (CTS). Methods: Seventy-five randomly chosen patients with clinically detected CTS underwent neurophysiological studies of median nerve sensory (SNAP) and motor (CMAP) fibers conduction at the wrist. Both the median and ulnar nerves were assessed to reduce the risk of misinterpretation related to anatomical variations. Results: This study provides evidence on the relatively high utility of Phalen\u2019s test in the early clinical detection of CTS within a general population of patients, whose positive results moderately correlate (rho = \u22120.327) with abnormalities in amplitudes rather than the distal latency parameters of SNAP recordings. The axonal injury type is more distinct than slowing-down impulses at the wrist following compression of the sensory nerve fibers in the early course of CTS. Positive Tinel\u2019s test results are useful in diagnosing CTS patients with advanced axonal and demyelinating changes in the motor fibers at the wrist, which weakly correlate with prolonged latency and decreased amplitude in SNAP recordings (rho = \u22120.214 and rho = \u22120.235, respectively), but not with abnormalities in recordings of both amplitudes and latencies in CMAP electroneurography. Conclusions: The correlations between clinical signs and neurophysiological findings in CTS indicate that provocative tests, such as Phalen\u2019s and Tinel\u2019s, have limited diagnostic value, demonstrating only weak-to-moderate associations with neural conduction parameters. A positive Tinel\u2019s sign should be regarded mainly as a marker of severe or chronic sensory impairment, often accompanied by motor fibers involvement in advanced pathological stages, rather than as an indicator of motor damage alone. Nerve conduction studies remain essential for confirming CTS, assessing its severity, and guiding treatment decisions, including surgical qualification. The presented correlation of clinical and functional neurophysiological results in CTS diagnosis allows us not only to specify the source and severity of the pathology of the median nerve fibers but also may influence the personalization of physiotherapeutic and surgical treatments.<\/jats:p>","DOI":"10.3390\/neurosci6040094","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T10:54:48Z","timestamp":1759229688000},"page":"94","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Correlations of Tinel and Phalen Signs with Nerve Conduction Study Test Results in a Randomly Chosen Population of Patients with Carpal Tunnel Syndrome"],"prefix":"10.3390","volume":"6","author":[{"given":"Katarzyna","family":"Kaczmarek","sequence":"first","affiliation":[{"name":"Department of Pathophysiology of Locomotor Organs, Pozna\u0144 University of Medical Sciences, 28 Czerwca 1956 No 135\/147, 61-545 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9995-5090","authenticated-orcid":false,"given":"J\u0119drzej","family":"Pepli\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology of Locomotor Organs, Pozna\u0144 University of Medical Sciences, 28 Czerwca 1956 No 135\/147, 61-545 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1521-2315","authenticated-orcid":false,"given":"Anna","family":"Kaczmarek","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Warsaw University of Medical Sciences, \u017bwirki i Wigury 101, 02-089 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5404-4359","authenticated-orcid":false,"given":"Dariusz","family":"Andrzejuk","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Warsaw University of Medical Sciences, \u017bwirki i Wigury 101, 02-089 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2514-9440","authenticated-orcid":false,"given":"Kacper","family":"Andruszkiewicz","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology of Locomotor Organs, Pozna\u0144 University of Medical Sciences, 28 Czerwca 1956 No 135\/147, 61-545 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6810-1110","authenticated-orcid":false,"given":"Alicja","family":"Wysocka","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology of Locomotor Organs, Pozna\u0144 University of Medical Sciences, 28 Czerwca 1956 No 135\/147, 61-545 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matylda","family":"Witkowska","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology of Locomotor Organs, Pozna\u0144 University of Medical Sciences, 28 Czerwca 1956 No 135\/147, 61-545 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8671-0497","authenticated-orcid":false,"given":"Juliusz","family":"Huber","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology of Locomotor Organs, Pozna\u0144 University of Medical Sciences, 28 Czerwca 1956 No 135\/147, 61-545 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1016\/S1474-4422(16)30231-9","article-title":"Carpal tunnel syndrome: Clinical features, diagnosis, and management","volume":"15","author":"Padua","year":"2016","journal-title":"Lancet Neurol."},{"key":"ref_2","first-page":"e7333","article-title":"Carpal Tunnel Syndrome: A Review of Literature","volume":"12","author":"Genova","year":"2020","journal-title":"Cureus"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"262","DOI":"10.3399\/bjgp14X679903","article-title":"Diagnosing and managing carpal tunnel syndrome in primary care","volume":"64","author":"Burton","year":"2014","journal-title":"Br. 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