{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T17:24:05Z","timestamp":1770225845297,"version":"3.49.0"},"reference-count":31,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Consejo Nacional de Ciencia y Tecnolog\u00eda (CONACYT), M\u00e9xico"},{"DOI":"10.13039\/100012047","name":"Marcos Moshinsky Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100012047","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NeuroSci"],"abstract":"<jats:p>Monosynaptic reflexes (MSRs) elicited by constant-intensity group I afferent stimulation exhibit marked amplitude variability, commonly attributed to stochastic presynaptic modulation and dynamic postsynaptic excitability. Here, we tested whether this variability could be attenuated using the Ott\u2013Grebogi\u2013Yorke (OGY) chaos\u2013control algorithm, which stabilizes unstable periodic orbits in low-dimensional nonlinear systems. In spinalized, anesthetized cats, real-time implementation of the OGY method failed to reduce MSR amplitude variability, as quantified by the coefficient of variation, and the return map structure showed no evidence of orbit stabilization. These negative results contrast with successful applications of OGY control in physical systems, cardiac tissue, hippocampal slices, and stochastic neuronal models. We interpret this failure in the context of the intense, ongoing synaptic bombardment characteristic of dorsal horn circuitry, which likely obscures or destroys the low-dimensional geometric structure required for OGY-based control. Our findings delineate a fundamental limit to classical chaos\u2013control algorithms in intact neural circuits and highlight the need for control strategies explicitly robust to high dimensionality and physiological noise.<\/jats:p>","DOI":"10.3390\/neurosci7010018","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T12:00:47Z","timestamp":1770033647000},"page":"18","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Noise-Limited Failure of OGY Chaos Control in Regulating Monosynaptic Reflex Variability in the In Vivo Cat Spinal Cord"],"prefix":"10.3390","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3277-0101","authenticated-orcid":false,"given":"Elias","family":"Manjarrez","sequence":"first","affiliation":[{"name":"Instituto de Fisiolog\u00eda, Benem\u00e9rita Universidad Aut\u00f3noma de Puebla, 14 Sur 6301, Col. San Manuel, Apartado Postal 406, Puebla 72570, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignacio","family":"M\u00e9ndez-Balbuena","sequence":"additional","affiliation":[{"name":"Facultad de Psicolog\u00eda, Benem\u00e9rita Universidad Aut\u00f3noma de Puebla, 3 Oriente 1413, Barrio de Analco, Puebla 72500, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saul M.","family":"Dominguez-Nicolas","sequence":"additional","affiliation":[{"name":"Centro de Micro y Nanotecnolog\u00eda, Universidad Veracruzana, Calzada Ruiz Cortines 455, Veracruz 94294, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9982-7571","authenticated-orcid":false,"given":"Oscar","family":"Arias-Carri\u00f3n","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n de Neurociencias, Cl\u00ednica, Instituto Nacional de Rehabilitaci\u00f3n Luis Guillermo Ibarra Ibarra, Mexico City 14389, Mexico"},{"name":"Escuela de Medicina y Ciencias de la Salud, Tecnol\u00f3gico de Monterrey, Mexico City 14380, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.tins.2022.08.007","article-title":"How critical is brain criticality?","volume":"45","author":"Jerbi","year":"2022","journal-title":"Trends Neurosci."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1103\/PhysRevLett.64.1196","article-title":"Controlling chaos","volume":"64","author":"Ott","year":"1990","journal-title":"Phys. Rev. Lett."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"3211","DOI":"10.1103\/PhysRevLett.65.3211","article-title":"Experimental control of chaos","volume":"65","author":"Ditto","year":"1990","journal-title":"Phys. Rev. Lett."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.chaos.2004.12.034","article-title":"Controlling the chaos using fuzzy estimation of OGY and Pyragas controllers","volume":"26","author":"Alasty","year":"2005","journal-title":"Chaos Solitons Fractals"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1126\/science.1519060","article-title":"Controlling cardiac chaos","volume":"257","author":"Garfinkel","year":"1992","journal-title":"Science"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1038\/370615a0","article-title":"Controlling chaos in the brain","volume":"370","author":"Schiff","year":"1994","journal-title":"Nature"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2782","DOI":"10.1103\/PhysRevLett.75.2782","article-title":"Controlling nonchaotic neuronal noise using chaos control techniques","volume":"75","author":"Christini","year":"1995","journal-title":"Phys. Rev. Lett."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"035254","DOI":"10.1088\/1402-4896\/ad2ad0","article-title":"Mechanistic insights of COVID-19 dynamics by considering the influence of neurodegeneration and memory trace","volume":"99","author":"Joshi","year":"2024","journal-title":"Phys. Scr."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"063113","DOI":"10.1063\/5.0203886","article-title":"Chaos and bifurcations of a two-dimensional hepatitis C virus model with hepatocyte homeostasis","volume":"34","author":"Khan","year":"2024","journal-title":"Chaos Interdiscip. J. Nonlinear Sci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"16118","DOI":"10.1038\/s41598-024-62439-8","article-title":"Exploring chaos and bifurcation in a discrete prey-predator based on coupled logistic map","volume":"14","author":"Elsadany","year":"2024","journal-title":"Sci. Rep."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"033106","DOI":"10.1063\/5.0248855","article-title":"Complex dynamics of a discrete prey-predator model with complex network and stochastic modeling incorporating a ratio-dependent Ivlev functional response","volume":"35","author":"Fahim","year":"2025","journal-title":"Chaos Interdiscip. J. Nonlinear Sci."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Mutakabbir Khan, M., and Jasim Uddin, M. (2025). Complexity analysis with chaos control: A discretized ratio-dependent Holling-Tanner predator-prey model with Fear effect in prey population. PLoS ONE, 20.","DOI":"10.1371\/journal.pone.0324299"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"32940","DOI":"10.1038\/s41598-025-04333-5","article-title":"Chaos and bifurcations of a discretized Holling-II prey-predator model including prey refuge and Allee effect","volume":"15","author":"Khan","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/S0006-3495(94)80526-0","article-title":"Stochastic versus deterministic variability in simple neuronal circuits: I. Monosynaptic spinal cord reflexes","volume":"67","author":"Chang","year":"1994","journal-title":"Biophys. J."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1152\/jn.1969.32.2.140","article-title":"Effects of conditioning afferent volleys on variability of monosynaptic responses of extensor motoneurons","volume":"32","author":"Rudomin","year":"1969","journal-title":"J. Neurophysiol."},{"key":"ref_16","first-page":"402","article-title":"Fractal correlation in human H-reflex","volume":"105","author":"Nozaki","year":"1995","journal-title":"Exp. Brain Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1007\/BF00227184","article-title":"Supraspinal effects on the fractal correlation in human H-reflex","volume":"112","author":"Nozaki","year":"1996","journal-title":"Exp. Brain Res."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Ceballos-Villegas, M.E., Salda\u00f1a Mena, J.J., Gutierrez Lozano, A.L., Sep\u00falveda-Ca\u00f1amar, F.J., Huidobro, N., Manjarrez, E., and Lomeli, J. (2017). The Complexity of H-wave Amplitude Fluctuations and Their Bilateral Cross-Covariance Are Modified According to the Previous Fitness History of Young Subjects under Track Training. Front. Hum. Neurosci., 11.","DOI":"10.3389\/fnhum.2017.00530"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"136264","DOI":"10.1016\/j.neulet.2021.136264","article-title":"Cross-correlated fractal components of H-wave amplitude fluctuations in medial gastrocnemius and soleus muscles","volume":"765","author":"Taki","year":"2021","journal-title":"Neurosci. Lett."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1111\/j.1469-7793.2000.00445.x","article-title":"Modulation of synaptic transmission from segmental afferents by spontaneous activity of dorsal horn spinal neurones in the cat","volume":"529","author":"Manjarrez","year":"2000","journal-title":"J. Physiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1152\/jn.1994.72.3.1227","article-title":"Fluctuations of excitability in the monosynaptic reflex pathway to lumbar motoneurons in the cat","volume":"72","author":"Gossard","year":"1994","journal-title":"J. Neurophysiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"eabb3989","DOI":"10.1126\/sciadv.abb3989","article-title":"Designing spontaneous behavioral switching via chaotic itinerancy","volume":"6","author":"Inoue","year":"2020","journal-title":"Sci. Adv."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Engelken, R., Ingrosso, A., Khajeh, R., Goedeke, S., and Abbott, L.F. (2022). Input correlations impede suppression of chaos and learning in balanced firing-rate networks. PLoS Comput. Biol., 18.","DOI":"10.1371\/journal.pcbi.1010590"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"4204","DOI":"10.1039\/D3SM00171G","article-title":"Physics of smart active matter: Integrating active matter and control to gain insights into living systems","volume":"19","author":"Levine","year":"2023","journal-title":"Soft Matter"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/0375-9601(92)90745-8","article-title":"Continuous control of chaos by self-controlling feedback","volume":"170","author":"Pyragas","year":"1992","journal-title":"Phys. Lett. A"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"3479","DOI":"10.1103\/PhysRevLett.69.3479","article-title":"Controlling chaos in high dimensional systems","volume":"69","author":"Auerbach","year":"1992","journal-title":"Phys. Rev. Lett."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"036203","DOI":"10.1103\/PhysRevE.67.036203","article-title":"Control of chaos by occasional bang-bang","volume":"67","author":"Starrett","year":"2003","journal-title":"Phys. Rev. E"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"063107","DOI":"10.1063\/5.0274411","article-title":"Elevated EEG fractal dimension in Parkinson\u2019s during timing tasks","volume":"35","author":"Davoodi","year":"2025","journal-title":"Chaos Interdiscip. J. Nonlinear Sci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0370-1573(99)00096-4","article-title":"The control of chaos: Theory and applications","volume":"329","author":"Boccaletti","year":"2000","journal-title":"Phys. Rep."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.chaos.2009.02.009","article-title":"Chaos control using an adaptive fuzzy sliding mode controller with application to a nonlinear pendulum","volume":"42","author":"Bessa","year":"2009","journal-title":"Chaos Solit. Fractals"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"134915","DOI":"10.1016\/j.physd.2025.134915","article-title":"KAN-enhanced deep reinforcement learning for chaos control: Achieving rapid stabilization via minor perturbations","volume":"482","author":"Liu","year":"2025","journal-title":"Phys. D Nonlinear Phenom."}],"container-title":["NeuroSci"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2673-4087\/7\/1\/18\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T05:25:51Z","timestamp":1770182751000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2673-4087\/7\/1\/18"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,2]]},"references-count":31,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,2]]}},"alternative-id":["neurosci7010018"],"URL":"https:\/\/doi.org\/10.3390\/neurosci7010018","relation":{},"ISSN":["2673-4087"],"issn-type":[{"value":"2673-4087","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,2]]}}}