{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T14:00:39Z","timestamp":1764597639904,"version":"3.46.0"},"reference-count":88,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Spanish Ministry of Economy and Competitiveness","award":["PSI2013-43594-R"],"award-info":[{"award-number":["PSI2013-43594-R"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NeuroSci"],"abstract":"<jats:p>Several recent studies have utilized neuroimaging to delineate the localization and function of brain regions involved in language. However, many uncertainties persist regarding the organization of the linguistic system in the human brain. The aim of the present study was to characterize the structural changes produced in a sample of 9 patients with post-stroke aphasia (4 women; mean age = 60 years, SD = 14.86) and their relationship with performance in the entire Boston Diagnostic Aphasia Examination (BDAE). Magnetic Resonance Imaging was acquired from the brain of each patient and brain lesions were assessed. Disconnection\u2019s severity of each white matter tract by embedding the lesion into the streamline tractography atlas of the Human Connectome Project was analyzed, and grey matter lesion load using a 7-Network Cortical parcellation template was estimated, with additional subcortical, cerebellar and brainstem parcels. Finally, all data obtained was correlated with performance in the BDAE. Somatomotor network correlated with repetition scale. The disconnection of the left acoustic radiation and inferior longitudinal fasciculus correlated with repetition sub-scale. Finally, the left U-fibers correlated with severity (a BDAE sub-scale that assesses the patient\u2019s communicative skills), conversational speech and reading sub-scales. These findings emphasized that the disconnection of these fronto-parieto-temporal structures correlate with deficits in repetition, beyond the classical hypothesis attributing such deficits solely to the impairment of the arcuate fasciculus.<\/jats:p>","DOI":"10.3390\/neurosci6040122","type":"journal-article","created":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T13:03:02Z","timestamp":1764594182000},"page":"122","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Relationship Between Brain Lesions in Patients with Post-Stroke Aphasia and Their Performance in Neuropsychological Language Assessment"],"prefix":"10.3390","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8366-6606","authenticated-orcid":false,"given":"Jorge","family":"Romero-Castillo","sequence":"first","affiliation":[{"name":"Department of Psychobiology and Behavioral Sciences Methodology, Universidad de M\u00e1laga, 29010 M\u00e1laga, Spain"},{"name":"Unit of Cognitive Neuroscience and Aphasia (UNCA), Centro de Investigaciones M\u00e9dico-Sanitarias (CIMES), Universidad de M\u00e1laga, 29010 M\u00e1laga, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel \u00c1ngel","family":"Rivas-Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Area of Developmental and Educational Psychology, Department of Psychology, Sociology and Philosophy, University of Le\u00f3n, 24071 Le\u00f3n, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5528-3093","authenticated-orcid":false,"given":"Benxam\u00edn","family":"Varela-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Department of Clinical Psychology and Psychobiology, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain"},{"name":"Applied Cognitive Neuroscience and Psychogerontology Research Group, Institute of Psychology, USC (IPsiUS), 15782 Santiago de Compostela, Spain"},{"name":"Cognitive Neuroscience Research Group, Health Research Institute of Santiago de Compostela (IDIS), 15706 Santiago de Compostela, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9739-4266","authenticated-orcid":false,"given":"Susana","family":"Cid-Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Applied Cognitive Neuroscience and Psychogerontology Research Group, Institute of Psychology, USC (IPsiUS), 15782 Santiago de Compostela, Spain"},{"name":"Cognitive Neuroscience Research Group, Health Research Institute of Santiago de Compostela (IDIS), 15706 Santiago de Compostela, Spain"},{"name":"Department of Developmental and Educational Psychology, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5242-3203","authenticated-orcid":false,"given":"Santiago","family":"Galdo-\u00c1lvarez","sequence":"additional","affiliation":[{"name":"Department of Clinical Psychology and Psychobiology, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain"},{"name":"Applied Cognitive Neuroscience and Psychogerontology Research Group, Institute of Psychology, USC (IPsiUS), 15782 Santiago de Compostela, Spain"},{"name":"Cognitive Neuroscience Research Group, Health Research Institute of Santiago de Compostela (IDIS), 15706 Santiago de Compostela, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"163","DOI":"10.2165\/00002512-200522020-00006","article-title":"Poststroke Aphasia","volume":"22","author":"Berthier","year":"2005","journal-title":"Drugs Aging"},{"key":"ref_2","unstructured":"Ardila, A. 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